In order for proliferation and differentiation of B-cells, as well as
antibody production to occur, a specific B-cell must come into contact
with a specific CD4+8- helper T-cell. This most often occurs in the
spleen. By what mechanism do the two cells "home in on" one another?
How do these two cells who are specific for one another, find
each other amongst all the cells in the spleen?...
One though I had was that they release a chemical signal, thus leaving a
trail for one another, but that would mean an unbelievable amount of
trails that were specific only for one other cell. I performed
literature searches for an answer, but came up with nothing. If anyone
has any thoughs, comments, or suggestions as to where I can fid an answer
to this question, it would be appreciated. Thanks, John Alessi, senior
biology student at Canisius College, Buffalo