In article <33A12771.5B09 at liverpool.ac.uk>,
Bernadette Brooks <ptbmb at liverpool.ac.uk> wrote:
>Can anyone tell me if there is an antibody available to CLIP ?
>Thanks
There are two antibodies that I know of which recognize human CLIP:
CerCLIP (Peter Cresswell, Yale) detects CLIP free or bound to MHC Class II,
but not whole Ii.
30-2 (Alexander Rudensky, UWash - Seattle) detects CLIP only in the context
of the murine A(b) molecule. There is some cross-reactivity with murine
CLIP, and it can also detect some of the larger Ii fragments (SLIP, LIP)
bound to A(b).
As far as I know, there is no monoclonal specifically against mouse CLIP,
although the epitope for P4H5 overlaps with CLIP (P4H5 can detect whole Ii,
but not CLIP-deleted fragments). I believe P4H5 is available from ATCC.
Hope that helps,
Ken Frauwirth
--
Ken Frauwirth (MiSTie #33025) _ _
frauwirt at mendel.berkeley.edu |_) * |/ (_ |\ |
http://www.ocf.berkeley.edu/~frauwirt/ |_) | () |\ (_ | \|
DNRC Title: Chairman of Joint Commission on In-duh-vidual Affairs
