IUBio

Pre-CTLs (fwd)

Dave Peritt peritt at mail.med.upenn.edu
Wed May 21 09:06:52 EST 1997


In article <Pine.SOL.3.91.970507120516.8616B-100000 at gort.canisius.edu>
Darren J Forcier, forcierd at GORT.CANISIUS.EDU writes:
>Pre-CTL cells are cells that have already been committed to the CTL cell 
>line.  However, they do not yet have cytolytic capabilities.  I'm 
>wondering what the signal is for them to be fully differentiated and 
>fully functionable.  I think that the explonation is probably the 
>immunology catch-all "cytokine interaction," but if so, does anyone know 
>what kind of cytokines and from what kind of T cells they come from?


If by CTL you mean CD8+CD3+ T cell and by pre-CTL you mean naive CD8 T
cell than my question to you is:  What is the signal for a naive CD4 T
cell???



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