Justin Fonte wrote:
>> Mary Kaye Zasada <marykaye at hooked.net> wrote in article
> <338D198F.16E4 at hooked.net>...
> > I am wondering what the difference is between Autoimmune Demyelination &
> > MS? This is very very important please any one who can help!
> >
> > Thank you
>> Autoimmune demyelination is one of the proposed mechanisms of MS. Many
> authors list MS as an auoimmune disease due to the presence of immune
> T-cells in the CNS of patients. Not all MS'ers, however, have antibodies
> to CNS bits. The T-cells are responsible for much of the damage in the CNS
> as well as the products of other immune-type cells (free radicals etc.)
[edit]
Great response, Justin!
I don't think that a lack of demonstrable antibodies precludes
an immunological mechanism of CNS and peripheral destruction.
I think the time has come for empirical treatment, and patiently
wait for the molecular biology and immunology to catch up.
I am consulting on this interesting case and will keep you
appraised of progress. It is not unlike the pathogenesis
we see in AIDS, silicone implant disease, diabetes,
arthritis, psoriasis, etc. The fundamental
gammaglutamyltransferase enzyme system is being ying-yanged
by foreign molecules or proteins, or endogenous proteins
that have lost "self" character sufficiently to upset the
elegant and efficient immunological system of biofeedback.
Keep a good thought. We're working on it.
Good luck and good hunting,
Charlie
Charles P. McCarthy, Clinical Specialist
Healthcare Consulting and
Medical Research
Carmichael, CA USA
"Life is a membrane that reproduces."
Pandoc
