Hi all,
I was reading an immunology book about the sensitivity of Haemopoietic
/immune cells to steroids, so I did a BIDS and a Medline search for
Cyto. P450's and haemopoeisis and Lymphopoiesis and drew a blank with
both.
However I know that a Cyto.P450 is expressed in CNS glial cells, that is
specific for pregnolone and has DHEA activity. Anybody know if any of
the steroid dehydrogenases/MFO etc are expressed in adult NK,
Macrophages lymphocytes, neutrophils or erthrocytes. Even in the bone
marrow would be useful.
Some references would go down a treat as there must be something out
there.
regards
Christopher Hatton
Immunotoxicology
University of Leicester
UK.