IUBio

Any refs. for MFO/Cyt. P450's in circulating cells.

Dansette Patrick dansette at citi2.fr
Fri Jan 23 10:29:35 EST 1998


In article <6a50d0$p1r at falcon.le.ac.uk>, "as above at le.ac.uk" <> wrote:

> Hi all,
> 
> I was reading an immunology book about the sensitivity of Haemopoietic
> /immune cells to steroids, so I did a BIDS and a Medline search for
> Cyto. P450's and haemopoeisis and Lymphopoiesis and drew a blank with
> both.
> 
> However I know that a Cyto.P450 is expressed in CNS glial cells, that is
> specific for pregnolone and has DHEA activity.  Anybody know if any of
> the steroid dehydrogenases/MFO etc are expressed in adult NK,
> Macrophages lymphocytes, neutrophils or erthrocytes. Even in the bone
> marrow would be useful.
> 
> Some references would go down a treat as there must be something out
> there.
> 
> In my reference file I could only find one relevant?? reference:

Lutton, J. D., Levere, R. D., Abraham, N. G. (1991), Physiologic Role of
Heme and Cytochrome-P-450 in Hematopoietic Cells, Proceedings of the
Society for Experimental Biology and Medicine , 196: 260-269.

Patrick Dansette



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