Andrew S. Louka wrote:
>> At 01:41 +0100 30-06-98, Robin Barclay wrote:
>> > They (the normally "non-pathogenic") become pathogenic when they (or their
> > products) translocate across the gut wall - e.g. endotoxins in septic shock
>> But my point is, how does the immune system recognise what should be seen
> as non-self (or danger), and what should not. Translocation of endotoxins
> across the gut wall is well documented and easy to understand, but I am
> more interested in how milk proteins, for example, are not regarded as a
> serious threat in a newborn child, despite the overwhelming quantities
> that are consumed. The milk proteins could not have been presented as
> self during T cell selection in the thymus.
HI, I'm gonna re-read polly matzingers danger hypothesis and maybe some
answers will come out--but...
markH
