F. Frank LeFever wrote:
>> A bit out of my depth, but if no one else will mention "oral
> tolerance", I will. Apparently one can (not only in infancy?)
> introduce substances through the oral route which thereby induce
> tolerance (even to subsequenty administration via other routes???)
>> Ther, you see the limits of my knowledge of this. Hope someone
> knowledgeable speaks up re oral tolerance.
>> And maybe say why this fails in some cases--possibly related to the
> "dangerous" (rather than traditional "non-self") concept of immune
> reactions. Sorry: do not recall the name of the woman who has
> developed and presented this concept (featured in NY Times sicence
> section last week???)
Hey good for her! any way one way that oral tolerance/suppression works is
via cells called th3 these cells appear to secrete il10,il4 and tgfb.,
another is the interesting findings regarding gut-t cells that are exposed to
ag in the presence of il10 the paper was in nature last winter. apparently
these cells are important in down-reg of the low grade inflamation in the gut
they were call tr cells for regulatory.
