In article <359BE6E8.507F at mail.tju.edu>,
mark <mark.haynes at mail.tju.edu> wrote:
>F. Frank LeFever wrote:
>>>> A bit out of my depth, but if no one else will mention "oral
>> tolerance", I will. Apparently one can (not only in infancy?)
>> introduce substances through the oral route which thereby induce
>> tolerance (even to subsequenty administration via other routes???)
>>>> Ther, you see the limits of my knowledge of this. Hope someone
>> knowledgeable speaks up re oral tolerance.
>>>> And maybe say why this fails in some cases--possibly related to the
>> "dangerous" (rather than traditional "non-self") concept of immune
>> reactions. Sorry: do not recall the name of the woman who has
>> developed and presented this concept (featured in NY Times sicence
>> section last week???)
>>Hey good for her!
I'm pretty sure that "her" is Dr. Polly Matzinger...
> any way one way that oral tolerance/suppression works is
>via cells called th3 these cells appear to secrete il10,il4 and tgfb.,
>another is the interesting findings regarding gut-t cells that are exposed to
>ag in the presence of il10 the paper was in nature last winter. apparently
>these cells are important in down-reg of the low grade inflamation in the gut
>they were call tr cells for regulatory.
--
Rainforest laid low.
"Wake up and smell the ozone,"
Says man with chainsaw. - John Ladasky
