I am posting this message in request of information on rheumatoid
arthritis.
I currently have the task of writing a rather extensive review on the
immunopathogenesis of rheumatoid arthritis. I have been lead to believe
that one possible theory, for which support has dwindled in recent times,
was that dysregulation of the innate immune response in the synovium could
be responsible for the recruitment of inflammatory cells and thus
initiation of the disease. Specifically, it was thought that a principle
defect in either macrophage or fibroblast derived synoviocytes results in
the release of inflammatory mediators and subsequent recruitment and
activation of effector cells. All of the information I have been able to
obtain relates to the interaction between CD4+ T cells and antigen
presenting cells, and although I need to write about this also, I would
like to be able to cover a number of views. If anyone out there knows of a
good reference, book or other source of useful information that can steer
me in the right direction they will be doing me a huge favour. Current
prevalence data would also be useful, particularly for Australia.
Thankyou for taking the time to read my request,
I look forward to hearing from you all,
Paul
email: t.s.griffin at picknowl.com.au
