Paul:
This is not a scientific discussion group. It is primarily a patient support
group, though a lot of very knowledgable people do post here. But, I think
you would be better off posting your question in sci.med.immunology or a
similar group. There is also a new listserve for rheumatologists, called
RA-Consult, that you might try. It has very little traffic though.
Walt Hanks
Paul Griffin wrote:
>> I am posting this message in request of information on rheumatoid
> arthritis.
> I currently have the task of writing a rather extensive review on the
> immunopathogenesis of rheumatoid arthritis. I have been lead to believe
> that one possible theory, for which support has dwindled in recent times,
> was that dysregulation of the innate immune response in the synovium could
> be responsible for the recruitment of inflammatory cells and thus
> initiation of the disease. Specifically, it was thought that a principle
> defect in either macrophage or fibroblast derived synoviocytes results in
> the release of inflammatory mediators and subsequent recruitment and
> activation of effector cells. All of the information I have been able to
> obtain relates to the interaction between CD4+ T cells and antigen
> presenting cells, and although I need to write about this also, I would
> like to be able to cover a number of views. If anyone out there knows of a
> good reference, book or other source of useful information that can steer
> me in the right direction they will be doing me a huge favour. Current
> prevalence data would also be useful, particularly for Australia.
> Thankyou for taking the time to read my request,
> I look forward to hearing from you all,
> Paul
> email: t.s.griffin at picknowl.com.au
