Celebrex (reg. trademark) is a cox-2 inhibitor which has been approved for
treatment of RA (while used for OA, NSAIDS have traditionally not proven as
effective in that disease)
The dogma is that cox-2 is the predominant isoform of cyclo-oxygenase found in
cells invading an inflamed site, such as macrophages. It's not that cox-2
inhibitors are MORE effective than the traditional cox inhibitors which appear
to have little isoenzyme selectivity - its that the GI isoenzyme, which produces
cytoprotective PGE and PGI is cox-1. THus cox-2 inhibitors should prove just as
effective while having fewer serious adverse effects.
Aside to asthmatics - at least two labs have reported that cox-2 is the
predominant isoenzyme in airway tissue - so cox-2 inhibitors may not reduce the
occurrence of aspirin-sensitivity to NSAIDS.
vborde at my-deja.com wrote:
>> I wanted to know if the NSAID's, more precisely the COX-2 inhibitors
> drugs, would be more efficient with patients suffering from Rheumatoid
> Arthritis or Osteoarthritis and why? Which effectors from the
> inflammation response would be responsible for that difference if we can
> see one?
>> Sent via Deja.com http://www.deja.com/> Before you buy.
