HHi, my wife is pregnant and she did the exams for th cytomegalovirus. Since
the IgG titer is above the threshold for positiveness and both IgG and IgM
are descending with time, we are worried that our baby has been exposed to
the virus in the first weeks of pregnancy and develop problems in the first
years of life. Could you please have a look at these titers and give us some
feedback?
Wife's age: 30 years (may help in evaluating the probability of a first vs
subsequent infections)
IgG and IgM titers:
DATE IgG IgM unit
05-Oct-98 37 20 E.U./ml
09-Dec-98 35 13 E.U./ml
17-Dec-98 29 10 E.U./ml
08-Feb-99 23.5 5 E.U./ml
Thresholds ( they depends on the test method so I include them for reference):
IgG is considered negative below 18 and positive above 23
IgM is considered negative below 30 and positive above 40
The pregnancy started around 20-Aug-98.
Here are the questions:
1. If you look at the titers you can extrapolate a descending curve:
does it mean that my wife has been recently exposed to the virus?
2. Can you identify the exact period of time when the virus was active and
understand if it happened before or after the 20-Aug-98 ?
3. Is is possible to distinguish between a first exposure to the virus and
a second one? I think that we should not see the IgG positiveness
the first time you get in contact with the CMV.Only IgM should raise(?)
Thank you very much for all the info and help you can give us.
Marco
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