IUBio

The danger of "Danger"

F. Frank LeFever flefever at ix.netcom.com
Sat Jun 5 21:11:00 EST 1999


In <7j9h3i$kup$1 at panix3.panix.com> iayork at panix.com (Ian A. York)
writes: 

- - - - - -(snip) - - - - - - - - - - - -

>As I've also said, it looks to me as if the "danger" hypothesis is
>becoming unfalsifiable.  Some of the original predictions have been
>falsified (apoptosis as a a non-danger signal; yet apoptotic cells are
>apparently good triggers for an immune response), and far from
falsifying
>the paradigm, they've sometimes been taken as *evidence* for it.  I'm
not
>at all comfortable with that.
>

Admittedly, my knowledge of immunology is very limited, but I am
surprised to hear this about apoptopic cells.  Will this be an easy
subject to search for (e.g. "aptoptosis or apoptopic" AND "immune")? 
If not, can you cite some articles for me?

How about "apoptosis" AND IL-1, etc. ?

F. Frank LeFever, Ph.D.
New York Neuropsychology Group



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