In article <7jclbk$bna at sjx-ixn10.ix.netcom.com>,
F. Frank LeFever <flefever at ix.netcom.com> wrote:
>>Admittedly, my knowledge of immunology is very limited, but I am
>surprised to hear this about apoptopic cells. Will this be an easy
>subject to search for (e.g. "aptoptosis or apoptopic" AND "immune")?
>If not, can you cite some articles for me?
Try:
J Immunol 1998 Nov 1;161(9):4467-71
Bystander apoptosis triggers dendritic cell maturation and
antigen-presenting function.
Rovere P, Vallinoto C, Bondanza A, Crosti MC, Rescigno M,
Ricciardi-Castagnoli P, Rugarli C, Manfredi AA
J Exp Med 1998 Oct 5;188(7):1359-68
Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and
CD36, and cross-present antigens to cytotoxic T lymphocytes.
Albert ML, Pearce SF, Francisco LM, Sauter B, Roy P, Silverstein RL,
Bhardwaj N
Nature 1998 Mar 5;392(6671):86-9
Dendritic cells acquire antigen from apoptotic cells and induce class
I-restricted CTLs.
Albert ML, Sauter B, Bhardwaj N
to start with.
Ian
--
Ian York (iayork at panix.com) <http://www.panix.com/~iayork/>
"-but as he was a York, I am rather inclined to suppose him a
very respectable Man." -Jane Austen, The History of England
