> Acctualy I believe the inflammatory response is a necassary component of a
> vaccination. It has been described by one immunologist (don't recall who)
> as immunology's dirty little secret. This is because immunity is believed
> to be the province of T-cells. However you need APC and even if you don't
> believ P. Matzingers model (ie danger) some mechanism for activating the
> APC is needed. This is provided by local inflammation. That is
> probably why complete Freunds works better than incomplete. Better
> inflammation. It is a problem for vaccination as most people don't want a
> huge scar from the inflammatory response. This is still an area of debate
> and it seams at least to me that the innate component of immunity is a
> much under recognised area. In fact there are some interesting theories
> going around about the interactions of the memory and innate immune
> responses.
see ya