Has anyone any information on the difference between human plasma and
serum in terms of activation of the alternative pathway of
complement-mediated lysis of sheep red cells? We are using this has a
positive control for another assay of the effect of complement (on
xeno-genetic islets), and have found that plasma has a remarkable
inability to lyse sheep red cells. Is this on the basis of complement
inhibitors ? I would suspect this is the sort of information that was
worked out many years back, I will be grateful if anyone can search
their memory for information or source of expertise.
Derek Gray
