Antibodies that react to the antigen binding domain (CDRs) of another
antibody are typically called anti-idiotype antibodies. This occurs
naturally in people and a chain reaction type of effect can occur with
the antibody (#2) that binds to the antigen binding domain of the first
antibody (#1), mimicing the original antigen target of the first
antibody. The second antibody then can actually initiate an immune
response that will recognize the original antigen. Similar strategies
are being employed in clinical trials to try to stimulate patients to
mount an immune response to tumor antigens.
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