On Fri, 21 May 1999, Mike Clark wrote:
> In article <Pine.A41.4.10.9905201917210.79322-100000 at dante21.u.washington.edu>,
>> One 'significance' of 'anti-iditoype antibodies' is that they can seriously
> screw up the efficacy in use of therapeutic monoclonal antibodies. Once a
> patient develops an anti-idiotype response it is usually impossible to
> carry on with the therapy.
Can you give me a reference on such a case? Just curious about the
kinetics.
So, that's one 'significant' outcome of an anti-idiotype antibody.
But Niels Jerne's idiotype cascade would predict that such an
anti-idiotype antibody will elicit an anti-anti-idiotype antibody
reaction, which (should? may?) have the same effect as the first
therapeutic antibody.
I don't buy the theory, but I was wondering if anybody has read any
research on it?
+-------------------------------------------------------------+
| Fumitaka Hayashi - hayashi at u.washington.edu |
|http://macrophage.immunol.washington.edu/~fumi/index.html |
| Aderem Lab - Dept. of Immunology - University of Washington |
+-------------------------------------------------------------+
