In article <374EA48E.3176FFA6 at zsu.edu.cn>, anlong xu
<URL:mailto:ls36 at ZSU.EDU.CN> wrote:
> 1-10% T cells can directly recognize the alloantigen, which is not
> self-MHC restricted. It seems to be controversial to the classical T
> cell recognition model of self-MHC restricted
> One explanation is that allo-MHC molecule mimic the structure of
> self-MHC and peptide complex. Is there any experiment verify this
> hypothesis?
> I would like to discuss with you.
> Thank you for your consideration
>>
I'm in the middle of examining so haven't time to pull out any of the
references but the explanation is as you say
allo-MHC plus peptide Y is seen by the same receptor as self MHC plus
peptide X. In some circumstances X and Y could be the same peptide but more
often they are not.
The other important thing to remember is that a single TCR may be able to
recognise several different MHC-peptide complexes even in the same host.
Cheers,
Mike Clark, <URL:http://www.path.cam.ac.uk/~mrc7/>
--
o/ \\ // || ,_ o M.R. Clark, PhD. Division of Immunology
<\__,\\ // __o || / /\, Cambridge University, Dept. Pathology
"> || _`\<,_ // \\ \> | Tennis Court Rd., Cambridge CB2 1QP
` || (_)/ (_) // \\ \_ Tel.+44 1223 333705 Fax.+44 1223 333875
