There are more than one monoclonal antibodies specific for peptide-MHC
complexes. The YaE antibody developed by I beleive Alexander Rudensky
while at Yale, and Both the Unanue and the Germain Lab published MHC
restricted antibodies for both Class I and II complexes. These reagents
are rare and obviously restricted in the use, but have been around for
some time.
Dan
On Thu, 30 Sep 1999 ladasky at my-deja.com wrote:
> In article <Pine.OSF.3.91.990929165822.20662A-100000 at imtech.ernet.in>,
>nsharma at IMTECH.ERNET.IN (Naresh Sharma) wrote:
> > Has anybody raised antibodies against MHC-peptide complex ?
> > reply to
> >
> > naresh76 at bigfoot.com>> There are many anti-MHC antibodies that recognize MHC complexed with
> peptide.
>> Or do you mean to ask whether there are antibodies against *specific*
> peptides bound to *specific* MHC molecules? Well, no, there are none of
> those. There are a few antibodies which recognize portions of the alpha
> helices plus an amino acid or two of the peptide, but that's as specific
> as they get.
>> --
> John J. Ladasky Jr., Ph.D.
> Department of Structural Biology
> Stanford University Medical Center
> Stanford, CA 94305
> --
>>> Sent via Deja.com http://www.deja.com/> Before you buy.
>>
