Dear reader,
We are looking for a collaboration with a
scientist, who is interested in the immunological
characterization of human blood cells with
a newly made specific antibody against the
human membrane-type 4 matrix-metalloproteinase
(MT4-MMP). Please send us a description
of your ideas and capabilities, if you want to
test this antibody for the use e.g. as specific
surface antigen for a subset of blood cells,
for the correlation with cancer, arthritis
or inflamation. Of course we provide this antibody
for free, if we can participate on your results.
Dr. Lutz Essers
Invitek GmbH
info at invitek.de
www.invitek.de/MMP.htm
Background:
Matrix metalloproteinases (MMP) constitute a
family of secreted and membrane-bound enzymes,
which hydrolyze extra-cellular matrix proteins.
The proteinases affect proliferation,
differentiation, migration and apoptosis of
cells. They are involved in diverse physiological
and pathological processes. MMPs are pharmacological
targets for treatment of cancer, arthitis and
inflammation. MT4-MMP transcripts are found in
mainly brain, leukocytes, the colon, the ovary,
and the testis. In addition MT4-MMP mRNA is
transcribed in invasive and noninvasive breast
carcinoma cell lines.
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Invitek GmbH
Robert-Rossle-Str. 10
Biomedizinischer Forschungscampus
13125 Berlin Buch
Tel. ++49 (0)30 / 9489 3796 Fax ++49 (0)30 / 9489 3795
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