Good days, everybody ,
I have a question :
Why there is not transgenic pigs expressing human CR1 to Overcome complement-mediated
hyperacute xenograft rejection ?
CR1 has extrinsic activity , i.e., it inactivates convertases assembled on external
membranes, and it also exhibits intrinsic activity ,i.e., it inactivates convertases
formed on the same membrane on which it is expressed. Among the members of the RCA
family , CR1 is the only one that possesses dcay-accelerating activity for both C3 and
C5 convertases in both the classical and alternative pathways,as well as factor I
cofactor activity for the degradation of both C3b and C4b .
Would you please send me the plasmid containing the sequence for CR1 ?
Department of immunology
The Third Military Medical University
Gao tanyan,Sha pingba
Chongqing , 400038
People's Republic of China.
sincerely,
Guo Bo
immuno06 at mail.tmmu.com.cn
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