I currently have a post-doctoral position available.
The details of the project are as follows
Title:
'Engineered Antibodies to The Human Vascular Endothelium Antigen VAP-1'
Location:
Cambridge University, Immunology Division, Department of
Pathology, Tennis Court Road, Cambridge, CB2 1QP
Position:
Post-doctoral research associate
Funding:
The funding currently runs until 31st August 2003 but there is the
likelihood of a renewal application beyond this date if the project
progresses well.
Description:
This project started out as an academic collaboration between my laboratory
in the Department of Pathology and Prof Sirpa Jalkanen's laboratory in the
University of Turku, Finland. During this collaboration an engineered
antibody with novel Fc receptor and complement binding properties, and with
specificity for the vascular endothelial activation antigen VAP-1 was
produced. This antibody, called HuVAP, is now in commercial development
with a Finnish biotech company, BioTie Therapies Inc, Turku, Finland.
The laboratory project represents an ongoing R&D collaboration between an
academic laboratory and the company which is based in Finland, and thus
presents the successful candidate the opportunity to join a
University research team with both academic as well as applied interests in
the exciting field of antibody engineering and therapeutic immunology.
Techniques:
Mammalian tissue culture of transfected cell lines.
Antibody purification and characterisation.
Assays of antibody effector function such as complement activation, FcR
binding and ADCC.
Immunoflourescence, FACS analysis and cell sorting (we have a new MoFlo
facility).
A small amount of straight forward molecular biology is involved in making
some new antibody constructs.
Further background:
Jaakkola, K., Nikula, T., Holopainen, R. et al (2000), American Journal of
Pathology 157, 463-471 In Vivo Detection of Vascular Adhesion Protein-1 in
Experimental Inflammation
Armour, K.L., Clark, M.R., Hadley, A.G. & Williamson L.M. (1999), Eur J
Immunol 29: 2613-2624 Recombinant human IgG molecules lacking Fc-gamma
Receptor I binding and monocyte triggering activities
Salmi, M. & Jalkanen, S. (2001) Trends in Immunology, 22: 171-225 VAP-1: an
adhesin and an enzyme.
Further details of my University research lab are at
<URL:http://www.path.cam.ac.uk/~mrc7/>
and the company website is at
<URL:http://www.biotie.com/>
I am looking for an appropriately experienced post-doc who is immediately
able and willing to work in Cambridge UK and also interact (probably with
regular travel to and from Finland) with our collaborators at BioTie.
If seriously interested please send your CV by email in pdf or rtf format
to my email address
mrc7 at cam.ac.uk
Please note I will ignore any attachments which are too large or not in one
of the two formats listed above.
Mike Clark,
--
M.R. Clark, PhD. Division of Immunology
Cambridge University, Dept. Pathology
Tennis Court Rd., Cambridge CB2 1QP
Tel.+44 1223 333705 Fax.+44 1223 333875
