IUBio

IL-1/IL-18 secretion

Denis Gaucher dgauch at po-box.mcgill.ca
Tue Feb 19 00:48:45 EST 2002


Hi!

Does anybody here know how IL-1B and IL-18 get secreted out of the cell once they are converted to
their mature form by caspase-1?? Every single article I have read so far about activation of these
cytokines seems to avoid the question....  How do they get secreted if they don't contain a
secretion signal sequence??

Thanks for your help!

Denis




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