You will probably find "supportive" articles referenced at my web site
helpful.
The old idea of (T-cell dominated) "immunity = good" - "immune
suppression = bad" is just about dead now. It is rapidly being replaced
by a realisation that "tissue homeostasis" is at the core of
(malignant) tumour development and T-cell involvement can be both
beneficial and detrimental (mostly T-reg activity). "Tissue
homeostasis" starts with an inflammatory reaction and leads,
inexorably, to regeneration of tissues. It is increasingly apparent
that it is around chronic, non resolving inflammation that malignancies
develop. The regenerative process, though stimulated, cannot close out
and, in peculiar circumstances, this tissue field becomes susceptible
to (usually normal) genetic growth factors that may have become mutated
for one reason or another. A fascinating development is that
haemotopoeitic stem cells might also be attracted to migrate to areas
where regeneration is necessary and take on the phenotype of the local
tissues - notwithstanding that tissue resident stem cells might also be
involved.
This is an exciting area to follow and I will attempt to add relevant
new articles to this web page. I have a couple, already, to add. So
come back to this page if you want to follow this up in the future.
It helps to abandon the older idea that the "immune system" is
primarily a micro-organism hunting and killing system for the concept
that it is primarily a "tissue homeostatic system". Pathogenic
micro-organisms have a hard time (get noticed) because they need to
disrupt tissues to create the substrate they need for "feeding".
Hope this helps.
Jamie
Agbeke9 at aol.com wrote:
> could you help me please! i need to give a presentation titled "Immune
> system is involved in the elimination of tumours" i cant find anything on
> practical work done on immune surveillance i will gladly appreciate any information
> or references
>> Thank you
> Samuel