In <Mercer-0312942101400001 at mac168.bio.caltech.edu>, Mercer at seqvax.caltech.edu (Eric H. Mercer) writes:
>In article <45322.minn at ctrmed.u-nancy.fr>, <minn at ctrmed.u-nancy.fr> wrote:
>>> On Thu, 24 Nov 1994 22:43:35 -0800,
>> Robert Dean Williams <bobcat at gladstone.uoregon.edu> wrote:
>>>> >Hello everyone,
>> >
>> > I am doing some research on application of new nerve cells. Is
>> >there any information about cloning nerve cells or making artificial
>> >nerves? The reason I would like to know is the possibility of replacing
>> >damaged nerves with new cloned cells or artificial cells. Let me know if
>> >there are some research going on with this subject.
>> >
>> >Thanks...Robert.
>> >
>>>> To my knowledge, there is presently no way to obtain cloned neurons...
>>>> Alain MINN ! Til.: (33) 83 17 88 30
>> Centre du Midicament ! Fax : (33) 83 32 13 22
>> 30 rue Lionnois ! E-mail minn at ctrmed.u-nancy.fr>> 54000 NANCY
>>I have to disagree. Both PC12 cell lines and MAH cells can be induced to
>form neurons, and both are clonal cell lines. There is no way they can be
>used for human therapy in the forseeable future, however, as both are rodent
>derived lines, both form neurons at a low frequency (most cells die during
>induction) and both contain exogenous oncogenes.
><<< STUFF DELETED >>>
There is a clonal human cell line available that can be induced to form neurons.
The neurons have been transplanted into rat brain witout any sign of
tumorogenesis. These cells (NTera2) have been described by Pleasure, et al.
J. Neurosci 12, 1802-1815 (1992).
>Eric H. Mercer California Institute of Technology
>Division of BIology; 216-76 Pasadena, CA 91125
>(818) 356-6822 Mercer at SeqVax.CalTech.Edu
Andrew M. Wertkin
Neuroscience Graduate Group
Institute of Neurological Sciences
University of Pennsylvania
Philadelphia, PA 19104
