In <3d4kv5$etv at nyx10.cs.du.edu> anon1167 at nyx10.cs.du.edu (M) writes:
>In article <3d09g8$f0m at newsbf01.news.aol.com>,
>Chipstein <chipstein at aol.com> wrote:
>>the latter in turn by pallidotomies guided by neurophysiological
>>recording. The latter produce near-miraculous improvement within 60
>>seconds of producing a lesion in the globus pallidus.
>>
>Huh? Could you provide a cite please, I have not heard anything about this.
Actually try Kandel and Schwartz for a general outline.
>Sounds interesting, though.
Lesioning the GP reduces the symptoms but does not prevent the further
deterioration of the substantia nigra. It doesn't even seem to be a long
term treatment since symptoms often reappear after some time.
The fetal transplants are aimed at providing the cells which produce dopamine.
In the long run, the transplants provide the best hope of long term treatment
I should think, although again I doubt that the actual cause would not be
reversed since Parkinson's is a very complex disorder. Also whatever is
causing the cell death in the SN (and other dopaminergice centres) could also
attack the transplanted cells?
