icv BSA injection/infusion in rats question

[jtrst4 at vms.cis.pitt.edu]

I was wondering if anyone had knew about any risk involved
with intracerebroventricular (icv) injection/infusion of
peptides which require the addition of bovine serum albumin(bsa)

The bsa addition is per manufacturer recommendation to limit
peptide adhesion to the containers, & infusion minipump.

Would a dilution in the bsa (0.1-1%), promote immune
responses in the rat receiving the icv infusion (14day duration)?

Would I be better off not using bsa?

Thanks,
-- 
                                                      _
                                                     (_)
                                              _______//
John T. Robicheau                            (________)
Pharmacodynamic Research Center               \ Pitt /
University of Pittsburgh                       | Rx |
JTRst4 at vms.cis.Pitt.Edu                       /______\
Robich at DrugInfonet.Pharm-Epid.Pitt.Edu       (________)
 
"A drug is something that when administered to a rat, produces a
scientific publication."