In article <3j4ieo$hph at epsilon.qmw.ac.uk> p.mapp at lhmc.ac.uk (Dr paul Mapp) writes:
>From: p.mapp at lhmc.ac.uk (Dr paul Mapp)
>Subject: peripheral nerve damage during inflammation
>Date: 2 Mar 1995 13:50:16 GMT
>...damage to periheral nerves by inflasmmatory
>responses ... possible dysregulation of the maintenace of vascular
>tone. Comments? Questions?
In the inflammatory state primary afferent C-fibres release
transmitters such as substance P and calcitonin gene-related peptide from
their periheral endings, thereby contributing to vasodilatation and plasma
extravasation. Inflammatory mediators such as histamine, interleukin 1beta or
nitric oxide can all stimulate or at least sensitize C-fibe endings. (See
papers by P. Holzer and M. Herbert, or by H.G. Schaible and/or R.F.Schmidt - I
apologize for not having the full citation at hand, please look them up in
MEDLINE!)
U. Holzer-Petsche
Dept. Pharmacology
University of Graz
