In article <3ksmea$27s at cronkite.ocis.temple.edu>,
<jimking at astro.ocis.temple.edu> writes:
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> From: jimking at astro.ocis.temple.edu (Country)
> Newsgroups: bionet.neuroscience
> Subject: Re: NSAID'S AND BBB
> Date: 23 Mar 1995 20:41:46 GMT
> Organization: Temple University, Academic Computer Services
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> References: <3jdtmj$p0q at dingo.cc.uq.oz.au> <3jfep5$a7u at tali.hsc.colorado.edu>
<3ji8el$iuu at cat.cis.Brown.EDU> <1995Mar07.234609.802 at uhura.neoucom.edu>
<3kdq97$sv5 at ixnews4.ix.netcom.com>
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>> John Friedberg (BrainiaC at ix.netcom.com) wrote:
> : In <1995Mar07.234609.802 at uhura.neoucom.edu> jk at uhura.neoucom.edu (Jeff
Kushner)
> : writes:
>> : >I would like to know what non-steroidal anti-inflammatories
> : cross the blood brain barrier.
>> : Thank you,
>
All NSAIDs cross into the CNS. NSAIDs of all classes cross the CNS. As a
toxicologist who treats patients who overdose on these agents, I see coma,
convulsions, confusion and lethargy. Convulsions are most common with
mefenemic acid, ibuprofen, ketoprofen, indomethacin and phenylbutazone. mental
status changes in the elderly taking these drugs are also well-documented.
>
