Right, agonists at this receptor can be neurotoxic. Glutamate (ie, MSG)
is suspected to be toxic to the brain because it overexcites these
receptors. As an aside, I personally doubt that (much) MSG crosses the
blood-brain barrier in healthy adult humans (it does in babies,
however) when given in the concentrations found in food. Please, correct
me on this, I'm playing devil's advocate a little here.
On 20 Oct 1995, Jason Kennerly wrote:
> LSCCLAB <lscclab at biovx1.biology.ucla.edu> writes:
> > What is NMDA receptor?
>> A receptor stimulated by NMDA.
> PCP and Ketamine block (antagonize) NMDA's effects at this receptor
> NMDA's neurotoxicity stems from its excitotoxic effect at this receptor
> (this isnt the best way to explaine it is it?)
>>> --
> ____ ______ ________ _____
> / \ | \| /\ | \ jkenner at cello.gina.calstate.edu> / \| _ \ \/ | _ \
> /___/\ \___|> > |__|> > BORN TO BE WIRED...
> / | / /\ | / All the sugar and twice the
> \_________|______/|___\/__|______/ caffeine of regular netusers!
> finger me and make a pgp key come.
>>
----------------------
sandraw at U.Arizona.EDU
