I am currently taking a course in the neurobiology of memory
and we have discussed at length LTP (Long Term Potentiation) in the
hyppocampus as a potential neural mechanism for memory storage. The
literature for the course (including journal articles) is 2 years + old
and I am sure more has been discovered. I would greatly appreciate any
one who could provide me with information on the following points, or
at least direct me to a more up to date paper on the subject. Thank
you:
1. An inital study showed LTP saturation in the Dentate Gyrus to
interfere with passive avoidence learning tasks. However several
subsequent studies could not confirm this. Has there been solid
confirmation or refutation of this issue?
2. What of laboratory induced LTP short time frame (a few days/weeks).
This makes it an unlikely vehicle for Long Term Memory (LTM). Has any
conclusive study supported the following:
a) Link LTP specifically to short term memory and perhaps identify
other potential mechanisms for LTM?
b) Demonstrated other versions/forms of LTP which have a sufficient
duration to account for LTM
c) provided confirmation for the memory indexing view point of
hippocampal involvement in memory.
Thank you for your assistence.
