GAMMA-OH(Gamma-Hydroxybutyrate):The First Authentic Anti-Depressant (4)
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As I do not have much time to answer,individually,all questions received
concerning Gamma-OH, you will find here more information about this
molecule.New information has been added,regularly,in this article so as to
answer to your questions.
Introduction
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Recently,the whole world was brainwashed by Lilly Company with a severe
blitzkrieg propaganda on an allegedly "new" anti-depressant called fluoxetine
or Prozac.Lilly lied when it presented Prozac as being the "first" marketed
anti-depressant of a "new" generation!The first marketed anti-depressant of
this new family of anti-depressants called the "SSRI" was ZIMELIDINE marketed
by Astra,in Europe,as Normud,and developped in Scandinavia.Zimelidine was
followed by INDALPINE in France(Upstène)and then by FLU
VOXAMINE in Holland(Floxyfral).
Only FLUVOXAMINE withstood the test of time as zimelidine and indalpine had
some unwanted side-effects,even though indalpine proved to be a remarkable
molecule for some treatment resistant persons.Fluvoxamine was marketed in
Europe perhaps 8 YEARS BEFORE its american equivalent Prozac!Even though it
did not reach the US market because American pharmaceutical companies could
not yet compete with Europeans...So Fluvoxamine was blocked to reach the US
market until Americans could develop properly their own
SSRI! This is what american businessmen,usually,call "fairplay".By doing
so,millions of Americans did not benefit of Fluvoxamine and,surely,many lives
could had been saved in America by Fluvoxamine....Alas,these lives WERE NOT
saved because of the greed and unfair practices of the american system towards
novel medications invented elsewhere.Millions of depressed Americans were
denied access to Fluvoxamine, for commercial purposes only.This is a moral
perversion of the ethic of medicine.
The sad irony of this situation is that Fluvoxamine is superior ,in all
respects,to Prozac!
For instance,Prozac has some unwanted side-effects which fluvoxamine does not
have.Moreover,fluvoxamine can SUPPRESS the side-effects of Prozac! So why use
Prozac at all? This is due to the fact that Lilly was very successful in
launching a blitzkrieg propaganda campaign,superbly ignoring our european
product and its anteriority.Moreover,the idea of developping a specific
serotonin reuptake blocker was a european idea and not an american idea as
Americans did not believe in the anti-depressant effects of
serotonin but favoured noradrenaline...
Prozac,frequently,induces insomnia and headaches while it is also slighly
sub-hallucinogenic.Fluvoxamine,on the contrary,promotes sleep and alleviates
headaches.Also no subhallucinogenic phenomena can be detected.One reason why
Prozac has these side-effects is because Prozac
should,preferentially,indirectly activate serotonin 5-HT2A
receptors.Activation of these receptors is a common effect of the
hallucinogens.
All the unwanted side-effects of,let say a dose of 4O mgr of Prozac are
abolished by an equipotent dose of IOO mgr of fluvoxamine.
Fluvoxamine also suppresses rapidly moral suffering(the hard-core of
depression)and suicidal ideation while Prozac is slower on onset.
So the big commercial problem for american companies was that fluvoxamine was
invented not in America but in Europe and marketed about 8 years before they
could SELL their own similar products....Moral perversion,as I said,and
totally unacceptable.
No comments!
Another good european anti-depressant of which Americans have no equivalent is
AMINEPTINE(Survector)and,naturally,Amineptine is not marketed in the USA even
though it is a dopaminergic anti-depressant and dopaminergic anti-depressants
are known to be more effective in treatment resistant patients.Why Americans
have not yet marketed dopaminergic anti-depressants remains an enigma.As
Japanese say:"kaouaï so" for american patients,meaning american patients are
most unfortunate(because money always comes bef
ore morality in the US).In fact,the activation of dopamine seems more crucial
in order to obtain a fast anti-depressant effect than modulation of other
neurotransmitters as the function of dopamine in the CNS is to metabolically
activate neuronal systems.Dopamine is an ubiquitous metabolic activator while
serotonin has,most frequently,the opposite action(this is called the
Dopamine/Serotonin balance hypothesis;there is also a Serotonin/Serotonin
balance hypothesis.This hypothesis states that the global m
etabolic action of serotonin is the ratio of activation of serotonin
receptors diminishing dopaminergic activity to those serotoninergic receptors
which increase dopamine activity,such as the 5-HT2A receptors).Concerning
novel anti-depressants the French have invented the very first Selective
Serotonin reuptake Accelerator(SSRA):Tianeptine.Tianeptine acts in an opposite
way as the SSRI but,still,instead of inducing depressions cure depressions! In
the naive understanding of serotonin in depression such
a fact cannot be understood...We will explain later on why tianeptine is,in
fact,an anti-depressant and even the FIRST authentic serotoninergic
anti-depressant!
So we are left with the morally unacceptable fact that America has banned
superior european anti-depressants because the same equivalent products did
not yet exist in America.
This behaviour of the american pharmaceutical companies has been
systematic.For instance a good anti-depressant invented in Italy and called
TRAZODONE was,recently, imitated in America with the creation of
NEFAZODONE(Serzone)in order to get more money! And another novel
anti-depressant invented in Europe,VILOXAZINE(the first selective
noradrenaline reuptake inhibitor),apparently never reached the US
market,etc,etc.
Now I will come to a fantastic anti-depressant called GAMMA-OH(brand name),and
which
could save lots of depressed people if it were marketed to that effect.
GAMMA-OH has never been studied as an anti-depressant because of what is
called the
IMIPRAMINOMIMETIC DOGMA .This dogma states that anti-depressants can only be
found by those pharmacological methods which have been applied to discover
imipramine,the first alleged anti-depressant!Clearly,this dogma is nonsense
and it has hampered research on anti-depressants since more than 30
years,forbidding the discovery of true fast-acting anti-depressants.This dogma
also states that it is not possible to achieve an anti-depressant effect
immediately but that one has to suffer for weeks before start
ing to feel better with medication...What is funny with this grotesque dogma
is that imipramine was discovered by chance!At that time nobody believed in
imipramine except one lone researcher whose obstinate perserverance was
rewarded...
GAMMA-OH(or gamma-hydroxybutyrate,a quite simple molecule with a vast array of
psychotropic properties)has proved that this statement was sheer nonsense.
GAMMA-OH was discovered by a friend of mine(the late Dr.Henri Laborit who
introduced the use of chlorpromazine in psychiatry around I952)in I96I in
France and since that time scientists were unable to discover some rather
extraordinary properties of this molecule on depression,anxiety and
sociability! Why? Because nobody seriously studied the psychotropic effects of
this molecule until I started to do the job.This stems from the fact that most
"scientists" are not real scientists or savants but only civi
l servants:they work to earn their food,not to really discover nature's
mysteries.These civil servants(called "fonctionnaires",in French,a simpler
word) work like soldiers in an Army,not like true researchers because they are
not authentic researchers!They have ideas and interests of "fonctionnaires"
not of savants...For some years GAMMA-OH was used as an hypnotic in France but
people complained that they did not sleep long enough with that and would
awake too early in the morning!Then,according to Henri
Laborit,came May I968 and Gamma-OH was considered subversive:it thus became a
medicine only available on prescription.And of course a medicine which can
enhance sociability is,indeed,subversive because sociability does not go well
along with business and merchants!To be a good merchant you
need,psychologically,to block your sociable feelings:you should cease to
consider other human beings as human beings but just as things which can bring
you money and power.You have to learn to be selfish,that is non-s
ociable!
GAMMA-OH is a remarkable molecule because it can suppress depressive ideation
and anxiety sometimes within less than 3O minutes.It also seems to be
immediately active on the most severe and treatment resistant forms of
depression.Because of such remarkable properties I used to
call,jokingly,GAMMA-OH "Or Potable",in French,which means "potable gold"!
Indeed a molecule which can block your depression and suicidal
ideas,anxiety,etc,in such an efficient way is as precious as gold because it
can save your lif
e.
GAMMA-OH saved my own life many times when all other anti-depressants
failed.For years I suffered of depressive episodes which did not react to
conventional "anti-depressants".Why? Because,in fact,most anti-depressants(an
anti-depressant is also called a THYMOANALEPTIC.A thymoanaleptic is a molecule
which stimulates mood)are not really "anti-depressants" per se but
THYMOANESTHESISERS.A thymoanesthesiser is a molecule which ANESTHESISES
emotions and which,thus,blunt feelings.For instance,if you give "anti
-depressants" to,let say,two lovers together you will notice that their love
feelings towards one another become anesthesised,blunted...Clearly,a molecule
which blunts rewarding emotions is definitely not an authentic anti-depressant
but,rather,a "mind Xylocaine"(xylocaine is an anesthesiser used for hemorhoids
and all kinds of similar pains!).A thymoanesthesiser takes away a part of your
personality and makes you a bit similar to people suffering from negative
schizophrenia.On the contrary if you admini
ster gamma-hydroxybutyrate to a pair of lovers you will notice that it will
enhance their love feelings because it stimulates sociability.
Prozac and Fluvoxamine and all SSRI are,in fact,thymoanesthesisers not
authentic thymoanaleptics.They block depression by SUPPRESSING or reducing
feelings,euphoric or dysphoric and you become a kind of satisfied zombie!
Another thymoanesthesiser,which is not a SSRI,and which blocks quite
spectacularly love feelings is MAPROTILINE,a slightly modified tricyclic.In my
opinion,maprotiline is psychotoxic because it can induce indifference in
otherwise normal subjects.No more suffering but no more real happine
ss.On the contrary,AMINEPTINE does not suppress emotions but it does not
intensify them either.So amineptine is an anti-depressant but still not the
ideal thymoanaleptic.Now we can come back to tianeptine.Why tianeptine is an
anti-depressant?We have seen that serotoninergics alleviate depression by
reducing emotions.Enhancing serotonin neurotransmission,in fact,anesthesises
emotions.Thus it is logical that reducing serotonin neurotransmission( in some
unknown brain areas )should stimulate the expression
of emotions.This is demonstrated by tianeptine and by some tryptophane
hydroxylase inhibitors such as MDA or MDMA.What is more interesting is that
even though MDMA selectively destroys the axons of the raphé nucleus the
behavioural consequences of that are,apparently,non-existent.Further reducing
serotonin neurotransmission in MDMA subjects having a depressive episode,with
tianeptine,can suppress depression in these people! One person who had taken
MDMA at high doses for 5 years and who became depressed
reported that,under tianeptine,he would feel like under MDMA!!! Of course no
normal patient has ever reported an MDMA-like effect with tianeptine...As
tianeptine activates emotions instead of reducing them TIANEPTINE CAN THUS BE
CONSIDERED AS THE FIRST AUTHENTIC SEROTONINERGIC ANTI-DEPRESSANT.But who knows
tianeptine in North-America? Nearly nobody because the French are very,very
bad businessmen not like those of Lilly! French can invent good novel products
but are not good at propaganda.Lilly invented
a mediocre product but persuaded everybody that their product was the best
ever...If the French had been so clever as Lilly,Amineptine,for instance,would
have invaded the whole world years and years ago,not to speak about
tianeptine! The French have invented many novel anti-depressant but did
practically nothing to spread them.Some of these
are:médifoxamine(Clédial),minaprine(Cantor),Viloxazine(Vivalan),not to speak
about amineptine and tianeptine! What's more they invented(by chance!)Gamma-OH
and never
discovered that this was a very novel anti-depressant! Knowledgeable people
just used Gamma-OH like Champagne or Beaujolais but did nothing
more...Gamma-OH stayed for the elite and the elite was not interested to study
the peculiar psychotropic effects of this molecule!
After years of reflexions on depression I realised,one day,that a real
anti-depressant should STIMULATE SOCIABILITY.Why? Because depression
is,basically,a defect of sociability.Depression is a state of LOWERED
SOCIABILITY and when natural sociability is lowered in a human brain(for
instance through competition,etc)then this brain starts to suffer
morally.Experience has shown that when sociability is ENHANCED then depression
vanishes.GAMMA-OH is the first molecule discovered which does just this:it
STIMUL
ATES SOCIABILITY.This is why GAMMA-OH is called a SOCIABILISER.
GAMMA-OH is hypothesised to cure depression by stimulation of brain OXYTOCIN
neurotransmission.Oxytocin is a very important molecule responsible of
sociable states,of the maternal instinct and of all activities related to the
maintainance of life.For instance,oxytocin is involved in sex and orgasm and
orgasm intensity seems directly linked to enhanced oxytocin neurotransmission.
GAMMA-OH suppresses depressed ideation with amazing rapidity.You may feel
uncurable dysphoria with suicidal ideation,anxiety,etc,and think that no
medicine or no one could help you until you try gamma-hydroxybutyrate! After
you may just think how crazy you were and feel how life is beautiful and
deserves to be lived and enjoyed!
Gamma-hydroxybutyrate strongly stimulates the desire to be and to remain alive
despite unfavourable circumstances.No conventional so-called anti-depressant
does that.
Gamma-OH is the fastest anti-depressant known and can,often,suppress severe
depressive ideation within just hours while conventional thymoanesthesisers
take WEEKS or MONTHS to alleviate suffering...GAMMA-OH therapy is also very
short:less than a month of treatment is effective,as opposed of months or
years of treatment with other treatments.
How to use Gamma-OH
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GAMMA-OH(this is the brand name of this molecule in France,as I said
before)should be used as follows:
Three doses of 2 gr per day on an empty stomach.For instance,2gr in the
morning,then 2gr before eating your first meal,at noon,then the last dose at
around 6 in the evening.
GAMMA-OH should always be associated with CLONAZEPAM(Rivotril)Imgr taken in
the morning.If you suffer from intractable moral pain you will be surprised to
feel that your blocked gratifying emotions come back very,very fast!
GAMMA-OH is a self-limiting medicine,which means that you discover by yourself
when it is time to stop medication.Why? Because GAMMA-OH induces EMOTIONAL
SATIETY and when you are emotionally satiated you do not feel like asking for
more joy as you feel already fed up with happiness!!! Yes,you can be fed up
with happiness!This is why people using GAMMA-OH do not become addicted.In
fact,GAMMA-OH is even used to treat alcohol and opiate addicts.
GAMMA-OH gives you a strong DESIRE TO LIVE whatever are the circumstances.This
is why it is the only authentic anti-depressant
available.Gamma-hydroxybutyrate was the first sociabiliser which I discovered
through Henri Laborit.Laborit is well-known in France for his many books on
society.He used to drink GAMMA-OH 3 times a week,which maintained him in an
amazing shape! However,Gamma-OH,normally,cannot be taken for a long period of
time continuously as it tends to induce fatigue and,sometimes,anxiety.So e
motional satiety or fatigue,etc,make Gamma-OH a non-addictive medicine as
people will,spontaneously,stop medication when they feel these phenomena!
GAMMA-OH is a so-called Gaba B agonist and a TYROSINE HYDROXYLASE ACTIVATOR.
At pharmacological doses,it has,recently,been found,in Strasbourg(France),to
be a tryptophan hydroxylase activator.At the normal doses used for depression
and anxiety Gamma-OH has a small regulatory dopaminergic activity:it
regularises dopaminergic activity.Gamma-OH is found,naturally,in the brain
together with another more rigid analog called
GAMMA-HYDROXY-TRANS-CROTONATE(G.H.T.C).GHTC is a close analogue of
GAMA-AMINO-TRANS-CROTONATE(G.A.T.C) which is one of the most potent agonist of
the newly discove
red Gaba C receptors.It is not known yet whether Gamma-OH or GHTC bind to
these Gaba C receptors.There are specific receptors to 4-OHB(another name of
Gamma-OH!)and GHTC in the brain.These receptors are called GHB
receptors.French scientists have found that some benzamide neuroleptics bind
with high affinity to these receptors.Nobody knows yet what 4-OHB and GHTC
do,exactly,in the brain! They may serve as neuromodulators.The only rather
clear thing we know is that stimulation of these receptors could be
involved in the generation of "petit mal" epilepsy.Gamma-OH can induce,very
rarely(and this is not dose-dependent!)slight subjective effects reminiscent
of petit mal epilepsy.These effects are adequately blocked by CLONAZEPAM and
this is the reason why Gamma-OH should,always,better be absorbed with
clonazepam or other benzodiazepines.Benzodiazepines seem to have a good
protective effects against the eventual minor side-effects of Gamma-OH.For
instance,short term use of Gamma-OH is strongly anxiolytic and
a very effective medication for panic attacks which are reversed within I5 to
2O minutes(on an empty stomach only).However,if Gamma-OH is taken for weeks it
can induce what looks like a "rebound" anxiety phenomenon.This anxiety
manifests itself as plain anxiety or a panic attack just when the psychotropic
effects of Gamma-OH start to wane.In such cases of
anxiety,clonazepam(2mgr),midazolam(I5mgr), triazolam(O.5mgr) or
chlorazépate(Tranxène,25 mgr)should be used.Gamma-OH invariably induces
vomiting in pe
ople chronically intoxicated with alcohol or people having liver problems.In
fact,Gamma-OH can be used as a test of liver functioning! However,as Gamma-OH
stimulates dopamine activity it can give rise to nausea and vomiting with very
slight increases in the normal dose range which should NEVER exceed 2.5gr
within 6 hours.Italians have used Gamma-OH ,to treat alcoholics and opiates
addicts, without serious side effects.They have been using shorter time
interval than what I recommend and big daily doses wi
th heroin addicts with no apparent serious side-effects.This is in
contradiction with what Americans have reported...So is there,now,an American
and a European science??? Why Gamma-OH side-effects are "serious" in
North-America and "neglegible" in Europe(Italy)? Are these differences of
opinions related to science OR culture???My opinion is that demonisation of so
and so is strongly entranched in North-American culture.In North-America
things have to be good OR bad,black OR white.Something cannot be good
and bad at the same time,out there...This is an ayatollah way of thinking:it
is cultural Inquisition.We are more realistic and pragmatic in Europe.Even
water can lead to intoxication if taken in sufficient amount...Words can also
intoxicate but words are far more potent than molecules! Adolf Hitler could
intoxicate and make millions of people hallucinate just with a few words...The
words of Hitler were hallucinogenic and far,far more potent than
lysergamide(LSD)! Hitler was a potential emotionnal halluc
inogen,like some mushrooms are potential hallucinogens.But this is a
philosophical discussion which does not have its place here! Just good to know
because some north-american "scientists" are also hallucinogenic and spread
hallucinations...The whole north-american system is strongly hallucinogenic
with its insidious commercial and puritanical flavour.This is another
debate...Concerning hallucinogens,Shulgin(a famous scientist)speculated once
that 5-Methoxy-DMT (a hallucinogen!)might lift rapidly depress
ive ideation.Hallucinogens have not been experimented as anti-depressants yet
but some facts suggest that some might have an action.This remains to be
determined.
Many years ago I discovered a second class of Sociabilisers(though less potent
because of a mixed pro-serotoninergic action)called the TRYPTOPHAN HYDROXYLASE
INHIBITORS,such as MDMA(3,4 methylenedioxymethylphenylisopropylamine)or
MDAI(5,6 methylenedioxyaminoindane).The sociabilising actions per se of MDMA
are similar but GAMMA-OH is more potent and perfectly safe while MDMA is
neurotoxic and cardiotoxic.MDAI is a non-neurotoxic analogue of MDMA.New
analogues of both GAMMA-OH and MDMA have been invented b
ut not yet tested.
The sociabilising action of MDMA is related to its indirect blocking of
SEROTONIN neurotransmission in a brain structure called the MEDIAN RAPHE
NUCLEUS.When the Median Raphe Nucleus is inactivated then
sociability,spontaneously,appears.In fact,both GAMMA-OH and MDMA could act at
a common site modulating oxytocinergic neurotransmission.I have now a
hypothesis which could link the effects on sociability of these two
molecules.Basically this hypothesis states that MDMA might be an indirect
tyrosine hydroxy
lase activator by suppressing the action of serotonin at post-synaptic 5-HT-IA
heteroreceptors,thus enhancing the activity of tyrosine hydroxylase in some
unidentified locus.There exists one molecule, called NAN-I9O ,which could help
in evaluating this hypothesis.GAMMA-OH is a pure sociabiliser while MDMA and
MDMA-mimetics are partial sociabilisers.At low doses of MDMA the sociabilising
action of this substance is masked by a pro-serotoninergic action as MDMA
is,also, a serotonin releaser.This effect of
MDMA produces a psychotropic action similar to the serotoninergic
thymoanesthesisers such as fluvoxamine,citalopram,sertraline,etc.At higher
dosage the sociabilising action of MDMA becomes manifest.Subjectively speaking
2.5gr of GAMMA-OH are equivalent to 2OOmgr of MDMA.Haloperidol Imgr does not
block the sociabilising actions of Gamma-OH while it blocks the dopaminergic
effects of a dose of 2OOmgr of Amineptine,a dopamine re-uptake
blocker.Haloperidol might block the sociabilising effects of MDMA.This i
s not clear yet.
GAMMA-OH might,theoretically,be also effective against the negative symptoms
of schizophrenia but this remains to be tested.
GAMMA-OH can be obtained in France under this name.It has been produced since
its discovery by the Laboratoire Egic,Amilly,France(telephone:30-67-I6-I6).Now
it is,apparently,produced by another company and this company does not know
yet that they have potential gold in their hands because if Gamma-OH is
demonstrated to be the superior anti-depressant which I claim,then it would
throw in the garbage can most of the antique anti-depressants!You get Gamma-OH
in vials of 2.5gr to be dissolved in orange juice
or milk(Henri Laborit's advice!),as its taste is not good.Gamma-OH boxes are
blue in colour and contain only 6 vials.A box costs about IO swiss
francs.Gamma-OH is,sometimes,very effective against migraines but only for one
hour and a half! The activity of Gamma-OH against migraines is not
predictable,like many other medicines used for that.MDMA is also very
effective against migraines but this has not been studied...
GAMMA-OH should never be mixed with alcohol,opiates,antibiotics, or anything
else except benzodiazepines, Amineptine, or Fluvoxamine.The psychotropic
effects of IOOmgr of fluvoxamine will be suppressed,for about one hour and a
half,by a dose of 2.5gr of Gamma-OH.Amineptine does not seem to modify the
psychotropic effects of Gamma-OH while L-Dopa intensifies the hypnotic effects
of this molecule.
The recommended dose of Gamma-OH should NOT be exceeded.If you overdose,you
fall into a hypnotic sleep from which you cannot be awaken for
hours.Moreover,it could promote "petit mal" epilepsy in such overdoses,plus
nausea and vomiting.Vomiting is a clear sign of relative over-dosage of
Gamma-OH and is related,apparently,both to the dopaminergic activity of this
molecule and to liver function.Anyhow there is no need for overdosing.If used
as prescribed here it is a very safe anti-depressant and anti-panic
medication.
GAMMA-OH is available only on prescription.I advise those people who see
everything in term of white or black to consider the considerable benefits for
suffering people that Gamma-OH could bring if it is demonstrated to be the
superior anti-depressant which I claim here.Afterwards,more research will,very
certainly,lead to refined versions of Gamma-OH with minimal side-effects.
The demonisation of Gamma-OH in North-America:A New Form of Inquisition
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We are living since the, I96O's,in a world of INQUISITION against all
psychotropic molecules which generate some forms of pleasure.This modern
Inquisition started in America as a puritanical expression of american
society to ban pleasure from life.This Inquisition should be fought against as
it has halted the development of scientific research on the mind.3O years of
research have been lost because Americans imposed an INTELLECTUAL EMBARGO on
many research involving the mind.For instance, all research
on the hallucinogens was stopped,thanks to this perverse Inquisition.This
intellectual embargo should be lifted and scientists and laymen should fight
for that.
No Inquisition can be accepted in the scientific field.American society has
systematically demonised all psychotropic molecules which can give
pleasure.(Even alcohol was demonised but this demonisation was not successful
and was abandonned when it was noticed that the creation of Al Capone and
other similar people was a consequence of this demonisation!)This is sheer
madness and should strongly be opposed.The right to use our brain in the way
we want should be a FUNDAMENTAL RIGHT OF MAN and put in the De
claration of Human Rights.I hope this goal will be achieved in the future.One
of the reason which motivated me to write what you are reading is that
GAMMA-OH has been in use,for knowledgeable people in Europe,for decades.Now it
reached the USA,unfortunately,because,as usual,some american INQUISITORS are
trying to demonise this very useful molecule.These pseudo-scientific
AYATOLLAHS should be put back in their middle-ages churchs.In Iran,ayatollahs
are condemning sex.In America,the american ayatollahs wan
t,desperately,to control the use of our mind.This is an untolerable
situation.Progress is made through freedom and knowledge,not under the
guidance of any ayattolah.Let us make a grassroot movement against all these
ayatollahs! Ayatollahs and similar Inquisitors should go back into their
dungeons!!! Middle-Age is over.The quest for Freedom is a never-ending
quest.It is surprising that you do not need,yet,a prescription for
Champagne,wines and other alcohols in North-America because if alcohol were
judged
by pharmaceutical standards it would have been banned a long time ago...
Gamma-OH in France and North-America
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Gamma-oh was invented by Dr.Wermuth,in France,for Dr.Henri Laborit who is the
father of chlorpromazine and modern psychopharmacology.Wermuth created
gamma-hydroxybutyrate in I96I in the search of a GABA analog which
could,readily,penetrate the blood-brain barrier.
Gamma-OH soon went to the market as an hypnotic which could be obtained with
no medical prescription.The French,until I started to study this molecule,were
unable to classify it under any class.For sometimes,it was an hypnotic
inducing a form of sleep very similar to normal sleep,then it became a
pre-anesthesiser,etc.About I5 years ago,I,finally,discovered that Gamma-OH
was,in fact,a molecule to be classified under the novel class of the
Sociabilisers,together with its butyrolactone form which is,readily
,transformed into Gamma-OH in the blood by a non specific lactonase.In
fact,butyrolactone is a pro-drug giving rise to gamma-hydroxybutyric
acid.Gamma-OH has a recognised peripheric oxytocinergic action while its
central oxytocin properties are still to be demonstrated but seem very likely.
Gamma-OH is known in France through the many books of Henri Laborit and his
conferences!
Laborit always praised the properties of Gamma-OH and,as France is definitely
not a puritanical society banning pleasure from existence,Gamma-OH has always
been available,even though its stimulates pleasure.Laborit always advocated
the general use of Gamma-OH in society,like butter or milk! Why? Because it
takes away your stress,makes you more positive towards life,suppresses
selectively,like a kind of "psychological diode",your painful
feelings,stimulates your sociability and makes you more tender,more
loving,more concerned by others.Also you become keenly aware that you have
only one life and that life should be a quest for happiness.Gamma-OH makes you
realise how much you need others(not something for businessmen and militaries
or gangsters!!!) and this is a highly positive thing.I always knew that when
Gamma-OH would arrive in puritanical North-America it would,one day,be
demonised...Unfortunately for North-Americans,the ayatollahs of the pleasure
INQUISITION have struck again and banned gamma-hydro
xybutyrate!Laborit just died,recently,a few months ago at an old
age.Sometimes,he used to joke that Gamma-OH made him live longer as he would
suppress his stress with this "drinkable gold",in case of need!!! He always
said that his two greatest discoveries were chlorpromazine and Gamma-OH but he
never fully realised that Gamma-OH could open a new era in the management of
depression and anxiety.He never fought in order to promote the study of the
psychotropic effects of Gamma-OH,he never discovered that G
amma-OH was the first molecule of a novel class:the Sociabilisers.He just
enjoyed Gamma-OH,with his friends,while conducting other researches.All the
people who have surrounded Laborit have,naturally,more or less been exposed to
Gamma-OH! I was lucky to be one of these people.Gamma-OH is still a crude
medicine.It should be properly studied and better analogs should be
invented.The use of sociabilisers may have tremendous effects on our
societies,reducing intra-specific aggression and enhancing cooperatio
n instead of competition.Gamma-OH is a convivial medicine as it shows you that
you need others to be happy.Long term on and off use seems to make you more
immune to stress and dysphoria,more loving towards people in general,more
active in your life as it stimulates your enthusiasm because you are so aware
that life can be a fantastic thing,everyday.The general use of sociabilisers
may be a temporary solution for the intra-specific aggressivity of the human
kind.Can Gamma-OH and novel analogs reduce wars,
at last? I leave this question opened for your reflexion.
I will summarise,now, the psychotropic profile of Gamma-OH,something which I
have done in a lenghty paper many years ago,in French.
Description of the Psychotropic Effects of Gamma-OH(I985)
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Gamma-OH have the following properties:
A.It stimulates sociability which means that you feel like communicating with
other people in all ways:emotionnal,intellectual,sexual.And from this
communication you feel a very strong and deep happiness.Why?
Because,probably,Gamma-OH inactivates a system which,normally,controls our
base-line level of paranoia.Gamma-OH seems to dissolve paranoia and induce
trust.It would had been very interesting to give Gamma-OH to both Mr.Bush and
Saddam Hussein before they started their silly war!
B.Gamma.OH gives you a strong desire to TOUCH others,physically and
psychologically.
C.Communication becomes extremely gratifying as you feel you want to become
close to people,not to isolate yourself.
D.Gamma-OH induces a strong sense of BEAUTY.Everything looks so beautiful,so
VIVID,so enjoyable,so pleasurable,so important,so "deep".
C.The perception of movement is enhanced.
D.Three-dimensional perception is enhanced and vision seems more clear,better
than usual.
