ALEXIS CORPORATION has a wide range of NOS inhibitors, including a
number of new products which are specific for different isoforms of this
important enzyme, as shown in the summary table.
We are in the process of setting up a Web page with details of all our
catalogues, latest products, technical information, etc. In the
meantime, we plan to post selected information about new products to
relevant newsgroups. We would welcome your comments on the usefulness /
acceptability (or otherwise!) of this information (see 'Contacting
Alexis' following the Lit. References).
Product Cat. No. Inhibitor of Refs.
================================================================
NG-Amino-L-Arginine 106-014 eNOS, iNOS 1-4
S-(2-Aminoethyl)-ITU 270-030 iNOS 5-6
Aminoguanidine 420-004 cNOS, iNOS 7-12
3-Bromo-7-nitroindazole 270-009 bNOS 13
S-Ethyl-ITU 270-025 i,e,nNOS 5-6
L-NIL 270-010 iNOS 14
L-NIO 270-002 eNOS 15-18
S-Isopropyl-ITU 270-028 iNOS 5-6
1,3-PB-ITU 270-026 iNOS 5-6
For further information about these, or any other ALEXIS products for
Nitric Oxide research, see 'Contacting ALEXIS' below (following the
reference list).
LITERATURE REFS.
================
1. J.M. Fukuto, K.S. Wood, R.E. Byrns and L.J. Ignarro; BBRC 168,
458(1990)
2. S.S. Gross, D.J. Stuehr, K. Aisaka, E.A. Jaffe, R. Levi and O.W.
Griffith; BBRC 170, 96 (1990)
3. H.M. Vargas, J.M. Cuevas, L.J. Ignarro and G. Chaudhuri; J.
Pharmacol.Exp.Ther. 257, 1208 (1991)
4. L. Lambert, J.P. Whitten, B.M. Baron, H.C. Cheng, N.S. Doherty and
I. McDonald; Life Sci. 48, 69 (1991)
5. E.P. Garvey, J.A. Oplinger, G.J. Tanoury, P.A. Sherman, M. Fowler,
S.Marhsall, M.F. Harmon, J.E. Paith and E.S. Furfine; J.Biol.Chem.
269, 26669 (1994)
6. G.J. Southan, C. Szabo and C. Thiemermann; Br.J.Pharmacol. 114, 510
(1995)
7. J.A. Corbett, R.G. Tilton, K. Chang, K.S. Hasan, Y. Ido, J.L. Wang,
M.A. Sweetland, J.R. Lancaster, J.R. Williamson, M.L. McDaniel;
Diabetes 41, 552 (1992)
8. T.P. Misko, W.M. Moore, T.P. Kasten, G.A. Nickols, J.A. Corbett,
R.G. Tilton, M.L. McDaniel, J.R. Williamson and M.G. Currie;
Eur.J.Pharmacol. 233, 119 (1993)
9. M.J.D. Griffith, M. Messent, R.J. MacAllister and T.W. Evans;
Br.J.Pharmacol. 110, 963 (1993)
10. A.H. Cross, T.P. Misko, R.F. Lin, W.F. Hickey, J.L. Trotter and R.G.
Tilton; J.Clin.Invest. 93, 2684 (1994)
11. G.A. Joly, M. Ayres, F. Chelly and R.G. Kilbourn; BBRC 199, 147
(1994)
12. F. Laszlo, S.M. Evans and B.J.R. Whittle; Eur.J.Pharmacol. 272, 169
(1995)
13. P.A. Bland-Ward, A. Pitcher, P. Wallace, Z. Gaffen, R.C. Babbedge
and P.K. Moore; Br.J.Pharmacol. 112, 351P (1994)
14. W.M. Moore, R.K. Webber, G.M. Jerome, F.S. Tjoeng, T.P. Misko and
M.G. Currie; J.Med.Chem. 37, 3886 (1994)
15. J.P. Scannell, H.A. Ax, D.L. Pruess, T. Williams, T.C. Demny and A.
Stempel; J.Antibiot. 25, 179 (1972)/M. Palacios, R.G. Knowles,
R.M.J. Palmer and S. Moncada; BBRC 165, 802 (1989)
16. D.D. Rees,R.M.J. Palmer, R. Schulz, H.F. Hodson and S. Moncada;
Br.J.Pharmacol. 101, 746 (1990)
17. T. B. McCall, M. Feelisch, R.M.J. Palmer and S. Moncada;
Br.J.Pharmacol. 102, 234 (1991)
18. M.S. Mulligan, S. Moncada and P.A. Ward; Br.J.Pharmacol. 107, 1159
(1992)
CONTACTING ALEXIS
=================
For technical / ordering information:
ALEXIS US TEL: 1-800-900-0065 or (619)658-0065
FAX: 1-800-900-9224 or (619)658-9224
ALEXIS SWITZERLAND TEL: +41(0)62 299 29 20
FAX: +41(0)62 299 24 80
ALEXIS GERMANY TEL: +49(0)6401 900770
FAX: +49(0)6401 3823
ALEXIS UK TEL: +44(0)1949 836111
FAX: +44(0)1949 836222
For comments / suggestions, e-mail: s.hoare at alexisuk.demon.co.uk
--
Dr. Stephen Hoare
Alexis Corporation (UK) Ltd.
TEL: +44 (0) 1949 836111
FAX: +44 (0) 1949 836222
