re Neal Prakash's commentary: my reply to the original query (reply is
header #16908, at least via my server) discussed the IL-1 angle. In
addition to Linda Watkins re vagus, check out Robert Dantzer re
exploratory behavior, operant behavior, etc.
In my earlier comment, I speculated re IL-1 effect on Ne
(noradrenaline), the target most prominent in theories of ritalin
(etc.) action in ADD (although dopamine should not be ignored). I did,
indeed find a very good review of IL-1 effects on classsical
neurotransmitters, including increasing Ne activity--but left it at
work! will try to bring it home tomorrow. Believe it was in
Neuroimmunology, 1996 or possibly 1995.
Frank LeFever
New York Neuropsychology Group
In <Pine.GSO.3.95.970202145837.25667A-100000 at taurus.oac.uci.edu> Neal
Prakash <nprakash at taurus.oac.uci.edu> writes:
>>Sorry, I missed the original post.
>>But I recall that there is a growing body of research linking "illness
>behaviors" (i.e. fever, decreased socialization, etc.) with immune
system
>cytokines acting directly on the brain. I don't recall the exact
authors
>right now, try L. Watkins [?] or keywords: IL1, fever, vagus, if you
have
>access to medline.
>>One belief is that peripheral nerves, but especially the vagus nerve,
have
>receptors for cytokines, such as IL1, TNF-b, and IL6. So when you have
an
>infection, local cytokines activate the vagus nerve, which in turn
>mediates illness responses in the central nervous system via the
>hypothalamus.
>>Perhaps, with ADHD, this response is altered. Or maybe the illness
>response in the hypothalamus counteracts the neurochemical pathways
>involved in ADHD...
>>>>>On 2 Feb 1997, Wernerson wrote:
>>> Why is my child less hyperactive and why does he get better
attention when
>> he have a fever ?
>> I wonder if science has ever picked up on this point and tried to
back
>> trace from there ?
>> There must be a connection between body temperature and brain
activity ?
>>>>>>----------------------------------------------------------------------
------
>-Neal Prakash
>Department of Psychobiology, College of Medicine
>http://meded.med.uci.edu:80/~nprakash/neal.html>lab:714-824-5031
>fax:714-824-2447
>
