The serial lesion paradigm (e.g. as described in the Finger & Stein
book on recovery from brain trauma a few years ago) typically involves
a first and second lesion separated by rather short intervals--e.g.
hours, days, at most 2-3 weeks. Ditto ischemic preconditioning:
resistance to a second ischemic event relatively soon after the first
one.
Does anyone know of studies (published, unpublished, old or still in
progress) of "conditioning" or "priming" lesions followed MUCH, MUCH
later than a second lesion?
I know, of course of "experiments of nature", in which humans suffering
a second concussion years after the first typically have more (rather
than less) severe symptoms than one might otherwise expect. I am
looking for animal studies.
I'm not fussy: I'll gladly accept studies with analyses at ANY level:
behavioral, neurochemical, histological, etc.
For replies too long for e-mail: FAX (914) 947-3350
or
LeFever, Helen Hayes Hospital
West Haverstraw, NY 10993, USA
F. Frank LeFever, Ph.D.
New York Neuropsychology Group
