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Head trauma: chronic studies

F. Frank LeFever flefever at ix.netcom.com
Sat Mar 15 00:38:06 EST 1997



This is the longer "chronic" query I thought was lost.  re-posting in
hopes of getting good leads from people who missed it before.

Frank


(F. Frank LeFever) writes: 
>
>
>I am looking for CHRONIC studies.  Ideally, fluid percussion procedure
>(rats), mild vs. moderate vs. severe grades, with animals looked at
>several months later.  Ideally, neurochemical, histological, and
>behavioral data.
>
>But I'll take what I can get.  Will not reject human studies
>(especially if you know of some I would not have found via
>Medline--Abstracts, works in progress, non-indexed journals, etc.),
but
>I am looking especially for chronic rat or other animal studies.
>
>At Society for Neuroscience (Nov. 96), Linda Phillips presented data
on
>rats surviving 30 days, but this is truly unusual, so far as I can
see.
> Most studies involve sacrifice after a day or so, rarely more than a
>week after trauma.
>
>I have posted a request for info on "serial lesion" or "priming" or
>"preconditioning" studies with intervals longer than the traditional
>ones (i.e. the ones looking at acute priming effects), but ANY
paradigm
>with long survival times is welcome.
>
>For replies too long for email:  FAX usa (914) 947-3350
>
>F. Frank LeFever, Ph.D.
>Helen Hayes Hospital
>West Haverstraw, NY 10993, USA




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