"PLEASE HELP" <domflag at istar.ca> wrote:
>Please Help -
>We are the parents of a twenty month old Baby Boy with a life threatening
>disease. To our knowledge this is the first case of fungal infection of
>this type known anywhere in the world. If you can provide any suggestions
>for helping our little boy we would be most grateful.
>>Infection: Aspergillus Nidulans in the Central Nervous System. The
>fungus surrounds the base of the brain and is present in other locations on
>the covering of the meninges. This was diagnosed following a biopsy taken
>from his lumbar region. Biopsy was taken September 13, 1996.
>>Cause of Infection: Unknown
>>Patient's Present Condition: No neurological deficits. Hydrocephalus
>was releived surgically.
>>Course of Treatment: Began treatment in September on Amphotericin B and
>5FC given by IV. Treatment was determined to be unsuccessful. After one
>month MRI showed disease had progressed.
>The next reatment was Amphotericin Liposomal given by IV and Oral
>Itraconazole. An MRI taken one month after this treatment was started,
>appeared to show a slight reduction in the size of the fungal growths,
>however a followup MRI taken thirty days later showed the fungus was once
>again growing. At this point the decision was made to put in a reservoir
>to administer ampho B directly into his CSF. On January 9, 1997 a second
>biopsy was taken from his spine. The biopsy confirmed the fungus was
>aspergillus, but the cultures would not grow so it could not be confirmed
>the fungus was Nidulans.
>An MRI taken February 3, 1997 has shown that the fungus increased in size
>considerably even with this treatment and there were new lesions.
>After this MRI the medication was switched to Itraconazole only. On March
>3 an MRI was taken showing the progression of the disease was virtually
>stopped. Since that time Itraconazole doses have been doubled in hope
>this will reduce the fungal lesions.
>He is also being given Gamma Interferon sub-cutaneously to boost immune
>function although no immune deficiency has ever been detected. He had a
>negative result when tested for CGD.
>
