Can anyone elucidate on the mechanism of
Amitryptiline in the brain? I am trying to evolve a
model linking Epinephrine deficiency, lipid
metabolism and Seratonin .
Could epinephrine deficiency be caused by
an intracranial tumour putting pressure on the Pituitary Gland ?
What I have so far is:-
Pituitary -> adrenals -> epinephrine->Epinephrine receptors
->cAMP-> triaglycerol lipase-> FA breakdown.
Also a separate pathway from Seratonin to Smooth muscle Contraction.
I am trying to elucidate a connection between the hormones Epinephrine
and Seratonin and obesity with the cause as a slow growing , benign
brain tumour.
Also, the chemical structures of Epinephrine and Seratonin
seem very different. Does this rule out an overlapping role where one
could (more or less) replace the other .
Any help much apreciated
RA Narton
