Have a look at:
Cortisol levels during human aging predict hippocampal atrophy and memory
deficits
nature neuroscience . volume 1 no 1 . may 1998
Sonia J. Lupien 1,2 , Mony de Leon 3 , Susan de Santi 3 , Antonio Convit 3 ,
Chaim Tarshish 3 , N.P.V.
Nair 1 , Mira Thakur 1 , Bruce S. McEwen 4 , Richard L. Hauger 5 and Michael
J. Meaney 1
Nocturnal Hormone Secretion and the Sleep EEG in Patients Several Months
After Traumatic Brain Injury
J Neuropsychiatry Clin Neurosci 11:3, Summer 1999: 354
Ralf-Michael Frieboes, M.D. Ulrich Mu¨ ller, M.D. Harald Murck, M.D. D. Yves
von Cramon, M.D. Florian Holsboer, M.D., Ph.D. Axel Steiger, M.D.
Abstract
After severe traumatic brain injury (TBI), sleep disturbances and changes in
hormone secretion are frequently observed. Similarly, in depression,
abnormalities of sleep and neuroendocrine regula-tion are common. To test
the hypothesis that the changes in brain-injured patients several months
after injury are similar to those seen in patients with depression, the
authors investigated simulta-neously the sleep EEG and nocturnal hormone
se-cretion in 13 young male nondepressed patients after TBI and 13
age-matched control subjects. The resulting data show a pattern of
sleep-endocrine changes in patients after TBI, which has some similarities
to that of patients with re-mitted depression.
Remember: TBI can bring forth depression.
--
I think I have something else lying around on this but generally you are
right, the current emphasis is tends to overlook cortisol. Additionally,
there are significant swings in cortisol and other neuroendocrines, it is
conceivable at least that if these are out of phase with other systems then
something is going astray.
I cannot say that these will provide you with the relevant refs but their
biblios should set you aright . Hey, you're the one doing the research! Me?
I'm going home.
John H.
North of you circa 1200 miles and its nice to know that someone else on this
continent is interested in this stuff!
Remove 4x in reply.
<jon_psych at my-deja.com> wrote in message news:89q9kb$od4$1 at nnrp1.deja.com...
> Hello everyone,
>> my name is Jon and I am a psychophysiological researcher from
> Melbourne, Australia. My current project is looking at the link between
> unipolar depression and abnormal cortisol secretion from the adrenal
> cortex during the evening.
>> This perspective seems to have been lost underneath the interest in the
> monamine (serotonin, noradrenalin) hypothesis, although it may be
> important for a sub-group of people with depression who can't fall
> asleep at night or suffer from early morning awakenings.
>> Does anyone have any knowledge of this area or know someone who has an
> interest in neuroendocrine pathology?
>> I can be contacted at jon_psych at my-deja.com>> Best regards,
>> Jon.
>>> Sent via Deja.com http://www.deja.com/> Before you buy.
