Logically, and based on a plentitude of corroborating evidence, depression
is "repression" (i.e. generalizable to be described as a "Hibernatory" form
of self-regulation) OF current and/or past "conditioned-in residues of
distressful life-situations [expressable by the acronym "CURSES", which is
approximately short for: Conditioned-in Unconscious-Rendered/Unconsiously
Remembered Stressors, Effecting Symptoms]. That is, adverse life-situations
with an additionally somehow "overwhelming" (=>best not reacted to, or
potentially maladaptively distress-inducing) meaning or significance
(having been instinctively and reflexively detected/registered as such)
normally tend to be handled -- as will normally any "overwhelming" life-time
adversity be handled due to the inevitable "phylogenetic (naturally
selective, thus generally phenotype-shaping) pressures" of such
life-situations -- as (what can be described as) "Hibernation imploring type
life-situations".
John H. <johnhkm at netsprintXXXX.net.au> wrote in message
news:89rapn$69c$1 at news1.wire.net.au...
> Have a look at:
>> Cortisol levels during human aging predict hippocampal atrophy and memory
> deficits
>> nature neuroscience . volume 1 no 1 . may 1998
> Sonia J. Lupien 1,2 , Mony de Leon 3 , Susan de Santi 3 , Antonio Convit 3
,
> Chaim Tarshish 3 , N.P.V.
> Nair 1 , Mira Thakur 1 , Bruce S. McEwen 4 , Richard L. Hauger 5 and
Michael
> J. Meaney 1
>> Nocturnal Hormone Secretion and the Sleep EEG in Patients Several Months
> After Traumatic Brain Injury
> J Neuropsychiatry Clin Neurosci 11:3, Summer 1999: 354
> Ralf-Michael Frieboes, M.D. Ulrich Mu¨ ller, M.D. Harald Murck, M.D. D.
Yves
> von Cramon, M.D. Florian Holsboer, M.D., Ph.D. Axel Steiger, M.D.
>>> Abstract
>> After severe traumatic brain injury (TBI), sleep disturbances and changes
in
> hormone secretion are frequently observed. Similarly, in depression,
> abnormalities of sleep and neuroendocrine regula-tion are common. To test
> the hypothesis that the changes in brain-injured patients several months
> after injury are similar to those seen in patients with depression, the
> authors investigated simulta-neously the sleep EEG and nocturnal hormone
> se-cretion in 13 young male nondepressed patients after TBI and 13
> age-matched control subjects. The resulting data show a pattern of
> sleep-endocrine changes in patients after TBI, which has some similarities
> to that of patients with re-mitted depression.
>> Remember: TBI can bring forth depression.
> --
>> I think I have something else lying around on this but generally you are
> right, the current emphasis is tends to overlook cortisol. Additionally,
> there are significant swings in cortisol and other neuroendocrines, it is
> conceivable at least that if these are out of phase with other systems
then
> something is going astray.
>> I cannot say that these will provide you with the relevant refs but their
> biblios should set you aright . Hey, you're the one doing the research!
Me?
> I'm going home.
>>>> John H.
> North of you circa 1200 miles and its nice to know that someone else on
this
> continent is interested in this stuff!
> Remove 4x in reply.
>>> <jon_psych at my-deja.com> wrote in message
news:89q9kb$od4$1 at nnrp1.deja.com...
> > Hello everyone,
> >
> > my name is Jon and I am a psychophysiological researcher from
> > Melbourne, Australia. My current project is looking at the link between
> > unipolar depression and abnormal cortisol secretion from the adrenal
> > cortex during the evening.
> >
> > This perspective seems to have been lost underneath the interest in the
> > monamine (serotonin, noradrenalin) hypothesis, although it may be
> > important for a sub-group of people with depression who can't fall
> > asleep at night or suffer from early morning awakenings.
> >
> > Does anyone have any knowledge of this area or know someone who has an
> > interest in neuroendocrine pathology?
> >
> > I can be contacted at jon_psych at my-deja.com> >
> > Best regards,
> >
> > Jon.
> >
> >
> > Sent via Deja.com http://www.deja.com/> > Before you buy.
>>
