Br J Cancer 2002 May 20;86(10):1615-21
Dietary restriction reduces angiogenesis and growth in an
orthotopic mouse brain tumour model.
Mukherjee P, El-Abbadi MM, Kasperzyk JL, Ranes MK, Seyfried TN.
Biology Department, Boston College, Chestnut Hill, Massachusetts,
MA 02467, USA.
Diet and lifestyle produce major effects on tumour incidence,
prevalence, and natural history. Moderate dietary restriction has
long been recognised as a natural therapy that improves health,
promotes longevity, and reduces both the incidence and growth of
many tumour types. Dietary restriction differs from fasting or
starvation by reducing total food and caloric intake without
causing nutritional deficiencies. No prior studies have evaluated
the responsiveness of malignant brain cancer to dietary
restriction. We found that a moderate dietary restriction of
30-40% significantly inhibited the intracerebral growth of the
CT-2A syngeneic malignant mouse astrocytoma by almost 80%. The
total dietary intake for the ad libitum control group (n=9) and
the dietary restriction experimental group (n=10) was about 20
and 13 Kcal day(-1), respectively. Overall health and vitality
was better in the dietary restriction-fed mice than in the ad
libitum-fed mice. Tumour microvessel density (Factor VIII
immunostaining) was two-fold less in the dietary restriction
mice than in the ad libitum mice, whereas the tumour apoptotic
index (TUNEL assay) was three-fold greater in the dietary
restriction mice than in the ad libitum mice. CT-2A tumour cell-
induced vascularity was also less in the dietary restriction mice
than in the ad libitum mice in the in vivo Matrigel plug assay.
These findings indicate that dietary restriction inhibited CT-2A
growth by reducing angiogenesis and by enhancing apoptosis.
Dietary restriction may shift the tumour microenvironment from
a proangiogenic to an antiangiogenic state through multiple
effects on the tumour cells and the tumour-associated host cells.
Our data suggest that moderate dietary restriction may be an
effective antiangiogenic therapy for recurrent malignant brain
cancers. DOI: 10.1038/sj/bjc/6600298 www.bjcancer.comCopyright
2002 Cancer Research UK
PMID: 12085212 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12085212&dopt=Abstracthttp://IanGoddard.net
"To lengthen thy life, lessen thy meals." Ben Franklin
Caloric Restriction: http://IanGoddard.net/cr.htm
