Please pardon my ignorance, but what the hell is AoK?
-- Eric
KP_PC wrote:
>> reflects the construction of experientially-correlated "biological
> mass" [AoK, Ap5], which, further, discloses the 'inappropriateness'
> of biochemical 'intervention'.
>> "Biological mass" derives in - is mapped to - experience.
>> Biochemical 'intervention' is not.
>> Do the latter =without= addressing experiential factors, and what one
> ends up with is a "supersystem" having 'fractured' functionality
> because the experientially-mapped "biological mass" remains extant
> within the nervous system involved.
>> This's definitely some of what's involved in instances of
> chemically-induced interactive violence.
>> Generalized communication of understanding of how nervous systems
> process information, of course with commensurate Learning with
> respect to such within individual nervous systems, will go a long way
> toward ameliorating the difficulties inherent.
>> K. P. Collins
>> --
> "Schmitd! Schmitd! Ve vill build a Shapel!"
>> "Eric Wilk" <Eric.Wilk at tufts.edu> wrote in message
> news:3ECC38DF.58BC833D at tufts.edu...> | CSF metabolite linked to affective disorder burden
> |
> | Copied wo/ permission from PsychiatryMatters.md
> |
> | Researchers have found a positive relationship between
> cerebrospinal
> | (CSF) concentrations of a
> | monoamine metabolite and the accumulated burden of mood swings in
> | patients with
> | treatment-refractory affective disorders.
> |
> | The finding supports theories that affective disorders may result
> in
> | allostasis as opposed to
> | homeostasis, in which the stress the body endures leads to
> catecholamine
> | systems adapting to new
> | levels, say Anna Ehnvall (Varberg, Hospital, Sweden) and
> colleagues.
> |
> | Reviewing a computerized program charting every previous affective
> | episode for 37 patients with
> | severe treatment-refractory affective disorders, the team
> calculated the
> | "accumulated burden of
> | mood swings" (ABMS). This included the length and severity of each
> episode.
> |
> | In addition, CSF concentrations of homovanillic acid (HVA),
> 3-methoxy-4-hydroxyphenylglycol
> | (MHPG), and 5-hydroxyindoleacetic acid (5-HIAA) were measured and
> | compared with those for
> | 27 healthy controls.
> |
> | Analyses showed that, of all the monoamine metabolites, CSF MHPG
> was the strongest
> | contributor to the overall variance of ABMS.
> |
> | Altogether, the eight predictive variables - CSF concentrations of
> HVA,
> | MHPG, 5-HIAA, gender,
> | the bipolar/unipolar distinction, age, body height, and Hamilton
> | Depression Rating Scale scores -
> | xplained 56% of the total variation in ABMS, with MHPG in
> isolation
> | explaining 23% of the
> | variation.
> |
> | "Our findings indicate that CSF concentrations of MHPG in severe
> | treatment-refractory affective
> | illness is positively related to the ABMS measure over a lifetime,
> | irrespective of age, gender, uni- or
> | bipolarity, and current severity of the illness," the team writes
> in the
> | Journal of Affective
> | Disorders.
> |
> | Thus, the involvement of norepinephrine turnover in the long-term
> burden
> | of affective illness is a
> | likely reality."
