From owner-sci-resources@net.bio.net Thu Apr 01 23:00:00 1993 Path: biosci!agate!doc.ic.ac.uk!daresbury!news!ajb From: ajb@s-crim1.dl.ac.uk (Alan Bleasby) Newsgroups: sci.bio,sci.med,sci.engr.biomed,talk.politics.drugs,talk.politics.medicine,talk.politics.misc,bionet.general,bionet.sci-resources,alt.politics.clinton,alt.politics.economics Subject: Re: Hillary Rodham Clinton's Sovietology Exercise Message-ID: Date: 2 Apr 93 02:59:17 GMT References: <1993Mar30.184548.28977@oracle.us.oracle.com> <1993Mar31.071008.6915@Princeton.EDU> <1993Apr1.034408.20615@oracle.us.oracle.com> Distribution: usa Organization: SERC Daresbury Laboratory, Warrington, UK Lines: 9 Xref: biosci sci.bio:2786 sci.med:11843 sci.engr.biomed:356 talk.politics.drugs:2898 talk.politics.medicine:1753 talk.politics.misc:36298 bionet.general:4456 bionet.sci-resources:687 alt.politics.clinton:6470 alt.politics.economics:898 NNTP-Posting-Host: s-crim1.dl.ac.uk In-reply-to: mfriedma@us.oracle.com's message of 1 Apr 93 03:44:08 GMT Forgive me, but I thought I was supporting the European/Asian/African dissemination of biology-related information. I would sincerely appreciate it if postings on this topic ceased. Alan Bleasby BIOSCI Europe/Asia/Africa SERC Daresbury Laboratory Warrington WA4 4AD UK From owner-sci-resources@net.bio.net Thu Apr 01 23:00:00 1993 Path: biosci!oracle!unrepliable!bounce From: mfriedma@us.oracle.com (Michael Friedman) Newsgroups: sci.bio,sci.med,sci.engr.biomed,talk.politics.drugs,talk.politics.medicine,talk.politics.misc,bionet.general,bionet.sci-resources,alt.politics.clinton,alt.politics.economics Subject: Re: Hillary Rodham Clinton's Sovietology Exercise Message-ID: <1993Apr1.034408.20615@oracle.us.oracle.com> Date: 1 Apr 93 03:44:08 GMT References: <1993Mar30.184548.28977@oracle.us.oracle.com> <1993Mar31.071008.6915@Princeton.EDU> Sender: usenet@oracle.us.oracle.com (Oracle News Poster) Distribution: usa Organization: Oracle Corporation, Redwood Shores CA Lines: 51 Xref: biosci sci.bio:2785 sci.med:11841 sci.engr.biomed:355 talk.politics.drugs:2895 talk.politics.medicine:1751 talk.politics.misc:36274 bionet.general:4455 bionet.sci-resources:686 alt.politics.clinton:6464 alt.politics.economics:894 Nntp-Posting-Host: hqsun4.us.oracle.com X-Disclaimer: This message was written by an unauthenticated user at Oracle Corporation. The opinions expressed are those of the user and not necessarily those of Oracle. In article <1993Mar31.071008.6915@Princeton.EDU> niepornt@phoenix.Princeton.EDU (David Marc Nieporent) writes: >In article <1993Mar30.184548.28977@oracle.us.oracle.com> mfriedma@us.oracle.com (Michael Friedman) writes: >>Jeff Sicherman blatantly lies in his post below... >But only if you're stupid enough, like Michael Friedman, to be unable to >understand the English language... No, I understand it, but you can't have it both ways. Either Bush just kept the meetings secret - which was totally legal, ask the courts - or Bush kept the members secret, which he didn't, but which would have been illegal and equivalent to Clinton's actions. Either way, Jeff Sicherman attempts to mislead us. We can argue over whether or not it is a blatant lie, but it's clearly not the truth. >>In article sichermn@csulb.edu (Jeff Sicherman) writes: >>>In <26MAR199313552586@cc.utah.edu> djs1539@cc.utah.edu(SEGAL, DAVID JAY) says: >>>>In article , smith@minerva.harvard.edu (Steven Smith) writes... >>>>{The WSJ requested help identifying these individuals, so I scanned the >>>>{list and present it here along with the accompanying article with the >>>>{hope that it will help to illuminate these proceedings whose outcome >>>>{could affect all Americans and their progeny, but are nevertheless >>>>{insulated from public inspection and debate. >>>>What's the big deal? There are hundreds of committees in Washington. Most >>>>people don't know who's on them; most people don't care. Why don't you >>>>wait to see what they come up with and spend your energy evaluating that? >>>>Isn't the message more important than the messenger? >>> Also note that these whiners were nowhere to be found when Danny's >>>Cabal on Competitiveness held its secret meetings to overturn >>>regulations which had been arrived at through the open proposal >>>and comment process. >>The Bush administration didn't try to keep the names of the members of >>the Council on Competitiveness secret. Jeff, you are a liar. >And, of course, Jeff never said that the Bush administration did do >this. What Jeff said, and what the Bush admin. did do, was keep the >actual *meetings* secret. >Meetings at which policies/regulations were enacted, not just discussed. Wrongo. Legally, there is no such thing as a policy. I challenge you to find a regulation enacted by the Council on Competitiveness. From owner-sci-resources@net.bio.net Thu Apr 01 23:00:00 1993 Path: biosci!oracle!unrepliable!bounce From: mfriedma@us.oracle.com (Michael Friedman) Newsgroups: sci.bio,sci.med,sci.engr.biomed,talk.politics.drugs,talk.politics.medicine,talk.politics.misc,bionet.general,bionet.sci-resources,alt.politics.clinton,alt.politics.economics Subject: Re: Hillary Rodham Clinton's Sovietology Exercise Message-ID: <1993Mar31.174409.20484@oracle.us.oracle.com> Date: 31 Mar 93 17:44:09 GMT References: <1993Mar30.185342.29473@oracle.us.oracle.com> <1pasjdINN3as@spim.mti.sgi.com> Sender: usenet@oracle.us.oracle.com (Oracle News Poster) Organization: Oracle Corporation, Redwood Shores CA Lines: 36 Xref: biosci sci.bio:2784 sci.med:11840 sci.engr.biomed:354 talk.politics.drugs:2894 talk.politics.medicine:1750 talk.politics.misc:36273 bionet.general:4454 bionet.sci-resources:685 alt.politics.clinton:6463 alt.politics.economics:893 Nntp-Posting-Host: hqsun4.us.oracle.com X-Disclaimer: This message was written by an unauthenticated user at Oracle Corporation. The opinions expressed are those of the user and not necessarily those of Oracle. Blatant lie below... In article <1pasjdINN3as@spim.mti.sgi.com> mpolen@suntory.mti.sgi.com (Mike Polen) writes: >Michael Friedman) writes: >|> Bernie Cosell) writes: >|> >Michael Friedman (mfriedma@us.oracle.com) wrote: >|> >} Kate E. Loomis) writes: >|> >} >Regarding the extensive list of names on the "top secret, Soviet-Style >|> >} >health reform task force" : there is no analogy here. These people are >|> >} >not creating policy, they are _drafting a plan_ . ... >|> >} >So what is the problem? >|> >} The problem is that we are supposed to have an open government. Plans >|> >} that do not require security are not supposed to be drafted in secret >|> >} by people whose names are not even released. >|> >} If nothing else, people who object to the makeup of the task force >|> >} have the right to know who is on it and to present their objections to >|> >} the people of the United States. >|> >By and large, NONE of the government >|> >'plan making' machinery is particularly open. >|> Phrases like "particularly open" or so vague that they are >|> meaningless. However, can you name another government committee whose >|> members are secret and which is not related to national defense or >|> sensitive foreign policy issues? >It took us about 6 years to find out that Nancy Reagan's astrologer >was a key member of the White House Committee for Planning and Decision >Making. Are you suggesting that she only advised on national defense >and sensitive foreign policy issues? Blatant lie. No such Committee exists. From owner-sci-resources@net.bio.net Fri Apr 02 23:00:00 1993 Path: biosci!agate!howland.reston.ans.net!usc!elroy.jpl.nasa.gov!jato!quake!brian From: brian@quake.sylmar.ca.us Newsgroups: sci.bio,sci.med,sci.engr.biomed,talk.politics.drugs,talk.politics.medicine,talk.politics.misc,bionet.general,bionet.sci-resources,alt.politics.clinton,alt.politics.economics Subject: Re: Hillary Rodham Clinton's Sovietology Exercise Message-ID: Date: 3 Apr 93 09:37:37 GMT References: <26MAR199313552586@cc.utah.edu> Distribution: usa Organization: Quake Public Access, San Fernando Valley, CA (818)362-6092 Lines: 34 Xref: biosci sci.bio:2805 sci.med:11923 sci.engr.biomed:359 talk.politics.drugs:2933 talk.politics.medicine:1773 talk.politics.misc:36718 bionet.general:4471 bionet.sci-resources:688 alt.politics.clinton:6539 alt.politics.economics:909 In article sichermn@csulb.edu (Jeff Sicherman) writes: >In article <26MAR199313552586@cc.utah.edu> djs1539@cc.utah.edu (SEGAL, DAVID JAY) writes: >>What's the big deal? There are hundreds of committees in Washington. Most >>people don't know who's on them; most people don't care. Why don't you >>wait to see what they come up with and spend your energy evaluating that? >>Isn't the message more important than the messenger? >>Besides, >>I don't understand why people are so focused on the publicity of this >>particular committee's meetings. I think the only ones who really have >>a problem with it are the MD types, who stand the most to lose from >>health care reform. For guys like me, who have the most to gain from >>reform, I say get off their backs. Why in the world do you think that having a bunch of socialists destroy the health care system will benefit you? If you want that kind of economy, go live in the USSR...oops, they can't stand socialism and are changing. Well, go live in CHina then...ummm, well, I guess they are busting their butts to abandon socialism too. Well, Cuba, yeah, Cuba. You'll be able to have socialism there for at least a few more years. >>Finally somebody's actually doing >>something. Almost anything is better than the system we've got now. >>Besides, the committee can't pass any legislation by itself anyway. > Also note that these whiners were nowhere to be found when Danny's >Cabal on Competitiveness held its secret meetings to overturn >regulations which had been arrived at through the open proposal >and comment process. Perhaps it is that Quayle's cabal was trying (for the most part) to protect people's rights, while Hillary's Cabal is fundamentally dedicated to violating them. --Brian From owner-sci-resources@net.bio.net Sat Apr 03 23:00:00 1993 Path: biosci!ICBR.IFAS.UFL.EDU!SJJ From: SJJ@ICBR.IFAS.UFL.EDU ("JONG, SONG-MUH J") Newsgroups: bionet.sci-resources Subject: Funding availability postings Message-ID: <9304041533.AA24859@net.bio.net> Date: 4 Apr 93 15:17:00 GMT Sender: daemon@net.bio.net Distribution: bionet Lines: 9 Hi, bionetters, So far, I have only seen posting from NIH and NSF in this newsgroup. Is it possible to invite Foundations or other funding sources to post in this newsgroup? Song-Muh Jong sjj@icbr.ifas.ufl.edu From owner-sci-resources@net.bio.net Sat Apr 03 23:00:00 1993 Path: biosci!NETCOM.COM!wick From: wick@NETCOM.COM (Potter Wickware) Newsgroups: bionet.sci-resources Subject: Re: Funding availability postings Message-ID: Date: 4 Apr 93 16:47:50 GMT References: <9304041533.AA24859@net.bio.net> Sender: daemon@net.bio.net Distribution: bionet Lines: 24 Yes, I would like to see announcements from USDA, NST (or whatever it's called now, the old Bureau of Standards), NOAA, etc. Trouble is, the output is so voluminous, and diffuse, it would be hard to plow thru it all. Look how much comes just from NIH. Their index is _some_ help, but unless the agency people could be persuaded to write concisely ;-> it would be a chore to have it coming in. What wld be really nice wld be to get quick news on what private funders are doing, ie $80M grant by Amgen to lab of Tak Mak (who discovered the T cell receptor). Not much hope for private outfits to come on line with their doings, though, I don't think. On 4 Apr 1993, JONG, SONG-MUH J wrote: > Hi, bionetters, > > So far, I have only seen posting from NIH and NSF in this newsgroup. > Is it possible to invite Foundations or other funding sources to > post in this newsgroup? > > Song-Muh Jong > sjj@icbr.ifas.ufl.edu > From owner-sci-resources@net.bio.net Sun Apr 04 23:00:00 1993 Path: biosci!CCF3.NRL.NAVY.MIL!EISENSTADT From: EISENSTADT@CCF3.NRL.NAVY.MIL ("ERIC EISENSTADT") Newsgroups: bionet.sci-resources Subject: ONR Biological Sciences Division Message-ID: <9304051254.AA20970@net.bio.net> Date: 5 Apr 93 13:38:00 GMT Sender: daemon@net.bio.net Distribution: bionet Lines: 470 PROGRAM INFORMATION BIOLOGICAL SCIENCES DIVISION OFFICE OF NAVAL RESEARCH INTRODUCTION The Office of Naval Research (ONR) has supported basic biological research at universities and other research centers since 1946. ONR also supports training, education programs, and conferences closely related to its programs. Funding decisions are based on scientific or educational quality, relevance to research programs, and availability of funds. Research awards vary in size; typically, awards are made for up to three years and range between $70,000 and $150,000 per year (direct + indirect costs). A summary of research projects supported by the Division of Biological Sciences is available upon request. Research programs supported by the Division fall into three broad programs: 1) Molecular, Cellular, and Environmental Biology; 2) Integrative Biology; and, 3) Sensory Biology. MOLECULAR, CELLULAR, AND ENVIRONMENTAL BIOLOGY PROGRAM The naval concerns that provide the primary focus and rationale for this program are: deterioration of ships and platforms in marine environments due to biocorrosion and biofouling; the need for novel materials and catalysts; requirements for highly sensitive and selective detector systems; and the quality of shipboard and near-shore marine environments. Guided by these naval concerns, this program emphasizes research activities that concentrate on molecular and cellular aspects of marine biology and on determining the principles governing molecular structure, function, and interactions. Specific research issues that are currently being addressed include the following: BIOCATALYSIS IN NON-AQUEOUS SOLVENTS Can we redesign enzymes to be soluble, stable, and highly active in non-aqueous solvents? BIODEGRADATION IN MARINE SEDIMENTS What are the basic biochemical and molecular mechanisms driving biodegradation of hazardous materials in marine sediments? Which microorganisms are the major participants in biodegradation in marine sediments? BIOFABRICATION What are the molecular (including cellular and biochemical) mechanisms used by cells to manufacture mineral structures in the 1 to 100 nm size range? What mechanisms control the size and shape of such structures? BIODETERIORATION What are the molecular mechanisms responsible for biofouling and biocorrosion in marine environments? BIOLUMINESCENCE How is light production in marine environments regulated? What are the molecular and physiological mechanisms governing bioluminescence? BIOMIMETICS How do we proceed from the principles of molecular recognition and enzyme mechanism to the design and synthesis of binding sites, catalytic sites and simplified (diffusible) group transfer co-enzymes? BIOSENSORS How can reusable biosensors be designed for assessment and quantification in real time of any analyte of interest in mixtures of analytes differing significantly in size, shape and concentration and in classes of analytes having similar size, shape and concentration (including group IIB and the divalent transition metal ions present at nanomolar concentrations in the ocean)? COMBINATORIAL SYNTHESIS How can we exploit massively parallel synthesis of polymers of defined length and sequence through biological, biomimetic and bioorganic strategies? ENVIRONMENTAL TOXICOLOGY What mechanisms are used by marine organisms to detect and detoxify hazardous waste? HIGH TEMPERATURE AND PRESSURE BIOLOGY What unique molecular adaptations have developed to permit organisms to function at temperatures above 90x C and/or high hydrostatic pressure? MARINE MAMMALS Are low frequency sounds important to the biology of marine mammals? Are human produced low frequency sound signals harmful to marine mammals? Do marine mammals and other marine vertebrates employ novel methods or mechanisms for aquatic locomotion? MARINE SYMBIOSIS What are the biochemical, genetic, and molecular mechanisms that govern symbiotic associations of marine organisms? How do hosts and symbionts recognize each other and regulate their genetic and metabolic interactions? MARINE VIRUSES How widely distributed are marine viruses? What impact do they have on marine life and oceanographic phenomena? How do they interact with their hosts? MOLECULAR BIOLOGY OF MARINE ORGANISMS What are the basic biological mechanisms governing the physiological activities of marine microbes (bacteria, fungi) and algae? Can novel molecular approaches be developed to analyze the abundance and physiology of natural populations of marine organisms? MOLECULAR RECOGNITION What are the atomic requisites for specific inter-/intramolecular recognition, binding, and reactivity in biomolecules? NANOTRANSPORT What are the requirements for microtubule-directed vesicular transport in vitro. How can cellular components be modified for in vitro transport of unnatural substrates? INTEGRATIVE BIOLOGY PROGRAM Navy and Marine Corps personnel, in both operational and training settings, commonly encounter unique and often highly stressful environments. The physiological response to these environments can compromise both health and performance of personnel in critical situations. A new class of peptide hormones, the cytokines, have recently been recognized as modulators of the stress response as well as of the immune response. In order to better understand the stress response at the molecular level and its role in acute disease processes, the Integrative Biology program is addressing the following research issues: NEUROIMMUNE INTERACTIONS How do cytokines induced in the periphery enter the brain? What are their neural targets? What are their sources in stress? How do cytokines modulate classical endocrine functions in stress and trauma? VIRAL ACUTE PHASE RESPONSE What cytokines mediate the "flu" syndrome associated with common acute viral infections? How are they triggered? How do they interact? Can human performance degradation by this syndrome be ameliorated without compromising disease recovery? SENSORY BIOLOGY PROGRAM The naval need for highly sensitive and selective detector systems that function in marine environments provides the primary focus and rationale for this program. Guided by this need, this program supports basic research on responses of complex organisms to environmental stimuli. The focus is on sensory systems and integrated responses at the cellular and molecular levels. The primary goal of the program is to achieve a better understanding of sensory system function. Sensory Biology Programs are grouped into two major areas, Sensory Biology and Environmental Biophysics. Sensory Biology is directed at the study of sensory transduction mechanisms in order to understand and exploit principles of biological sensors such as amplification, adaptation, selectivity, signal from noise discrimination, and dynamic range. Environmental Biophysics is directed at investigating membrane events involved in sensing environmental changes, particularly those that rely upon mechanisms of ion regulation and signal transduction. Specific research issues that are currently being addressed include the following: BIODETECTION OF WEAK ELECTRIC FIELDS What are the cellular functions associated with the detection and localization of weak electromagnetic fields? How do electric fields interact with the plasma membrane, membrane receptors, channel proteins, and components of signal transduction pathways? ODORANT DISCRIMINATION What are the molecular mechanisms associated with the detection and recognition of chemicals by olfactory receptor neurons and other chemosensory cells of vertebrates, marine invertebrates, and microorganisms? NEAR-FIELD ACOUSTIC DETECTION IN FISH What are the mechanisms that allow fish to use near field low frequency acoustic information for orientation and localization of the acoustic source? SINGLE NEURON COMPUTATION Can one formalize the computations performed by neurons as a basis for designing enhanced processor elements for the next generation of neural networks? What is the distribution of neuronal membrane potentials and ion channels: Is there cooperativity among ion channels? WATER AT BIOLOGICAL INTERFACES What are the physical and chemical mechanisms governing the influence of water on membranes, transport, and receptor action? EDUCATION & TRAINING PROGRAMS Training programs in Molecular, Cellular and Environmental Biology, Sensory Biology and Integrative Biology are intended to provide promising young scientists at the graduate and postdoctoral levels with state-of-the-art training in research areas outlined in this brochure. We also support education programs at historically black colleges and universities and minority institutions. The purpose of these education programs is to increase the number of minority students who enter graduate schools to earn doctoral degrees in science. To this end we support efforts to prepare undergraduates for graduate study in the biological sciences at major research institutions. Education programs supported by us typically involve recruiting and retention efforts, curriculum enhancement, and undergraduate research programs. PROPOSAL SUBMISSION & EVALUATION PROCEDURES Generally, investigators will submit a brief preproposal that allows ONR scientific staff listed at the end of this document to evaluate the relevance and importance of the idea. Investigators whose preproposals are judged to be both relevant and interesting will be encouraged to submit a full proposal. Proposals will be subjected to review against the following criteria: 1. Overall scientific, technical, or socio-economic merit 2. Potential contribution of the effort to ONR's mission 3. Qualifications, capabilities, and experience of the Principal Investigator(s) and key personnel who are critical in achieving the proposed objectives 4. Realism of the proposed cost and availability of funds 5. Extent to which the cost effectiveness of the proposed research is diminished by expenditures for unproductive administrative and overhead expenses. Full proposals, including competitive renewals, are reviewed twice a year and should be postmarked by 1 May or 1 November. The current reviewing schedule calls for a response to preproposals within 8 weeks of receipt. A preproposal should, therefore, be submitted well in advance of the 1 May and 1 November deadlines. THE PREPROPOSAL A preproposal, in three (3) or fewer pages of text, should explain your idea and why it is important. Please include a CV for each principal investigator and a budget estimate. Submit the original and three (3) copies to the address given on the next page. THE FULL PROPOSAL The proposal allows you to explain your idea in sufficient detail to permit colleagues to evaluate its scientific novelty, validity, and feasibility. Proposal instructions are outlined on the following page. FULL PROPOSAL INSTRUCTIONS Please submit the original and five (5) copies of the full proposal (except for Section N as noted below). Text for full proposals should be at least 10 point type (12 point preferred) with 1.5 line spacing and 1" margins (top, sides, bottom). All materials should be sent to: Director, Biological Sciences Division, Office of Naval Research Code 1141, 800 N. Quincy Street, Arlington, Virginia 22217-5660. If you have questions about proposal submission please call 703-696-4760. ORDER AND CONTENT OF THE FULL PROPOSAL A. Title Page (see Attachment 1) B. Table of Contents C. Statement of Objectives (< 100 words, What biological questions will you address?) D. Statement of the Approach (< 100 words, How will you address the questions experimentally?) E. Statement of Significance (< 100 words, Why are your ideas interesting?) F. Key Word/Phrase Listing (4-10 items) G. Body of Proposal (up to 12 pages for new proposals; up to 17 pages for competitive renewals) 1. Introduction and Background Information (up to 3 pages; Help the reviewers understand why the biological problem you are attempting to solve is important and how your ideas relate to existing knowledge that has been generated by others in the field and by you. Preliminary data, manuscripts, and reprints that are relevant to this section should be compiled as an appendix in Section N) 2. Progress (up to 5 pages; this section should only be included for competitive renewal proposals) 3. Technical Approach 4. References H. Facilities available, especially unique facilities or capabilities I. Annual Budget (indicate institutional matching where appropriate) 1. Personnel salaries, wages and fringe benefits (indicate % effort) 2. Equipment - purchase and maintenance, and justification for purchase. 3. Materials and supplies 4. Travel (indicate purpose; identify and justify foreign travel) 5. Indirect Costs 6. Totals (provide annual breakdown and cumulative summary) J. CV's for investigators and consultants K. For all current and pending support (including proposals under review) of each investigator list: 1. Project title and summary 2. Source and amount of funding (annual direct costs; provide grant numbers for current grants) 3. Percentage effort devoted to each project 4. State how projects are related to proposed effort and indicate degree of overlap L. List other agencies to which this proposal has been submitted M. Special information regarding certain types of experiments 1. Experiments involving animals - Species justification, pain causation, or pain control. - Statement of compliance with DOD-FAR 52.235-7003 (see Attachment 2) - Copy of Institutional Animal Care and Use Committee approval 2. Experiments involving human subjects - Statement of compliance with DHHS regulations, Protection of Human Subjects (45 Code of Federal Regulations 46, 1/26/81) - Institutional Review Board Form 3. Experiments involving recombinant DNA - Statement of compliance with DHHS rDNA regulations N. Appendices - Preliminary data, manuscripts, reprints, and any other supporting materials (2 copies only) ___________________________________________________________________ Attachment 1: Sample Title Page RESEARCH PROPOSAL SUBMITTED TO THE OFFICE OF NAVAL RESEARCH TITLE: Full title of proposal ABBREVIATED TITLE: (up to 26 characters) INSTITUTION: Name and address of institution PRINCIPAL INVESTIGATOR(S): _______________________________ _______________________________ Principal Investigator Date Co-Principal Investigator Date Address: Address: Phone: Phone: Fax: Fax: INSTITUTIONAL ENDORSEMENTS _______________________________ _______________________________ Administrative Head Date Financial Officer Date Address: Address: Phone: Phone: TOTAL COST: Dollar amount requested (include direct & indirect costs) DURATION: Duration of project and proposed starting date DATE SUBMITTED: THIS PROPOSAL IS SUBMITTED PURSUANT TO THE ONR GUIDE TO PROGRAMS, BROAD AGENCY ANNOUNCEMENT, DATED 25 June 1992 ___________________________________________________________________ Attachment 2: Department of Defense-Federal Acquisition Regulation 52.235-7003 a. Before undertaking performance of any contract involving the use of laboratory animals, the Grantee shall register with the Secretary of Agriculture of the United States in accordance with Section 6, P.L. 89-544, Laboratory Animal Welfare Act, 24 August 1966 as amended by P.L. 91-579, Animal Welfare Act of 1970, 24 December 1970. The Grantee shall furnish evidence of such registration to the contracting officer. b. The Grantee shall acquire animals used in research and development programs from a dealer licensed by the Secretary of Agriculture or from exempted sources in accordance with the Public Laws enumerated in (a) above. c. In the care of any live animals used or intended for use in the performance of a contract, the Grantee shall adhere to the principles enunciated in the "Guide for Care and Use of Laboratory Animals" prepared by the Institute of Laboratory Animal Resources, National Academy of Science-National Research Council and in the United States Department of Agriculture's regulations and standards issued under the Public Laws enumerated in (a) above. In the case of conflict between standards, the higher standard shall be used. Grantee reports on portions of the contract in which animals were used shall contain a certificate stating that the animals are cared for in accordance with the principles enunciated in the "Guide for Care and Use of Laboratory Animals" prepared by the Institute of Laboratory Animal Resources, NAS-NRC, and/or in the regulations and standards are promulgated by the Agricultural Research Service, USDA, pursuant to the Laboratory Animal Welfare Act of 24 August 1966, as amended (P.L. 89-544 and P.L. 91-579). Note: The Grantee may request registration of his facility and a current listing of licensed dealers from the Regional Office of the Animal and Plant Health Inspection Service (APHIS), USDA, for the region in which the research facility is located. The location of the appropriate APHIS Regional Office as well as information concerning this program may be obtained by contacting the Staff Officer, Animal Care Staff, USDA/APHIS, Federal Center Building, Hyattsville, Maryland, 20782. _____________________________________________________________________ THE SCIENTIFIC STAFF LIFE SCIENCES DIRECTORATE Dr. Steven F. Zornetzer, Director . . . . . . . . . (703) 696-4501 BIOLOGICAL SCIENCES DIVISION Dr. Robert W. Newburgh, Director. . . . . . . . . (703) 696-4986 Ms. Sevgi Bullock, Division Secretary . . . . . . (703) 696-4760 General Information for Biological Sciences MOLECULAR, CELLULAR, AND ENVIRONMENTAL BIOLOGY PROGRAM Dr. Michael Marron, Program Manager. . . . . . .(703) 696-4038 Molecular Biology Dr. Randall S. Alberte . . . . . . . . . . . . .(703) 696-4039 Molecular Marine Biology Dr. Harold Bright. . . . . . . . . . . . . . . .(703) 696-4054 Biochemistry Dr. Daniel P. Costa. . . . . . . . . . . . . . .(703) 696-2085 Marine Mammals and Physiology Dr. Eric Eisenstadt. . . . . . . . . . . . . . .(703) 696-4596 Microbial Genetics Dr. Constance Oliver . . . . . . . . . . . . . .(703) 696-4053 Cell Biology, Environmental Toxicology Dr. Anna C. Palmisano. . . . . . . . . . . . . .(703) 696-2660 Environmental Biology, Microbial Ecology INTEGRATIVE BIOLOGY PROGRAM Dr. Jeannine A. Majde, Program Manager . . . . .(703) 696-4055 Immunophysiology, Medical Materials SENSORY BIOLOGY PROGRAM Dr. Igor Vodyanoy, Program Manager . . . . . . .(703) 696-4056 Biophysics, Sensory Biology FAX Number for the Biological Sciences Division. . . (703) 696-1212 18 March 1993 From owner-sci-resources@net.bio.net Mon Apr 05 23:00:00 1993 Path: biosci!daresbury!keele!uknet!mcsun!uunet!usc!howland.reston.ans.net!usenet.ins.cwru.edu!cleveland.Freenet.Edu!dd544 From: dd544@cleveland.Freenet.Edu (Paul F. Lehmann Ph.d.) Newsgroups: bionet.sci-resources Subject: listing opportunities one at a time NIH/USNAval Research etc Message-ID: <1ps8cj$7n2@usenet.INS.CWRU.Edu> Date: 6 Apr 93 15:42:11 GMT Organization: Case Western Reserve University, Cleveland, Ohio (USA) Lines: 9 NNTP-Posting-Host: hela.ins.cwru.edu It is hard to wade through NIH Guide the way it is posted. Could the NIH and other gencies put each opportunity into a different message? Then I wouldn't have to read about things of no significance to my resera research in the hope that some gold mine lies further on! Paul F. Lehmann lehmann%opus@mcoiarc.bitnet From owner-sci-resources@net.bio.net Mon Apr 05 23:00:00 1993 Path: biosci!bcm!cs.utexas.edu!uunet!haven.umd.edu!darwin.sura.net!welchgate.welch.jhu.edu!danj From: danj@welchgate.welch.jhu.edu (Dan Jacobson) Newsgroups: bionet.sci-resources Subject: Re: listing opportunities one at a time NIH/USNAval Research etc Message-ID: <1993Apr6.175306.6194@welchgate.welch.jhu.edu> Date: 6 Apr 93 17:53:06 GMT References: <1ps8cj$7n2@usenet.INS.CWRU.Edu> Organization: Johns Hopkins Univ. Welch Medical Library Lines: 33 In article <1ps8cj$7n2@usenet.INS.CWRU.Edu> dd544@cleveland.Freenet.Edu (Paul F. Lehmann Ph.d.) writes: > >It is hard to wade through NIH Guide the way it is posted. >Could the NIH and other gencies put each opportunity into a >different message? Then I wouldn't have to read about things >of no significance to my resera research in the hope that >some gold mine lies further on! > >Paul F. Lehmann >lehmann%opus@mcoiarc.bitnet You might want to try reading it by gopher - point you gopher client at helix.nih.gov and select the following directories: --> 2. NIH Information/ --> 2. NIH Guide to Grants and Contracts/ Where you'll see: --> 1. About the NIH Guide. 2. Search NIH Guide (most recent 6 weeks) 3. Search NIH Guide (Jan 1992 - the present) 4. NIH Guide - Flat Text Files/ 5. Request for Applications (RFAs) - Full Text / 6. Program Announcements - Full Text/ Best of luck, Dan Jacobson danj@welchgate.welch.jhu.edu From owner-sci-resources@net.bio.net Tue Apr 06 23:00:00 1993 Path: biosci!CU.NIH.GOV!CZJ From: CZJ@CU.NIH.GOV Newsgroups: bionet.sci-resources Subject: Re: listing opportunities one at a time NIH/USNAval Research etc Message-ID: <9304071727.AA24420@net.bio.net> Date: 7 Apr 93 13:12:23 GMT Sender: daemon@net.bio.net Distribution: bionet Lines: 31 > > It is hard to wade through NIH Guide the way it is posted. > Could the NIH and other gencies put each opportunity into a > different message? Then I wouldn't have to read about things > of no significance to my resera research in the hope that > some gold mine lies further on! > > Paul F. Lehmann > lehmann%opus@mcoiarc.bitnet > > What you propose is difficult and I am not sure desireable. I think it would be difficult to determine how to do a breakdown to satisify everyone's interests. For example, a breakdown by institute, might not work because several Institutes support basic research in molecular biology. I generally do not read the postings because I get hard copy. But the first page should be a table of contents that should guide you to items of interest. I hate to say it, but this is one case where hard copy works best. Given hard copy you can go directly to items of interest without going through the whole document. Solution: At our end, I would just have the files sent directly to a high speed printer and take it from there. Jim Cassatt From owner-sci-resources@net.bio.net Wed Apr 07 23:00:00 1993 Path: biosci!NET.BIO.NET!kristoff From: kristoff@NET.BIO.NET (Dave Kristofferson) Newsgroups: bionet.sci-resources Subject: NIH Guide, vol. 22, no. 13, pt. 1, 2 April 1993 Message-ID: Date: 8 Apr 93 20:22:04 GMT Sender: kristoff@net.bio.net Distribution: bionet Lines: 1506 NOTE: The NIH Guide may be split into more than one mail message to avoid truncation during e-mail distribution. The first message always begins with the RFP/RFA summary sections followed by the appended texts of the full RFP/RFAs. ---------------------------------------------------------------------- $$XID NIHGUIDE 19930402 V22N13 P1O2 ************************************ X-comment: RFAs described: OH-93-001, RR-93-002, PA-93-068 NIH GUIDE - Vol. 22, No. 13 - April 2, 1993 $$INDEX BEGIN ******************************************************* NOTICES OF AVAILABILITY (RFPs AND RFAs) $$INDEX R1 ********************************************************** CLINICAL OPERATIONS CONTRACT FOR MEDICATIONS DEVELOPMENT PROGRAM (RFP N01DA-3-8400) National Institute on Drug Abuse INDEX: DRUG ABUSE $$INDEX R2 ********************************************************** ACQUISITION OF DATA FOR ESTABLISHING AND IMPROVING STRATEGIES FOR TRANSPLANTATION OF BONE MARROW (BAA NIH-NIAID-DAIT-BAA-93-26) National Institute of Allergy and Infectious Diseases INDEX: ALLERGY, INFECTIOUS DISEASES $$INDEX R3 ********************************************************** PNEUMOCOCCAL REFERENCE LABORATORY (RFP NIH-NIAID-DMID-94-13) National Institute of Allergy and Infectious Diseases INDEX: ALLERGY, INFECTIOUS DISEASES $$INDEX R4 06/08/93 ************************************************* CONSTRUCTION HEALTH AND SAFETY (RFA OH-93-001) National Institute for Occupational Safety and Health INDEX: OCCUPATIONAL SAFETY, HEALTH $$INDEX R5 06/23/93 ************************************************* NATIONAL RESOURCE FOR TRANSGENIC ANIMALS (RFA RR-93-002) National Center for Research Resources INDEX: RESEARCH RESOURCES ONGOING PROGRAM ANNOUNCEMENTS $$INDEX P1 06/04/93 ************************************************* RESEARCH SUPPLEMENTS TO PROMOTE REENTRY INTO BIOMEDICAL AND BEHAVIORAL RESEARCH CAREERS (PA-93-067) National Institutes of Health INDEX: NATIONAL INSTITUTES OF HEALTH $$INDEX P2 06/15/93 ************************************************* THE HUMAN BRAIN PROJECT: PHASE I FEASIBILITY STUDIES (PA-93-068) National Institute of Mental Health National Institute on Drug Abuse National Science Foundation National Institute on Aging National Institute of Child Health and Human Development National Institute on Deafness and Other Communication Disorders National Center for Research Resources National Library of Medicine Office of Naval Research National Aeronautics and Space Administration INDEX: MENTAL HEALTH; DRUG ABUSE; NATIONAL SCIENCE FOUNDATION; AGING; CHILD HEALTH, HUMAN DEVELOPMENT, DEAFNESS, COMMICATION DISORDERS; RESEARCH RESOURCES; NATIONAL LIBRARY OF MEDICINE; NAVAL RESEARCH; AERONAUTICS, SPACE ADMINISTRATION This publication is also available electronically to institutions via BITNET or INTERNET. Alternative access is through the NIH Grant Line using a personal computer (data line 301/402-2221). Contact Dr. John James at 301/594-7270 for details. $$INDEX END ********************************************************* NOTICES OF AVAILABILITY (RFPs AND RFAs) $$R1 BEGIN N01DA-3-8400 ********************************************* CLINICAL OPERATIONS CONTRACT FOR MEDICATIONS DEVELOPMENT PROGRAM NIH Guide, Volume 22, Number 13, April 2, 1993 RFP AVAILABLE: N01DA-3-8400 P.T. 34; K.W. 0785035, 0740025 National Institute on Drug Abuse The National Institute on Drug Abuse (NIDA) is soliciting proposals from organizations capable of selecting sites for the conduct of clinical trials and supervising their operation. These will be Phase I and II trials, primarily for the treatment of cocaine and opiate addiction under the current Food and Drug Administration (FDA) regulations and Good Clinical Practice (GPC) guidelines. Performance of the work shall involve: protocol development and review; solicitation and recruitment of a network of qualified clinical trial centers; obtaining FDA registration, DEA registration, and ongoing regulatory compliance; initiation, coordination, monitoring, and management of clinical trials; selection of a central pharmacy and supervision of the distribution of clinical supplies; selection of a central laboratory to accomplish the routine laboratory tests (e.g., CBC, urinalysis) performed at the clinical center; data management; clinical and statistical analysis; and preparation of a written study summary report of adequate quality to support NDA submission(s). The nature of the clinical trials will be to determine the tolerated dose range, the dosing regimen, the safety profile, and estimates of pharmacokinetics and pharmacodynamic parameters. The contractor also will evaluate the efficacy of the investigational compounds or marketed medications. Estimated issuance date of RFP No. N01DA-3-8400 is April 16, 1993, and responses are due to be received by the Contracting Officer 45 calendar days thereafter. The NIDA plans to make one award from this solicitation. INQUIRIES Written requests are to be forwarded to: Kenneth E. Goodling, Contract Specialist National Institute on Drug Abuse Parklawn Building, Room 10-49 5600 Fishers Lane Rockville, MD 20857 This advertisement does not commit the Government to make an award. $$R1 END ************************************************************ $$R2 BEGIN NIH-NIAID-DAIT-BAA-93-26 ********************************* ACQUISITION OF DATA FOR ESTABLISHING AND IMPROVING STRATEGIES FOR TRANSPLANTATION OF BONE MARROW NIH Guide, Volume 22, Number 13, April 2, 1993 BAA AVAILABLE: NIH-NIAID-DAIT-BAA-93-26 P.T. 34; K.W. 0745065, 1002004, 1002008, 0710125 National Institute of Allergy and Infectious Diseases The Basic Immunology and the Genetics and Transplantation Branches of the Division of Allergy, Immunology and Transplantation (DAIT), National Institute of Allergy and Infectious Diseases (NIAID), promote and support research leading to a better understanding of the development of the immune system and the fundamental cellular and molecular biology of immune responses in health and disease. The focus of the Broad Agency Announcement (BAA) is on basic research that will serve to acquire the data necessary for advancing clinical protocols for successful bone marrow transplantation and effective therapeutic treatment for GVHD. Offerors are encouraged to submit proposals relevant to any one of the general areas of research interest described in the BAA in accordance with the instructions in the BAA. Topics include: Development of an experimental model for bone marrow transplantation using isolated hematopoietic stem cells; development of in vitro culture methods of stem cells to study the cellular and molecular nature of purified stem cells with the ultimate goal of ex vivo expansion (self renewal); establishment of pre and/or post transplant conditioning regimens for BM engraftment; characterization of immunological mechanisms responsible for failure or rejection of transplanted BM; and development of prophylactic conditioning or therapeutic regimens for GVHD. Several contract awards are anticipated as a result of this announcement. It is anticipated that the awards will be made on a cost reimbursement basis over a multi-year period. Awards will be subject to DHHS regulations regarding the use of laboratory animals and/or human subjects in research. The issuance of the BAA was February 22, 1993 and proposals are due on May 10, 1993 at 4:00 p.m. INQUIRIES To receive a copy of the BAA, submit a written request along with two self-addressed mailing labels to: Rosemary McCabe Hamill, Contracting Officer Contract Management Branch National Institute of Allergy and Infectious Diseases Solar Building, Room 3C07 6003 Executive Boulevard Bethesda, MD 20892 Telephone inquiries will not be honored and all inquiries must be in writing. Any responsible offeror may submit a proposal that will be considered by the Government. This advertisement does not commit the Government to award a contract. $$R2 END ************************************************************ $$R3 BEGIN NIH-NIAID-DMID-94-13 ************************************* PNEUMOCOCCAL REFERENCE LABORATORY NIH Guide, Volume 22, Number 13, April 2, 1993 RFP AVAILABLE: NIH-NIAID-DMID-94-13 P.T. 34; K.W. 1002027, 0780005 National Institute of Allergy and Infectious Diseases The Respiratory Diseases Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID) has a requirement for a pneumococcal reference laboratory that will: (1) contribute to the development and optimization of a standardized pneumococcal antibody assay, (2) serve as a reference center through which assays will be standardized for the vaccine community, (3) prepare antigens and reagents, and (4) perform serological assays. This contract will also make available antigens and critical reagents for Hib assays. It is anticipated that one award will be made on a cost-reimbursement basis over a four-year period. The award may be subject to DHHS regulations regarding the use of laboratory animals and/or human subjects in research. INQUIRIES To receive a copy of the RFP, submit a written request along with two self-addressed mailing labels to: Rosemary McCabe Hamill, Contracting Officer Contract Management Branch National Institute of Allergy and Infectious Diseases Solar Building, Room 3C07 6003 Executive Boulevard Bethesda, MD 20892 Telephone inquiries will not be honored and all inquiries must be in writing. This RFP will be available on or about April 5, 1993 and proposals will be due in this office by 4:00 p.m. on June 30, 1993. Any responsible offeror may submit a proposal that will be considered by the Government. This advertisement does not commit the Government to award a contract. $$R3 END ************************************************************ $$R4 BEGIN OH-93-001 FULL-TEXT ************************************** CONSTRUCTION HEALTH AND SAFETY NIH Guide, Volume 22, Number 13, April 2, 1993 RFA AVAILABLE: OH-93-001 P.T. 02; K.W. 0725020 National Institute for Occupational Safety and Health Letter of Intent Receipt Date: April 30, 1993 Application Receipt Date: June 8, 1993 THE REQUEST FOR APPLICATIONS (RFA) ANNOUNCED IN THIS NOTICE CONTAINS ESSENTIAL INFORMATION FOR THE PREPARATION OF AN APPLICATION. POTENTIAL APPLICANTS MAY OBTAIN THE RFA FROM THE CONTACT NAMED IN INQUIRIES, BELOW. PURPOSE The Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), is soliciting grant applications for research and demonstration projects relating to occupational safety and health in the construction industry. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This RFA, Construction Health and Safety, is related to the priority area occupational safety and health. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Eligible applicants include domestic and foreign non-profit and for-profit organizations, universities, colleges, research institutions, and other public and private organizations, including State and local governments and small, minority and/or woman-owned businesses. Applicants for the Special Emphasis Research Career Award (SERCA) grants (K01) must be employed at a domestic institution; and be citizens or non-citizen nationals of the U.S. or its possessions or territories or must have been lawfully admitted to the U.S. for permanent residence at the time of application. Applicants for small grants (R03) must be U.S. citizens or non-citizen U.S. nationals who are predoctoral students, post-doctoral researchers (within three years following completion of doctoral degree or completion of residency or public health training), and junior faculty members (no higher than assistant professor). FUNDS AVAILABLE $1,000,000 is set aside for new projects addressing hazards in the construction industry. SERCA (K01) grants may not exceed $50,000 per year in direct costs for salary support (plus fringe benefits), technical assistance, equipment, supplies, consultant costs, domestic travel, publications, and other costs. Small grants (R03) may not exceed $25,000 per year in direct costs for salary support (plus fringe benefits), technical assistance, equipment, supplies, consultant costs, domestic travel, publications, and other costs. MECHANISMS OF SUPPORT The support mechanisms for this program are the individual research project grants (R01); demonstration project grants (R18); Special Emphasis Research Career Award (SERCA) grants (K01); and small grants (R03). A more detailed description of each of these mechanisms is given in the RFA. RESEARCH OBJECTIVES The NIOSH program priorities applicable to this RFA are occupational lung disease, musculoskeletal injuries, occupational cancers, severe occupational traumatic injuries, cardiovascular diseases, disorders of reproduction, neurotoxic disorders, noise-induced loss of hearing, dermatologic conditions, psychological disorders, control techniques, respirator research. These priority areas represent the leading diseases and injuries related to risks on the job, and NIOSH intends to support projects that facilitate progress in preventing such adverse effects among construction workers. Investigators may also apply in other areas related to construction safety and health, but the rationale for the significance of the research to construction must be developed in the application. Construction workers suffer far more serious injuries and fatalities than the general work force population. They die from work-related trauma at a rate three times the national average for workers in all industrial sectors; they suffer disproportionately from nonfatal injuries, from lung diseases, musculoskeletal disorders, hearing loss, and dermatologic conditions. For the construction industry, the national cost from lost production, medical care, workers' compensation, and related claims, is very high. Workers' compensation insurance premiums alone cost $7 billion annually. The construction industry is faced with unique safety and health problems that require special attention. Construction workers must perform work in an environment containing a variety of hazardous energy sources. They often work in the presence of excessive noise levels and with tools and equipment that produce potentially hazardous vibrations; perform repetitive, forceful motions and assume awkward working postures; frequently use a variety of toxic and volatile substances; and must cope with the complications of frequently changing work sites with multiple employers and work crews engaged in separate concurrent activities, while being self-supervised during much of the day. Construction includes not only the building of new structures, but also the destruction or renovation of existing structures. Thus, the potential hazards may be new or old, known or unknown, and simple or complex to control. A complete picture of the extent and severity of the adverse effects is not available, but a partial list of concerns is as follows: 1. Lung diseases resulting from exposure to asbestos, man-made mineral fibers, silica, and other agents that lead to cancer and chronic obstructive pulmonary disease 2. Injuries caused by falls, electricity, person- machine interactions, and environmental conditions 3. Cumulative trauma, vibration-induced disorders, and osteoarthritis 4. Skin disorders caused by irritants, allergens, and photosensitization 5. Systemic toxicity from lead, cadmium, solvents, and other "poisons" 6. Noise-induced hearing loss Potential applicants with questions concerning the acceptability of their proposed work are strongly encouraged to contact the program staff listed under INQUIRIES. STUDY POPULATIONS Applicants are required to give added attention (where feasible and appropriate) to the inclusion of minorities and/or women study populations for research into the etiology of diseases, research in behavioral and social sciences, clinical studies of treatment and treatment outcomes, research on the dynamics of health care and its impact on disease, and appropriate interventions for disease prevention and health promotion. Exceptions would be studies of diseases which exclusively affect males or where involvement of pregnant women may expose the fetus to undue risks. If minorities and/or women are not included in a given study, a clear rationale for their exclusion must be provided. LETTER OF INTENT Prospective applicants are asked to submit, by April 30, 1993, a letter of intent that includes a reference to the number and title of this RFA, a descriptive title of the proposed effort, the name and address of the Principal Investigator, the names of other key personnel, and the participating institutions. The letter of intent is requested in order to provide an indication of the number and scope of applications to be reviewed. This letter of intent does not commit the sender to submit an application, nor is it a requirement for submission of an application. The letter of intent is to be sent to Dr. Roy M. Fleming at the address listed under INQUIRIES. APPLICATION PROCEDURES Applications submitted in response to this RFA must be received on June 8, 1993. Applications are to be submitted on form PHS 398 (rev. 9/91). State and local government applicants may use form PHS 5161-1 (rev. 7/92); however, form PHS 398 is preferred. Forms are available from the contacts listed under INQUIRIES and from the Office of Grants Inquiries, Division of Research Grants, National Institutes of Health, Westwood Building, Room 449, Bethesda, MD 20892, telephone (301) 594- 7248. The RFA label available in the PHS 398 application form must be affixed to the bottom of the face page of the application. Failure to use this label could result in delayed processing of the application such that it may not reach the review committee in time for review. In addition, the RFA title and number (OH-93-001, CONSTRUCTION HEALTH AND SAFETY) must be typed on line 2a of the face page of the application form PHS 398 (or the top of the face page of the PHS 5161-1) and the YES box must be marked." The original and five copies of the PHS 398 or the original and two copies of the PHS 5161-1 application must be submitted to: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** The timetable for receiving applications and awarding grants in fiscal year 1993 is given below. Letter of Intent Receipt Date: April 30, 1993 Application Receipt Date: June 8, 1993 Initial Review: August 1993 Secondary Review September 1993 Earliest Possible Start Date: September 30, 1993 Applications must be received on the above receipt date. To guard against problems caused by carrier delays, retain a legible proof-of-mailing receipt from the carrier, dated no later than one week prior to the receipt date. Applicants must follow the guidance provided in the application package. REVIEW CONSIDERATIONS The initial (peer) review is based on scientific merit and significance of the project, competence of the proposed staff in relation to the type of research involved, feasibility of the project, likelihood of its producing meaningful results, appropriateness of the proposed project period, adequacy of the applicant's resources available for the project, and appropriateness of the budget request. AWARD CRITERIA Applicants will compete for available funds with all other approved applications assigned to NIOSH. The following will be considered in making funding decisions: o Quality of the proposed project as determined by peer review o Availability of funds o Program balance among research areas of the announcement INQUIRIES Written and telephone inquiries are encouraged. The opportunity clarify any issues or questions from potential applicants is welcome. Direct requests for the RFA, inquiries regarding programmatic issues, and address the letter of intent to: Roy M. Fleming, Sc.D. National Institute for Occupational Safety and Health Centers for Disease Control and Prevention 1600 Clifton Road, NE Building 1, Room 2053, Mail Stop D-30 Atlanta, GA 30333 Telephone: (404) 639-3343 For business information contact: Ms. Carole J. Tully Grants Management Branch National Institute for Occupational Safety and Health Centers for Disease Control and Prevention 255 E. Paces Ferry Road, NE Room 300, Mail Stop E-09 Atlanta, GA 30305 Telephone: (404) 842-6880 AUTHORITY AND REGULATIONS This program is authorized under the Public Health Service Act, as amended, Section 301 (42 U.S.C. 241); the Occupational Safety and Health Act of 1970, Section 20 (a)(29 U.S.C. 669[a]); and the Federal Mine Safety and Health Amendments Act of 1977, as amended, Section 501(30 U.S.C. 951). The applicable program regulations are in 42 CFR Part 52. Applications are not subject to review as governed by Executive Order 12372, Intergovernmental Review of Federal Programs. The Catalog of Federal Domestic Assistance number is 93.262. This program is not subject to the Public Health System Reporting Requirements. $$R4 END ************************************************************ $$R5 BEGIN RR-93-002 FULL-TEXT ************************************** NATIONAL RESOURCE FOR TRANSGENIC ANIMALS NIH Guide, Volume 22, Number 13, April 2, 1993 RFA AVAILABLE: RR-93-002 P.T. 34; K.W. 1002002, 1002019 National Center for Research Resources Application Receipt Date: June 23, 1993 THE REQUEST FOR APPLICATIONS (RFA) ANNOUNCED IN THIS NOTICE CONTAINS ESSENTIAL INFORMATION FOR THE PREPARATION OF AN APPLICATION. POTENTIAL APPLICANTS MAY OBTAIN THE RFA FROM THE CONTACT NAMED IN INQUIRIES, BELOW. PURPOSE The National Center for Research Resources (NCRR) invites applications to establish National Resource(s) for Transgenic Animals, to be awarded competitively in Fiscal Year 1993. The primary objectives of this initiative are to: (1) create a repository of embryos of transgenic rodents and lagomorphs and (2) conduct research to perfect cryopreservation methods for important animal species. This award will establish a resource center where embryos are preserved, maintained (banked), and distributed; where transgenic animals are produced at request from the maintained embryos; and where research is conducted on cryopreservation techniques. ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic, for-profit and non-profit organizations, public and private, such as universities, colleges, laboratories, hospitals, or medical centers. Applications from foreign institutions are ineligible for the P40 mechanism. Applicant institutions must demonstrate an established research and resource base in areas related to the RFA. Underrepresented minorities, persons with disabilities, and women are encouraged to apply. MECHANISM OF SUPPORT Grants awarded in response to this initiative will be via the NCRR Animal (Mammalian and Nonmammalian Model), and Animal and Biological Material Resource Grant (P40) mechanism. Responsibility for the planning, direction, and execution of the proposed project will be solely that of the applicant. Awards will be administered under Public Health Service (PHS) grants policy as stated in the PHS Grants Policy Statement and in this RFA. This RFA is a one-time solicitation. Future unsolicited competing continuation applications will compete with all investigator-initiated applications and will be reviewed according to the customary peer review procedures. The total project period for applications submitted in response to the RFA may not exceed five years and is renewable. The earliest expected award date is September 30, 1993. Applicants must limit their requests to not more than $350,000 direct costs for the initial budget period. Future budget period escalations may not exceed a four percent increase over the previous budget period. FUNDS AVAILABLE The estimated funds (total costs) available for the first year of support for this activity are approximately $1,000,000. It is anticipated that one or two awards will be made in FY 93 with an average size of approximately $500,000 total costs. However, the specific number of awards will depend upon the scientific merit and scope of the applications received and the availability of funds. RESEARCH OBJECTIVE Background The laboratory mouse is presently the most widely used, available, and economical animal model used in biomedical research and, in particular, transgenic research. In addition to the many traditional mutant mouse strains, hundreds of additional strains of mice have been created in recent years through transgenic technology. The methods presently available to preserve, maintain, and produce this proliferating number of strains include active breeding programs and embryo cryopreservation. Breeding is expensive and often duplicative. Cryopreservation of embryos is less expensive, but is technologically intensive and heavily dependent on mouse husbandry. These handicaps are clearly resulting in the loss of many strains and limiting access to other users. The development of refined technology for harvesting and successfully cryopreserving mouse sperm and reconstitution of strains through in vitro fertilization or artificial insemination and relatively simple breeding procedures offer a very promising alternative to the current situation. Objectives The objective of this RFA is to initiate a long-term, stable, integrated program for safeguarding national research animal resources of importance to research projects sponsored by the PHS. This initiative will: (1) Provide support to a limited number of centers to serve as multi- categorical research and service resources for the preservation and supply of transgenic rodent and lagomorph strains. These centers are to be regional in nature, and serve users throughout the United States. (2) Encourage applied research on the development of improved techniques for cryopreservation of eggs, sperm, and embryos of numerous rodent and lagomorph species. (3) Incorporate the resources/equipment for the freezing and maintenance of embryos, sperm, and eggs of transgenic animals, and provide, on a full cost recovery basis, live animals from the embryos. A plan will be developed that describes the cost recovery procedures to be implemented. (4) Provide a means for more extensive and long term support to maintain the embryos of those rodent and lagomorph species and models considered to be of national importance and that cannot be preserved through alternate methods. (5) Establish a national advisory committee to review, plan, and prioritize national needs for preservation of important laboratory animal resources. This committee will also act as a central point for the review and evaluation of stocks to be accepted into the repository. It is suggested that the committee be composed of no fewer than five members, with the Principal Investigator serving as the chairperson of the committee. It is encouraged that a minimum of two members be appointed from outside the institution receiving the grant. It is suggested that the committee meet formally at least twice a year during the first year, and then at least once a year thereafter. Conference calls may be held on an as-needed basis to coordinate and plan the activities of the center. (6) Establish effective cooperation with other institutions and organizations with similar interests to minimize costs and avoid duplication. (7) Establish a modern database for classification of all embryos maintained by the resource, maintenance of nomenclature for transgenic embryos being held, and tracking distribution of all embryos or animals provided to users of the resource. (8) Encourage users who have developed transgenic animals with research funds provided through the National Institutes of Health (NIH) to store constructs in these centers. (9) Encourage self-sufficiency of the centers at the end of the project period. A detailed plan will be developed that describes how self- sufficiency will be achieved. For the purposes of this RFA, users of the centers are defined as those individuals who have peer-reviewed research projects involving transgenic animals, with first priority given to those funded by the NIH, followed by those funded by other agencies of the PHS, followed by other sources of peer-reviewed research support. APPLICATION PROCEDURES Applications are to be submitted on form PHS 398 (rev. 09/91), available at most institutional offices of sponsored research and from the Office of Grants Inquiries, Division of Research Grants, National Institute of Health, 5333 Westbard Avenue, Room 449, Bethesda, MD 20892, telephone (301) 594-7248. Applicants must request a copy of the RFA for instructions regarding completion of the form PHS 398, including information on budgetary considerations. The RFA is available from the program staff contact listed under INQUIRIES. Applications must be received by close of business June 23, 1993. If an application is received after this date, it will be returned to the applicant. REVIEW CONSIDERATIONS Upon receipt, applications will be examined initially by the Division of Research Grants (DRG) for completeness. Incomplete applications will be returned to the applicant without further consideration. Evaluation of responsiveness to the program requirements and criteria stated in this RFA is an NCRR staff function. Applications that are considered complete and responsive will be evaluated in accordance with the criteria stated below by an appropriate peer review group convened by the Office of Review of NCRR. It is essential that the written application be in a form that can be reviewed on its own merit, since no site visit is anticipated. If the number of applications is large compared to the number of awards to be made, the NCRR may conduct a preliminary scientific peer review to eliminate those applications that are clearly not competitive. The NCRR will administratively withdraw from competition those applications judged to be noncompetitive, and will so notify the applicant and the institutional business official. Applications judged to be both competitive and responsive to the RFA will be evaluated further, according to the review criteria stated below. Following initial merit review, the applications will receive a second-level review by the National Advisory Research Resources Council. The review of the grant applications will focus on scientific merit, and will include the following criteria (detailed review criteria can be found in the full text RFA): o Overall Program o Administration and Planning o Scientific Expertise of Participants o Institutional Commitment Schedule Application Receipt Date: June 23, 1993 Initial Review: July/August 1993 Second Level Review: September 1993 Anticipated Award: September 1993 INQUIRIES Written and telephone inquiries concerning this RFA are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues and requests for the RFA to: Dr. Cynthia L. Pond Laboratory Animal Sciences Program National Center for Research Resources Westwood Building, Room 857 Bethesda, MD 20892 Telephone: (301) 594-7933) Direct inquiries regarding fiscal matters to: Ms. Kathy Springmann Office of Grants and Contracts Management National Center for Research Resources Westwood Building, Room 853 Bethesda, MD 20892 Telephone: (301) 594-7955) AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.306, Laboratory Animal Sciences and Primate Research. Awards will be made under authorization of the Public Health Service Act, Title III, Section 301 (Public Law 78.410, as amended; 42 USC 241) and administered under PHS grant policies and Federal Regulations 42 CFR Part 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. $$R5 END ************************************************************ ONGOING PROGRAM ANNOUNCEMENTS $$P1 BEGIN PA-93-067 ************************************************ RESEARCH SUPPLEMENTS TO PROMOTE REENTRY INTO BIOMEDICAL AND BEHAVIORAL RESEARCH CAREERS NIH Guide, Volume 22, Number 13, April 2, 1993 PA NUMBER: PA-93-067 P.T. 34; K.W. 0404000, 0710030 National Institutes of Health Application Receipt Date: June 4, 1993 PURPOSE The Office of Research on Women's Health (ORWH) and the Office of Extramural Research, National Institutes of Health (NIH) announce a program of a limited number of supplements to research grants to encourage fully trained women and men to reenter an active research career after taking time off to care for children or parents or to attend to other family responsibilities. The goal of this program is to assist fully trained individuals who have not reentered the research arena. In keeping with this goal, at the time of application a candidate may not be engaged in paid research for more than 10 hours per week. This program will provide administrative supplements to existing NIH research grants for the purpose of supporting full-time or part-time research tailored to update existing research skills and knowledge. The NIH considers the appropriate and adequate representation of women and minorities in biomedical and behavioral research careers essential. The proportion of women Principal Investigators successfully competing for NIH funds has increased steadily since 1982. In FY 1991, women accounted for about 19 percent of the NIH applications and received about 18 percent of competing Research Project Grants awards. Similarly, the proportion of NIH predoctoral and postdoctoral research training positions filled by women has increased steadily with women occupying approximately 40 percent of the research training positions supported by the NIH (see the NIH Report on Women in NIH Extramural Grant Programs, FY 1982-91, Division of Research Grants, 1992). However, the NIH recognizes that this situation can be improved. Thus, NIH encourages women and individuals from ethnic minority groups to enter research careers. Some of the reasons for the low representation of women may be in part related to the fact that women bear a preponderance of the responsibilities surrounding child and family care. As such, this program is specifically designed to offer opportunities to individuals, especially women, who have interrupted their research careers to care for children or parents, to attend to other family responsibilities. The objective of the program is for those who receive support to reestablish careers in biomedical or behavioral research. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This program announcement of Research Supplements to Promote Reentry into Biomedical and Behavioral Research Careers is related to the priority area of women's health. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy people 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Grants and Cooperative Agreements: Only the following active NIH awards at domestic institutions are eligible for Research Supplements to Promote Reentry into Biomedical and Behavioral Research Careers: R01, R10, R24, R35, R37, P01, P40, P41, P50, P51, P60, U01, U10. Principal Investigators on such awards are invited to submit a request for an administrative supplement to the awarding component of the parent grant to support an eligible candidate interested in reestablishing a research career. The parent grant must have at least two years of support remaining on September 1, 1993. The rationale underlying this policy is to provide the candidate an opportunity to accommodate her or his research during the duration of the supplement. Usually, a parent grant would support only one administrative supplement including Research Supplements for Underrepresented Minorities, Research Supplements to Promote the Recruitment of Individuals with Disabilities into Biomedical Research Careers, and the Research Supplement to Promote Reentry into Biomedical and Behavioral Research Careers. Grants most likely to support more than a single administrative supplement are multicomponent awards. Candidates: This program is to support individuals who have interrupted career development to care for children or parents, or to attend to other family responsibilities. Family responsibilities may include relocation to accommodate a family member, or retirement of the candidate's educational debt. This supplement is not intended to support graduate or postdoctoral training and is not intended to cover career changes from non-research to research careers. Candidates who have begun the reentry process through a fellowship or similar mechanism are not eligible for this program. The candidate must have a doctoral degree, such as M.D., D.D.S., Ph.D., D.V.M. or equivalent and must demonstrate evidence of excellence in research prior to the career hiatus. The duration of the hiatus in the research career may not be fewer than two or more than eight years in duration. At the time of application a candidate may not be engaged in paid research for more than 10 hours per week. The candidate must have had sufficient prior research experience to qualify for a faculty appointment at the assistant professor or equivalent level. Candidates must be citizens or noncitizen nationals or have been lawfully admitted for permanent residence (i.e., in possession of an Alien Registration Receipt Card). MECHANISM OF SUPPORT In all cases, the proposed research must be directly related to the approved ongoing research of the parent grant or cooperative agreement. The individual supported under this supplemental award, hereafter called the candidate, must be afforded the opportunity to act as a full participant in the research project and must be given an opportunity to update and enhance her or his research capabilities. This will allow the candidate to establish a career as an independent, competitive research investigator. Supplemental awards will be consistent with the goals of strengthening the existing research program and with the overall programmatic balance and priorities of the funding component of the NIH. Awards will be made according to the policies and provisions stated in this announcement and in the PHS Grants Policy Statement. Administrative supplements (S01) provided under this program may be for either part-time or full-time support for the candidate and all supported time is to be spent updating and enhancing research skills. Proposed part-time appointments may not be less than 20 hours per week. Supplemental awards may be made for up to two years and may not exceed $50,000 in direct costs per year. A maximum of $40,000 may be requested for the salary and fringe benefits for the candidate. The amount of salary requested must be consistent with the policies of the grantee institution for individuals occupying similar positions and must be related to the percent effort requested for the supplement. An additional amount up to $10,000 may be requested for supplies, travel and publication costs. Equipment may not be purchased as a part of this supplement without the prior approval of the NIH awarding component. These awards are not renewable. FUNDS AVAILABLE The ORWH estimates that approximately $1,000,000 will be available for up to 10 supplemental awards in FY 1993. APPLICATION PROCEDURES A request for this supplement must be submitted by June 4, 1993, by the grantee institution, on behalf of the Principal Investigator of the parent grant and in cooperation with the candidate to: Office of Research on Women's Health Westwood Building, Room 854 Bethesda, MD 20892** Because of the expedited review process, the original and five copies of the complete application are required. Please note that the initial step in the administrative review process will be a determination of eligibility. It is incumbent upon the applicant to submit a complete and accurate application, because there will not be an opportunity to make additions or corrections. The request for a supplemental award must include the following: 1. A completed face page (with appropriate signatures) from Grant Application Form PHS 398 (rev. 9/91). Include the title and grant number of the parent grant and "Reentry Supplement" on line 1; 2. A brief, three to four page description, prepared by the Principal Investigator of the parent grant that includes: a. A summary or abstract of the funded grant or project, b. A description of the research proposed for the candidate, c. How the supplement will expand and foster the independent research capabilities of the candidate, d. How the proposed research relates to the specific research goals and objectives of the parent grant; and e. A description of the scope and nature of the mentoring relationship between the Principal Investigator and the candidate. 3. A brief description, prepared by the candidate, that includes: a. research objectives and career goals; b. length of and reason for career hiatus; c. description of how the candidate has kept current in her/his field; and d. identification of steps taken toward reentry, (if any). 4. A biographical sketch of the candidate that includes: a. curriculum vitae; b. social security number; c. citizenship status; d. publications; and e. other evidence of scientific achievement. 5. A proposed budget entered on budget pages from the Grant Application Form PHS 398, related to the percent effort for the research proposed for the candidate during the first and future budget period(s). The amount requested for the supplement must coincide with the current period of support. Thus, if the initial budget period requested is less than 12 months, the budget must be prorated accordingly; 6. Documentation, if applicable, that the proposed research is approved by the Institutional Animal Care and Use Committee (IACUC) or human subjects Institutional Review Board (IRB) of the grantee institution; 7. Under unusual circumstances where the applicant and mentor would be at a site other than the grantee institution, an appropriately signed letter from the institution where the research is to be conducted must also be submitted. The request must be signed by the Principal Investigator, the candidate, and the appropriate institution business official. REVIEW CONSIDERATIONS An NIH review committee convened by the ORWH will review applications for eligibility according to the guidelines described in this announcement. Eligible applications will be further reviewed according to the following criteria: o qualifications of the candidate including career goals, o evidence of excellence of prior research training and experience, o evidence that the proposed research will achieve the stated objectives of the reentry supplements; o the plan for the proposed research in the supplemental request and its relationship to the parent grant; o evidence from the Principal Investigator of appropriate guidance that will enhance the research, knowledge, and/or skills of the candidate; o evidence from the Principal Investigator that the activities of the candidate will be directly related to the approved scope of the parent grant; and o evidence of effort by the candidate to initiate the reentry process, such as attending scientific meetings, keeping current with journals, etc. Funding decisions will be made by the ORWH based upon the recommendations provided by an NIH-wide review committee. These decisions will be communicated to the candidate's Principal Investigator by the Director, ORWH. Since these applications will undergo administrative review, summary statements will not be produced. This is consistent with NIH practice for other similar programs, such as those referenced in the ELIGIBILITY REQUIREMENTS section of this announcement. AWARD CRITERIA The decision to fund a supplement will take up to twelve weeks from the June 4, 1993, application receipt date. A September 1, 1993, award date is anticipated but other award dates will be considered. Second year funding for the supplement is contingent on funding of the parent grant and cannot extend beyond the current competitive segment of the parent grant. Reporting Requirements For non-competing continuation applications, the progress report for the supplement must be clearly delineated as a separate section in the progress report for the parent grant. The progress report must include information about the research accomplishments of the individual supported by the supplement, including research progress, scientific meetings attended, manuscripts in preparation or submitted or accepted for publication, other professional activities within the institution in which the recipient is involved, applications for research support that have been submitted or other evidence of successful reentry. INQUIRIES For general information about the reentry supplements, candidates and Principal Investigators should contact the program official of the appropriate awarding Institute or Center. Candidates who have not yet made contact with a Principal Investigator are encouraged to contact the program official whose institute or center is specific to the research interest. To discuss business aspects of the parent grant or the supplement, Principal Investigators should contact their grants management official. Program officials and grants management contacts and the respective awarding institutes or centers are listed below. National Cancer Institute Mrs. Toby Friedbert, Program Official or Leo Buscher, Grants Management Official Executive Plaza North, Room 636 6130 Executive Boulevard Bethesda, MD 20892 Telephone: (301) 496-3428 or (301) 496-7753 FAX: (301) 402-0275 National Eye Institute Ralph J. Helmsen, Ph.D., Program Official or Carolyn Grimes, Grants Management Official Building 31, Room 6A49 Bethesda, MD 20892 Telephone: (301) 496-5983 or (301) 496-5884 FAX: (301) 402-0528 National Heart, Lung, and Blood Institute Ronald Geller, Ph.D., Program Official or Tom Turley, Grants Management Official Westwood Building, Room 7A17 Bethesda, MD 20892 Telephone: (301) 594-7454 or (301) 594-7434 FAX: (301) 594-7424 National Institute on Aging Phyllis Eveleth, Ph.D., Program Official or Joseph Ellis, Grants Management Official 7201 Wisconsin Avenue, Room 218 Bethesda, MD 20892 Telephone: (301) 496-9322 or (301) 496-1472 FAX: (301) 402-2945 National Institute of Alcohol Abuse and Alcoholism Helen Chao, Ph.D., Program Official or Joe Weeda, Grants Management Official 5600 Fishers Lane, Room 16C-06 Rockville, MD 20857 Telephone: (301) 443-2530 or (301) 443-4703 FAX: (301) 227-8673 National Institute of Allergy and Infectious Disease Milton Hernandez, Ph.D., Program Official or Gary Thompson, Grants Management Official Solar Building, Room 4C10 Bethesda, MD 20892 Telephone: (301) 496-7291 or (301) 496-7231 FAX: (301) 402-0369 National Institute of Arthritis and Musculoskeletal and Skin Disease Julia Freeman, Ph.D., Program Official or Diane Watson, Grants Management Official 5333 Westbard Avenue Westwood Building, Room 403 Bethesda, MD 20892 Telephone: (301) 594-9961 or (301) 594-9965 FAX: (301) 480-7881 National Institute of Child Health and Human Development Ms. Hildegard Topper, Program Official or Donald Clark, Grants Management Official Building 31, Room 2A03 Bethesda, MD 20892 Telephone: (301) 496-0104 or (301) 496-5001 FAX: (301) 402-1104 National Institute of Dental Research Patricia S. Bryant, Ph.D., Program Official or Theresa Ringler, Grants Management Official 5333 Westbard Avenue Westwood Building, Room 509 Bethesda, MD 20892 Telephone: (301) 594-7648 or (301) 594-7629 FAX: (301) 402-4620 National Institute of Diabetes and Digestive and Kidney Diseases Walter S. Stolz, Ph.D., Program Official or John Garthune, Grants Management Official Westwood Building, Room 657 Bethesda, MD 20892 Telephone: (301) 594-7527 or (301) 594-7543 FAX: (301) 594-7594 National Institute on Drug Abuse Eleanor C. Friedenberg, R.N., Program Official or Shirley Denney, Grants Management Official 5600 Fishers Lane, Room 10-42 Rockville, MD 20857 Telephone: (301) 443-2755 or (301) 443-6710 FAX: (301) 443-0538 National Institute of Environmental Health Sciences Anne P. Sassaman, Ph.D., Program Official or Dave Mineo, Grants Management Official P.O. Box 12233 Research Triangle Park, NC 27709 Telephone: (919) 541-7723 or (919) 541-7628 FAX: (919) 541-2843 National Institute of General Medical Sciences Anthony Rene, Ph.D., Program Official or Carol Tippery, Grants Management Official Westwood Building, Room 925 5333 Westbard Avenue Bethesda, MD 20892 Telephone: (301) 594-7706 or (301) 594-7813 FAX: (301) 594-7701 National Institute of Mental Health Delores L. Parron, Ph.D., Program Official or Bruce Ringler, Grants Management Official Parklawn Building, Room 17C-16 5600 Fishers Lane Rockville, MD 20857 Telephone: (301) 443-2847 or (301) 443-3065 FAX: (301) 443-2578 National Institute of Neurological Disorders and Stroke Mr. Edward Donohue, Program Official or Mary Whitehead, Grants Management Official Federal Building, Room 1016 7550 Wisconsin Avenue Bethesda, MD 20892 Telephone: (301) 496-4188 or (301) 496-9231 FAX: (301) 402-4370 National Institute on Deafness and Other Communication Disorders Amy M. Donahue, Ph.D., Program Official or Sharon Hunt, Grants Management Official Executive Plaza South, Room 400B 6120 Executive Boulevard Rockville, MD 20892 Telephone: (301) 402-3458 or (301) 402-0909 FAX: (301) 402-6251 National Center for Human Genome Research Bettie Graham, Ph.D., Program Official or Jean Cahill, Grants Management Official Building 38A, Room 613 Bethesda, MD 20892 Telephone: (301) 496-7531 or (301) 402-0733 FAX: (301) 480-2770 National Center for Nursing Research Sharlene M. Weiss, Ph.D., R.N., Program Official or Sally Nichols, Grants Management Official Westwood Building, Room 757 Bethesda, MD 20892 Telephone: (301) 594-9612 or (301) 594-9615 FAX: (301) 402-2402 National Center for Research Resources Louise E. Ramm, Ph.D., Program Official or Lacey Durham, Grants Management Official Westwood Building, Room 854 Bethesda, MD 20892 Telephone: (301) 594-7906 or (301) 594-7955 FAX: (301) 594-9161 John E. Fogarty International Center David Wolff, Ph.D., Program Official or Silvia Mandes, Grants Management Official Building 31, Room B2C39 Bethesda, MD 20892 Telephone: (301) 496-1653 or (301) 496-1653 FAX: (301) 402-0779 AUTHORITY AND REGULATIONS Supplemental awards will be made under authorities applicable to the parent grant and administered under PHS grants policies and Federal Regulations 42 CFR 52 and 45 CFR Parts 74 and 92. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. $$P1 END ************************************************************ $$P2 BEGIN PA-93-068 FULL-TEXT ************************************** THE HUMAN BRAIN PROJECT: PHASE I FEASIBILITY STUDIES NIH Guide, Volume 22, Number 13, April 2, 1993 PA AVAILABLE: PA-93-068 P.T. 34; K.W. 0705010, 1002030, 1004017 National Institute of Mental Health National Institute on Drug Abuse National Science Foundation National Institute on Aging National Institute of Child Health and Human Development National Institute on Deafness and Other Communication Disorders National Center for Research Resources National Library of Medicine Office of Naval Research National Aeronautics and Space Administration Letter of Intent Receipt Date: April 19, 1993 Application Receipt Date: June 15, 1993 THE PROGRAM ANNOUNCEMENT (PA) ANNOUNCED IN THIS NOTICE CONTAINS ESSENTIAL INFORMATION FOR THE PREPARATION OF AN APPLICATION. POTENTIAL APPLICANTS MAY OBTAIN THE RFA FROM THE CONTACTS NAMED IN INQUIRIES, BELOW. PURPOSE The Human Brain Project is a broadly based federal research initiative that encourages and supports investigator-initiated basic and clinical neuroscience research and investigator-initiated research on informatics resources that could be used to facilitate neuroscience research. Particular emphasis is placed on research on computer storage and manipulation of neuroscience information, network systems, and associated tools that will give neuroscientists access to the stored information. The networks will also provide electronic channels of communication and collaboration to geographically distant laboratories. To optimize the utility of these technologies to neuroscience researchers, they will be developed in the context of specific neuroscience research. It is important to emphasize that the scientific question being addressed is as important as the technology being developed. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This program announcement, The Human Brain Project: Phase I Feasibility Studies, is related to the priority area of mental health and mental disorders. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3228). ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic and foreign, public and private, non-profit and for-profit organizations such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal government. Women and minority investigators are encouraged to apply. MECHANISMS OF SUPPORT This program will use research project grant (R01) and exploratory grant (P20) mechanisms. The R01 mechanism will be used for research project grants, which will allow investigators to work on highly focused projects related to the integration of neuroscience and informatics research. R01 mechanisms can be used for collaborative research initiation grants that will be directed towards fostering the interactions of computer and mathematical scientists or engineers and neuroscientists to design and implement novel technological solutions to particular neuroscience questions. Applications may include support for expenses for travel and per diem expenses to several laboratories to initiate or to explore the possibility of setting up a collaboration. It is essential that the scientific questions to be pursued and the unique contribution of each potential group member should be explicitly stated. The Exploratory Grant (P20) mechanism will provide the opportunity for several investigators using different approaches to focus on a common problem, and will facilitate coordinated communication across disciplinary and geographic boundaries. Anticipated maximum annual budgets (direct and indirect costs) at time of award are $230,000 for the R01 mechanism and $1.1 million for the P20 mechanism. Support may be requested for a period of up to 5 years for R01 and P20 grant mechanisms (foreign grants are limited to 3 years duration). Applicants are strongly encouraged to contact the appropriate individual listed at the end of this announcement for information on specific grant mechanisms. RESEARCH OBJECTIVES Neuroscience is a vigorous, multidisciplinary field that has grown tremendously in the last two decades. This progress has, to a large extent, been fueled by information from many disciplines and across many levels of neural organization. An explosion of information at each of these levels, from gene to behavior, makes it increasingly difficult for individual neuroscientists to keep up with developments in their own circumscribed areas of interest. It is more difficult still for investigators to relate their findings to an integrated understanding of the nervous system. Yet it is precisely such integration that is necessary for the generation of meaningful hypotheses and continued rapid scientific progress. Phase I of the Human Brain Project will support the research related to the development, storage, management, analysis, integration and dissemination of neuroscience information. This initiative will incorporate cutting-edge informatics research with neuroscience research in order to facilitate the integration of neuroscience information and to promote communication and collaboration across scientific disciplines and geographic locations. Broad research objectives appropriate to the Human Brain Project are described in the program announcement. STUDY POPULATIONS SPECIAL INSTRUCTIONS FOR INCLUSION OF WOMEN AND MINORITIES IN CLINICAL RESEARCH STUDIES For projects involving clinical research, NIH requires applicants to give special attention to the inclusion of women and minorities in study populations. If women or minorities are not included in the study populations for clinical studies, a specific justification for this exclusion must be provided. Applications without such documentation will not be accepted for review. LETTER OF INTENT It may be beneficial for applicants to contact the appropriate program official(s) listed below and submit a letter of intent. The letter should include a descriptive title of the proposed research, the name, address, and telephone number of the Principal Investigator (or Director) the identities of other key personnel, and participating institutions. Although a letter of intent is not required, is not binding, and does not enter into the review of subsequent applications, the information that it contains is helpful in planning for the review of applications. The letter is to be submitted to Dr. Michael F. Huerta at the address listed under INQUIRIES. Each letter of intent will be distributed to all of the sponsoring agencies, institutes and centers. APPLICATION PROCEDURES Applicants are to use the grant application form PHS 398 (rev. 9/91). The number and title of the program announcement, "PA-93-068 THE HUMAN BRAIN PROJECT: PHASE I" must be typed in item number 2a on the face page of the PHS 398 application form. The mechanism, either R01 or P20, should be typed in item 2b on the face page of the PHS 398 application form. When applicable, consultant/collaborator information should be provided in section 7, and consortium/contractual arrangements should be provided in section 8 of the PHS 398 application form. This form may be obtained from business offices or offices of sponsored research at most universities, colleges, medical schools, and other major research facilities; from the Office of Grants Inquiries, Division of Research Grants, National Institutes of Health, Westwood Building, Room 449, Bethesda, MD, telephone 301/594-7248; and from the program officials listed under INQUIRIES. Applications must be received by June 15, 1993. For the R01 mechanism, applicants must follow the instructions provided in grant application form PHS 398 (rev. 9/91). Each application for the P20 mechanism must have a director with a demonstrated ability to organize, administer, and direct the group of constituent projects. The director must commit at least 25 percent effort to the P20 Exploratory Grant and be Principal Investigator on one of the projects. It is expected that all of the Principal Investigators of projects funded with the P20 mechanism will be leaders in their fields. Applicants intending to submit an application for a P20 Exploratory Grant are advised to contact a project officer listed under INQUIRIES for more information. Dates for the submission of Phase I Human Brain Project applications for Fiscal Year 1993 and review cycles are: Letter of Intent Receipt Date: April 19, 1993 Application Receipt Date: June 15, 1993 Administrative Review: June 1993 Scientific Review: July/August 1993 Advisory Council Review: September 1993 Earliest Starting Date: September 1993 In subsequent years, the dates for the submission of Phase I Human Brain Project applications and review cycles will be: Letter of Intent Receipt Date: July 1 Application Receipt Date: October 15 Administrative Review: October Scientific Review: February/March Advisory Council Review: May/June Earliest Starting Date: July REVIEW CONSIDERATIONS Applications will be assigned to the appropriate agencies, institutes and center according to their goals and designs and in accordance with standard referral guidelines. Those deemed by the Division of Research Grants to be appropriate for this program announcement will be reviewed for scientific and technical merit by a special review committee (SRC) composed primarily of non-Federal scientists. The members of this committee will be determined by the participating agencies, institutes, and centers. Summaries of SRC recommendations will be sent to applicants as soon as possible after the meeting of the SRC. Subsequent processing of the application will follow the procedures of the respective agency, institute and/or center to which it has been assigned. For applications assigned to a Public Health Service (PHS) institute or center, the application will receive further review by the appropriate National Advisory Council. AWARD CRITERIA Criteria for grant awards include the scientific merit of the proposed research as determined during the review process, responsiveness to the objectives outlined in this announcement and relevance of the research to the mission of the Human Brain Project, availability of the research funds, and the competing demands of other research funding requirements. INQUIRIES The following representatives from each of the participating agencies, institutes, and center can be contacted for further information or clarification. Potential applicants are strongly encouraged to contact the agency or institute representative to discuss their plans prior to preparing an application, and to obtain the full length program announcement for the Human Brain Project. Michael F. Huerta, Ph.D. National Institute of Mental Health 5600 Fishers Lane, Room 11-95 Rockville, MD 20857 Telephone: (301) 443-3948 FAX: (301) 443-4822 E-mail: HMI@CU.NIH.GOV Christine R. Hartel, Ph.D. National Institute on Drug Abuse 5600 Fishers Lane, Room 10A-31 Rockville, MD 20857 Telephone: (301) 443-1887 FAX: (301) 227-6043 E-mail: CHARTEL@AOADA.SSW.DHHS.GOV Christiana Leonard, Ph.D. National Science Foundation 1800 G Street, NW, Room 321 Washington, DC 20550 Telephone: (202) 357-7041 FAX: (202) 357-7846 E-mail: CMLEONAR@NSF.GOV Deborah Claman, Ph.D. National Institute on Aging Gateway Building, Room 3C307 7201 Wisconsin Avenue Bethesda, MD 20872 Telephone: (301) 496-9350 FAX: (301) 496-1494 E-mail: CLAMAN@NIHNIAGW Norman Krasnegor, Ph.D. National Institute of Child Health and Human Development 6100 Building, Room 4B05 Bethesda, MD 20892 From owner-sci-resources@net.bio.net Wed Apr 07 23:00:00 1993 Path: biosci!NET.BIO.NET!kristoff From: kristoff@NET.BIO.NET (Dave Kristofferson) Newsgroups: bionet.sci-resources Subject: NIH Guide, vol. 22, no. 13, pt. 2, 2 April 1993 Message-ID: Date: 8 Apr 93 20:24:11 GMT Sender: kristoff@net.bio.net Distribution: bionet Lines: 1962 $$XID NIHGUIDE 19930402 V22N13 P2O2 ************************************ Telephone: (301) 496-6591 FAX: (301) 402-2085 Judith Cooper, Ph.D. National Institute on Deafness and Other Communication Disorders Executive Plaza South, Room 400B 6120 Executive Boulevard Rockville, MD 20852 Telephone: (301) 496-5061 FAX: (301) 402-6251 Charles L. Coulter, Ph.D. National Center for Research Resources Westwood Building, Room 8A15 Bethesda, MD 20892 Telephone: (301) 594-7934 FAX: (301) 594-9187 E-mail: CCO@CU.NIH.GOV Peter A. Clepper National Library of Medicine Building 38A, Room 5S518 Bethesda, MD 20894 Telephone: (301) 496-4221 FAX: (301) 402-0421 E-mail: CLEPPER@NLM.NIH.GOV Terry Allard, Ph.D. Office of Naval Research 800 N. Quincy Street, Room 1142 Arlington, VA 22217-5660 Telephone: (703) 696-4502 FAX: (703) 696-1212 E-mail: TERRY@TOMCAT.ONR.NAVY.MIL Frank M. Sulzman, Ph.D. National Aeronautics and Space Administration Code SBM, NASA Headquarters Washington, DC 20546 Telephone: (202) 358-2359 FAX: (202) 358-4168 E-mail: FSULZMAN@SMTPGMGW.OSSA.HQ.NASA.GOV Direct inquiries regarding fiscal matters to: Diana Trunnell Assistant Chief, Grants Management Branch National Institute of Mental Health 5600 Fishers Lane, Room 7C-23 Rockville, MD 20857 Telephone: (301) 443-3065 Shirley Denney Chief, Grants Management Branch National Institute on Drug Abuse 5600 Fishers Lane, Room 8A54 Rockville, MD 20857 Telephone: (301) 443-6710 Jean Feldman, Policy Officer Division of Grants and Contracts Policy Office National Science Foundation 1800 G Street, NW, Room 1140 Washington, DC 20550 Telephone: (202) 357-7880 Joseph Ellis Office of Extramural Affairs National Institute on Aging Gateway Building, Room 2N210 7201 Wisconsin Avenue Bethesda, MD 20872 Telephone: (301) 496-1472 Doug Shawver Office of Grants and Contracts National Institute of Child Health and Human Development 6100 Executive Boulevard, Room 8A17 Rockville, MD 20852 Telephone: (301) 496-1303 Sharon Hunt Division of Extramural Activities National Institute on Deafness and Other Communication Disorders 6120 Executive Boulevard, Room 400-B Rockville, MD 20852 Telephone: (301) 402-0909 Paul Karadbil Office of Grants and Contracts Management National Center for Research Resources Westwood Building, Room 849 5333 Westbard Avenue Bethesda, MD 20892 Telephone: (301) 594-7955 Shelly Carow Office of Extramural Programs National Library Medicine Building 38A, Room 5N517 Bethesda, MD 20894 Telephone: (301) 496-4195 Willard Vaughan, Ph.D. Cognitive and Neural Sciences Division Office of Naval Research 800 N. Quincy Street, Room 823 Arlington, VA 22217-5660 Telephone: (703) 696-4505 The National Institute of Neurological Disorders and Stroke (NINDS) and the National Eye Institute (NEI), while not cosponsors of this Program Announcement, have continuing interest in the scientific areas related to the Human Brain Project. NINDS and NEI will continue to fund research on these topics through applications received through the regular receipt and referral processes of the Division of Research Grants. Applicants should contact the relevant NINDS or NEI program staff for further information. AUTHORITY AND REGULATIONS This program is described in the Catalogue of Federal Domestic Assistance Nos. 93.242 (NIMH), 93.279 (NIDA), 47.074 (NSF), 93.866 (NIA), 93.865 (NICHD), 93.173 (NIDCD), 93.371 (NCRR), 93.879 (NLM) and 12.300 (ONR). Awards are made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grants policies and Federal regulations 42 CFR 52 and 45 CFR part 74. Applications submitted in response to this announcement are not subject to the intergovernmental review requirements of Executive Order 12372 as implemented through Department of Health and Human Services regulations at 45 CFR part 100 or Health Systems Agency review. $$P2 END ************************************************************ $$XID RFA OH93001 OH-93-001 P1O1 *************************************** CONSTRUCTION HEALTH AND SAFETY NIH Guide, Volume 22, Number 13, April 2, 1993 RFA: OH-93-001 P.T. 02; K.W. 0725020 National Institute for Occupational Safety and Health Letter of Intent Receipt Date: April 30, 1993 Application Receipt Date: June 8, 1993 PURPOSE The Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), is soliciting grant applications for research and demonstration projects relating to occupational safety and health in the construction industry. The purpose of this Request for Applications (RFA) is to develop knowledge that can be used in preventing occupational diseases and injuries. The NIOSH will support the following types of applied research projects: causal research to identify and investigate the relationships between hazardous working conditions and associated occupational diseases and injuries; methods research to develop more sensitive means of evaluating hazards at work sites, as well as methods for measuring early markers of adverse health effects and injuries; control research to develop new protective equipment, engineering control technology, and work practices to reduce the risks of occupational hazards; and demonstrations to evaluate the technical feasibility or application of a new or improved occupational safety and health procedure, method, technique, or system. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This RFA, Construction Health and Safety, is related to the priority area of occupational safety and health. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Eligible applicants include domestic and foreign non-profit and for-profit organizations, universities, colleges, research institutions, and other public and private organizations, including State and local governments and small, minority and/or woman-owned businesses. FUNDS AVAILABLE $1,000,000 is set aside for new projects addressing hazards in the construction industry. MECHANISMS OF SUPPORT The types of grants NIOSH supports are described below. Applications responding to this announcement will be reviewed by staff for their responsiveness to the following program requirements. Grants are funded for 12-month budget periods in project periods up to five years for research project grants and demonstration project grants; three years for SERCA grants; and up to two years for small grants. Continuation awards within the project period are made on the basis of satisfactory progress and on the availability of funds. Research Project Grants (R01). A research project grant application should be designed to establish, discover, develop, elucidate, or confirm information relating to occupational safety and health, including innovative methods, techniques, and approaches for dealing with occupational safety and health problems. These studies may generate information that is readily available to solve problems or contribute to a better understanding of underlying causes of diseases and injuries. Demonstration Project Grants (R18). A demonstration project grant application should address, either on a pilot or full-scale basis, the technical or economic feasibility of implementing a new/improved innovative procedure, method, technique, or system, for preventing occupational safety or health problems. The project should be conducted in an actual workplace where a baseline measure of the occupational problem will be defined, the new/improved approach will be implemented, a follow-up measure of the problem will be documented, and an evaluation of the benefits will be conducted. Special Emphasis Research Career Award (SERCA) Grants (K01). The SERCA grant is intended to provide opportunities for individuals to acquire experience and skills essential to the study of work-related hazards, and in so doing create a pool of highly qualified investigators who can make future contributions to research in the area of occupational safety and health. SERCA grants are not intended either for individuals without research experience or for productive, independent investigators with a significant number of publications and of senior academic rank. Moreover, the award is not intended to substitute one source of salary support for another for an individual who is already conducting full-time research; nor is it intended to be a mechanism for providing institutional support. Candidates must: (1) hold a doctoral degree; (2) have research experience at or above the doctoral level; (3) not be above the rank of associate professor; (4) be employed at a domestic institution; and (5) be citizens or non-citizen nationals of the U.S. or its possessions or territories or must have been lawfully admitted to the U.S. for permanent residence at the time of application. This non-renewable award provides support for a three-year period for individuals engaged in full-time research and related activities. Awards will not exceed $50,000 per year in direct costs for salary support (plus fringe benefits), technical assistance, equipment, supplies, consultant costs, domestic travel, publications, and other costs. The indirect cost rate applied is limited to 8 percent of the direct costs, excluding tuition and related fees and equipment expenses, or to the actual indirect cost rate, whichever results in the lesser amount. A minimum of 60 percent time must be committed to the proposed research project, although full-time is desirable. Other work in the area of occupational safety and health will enhance the candidate's qualifications but is not a substitute for this requirement. Related activities may include research career development activities as well as involvement in patient care to the extent that it will strengthen research skills. Fundamental/basic research will not be supported unless the project will make an original contribution for applied technical knowledge in the identification, evaluation, and/or control of occupational safety and health hazards (e.g., development of a diagnostic technique for early detection of an occupational disease). Research project proposals must be of the applicants' own design and of such scope that independent investigative capability will be evident within three years. At the completion of this three-year award, it is intended that awardees should be better able to compete for individual research project grants awarded by NIOSH. SERCA grant applications should be identified as such on the application form. Section 2 of the application (the Research Plan) should include a statement regarding the applicant's career plans and how the proposed research will contribute to a career in occupational safety and health research. This section should also include a letter of recommendation from the proposed advisor(s). Small Grants (R03). The small grant program is intended to stimulate applications from individuals who are considering a research career in occupational safety and health; as such, the minimum time commitment is 10 percent. It is expected that a recipient would subsequently compete for a career development grant (K01) or for a traditional research project grant (R01) related to occupational safety and health. The award is not intended to supplement ongoing or other proposed research; nor is it intended to be a mechanism for providing institutional support. The small grant investigators must be U.S. citizens or non-citizen nationals who are predoctoral students, post-doctoral researchers (within 3 years following completion of doctoral degree or completion of residency or public health training), or junior faculty members (no higher than assistant professor). If university policy requires that a more senior person be listed as Principal Investigator, it should be clear in the application which person is the small grant investigator. Except for applicants who are assistant professors, there must be one or more named mentors to assist with the project. A biographical sketch is required for the small grant investigator, as well as for the supervisor and other key consultants, as appropriate. This non-renewable award provides support for project periods of up to two years to carry out exploratory or pilot studies, to develop or test new techniques or methods, or to analyze data previously collected. Awards will not exceed $25,000 per year in direct costs for salary support (plus fringe benefits), technical assistance, equipment, supplies, consultant costs, domestic travel, publications, and other costs. The indirect costs will be based upon the negotiated indirect cost rate of the applicant organization. An individual may not receive more than two small grant awards, and then, only if the awards are at different stages of development (e.g., doctoral student, post-doctoral researcher, or junior faculty member). RESEARCH OBJECTIVES The NIOSH program priorities applicable to this RFA are occupational lung disease, musculoskeletal injuries, occupational cancers, severe occupational traumatic injuries, cardiovascular diseases, disorders of reproduction, neurotoxic disorders, noise-induced loss of hearing, dermatologic conditions, psychological disorders, control techniques, respirator research. These priority areas represent the leading diseases and injuries related to risks on the job, and NIOSH intends to support projects that facilitate progress in preventing such adverse effects among workers. Investigators may also apply in other areas related to the occupational safety and health of construction workers, but the rationale for the significance of the research to the field of occupational safety and health must be developed in the application. Construction workers suffer far more serious injuries and fatalities than the general work force population. They die from work-related trauma at a rate three times the national average for workers in all industrial sectors; they suffer disproportionately from nonfatal injuries, from lung diseases, musculoskeletal disorders, hearing loss, and dermatologic conditions. For the construction industry, the national cost from lost production, medical care, workers' compensation, and related claims, is very high. Workers' compensation insurance premiums alone cost $7 billion annually. The construction industry is faced with unique safety and health problems that require special attention. Construction workers must perform work in an environment containing a variety of hazardous energy sources. They often work in the presence of excessive noise levels and with tools and equipment that produce potentially hazardous vibrations; perform repetitive, forceful motions and assume awkward working postures; frequently use a variety of toxic and volatile substances; and must cope with the complications of frequently changing work sites with several employers and work crews engaged in separate concurrent activities, while being self-supervised during much of the day. Construction includes not only the building of new structures, but also the destruction or renovation of existing structures. Thus, the potential hazards may be new or old, known or unknown, and simple or complex to control. A complete picture of the extent and severity of the adverse effects is not available, but a partial list of concerns is as follows: 1. Lung diseases resulting from exposure to asbestos, man-made mineral fibers, silica, and other agents that lead to cancer and chronic obstructive pulmonary disease 2. Injuries caused by falls, electricity, person-machine interactions, and environmental conditions 3. Cumulative trauma, vibration-induced disorders, and osteoarthritis 4. Skin disorders caused by irritants, allergens, and photosensitization 5. Systemic toxicity from lead, cadmium, solvents, and other "poisons" 6. Noise-induced hearing loss Priorities The NIOSH program priorities listed below are applicable to all of the support mechanisms listed in this RFA. These priority areas represent the leading diseases and injuries related to risks on the job, and NIOSH intends to support projects that facilitate progress in preventing such adverse effects among workers. The conditions or examples listed under each category are selected examples, not comprehensive definitions of the category. The NIOSH Program Priorities are: o Occupational lung disease: asbestosis, byssinosis, silicosis, coal workers' pneumoconiosis, lung cancer, occupational asthma o Musculoskeletal injuries: disorders of the back, trunk, upper extremity, neck, lower extremity: traumatically induced Raynaud's phenomenon o Occupational cancers (other than lung): leukemia, mesothelioma, cancers of the bladder, nose and liver o Severe occupational traumatic injuries: amputations, fractures, eye loss, and lacerations o Cardiovascular diseases: hypertension, coronary artery disease, acute myocardial infraction Disorders of reproduction: infertility, spontaneous abortion, teratogenesis o Neurotoxic disorders: peripheral neuropathy, toxic encephalitis, neuroses, extreme personality changes (exposure-related) o Noise-induced loss of hearing o Dermatologic conditions: dermatoses, burns (scalding), chemical burns, contusions (abrasions) o Psychological disorders: affective disturbances such as anxiety, depression and job dissatisfaction; mal-adaptive behavior and lifestyle patterns; aggression; stress and post traumatic stress disorders; substance abuse o Control Techniques: new technology performance evaluation, preconstruction review, equipment redesign, containment of hazards at the source, fundamental dust generation mechanisms, machine guarding/avoidance methods, explosion control, removal of emissions after generation, dispersion models, monitoring and warning techniques, technology transfer o Respirator research: new and innovative respiratory protective devices, techniques to predict performance, effectiveness of respirator programs, physiologic and ergonomic factors, medical surveillance strategies, psychological and motivational aspects, effectiveness of sorbents and filters, including chemical and physical properties STUDY POPULATIONS SPECIAL INSTRUCTIONS TO APPLICANTS REGARDING IMPLEMENTATION OF NIH POLICIES CONCERNING INCLUSION OF WOMEN AND MINORITIES IN CLINICAL RESEARCH STUDY POPULATIONS NIH policy is that applicants for NIH clinical research grants and cooperative agreements will be required to include minorities and women in study populations so that research findings can be of benefit to all persons at risk of the disease, disorder or condition under study; special emphasis should be placed on the need for inclusion of minorities and women in studies of diseases, disorders and conditions which disproportionately affect them. This policy is intended to apply to males and females of all ages. If women or minorities are excluded or inadequately represented in clinical research, particularly in proposed population-based studies, a clear compelling rationale should be provided. The composition of the proposed study population must be described in terms of gender and racial/ethnic group. In addition, gender and racial/ethnic issues should be addressed in developing a research design and sample size appropriate for the scientific objectives of the study. This information should be included in the form PHS 398 in Sections 1-4 of the Research Plan AND summarized in Section 5, Human Subjects. Applicants are urged to assess carefully the feasibility of including the broadest possible representation of minority groups. However, NIH recognizes that it may not be feasible or appropriate in all research projects to include representation of the full array of United States racial/ethnic minority populations (i.e., Native Americans (including American Indians or Alaskan Natives), Asian/Pacific Islanders, Blacks, Hispanics). The rationale for studies on single minority population groups should be provided. For the purpose of this policy, clinical research includes human biomedical and behavioral studies of etiology, epidemiology, prevention (and preventive strategies), diagnosis, or treatment of diseases, disorders or conditions, including but not limited to clinical trials. The usual NIH policies concerning research on human subjects also apply. Basic research or clinical studies in which human tissues cannot be identified or linked to individuals are excluded. However, every effort should be made to include human tissues from women and racial/ethnic minorities when it is important to apply the results of the study broadly, and this should be addressed by applicants. For foreign awards, the policy on inclusion of women applies fully; since the definition of minority differs in other countries, the applicant must discuss the relevance of research involving foreign population groups to the United States' populations, including minorities. If the required information is not contained within the application, the application will be returned. Peer reviewers will address specifically whether the research plan in the application conforms to these policies. If the representation of women or minorities in a study design is inadequate to answer the scientific question(s) addressed AND the justification for the selected study population is inadequate, it will be considered a scientific weakness or deficiency in the study design and will be reflected in assigning the priority score to the application. All applications for clinical research submitted to NIH are required to address these policies. NIH funding components will not award grants or cooperative agreements that do not comply with these policies. LETTER OF INTENT Prospective applicants are asked to submit, by April 30, 1993, a letter of intent that includes a reference to the number and title of this RFA, a descriptive title of the proposed effort, the name and address of the Principal Investigator, the names of other key personnel, and the participating institutions. The letter of intent is requested in order to provide an indication of the number and scope of applications to be reviewed. This letter of intent does not commit the sender to submit an application, nor is it a requirement for submission of an application. The letter of intent is to be sent to Dr. Fleming at the address listed under INQUIRIES. APPLICATION PROCEDURES Applications submitted in response to this RFA must be received on June 8, 1993. Applications are to be submitted on form PHS 398 (rev. 9/91). State and local government applicants may use form PHS 5161-1 (rev. 7/92); however, form PHS 398 is preferred. Forms are available from the contacts listed under INQUIRIES and from the Office of Grants Inquiries, Division of Research Grants, National Institutes of Health, Westwood Building, Room 449, Bethesda, MD 20892, telephone (301) 594- 7248. The RFA label available in the PHS 398 application form must be affixed to the bottom of the face page of the application. Failure to use this label could result in delayed processing of the application such that it may not reach the review committee in time for review. In addition, the RFA title and number (OH-93-001, CONSTRUCTION HEALTH AND SAFETY) must be typed on line 2a of the face page of the application form PHS 398 (or the top of the face page of the PHS 5161-1) and the YES box must be marked." The original and five copies of the PHS 398 or the original and two copies of the PHS 5161-1 application must be submitted to: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** The timetable for receiving applications and awarding grants in fiscal year 1993 is given below. Letter of Intent Receipt Date: April 30, 1993 Application Receipt Date: June 8, 1993 Initial Review: August 1993 Secondary Review September 1993 Earliest Possible Start Date: September 30, 1993 Applications must be received on the above receipt date. To guard against problems caused by carrier delays, retain a legible proof-of-mailing receipt from the carrier, dated no later than one week prior to the receipt date. Applicants must follow the guidance provided in the application package. REVIEW CONSIDERATIONS Applications received under this RFA will be assigned to an Initial Review Group (IRG). The IRGs, consisting primarily of non-Federal scientific and technical experts, will review the applications for scientific and technical merit. Notification of the review recommendations will be sent to the applicants after the initial review. Applications will also be reviewed for programmatic importance by NIOSH. Awards will be made based on results of the initial and secondary reviews, as well as availability of funds. The initial (peer) review is based on scientific merit and significance of the project, competence of the proposed staff in relation to the type of research involved, feasibility of the project, likelihood of its producing meaningful results, appropriateness of the proposed project period, adequacy of the applicant's resources available for the project, and appropriateness of the budget request. Demonstration grant applications will be reviewed additionally on the basis of the following criteria: o Degree to which project objectives are clearly established, obtainable, and for which progress toward attainment can and will be measured. o Availability, adequacy, and competence of personnel, facilities, and other resources needed to carry out the project. o Degree to which the project can be expected to yield or demonstrate results that will be useful and desirable on a national or regional basis. o Documentation of cooperation from industry, unions, or other participants in the project, where applicable. SERCA grant applications will be reviewed additionally on the basis of the following criteria: o The review process will consider the applicant's scientific achievements, the applicant's research career plan in occupational safety and health, and the degree to which the applicant's institution offers a superior research environment (supportive nature, including letter(s) of reference from advisor(s), which should accompany the application). Small grant applications will be reviewed additionally on the basis of the following criteria: o The review process will take into consideration the fact that the applicants do not have extensive experience with the grant process. AWARD CRITERIA In the secondary review, the following factors will be considered: o The results of the initial review. o The significance of the proposed study to the mission of NIOSH. o Relevance to occupational safety and health, by contributing to achievement of the research objectives specified in Section 20(a) of the Occupational Safety and Health Act of 1970 and Section 501 of the Federal Mine Safety and Health Amendments Act of 1977, o Magnitude of the problem in terms of numbers of workers affected, o Severity of the disease or injury in the worker population, o Potential contribution to applied technical knowledge in the identification, evaluation, and/or control of occupational safety and health hazards, and o Program balance, and o Policy and budgetary considerations. Questions regarding the above criteria may be addressed to the program staff listed under INQUIRIES. INQUIRIES Written and telephone inquiries are encouraged. The opportunity clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues, questions concerning the acceptability of a proposed project, and address the letter of intent to: Roy M. Fleming, Sc.D. National Institute for Occupational Safety and Health Centers for Disease Control and Prevention 1600 Clifton Road, NE Building 1, Room 2053, Mail Stop D-30 Atlanta, GA 30333 Telephone: (404) 639-3343 For business information contact: Ms. Carole J. Tully Grants Management Branch National Institute for Occupational Safety and Health Centers for Disease Control and Prevention 255 E. Paces Ferry Road, NE Room 300, Mail Stop E-09 Atlanta, GA 30305 Telephone: (404) 842-6880 AUTHORITY AND REGULATIONS This program is authorized under the Public Health Service Act, as amended, Section 3