From owner-sci-resources@net.bio.net Thu Apr 01 23:00:00 1993 Path: biosci!agate!doc.ic.ac.uk!daresbury!news!ajb From: ajb@s-crim1.dl.ac.uk (Alan Bleasby) Newsgroups: sci.bio,sci.med,sci.engr.biomed,talk.politics.drugs,talk.politics.medicine,talk.politics.misc,bionet.general,bionet.sci-resources,alt.politics.clinton,alt.politics.economics Subject: Re: Hillary Rodham Clinton's Sovietology Exercise Message-ID: Date: 2 Apr 93 02:59:17 GMT References: <1993Mar30.184548.28977@oracle.us.oracle.com> <1993Mar31.071008.6915@Princeton.EDU> <1993Apr1.034408.20615@oracle.us.oracle.com> Distribution: usa Organization: SERC Daresbury Laboratory, Warrington, UK Lines: 9 Xref: biosci sci.bio:2786 sci.med:11843 sci.engr.biomed:356 talk.politics.drugs:2898 talk.politics.medicine:1753 talk.politics.misc:36298 bionet.general:4456 bionet.sci-resources:687 alt.politics.clinton:6470 alt.politics.economics:898 NNTP-Posting-Host: s-crim1.dl.ac.uk In-reply-to: mfriedma@us.oracle.com's message of 1 Apr 93 03:44:08 GMT Forgive me, but I thought I was supporting the European/Asian/African dissemination of biology-related information. I would sincerely appreciate it if postings on this topic ceased. Alan Bleasby BIOSCI Europe/Asia/Africa SERC Daresbury Laboratory Warrington WA4 4AD UK From owner-sci-resources@net.bio.net Thu Apr 01 23:00:00 1993 Path: biosci!oracle!unrepliable!bounce From: mfriedma@us.oracle.com (Michael Friedman) Newsgroups: sci.bio,sci.med,sci.engr.biomed,talk.politics.drugs,talk.politics.medicine,talk.politics.misc,bionet.general,bionet.sci-resources,alt.politics.clinton,alt.politics.economics Subject: Re: Hillary Rodham Clinton's Sovietology Exercise Message-ID: <1993Apr1.034408.20615@oracle.us.oracle.com> Date: 1 Apr 93 03:44:08 GMT References: <1993Mar30.184548.28977@oracle.us.oracle.com> <1993Mar31.071008.6915@Princeton.EDU> Sender: usenet@oracle.us.oracle.com (Oracle News Poster) Distribution: usa Organization: Oracle Corporation, Redwood Shores CA Lines: 51 Xref: biosci sci.bio:2785 sci.med:11841 sci.engr.biomed:355 talk.politics.drugs:2895 talk.politics.medicine:1751 talk.politics.misc:36274 bionet.general:4455 bionet.sci-resources:686 alt.politics.clinton:6464 alt.politics.economics:894 Nntp-Posting-Host: hqsun4.us.oracle.com X-Disclaimer: This message was written by an unauthenticated user at Oracle Corporation. The opinions expressed are those of the user and not necessarily those of Oracle. In article <1993Mar31.071008.6915@Princeton.EDU> niepornt@phoenix.Princeton.EDU (David Marc Nieporent) writes: >In article <1993Mar30.184548.28977@oracle.us.oracle.com> mfriedma@us.oracle.com (Michael Friedman) writes: >>Jeff Sicherman blatantly lies in his post below... >But only if you're stupid enough, like Michael Friedman, to be unable to >understand the English language... No, I understand it, but you can't have it both ways. Either Bush just kept the meetings secret - which was totally legal, ask the courts - or Bush kept the members secret, which he didn't, but which would have been illegal and equivalent to Clinton's actions. Either way, Jeff Sicherman attempts to mislead us. We can argue over whether or not it is a blatant lie, but it's clearly not the truth. >>In article sichermn@csulb.edu (Jeff Sicherman) writes: >>>In <26MAR199313552586@cc.utah.edu> djs1539@cc.utah.edu(SEGAL, DAVID JAY) says: >>>>In article , smith@minerva.harvard.edu (Steven Smith) writes... >>>>{The WSJ requested help identifying these individuals, so I scanned the >>>>{list and present it here along with the accompanying article with the >>>>{hope that it will help to illuminate these proceedings whose outcome >>>>{could affect all Americans and their progeny, but are nevertheless >>>>{insulated from public inspection and debate. >>>>What's the big deal? There are hundreds of committees in Washington. Most >>>>people don't know who's on them; most people don't care. Why don't you >>>>wait to see what they come up with and spend your energy evaluating that? >>>>Isn't the message more important than the messenger? >>> Also note that these whiners were nowhere to be found when Danny's >>>Cabal on Competitiveness held its secret meetings to overturn >>>regulations which had been arrived at through the open proposal >>>and comment process. >>The Bush administration didn't try to keep the names of the members of >>the Council on Competitiveness secret. Jeff, you are a liar. >And, of course, Jeff never said that the Bush administration did do >this. What Jeff said, and what the Bush admin. did do, was keep the >actual *meetings* secret. >Meetings at which policies/regulations were enacted, not just discussed. Wrongo. Legally, there is no such thing as a policy. I challenge you to find a regulation enacted by the Council on Competitiveness. From owner-sci-resources@net.bio.net Thu Apr 01 23:00:00 1993 Path: biosci!oracle!unrepliable!bounce From: mfriedma@us.oracle.com (Michael Friedman) Newsgroups: sci.bio,sci.med,sci.engr.biomed,talk.politics.drugs,talk.politics.medicine,talk.politics.misc,bionet.general,bionet.sci-resources,alt.politics.clinton,alt.politics.economics Subject: Re: Hillary Rodham Clinton's Sovietology Exercise Message-ID: <1993Mar31.174409.20484@oracle.us.oracle.com> Date: 31 Mar 93 17:44:09 GMT References: <1993Mar30.185342.29473@oracle.us.oracle.com> <1pasjdINN3as@spim.mti.sgi.com> Sender: usenet@oracle.us.oracle.com (Oracle News Poster) Organization: Oracle Corporation, Redwood Shores CA Lines: 36 Xref: biosci sci.bio:2784 sci.med:11840 sci.engr.biomed:354 talk.politics.drugs:2894 talk.politics.medicine:1750 talk.politics.misc:36273 bionet.general:4454 bionet.sci-resources:685 alt.politics.clinton:6463 alt.politics.economics:893 Nntp-Posting-Host: hqsun4.us.oracle.com X-Disclaimer: This message was written by an unauthenticated user at Oracle Corporation. The opinions expressed are those of the user and not necessarily those of Oracle. Blatant lie below... In article <1pasjdINN3as@spim.mti.sgi.com> mpolen@suntory.mti.sgi.com (Mike Polen) writes: >Michael Friedman) writes: >|> Bernie Cosell) writes: >|> >Michael Friedman (mfriedma@us.oracle.com) wrote: >|> >} Kate E. Loomis) writes: >|> >} >Regarding the extensive list of names on the "top secret, Soviet-Style >|> >} >health reform task force" : there is no analogy here. These people are >|> >} >not creating policy, they are _drafting a plan_ . ... >|> >} >So what is the problem? >|> >} The problem is that we are supposed to have an open government. Plans >|> >} that do not require security are not supposed to be drafted in secret >|> >} by people whose names are not even released. >|> >} If nothing else, people who object to the makeup of the task force >|> >} have the right to know who is on it and to present their objections to >|> >} the people of the United States. >|> >By and large, NONE of the government >|> >'plan making' machinery is particularly open. >|> Phrases like "particularly open" or so vague that they are >|> meaningless. However, can you name another government committee whose >|> members are secret and which is not related to national defense or >|> sensitive foreign policy issues? >It took us about 6 years to find out that Nancy Reagan's astrologer >was a key member of the White House Committee for Planning and Decision >Making. Are you suggesting that she only advised on national defense >and sensitive foreign policy issues? Blatant lie. No such Committee exists. From owner-sci-resources@net.bio.net Fri Apr 02 23:00:00 1993 Path: biosci!agate!howland.reston.ans.net!usc!elroy.jpl.nasa.gov!jato!quake!brian From: brian@quake.sylmar.ca.us Newsgroups: sci.bio,sci.med,sci.engr.biomed,talk.politics.drugs,talk.politics.medicine,talk.politics.misc,bionet.general,bionet.sci-resources,alt.politics.clinton,alt.politics.economics Subject: Re: Hillary Rodham Clinton's Sovietology Exercise Message-ID: Date: 3 Apr 93 09:37:37 GMT References: <26MAR199313552586@cc.utah.edu> Distribution: usa Organization: Quake Public Access, San Fernando Valley, CA (818)362-6092 Lines: 34 Xref: biosci sci.bio:2805 sci.med:11923 sci.engr.biomed:359 talk.politics.drugs:2933 talk.politics.medicine:1773 talk.politics.misc:36718 bionet.general:4471 bionet.sci-resources:688 alt.politics.clinton:6539 alt.politics.economics:909 In article sichermn@csulb.edu (Jeff Sicherman) writes: >In article <26MAR199313552586@cc.utah.edu> djs1539@cc.utah.edu (SEGAL, DAVID JAY) writes: >>What's the big deal? There are hundreds of committees in Washington. Most >>people don't know who's on them; most people don't care. Why don't you >>wait to see what they come up with and spend your energy evaluating that? >>Isn't the message more important than the messenger? >>Besides, >>I don't understand why people are so focused on the publicity of this >>particular committee's meetings. I think the only ones who really have >>a problem with it are the MD types, who stand the most to lose from >>health care reform. For guys like me, who have the most to gain from >>reform, I say get off their backs. Why in the world do you think that having a bunch of socialists destroy the health care system will benefit you? If you want that kind of economy, go live in the USSR...oops, they can't stand socialism and are changing. Well, go live in CHina then...ummm, well, I guess they are busting their butts to abandon socialism too. Well, Cuba, yeah, Cuba. You'll be able to have socialism there for at least a few more years. >>Finally somebody's actually doing >>something. Almost anything is better than the system we've got now. >>Besides, the committee can't pass any legislation by itself anyway. > Also note that these whiners were nowhere to be found when Danny's >Cabal on Competitiveness held its secret meetings to overturn >regulations which had been arrived at through the open proposal >and comment process. Perhaps it is that Quayle's cabal was trying (for the most part) to protect people's rights, while Hillary's Cabal is fundamentally dedicated to violating them. --Brian From owner-sci-resources@net.bio.net Sat Apr 03 23:00:00 1993 Path: biosci!ICBR.IFAS.UFL.EDU!SJJ From: SJJ@ICBR.IFAS.UFL.EDU ("JONG, SONG-MUH J") Newsgroups: bionet.sci-resources Subject: Funding availability postings Message-ID: <9304041533.AA24859@net.bio.net> Date: 4 Apr 93 15:17:00 GMT Sender: daemon@net.bio.net Distribution: bionet Lines: 9 Hi, bionetters, So far, I have only seen posting from NIH and NSF in this newsgroup. Is it possible to invite Foundations or other funding sources to post in this newsgroup? Song-Muh Jong sjj@icbr.ifas.ufl.edu From owner-sci-resources@net.bio.net Sat Apr 03 23:00:00 1993 Path: biosci!NETCOM.COM!wick From: wick@NETCOM.COM (Potter Wickware) Newsgroups: bionet.sci-resources Subject: Re: Funding availability postings Message-ID: Date: 4 Apr 93 16:47:50 GMT References: <9304041533.AA24859@net.bio.net> Sender: daemon@net.bio.net Distribution: bionet Lines: 24 Yes, I would like to see announcements from USDA, NST (or whatever it's called now, the old Bureau of Standards), NOAA, etc. Trouble is, the output is so voluminous, and diffuse, it would be hard to plow thru it all. Look how much comes just from NIH. Their index is _some_ help, but unless the agency people could be persuaded to write concisely ;-> it would be a chore to have it coming in. What wld be really nice wld be to get quick news on what private funders are doing, ie $80M grant by Amgen to lab of Tak Mak (who discovered the T cell receptor). Not much hope for private outfits to come on line with their doings, though, I don't think. On 4 Apr 1993, JONG, SONG-MUH J wrote: > Hi, bionetters, > > So far, I have only seen posting from NIH and NSF in this newsgroup. > Is it possible to invite Foundations or other funding sources to > post in this newsgroup? > > Song-Muh Jong > sjj@icbr.ifas.ufl.edu > From owner-sci-resources@net.bio.net Sun Apr 04 23:00:00 1993 Path: biosci!CCF3.NRL.NAVY.MIL!EISENSTADT From: EISENSTADT@CCF3.NRL.NAVY.MIL ("ERIC EISENSTADT") Newsgroups: bionet.sci-resources Subject: ONR Biological Sciences Division Message-ID: <9304051254.AA20970@net.bio.net> Date: 5 Apr 93 13:38:00 GMT Sender: daemon@net.bio.net Distribution: bionet Lines: 470 PROGRAM INFORMATION BIOLOGICAL SCIENCES DIVISION OFFICE OF NAVAL RESEARCH INTRODUCTION The Office of Naval Research (ONR) has supported basic biological research at universities and other research centers since 1946. ONR also supports training, education programs, and conferences closely related to its programs. Funding decisions are based on scientific or educational quality, relevance to research programs, and availability of funds. Research awards vary in size; typically, awards are made for up to three years and range between $70,000 and $150,000 per year (direct + indirect costs). A summary of research projects supported by the Division of Biological Sciences is available upon request. Research programs supported by the Division fall into three broad programs: 1) Molecular, Cellular, and Environmental Biology; 2) Integrative Biology; and, 3) Sensory Biology. MOLECULAR, CELLULAR, AND ENVIRONMENTAL BIOLOGY PROGRAM The naval concerns that provide the primary focus and rationale for this program are: deterioration of ships and platforms in marine environments due to biocorrosion and biofouling; the need for novel materials and catalysts; requirements for highly sensitive and selective detector systems; and the quality of shipboard and near-shore marine environments. Guided by these naval concerns, this program emphasizes research activities that concentrate on molecular and cellular aspects of marine biology and on determining the principles governing molecular structure, function, and interactions. Specific research issues that are currently being addressed include the following: BIOCATALYSIS IN NON-AQUEOUS SOLVENTS Can we redesign enzymes to be soluble, stable, and highly active in non-aqueous solvents? BIODEGRADATION IN MARINE SEDIMENTS What are the basic biochemical and molecular mechanisms driving biodegradation of hazardous materials in marine sediments? Which microorganisms are the major participants in biodegradation in marine sediments? BIOFABRICATION What are the molecular (including cellular and biochemical) mechanisms used by cells to manufacture mineral structures in the 1 to 100 nm size range? What mechanisms control the size and shape of such structures? BIODETERIORATION What are the molecular mechanisms responsible for biofouling and biocorrosion in marine environments? BIOLUMINESCENCE How is light production in marine environments regulated? What are the molecular and physiological mechanisms governing bioluminescence? BIOMIMETICS How do we proceed from the principles of molecular recognition and enzyme mechanism to the design and synthesis of binding sites, catalytic sites and simplified (diffusible) group transfer co-enzymes? BIOSENSORS How can reusable biosensors be designed for assessment and quantification in real time of any analyte of interest in mixtures of analytes differing significantly in size, shape and concentration and in classes of analytes having similar size, shape and concentration (including group IIB and the divalent transition metal ions present at nanomolar concentrations in the ocean)? COMBINATORIAL SYNTHESIS How can we exploit massively parallel synthesis of polymers of defined length and sequence through biological, biomimetic and bioorganic strategies? ENVIRONMENTAL TOXICOLOGY What mechanisms are used by marine organisms to detect and detoxify hazardous waste? HIGH TEMPERATURE AND PRESSURE BIOLOGY What unique molecular adaptations have developed to permit organisms to function at temperatures above 90x C and/or high hydrostatic pressure? MARINE MAMMALS Are low frequency sounds important to the biology of marine mammals? Are human produced low frequency sound signals harmful to marine mammals? Do marine mammals and other marine vertebrates employ novel methods or mechanisms for aquatic locomotion? MARINE SYMBIOSIS What are the biochemical, genetic, and molecular mechanisms that govern symbiotic associations of marine organisms? How do hosts and symbionts recognize each other and regulate their genetic and metabolic interactions? MARINE VIRUSES How widely distributed are marine viruses? What impact do they have on marine life and oceanographic phenomena? How do they interact with their hosts? MOLECULAR BIOLOGY OF MARINE ORGANISMS What are the basic biological mechanisms governing the physiological activities of marine microbes (bacteria, fungi) and algae? Can novel molecular approaches be developed to analyze the abundance and physiology of natural populations of marine organisms? MOLECULAR RECOGNITION What are the atomic requisites for specific inter-/intramolecular recognition, binding, and reactivity in biomolecules? NANOTRANSPORT What are the requirements for microtubule-directed vesicular transport in vitro. How can cellular components be modified for in vitro transport of unnatural substrates? INTEGRATIVE BIOLOGY PROGRAM Navy and Marine Corps personnel, in both operational and training settings, commonly encounter unique and often highly stressful environments. The physiological response to these environments can compromise both health and performance of personnel in critical situations. A new class of peptide hormones, the cytokines, have recently been recognized as modulators of the stress response as well as of the immune response. In order to better understand the stress response at the molecular level and its role in acute disease processes, the Integrative Biology program is addressing the following research issues: NEUROIMMUNE INTERACTIONS How do cytokines induced in the periphery enter the brain? What are their neural targets? What are their sources in stress? How do cytokines modulate classical endocrine functions in stress and trauma? VIRAL ACUTE PHASE RESPONSE What cytokines mediate the "flu" syndrome associated with common acute viral infections? How are they triggered? How do they interact? Can human performance degradation by this syndrome be ameliorated without compromising disease recovery? SENSORY BIOLOGY PROGRAM The naval need for highly sensitive and selective detector systems that function in marine environments provides the primary focus and rationale for this program. Guided by this need, this program supports basic research on responses of complex organisms to environmental stimuli. The focus is on sensory systems and integrated responses at the cellular and molecular levels. The primary goal of the program is to achieve a better understanding of sensory system function. Sensory Biology Programs are grouped into two major areas, Sensory Biology and Environmental Biophysics. Sensory Biology is directed at the study of sensory transduction mechanisms in order to understand and exploit principles of biological sensors such as amplification, adaptation, selectivity, signal from noise discrimination, and dynamic range. Environmental Biophysics is directed at investigating membrane events involved in sensing environmental changes, particularly those that rely upon mechanisms of ion regulation and signal transduction. Specific research issues that are currently being addressed include the following: BIODETECTION OF WEAK ELECTRIC FIELDS What are the cellular functions associated with the detection and localization of weak electromagnetic fields? How do electric fields interact with the plasma membrane, membrane receptors, channel proteins, and components of signal transduction pathways? ODORANT DISCRIMINATION What are the molecular mechanisms associated with the detection and recognition of chemicals by olfactory receptor neurons and other chemosensory cells of vertebrates, marine invertebrates, and microorganisms? NEAR-FIELD ACOUSTIC DETECTION IN FISH What are the mechanisms that allow fish to use near field low frequency acoustic information for orientation and localization of the acoustic source? SINGLE NEURON COMPUTATION Can one formalize the computations performed by neurons as a basis for designing enhanced processor elements for the next generation of neural networks? What is the distribution of neuronal membrane potentials and ion channels: Is there cooperativity among ion channels? WATER AT BIOLOGICAL INTERFACES What are the physical and chemical mechanisms governing the influence of water on membranes, transport, and receptor action? EDUCATION & TRAINING PROGRAMS Training programs in Molecular, Cellular and Environmental Biology, Sensory Biology and Integrative Biology are intended to provide promising young scientists at the graduate and postdoctoral levels with state-of-the-art training in research areas outlined in this brochure. We also support education programs at historically black colleges and universities and minority institutions. The purpose of these education programs is to increase the number of minority students who enter graduate schools to earn doctoral degrees in science. To this end we support efforts to prepare undergraduates for graduate study in the biological sciences at major research institutions. Education programs supported by us typically involve recruiting and retention efforts, curriculum enhancement, and undergraduate research programs. PROPOSAL SUBMISSION & EVALUATION PROCEDURES Generally, investigators will submit a brief preproposal that allows ONR scientific staff listed at the end of this document to evaluate the relevance and importance of the idea. Investigators whose preproposals are judged to be both relevant and interesting will be encouraged to submit a full proposal. Proposals will be subjected to review against the following criteria: 1. Overall scientific, technical, or socio-economic merit 2. Potential contribution of the effort to ONR's mission 3. Qualifications, capabilities, and experience of the Principal Investigator(s) and key personnel who are critical in achieving the proposed objectives 4. Realism of the proposed cost and availability of funds 5. Extent to which the cost effectiveness of the proposed research is diminished by expenditures for unproductive administrative and overhead expenses. Full proposals, including competitive renewals, are reviewed twice a year and should be postmarked by 1 May or 1 November. The current reviewing schedule calls for a response to preproposals within 8 weeks of receipt. A preproposal should, therefore, be submitted well in advance of the 1 May and 1 November deadlines. THE PREPROPOSAL A preproposal, in three (3) or fewer pages of text, should explain your idea and why it is important. Please include a CV for each principal investigator and a budget estimate. Submit the original and three (3) copies to the address given on the next page. THE FULL PROPOSAL The proposal allows you to explain your idea in sufficient detail to permit colleagues to evaluate its scientific novelty, validity, and feasibility. Proposal instructions are outlined on the following page. FULL PROPOSAL INSTRUCTIONS Please submit the original and five (5) copies of the full proposal (except for Section N as noted below). Text for full proposals should be at least 10 point type (12 point preferred) with 1.5 line spacing and 1" margins (top, sides, bottom). All materials should be sent to: Director, Biological Sciences Division, Office of Naval Research Code 1141, 800 N. Quincy Street, Arlington, Virginia 22217-5660. If you have questions about proposal submission please call 703-696-4760. ORDER AND CONTENT OF THE FULL PROPOSAL A. Title Page (see Attachment 1) B. Table of Contents C. Statement of Objectives (< 100 words, What biological questions will you address?) D. Statement of the Approach (< 100 words, How will you address the questions experimentally?) E. Statement of Significance (< 100 words, Why are your ideas interesting?) F. Key Word/Phrase Listing (4-10 items) G. Body of Proposal (up to 12 pages for new proposals; up to 17 pages for competitive renewals) 1. Introduction and Background Information (up to 3 pages; Help the reviewers understand why the biological problem you are attempting to solve is important and how your ideas relate to existing knowledge that has been generated by others in the field and by you. Preliminary data, manuscripts, and reprints that are relevant to this section should be compiled as an appendix in Section N) 2. Progress (up to 5 pages; this section should only be included for competitive renewal proposals) 3. Technical Approach 4. References H. Facilities available, especially unique facilities or capabilities I. Annual Budget (indicate institutional matching where appropriate) 1. Personnel salaries, wages and fringe benefits (indicate % effort) 2. Equipment - purchase and maintenance, and justification for purchase. 3. Materials and supplies 4. Travel (indicate purpose; identify and justify foreign travel) 5. Indirect Costs 6. Totals (provide annual breakdown and cumulative summary) J. CV's for investigators and consultants K. For all current and pending support (including proposals under review) of each investigator list: 1. Project title and summary 2. Source and amount of funding (annual direct costs; provide grant numbers for current grants) 3. Percentage effort devoted to each project 4. State how projects are related to proposed effort and indicate degree of overlap L. List other agencies to which this proposal has been submitted M. Special information regarding certain types of experiments 1. Experiments involving animals - Species justification, pain causation, or pain control. - Statement of compliance with DOD-FAR 52.235-7003 (see Attachment 2) - Copy of Institutional Animal Care and Use Committee approval 2. Experiments involving human subjects - Statement of compliance with DHHS regulations, Protection of Human Subjects (45 Code of Federal Regulations 46, 1/26/81) - Institutional Review Board Form 3. Experiments involving recombinant DNA - Statement of compliance with DHHS rDNA regulations N. Appendices - Preliminary data, manuscripts, reprints, and any other supporting materials (2 copies only) ___________________________________________________________________ Attachment 1: Sample Title Page RESEARCH PROPOSAL SUBMITTED TO THE OFFICE OF NAVAL RESEARCH TITLE: Full title of proposal ABBREVIATED TITLE: (up to 26 characters) INSTITUTION: Name and address of institution PRINCIPAL INVESTIGATOR(S): _______________________________ _______________________________ Principal Investigator Date Co-Principal Investigator Date Address: Address: Phone: Phone: Fax: Fax: INSTITUTIONAL ENDORSEMENTS _______________________________ _______________________________ Administrative Head Date Financial Officer Date Address: Address: Phone: Phone: TOTAL COST: Dollar amount requested (include direct & indirect costs) DURATION: Duration of project and proposed starting date DATE SUBMITTED: THIS PROPOSAL IS SUBMITTED PURSUANT TO THE ONR GUIDE TO PROGRAMS, BROAD AGENCY ANNOUNCEMENT, DATED 25 June 1992 ___________________________________________________________________ Attachment 2: Department of Defense-Federal Acquisition Regulation 52.235-7003 a. Before undertaking performance of any contract involving the use of laboratory animals, the Grantee shall register with the Secretary of Agriculture of the United States in accordance with Section 6, P.L. 89-544, Laboratory Animal Welfare Act, 24 August 1966 as amended by P.L. 91-579, Animal Welfare Act of 1970, 24 December 1970. The Grantee shall furnish evidence of such registration to the contracting officer. b. The Grantee shall acquire animals used in research and development programs from a dealer licensed by the Secretary of Agriculture or from exempted sources in accordance with the Public Laws enumerated in (a) above. c. In the care of any live animals used or intended for use in the performance of a contract, the Grantee shall adhere to the principles enunciated in the "Guide for Care and Use of Laboratory Animals" prepared by the Institute of Laboratory Animal Resources, National Academy of Science-National Research Council and in the United States Department of Agriculture's regulations and standards issued under the Public Laws enumerated in (a) above. In the case of conflict between standards, the higher standard shall be used. Grantee reports on portions of the contract in which animals were used shall contain a certificate stating that the animals are cared for in accordance with the principles enunciated in the "Guide for Care and Use of Laboratory Animals" prepared by the Institute of Laboratory Animal Resources, NAS-NRC, and/or in the regulations and standards are promulgated by the Agricultural Research Service, USDA, pursuant to the Laboratory Animal Welfare Act of 24 August 1966, as amended (P.L. 89-544 and P.L. 91-579). Note: The Grantee may request registration of his facility and a current listing of licensed dealers from the Regional Office of the Animal and Plant Health Inspection Service (APHIS), USDA, for the region in which the research facility is located. The location of the appropriate APHIS Regional Office as well as information concerning this program may be obtained by contacting the Staff Officer, Animal Care Staff, USDA/APHIS, Federal Center Building, Hyattsville, Maryland, 20782. _____________________________________________________________________ THE SCIENTIFIC STAFF LIFE SCIENCES DIRECTORATE Dr. Steven F. Zornetzer, Director . . . . . . . . . (703) 696-4501 BIOLOGICAL SCIENCES DIVISION Dr. Robert W. Newburgh, Director. . . . . . . . . (703) 696-4986 Ms. Sevgi Bullock, Division Secretary . . . . . . (703) 696-4760 General Information for Biological Sciences MOLECULAR, CELLULAR, AND ENVIRONMENTAL BIOLOGY PROGRAM Dr. Michael Marron, Program Manager. . . . . . .(703) 696-4038 Molecular Biology Dr. Randall S. Alberte . . . . . . . . . . . . .(703) 696-4039 Molecular Marine Biology Dr. Harold Bright. . . . . . . . . . . . . . . .(703) 696-4054 Biochemistry Dr. Daniel P. Costa. . . . . . . . . . . . . . .(703) 696-2085 Marine Mammals and Physiology Dr. Eric Eisenstadt. . . . . . . . . . . . . . .(703) 696-4596 Microbial Genetics Dr. Constance Oliver . . . . . . . . . . . . . .(703) 696-4053 Cell Biology, Environmental Toxicology Dr. Anna C. Palmisano. . . . . . . . . . . . . .(703) 696-2660 Environmental Biology, Microbial Ecology INTEGRATIVE BIOLOGY PROGRAM Dr. Jeannine A. Majde, Program Manager . . . . .(703) 696-4055 Immunophysiology, Medical Materials SENSORY BIOLOGY PROGRAM Dr. Igor Vodyanoy, Program Manager . . . . . . .(703) 696-4056 Biophysics, Sensory Biology FAX Number for the Biological Sciences Division. . . (703) 696-1212 18 March 1993 From owner-sci-resources@net.bio.net Mon Apr 05 23:00:00 1993 Path: biosci!daresbury!keele!uknet!mcsun!uunet!usc!howland.reston.ans.net!usenet.ins.cwru.edu!cleveland.Freenet.Edu!dd544 From: dd544@cleveland.Freenet.Edu (Paul F. Lehmann Ph.d.) Newsgroups: bionet.sci-resources Subject: listing opportunities one at a time NIH/USNAval Research etc Message-ID: <1ps8cj$7n2@usenet.INS.CWRU.Edu> Date: 6 Apr 93 15:42:11 GMT Organization: Case Western Reserve University, Cleveland, Ohio (USA) Lines: 9 NNTP-Posting-Host: hela.ins.cwru.edu It is hard to wade through NIH Guide the way it is posted. Could the NIH and other gencies put each opportunity into a different message? Then I wouldn't have to read about things of no significance to my resera research in the hope that some gold mine lies further on! Paul F. Lehmann lehmann%opus@mcoiarc.bitnet From owner-sci-resources@net.bio.net Mon Apr 05 23:00:00 1993 Path: biosci!bcm!cs.utexas.edu!uunet!haven.umd.edu!darwin.sura.net!welchgate.welch.jhu.edu!danj From: danj@welchgate.welch.jhu.edu (Dan Jacobson) Newsgroups: bionet.sci-resources Subject: Re: listing opportunities one at a time NIH/USNAval Research etc Message-ID: <1993Apr6.175306.6194@welchgate.welch.jhu.edu> Date: 6 Apr 93 17:53:06 GMT References: <1ps8cj$7n2@usenet.INS.CWRU.Edu> Organization: Johns Hopkins Univ. Welch Medical Library Lines: 33 In article <1ps8cj$7n2@usenet.INS.CWRU.Edu> dd544@cleveland.Freenet.Edu (Paul F. Lehmann Ph.d.) writes: > >It is hard to wade through NIH Guide the way it is posted. >Could the NIH and other gencies put each opportunity into a >different message? Then I wouldn't have to read about things >of no significance to my resera research in the hope that >some gold mine lies further on! > >Paul F. Lehmann >lehmann%opus@mcoiarc.bitnet You might want to try reading it by gopher - point you gopher client at helix.nih.gov and select the following directories: --> 2. NIH Information/ --> 2. NIH Guide to Grants and Contracts/ Where you'll see: --> 1. About the NIH Guide. 2. Search NIH Guide (most recent 6 weeks) 3. Search NIH Guide (Jan 1992 - the present) 4. NIH Guide - Flat Text Files/ 5. Request for Applications (RFAs) - Full Text / 6. Program Announcements - Full Text/ Best of luck, Dan Jacobson danj@welchgate.welch.jhu.edu From owner-sci-resources@net.bio.net Tue Apr 06 23:00:00 1993 Path: biosci!CU.NIH.GOV!CZJ From: CZJ@CU.NIH.GOV Newsgroups: bionet.sci-resources Subject: Re: listing opportunities one at a time NIH/USNAval Research etc Message-ID: <9304071727.AA24420@net.bio.net> Date: 7 Apr 93 13:12:23 GMT Sender: daemon@net.bio.net Distribution: bionet Lines: 31 > > It is hard to wade through NIH Guide the way it is posted. > Could the NIH and other gencies put each opportunity into a > different message? Then I wouldn't have to read about things > of no significance to my resera research in the hope that > some gold mine lies further on! > > Paul F. Lehmann > lehmann%opus@mcoiarc.bitnet > > What you propose is difficult and I am not sure desireable. I think it would be difficult to determine how to do a breakdown to satisify everyone's interests. For example, a breakdown by institute, might not work because several Institutes support basic research in molecular biology. I generally do not read the postings because I get hard copy. But the first page should be a table of contents that should guide you to items of interest. I hate to say it, but this is one case where hard copy works best. Given hard copy you can go directly to items of interest without going through the whole document. Solution: At our end, I would just have the files sent directly to a high speed printer and take it from there. Jim Cassatt From owner-sci-resources@net.bio.net Wed Apr 07 23:00:00 1993 Path: biosci!NET.BIO.NET!kristoff From: kristoff@NET.BIO.NET (Dave Kristofferson) Newsgroups: bionet.sci-resources Subject: NIH Guide, vol. 22, no. 13, pt. 1, 2 April 1993 Message-ID: Date: 8 Apr 93 20:22:04 GMT Sender: kristoff@net.bio.net Distribution: bionet Lines: 1506 NOTE: The NIH Guide may be split into more than one mail message to avoid truncation during e-mail distribution. The first message always begins with the RFP/RFA summary sections followed by the appended texts of the full RFP/RFAs. ---------------------------------------------------------------------- $$XID NIHGUIDE 19930402 V22N13 P1O2 ************************************ X-comment: RFAs described: OH-93-001, RR-93-002, PA-93-068 NIH GUIDE - Vol. 22, No. 13 - April 2, 1993 $$INDEX BEGIN ******************************************************* NOTICES OF AVAILABILITY (RFPs AND RFAs) $$INDEX R1 ********************************************************** CLINICAL OPERATIONS CONTRACT FOR MEDICATIONS DEVELOPMENT PROGRAM (RFP N01DA-3-8400) National Institute on Drug Abuse INDEX: DRUG ABUSE $$INDEX R2 ********************************************************** ACQUISITION OF DATA FOR ESTABLISHING AND IMPROVING STRATEGIES FOR TRANSPLANTATION OF BONE MARROW (BAA NIH-NIAID-DAIT-BAA-93-26) National Institute of Allergy and Infectious Diseases INDEX: ALLERGY, INFECTIOUS DISEASES $$INDEX R3 ********************************************************** PNEUMOCOCCAL REFERENCE LABORATORY (RFP NIH-NIAID-DMID-94-13) National Institute of Allergy and Infectious Diseases INDEX: ALLERGY, INFECTIOUS DISEASES $$INDEX R4 06/08/93 ************************************************* CONSTRUCTION HEALTH AND SAFETY (RFA OH-93-001) National Institute for Occupational Safety and Health INDEX: OCCUPATIONAL SAFETY, HEALTH $$INDEX R5 06/23/93 ************************************************* NATIONAL RESOURCE FOR TRANSGENIC ANIMALS (RFA RR-93-002) National Center for Research Resources INDEX: RESEARCH RESOURCES ONGOING PROGRAM ANNOUNCEMENTS $$INDEX P1 06/04/93 ************************************************* RESEARCH SUPPLEMENTS TO PROMOTE REENTRY INTO BIOMEDICAL AND BEHAVIORAL RESEARCH CAREERS (PA-93-067) National Institutes of Health INDEX: NATIONAL INSTITUTES OF HEALTH $$INDEX P2 06/15/93 ************************************************* THE HUMAN BRAIN PROJECT: PHASE I FEASIBILITY STUDIES (PA-93-068) National Institute of Mental Health National Institute on Drug Abuse National Science Foundation National Institute on Aging National Institute of Child Health and Human Development National Institute on Deafness and Other Communication Disorders National Center for Research Resources National Library of Medicine Office of Naval Research National Aeronautics and Space Administration INDEX: MENTAL HEALTH; DRUG ABUSE; NATIONAL SCIENCE FOUNDATION; AGING; CHILD HEALTH, HUMAN DEVELOPMENT, DEAFNESS, COMMICATION DISORDERS; RESEARCH RESOURCES; NATIONAL LIBRARY OF MEDICINE; NAVAL RESEARCH; AERONAUTICS, SPACE ADMINISTRATION This publication is also available electronically to institutions via BITNET or INTERNET. Alternative access is through the NIH Grant Line using a personal computer (data line 301/402-2221). Contact Dr. John James at 301/594-7270 for details. $$INDEX END ********************************************************* NOTICES OF AVAILABILITY (RFPs AND RFAs) $$R1 BEGIN N01DA-3-8400 ********************************************* CLINICAL OPERATIONS CONTRACT FOR MEDICATIONS DEVELOPMENT PROGRAM NIH Guide, Volume 22, Number 13, April 2, 1993 RFP AVAILABLE: N01DA-3-8400 P.T. 34; K.W. 0785035, 0740025 National Institute on Drug Abuse The National Institute on Drug Abuse (NIDA) is soliciting proposals from organizations capable of selecting sites for the conduct of clinical trials and supervising their operation. These will be Phase I and II trials, primarily for the treatment of cocaine and opiate addiction under the current Food and Drug Administration (FDA) regulations and Good Clinical Practice (GPC) guidelines. Performance of the work shall involve: protocol development and review; solicitation and recruitment of a network of qualified clinical trial centers; obtaining FDA registration, DEA registration, and ongoing regulatory compliance; initiation, coordination, monitoring, and management of clinical trials; selection of a central pharmacy and supervision of the distribution of clinical supplies; selection of a central laboratory to accomplish the routine laboratory tests (e.g., CBC, urinalysis) performed at the clinical center; data management; clinical and statistical analysis; and preparation of a written study summary report of adequate quality to support NDA submission(s). The nature of the clinical trials will be to determine the tolerated dose range, the dosing regimen, the safety profile, and estimates of pharmacokinetics and pharmacodynamic parameters. The contractor also will evaluate the efficacy of the investigational compounds or marketed medications. Estimated issuance date of RFP No. N01DA-3-8400 is April 16, 1993, and responses are due to be received by the Contracting Officer 45 calendar days thereafter. The NIDA plans to make one award from this solicitation. INQUIRIES Written requests are to be forwarded to: Kenneth E. Goodling, Contract Specialist National Institute on Drug Abuse Parklawn Building, Room 10-49 5600 Fishers Lane Rockville, MD 20857 This advertisement does not commit the Government to make an award. $$R1 END ************************************************************ $$R2 BEGIN NIH-NIAID-DAIT-BAA-93-26 ********************************* ACQUISITION OF DATA FOR ESTABLISHING AND IMPROVING STRATEGIES FOR TRANSPLANTATION OF BONE MARROW NIH Guide, Volume 22, Number 13, April 2, 1993 BAA AVAILABLE: NIH-NIAID-DAIT-BAA-93-26 P.T. 34; K.W. 0745065, 1002004, 1002008, 0710125 National Institute of Allergy and Infectious Diseases The Basic Immunology and the Genetics and Transplantation Branches of the Division of Allergy, Immunology and Transplantation (DAIT), National Institute of Allergy and Infectious Diseases (NIAID), promote and support research leading to a better understanding of the development of the immune system and the fundamental cellular and molecular biology of immune responses in health and disease. The focus of the Broad Agency Announcement (BAA) is on basic research that will serve to acquire the data necessary for advancing clinical protocols for successful bone marrow transplantation and effective therapeutic treatment for GVHD. Offerors are encouraged to submit proposals relevant to any one of the general areas of research interest described in the BAA in accordance with the instructions in the BAA. Topics include: Development of an experimental model for bone marrow transplantation using isolated hematopoietic stem cells; development of in vitro culture methods of stem cells to study the cellular and molecular nature of purified stem cells with the ultimate goal of ex vivo expansion (self renewal); establishment of pre and/or post transplant conditioning regimens for BM engraftment; characterization of immunological mechanisms responsible for failure or rejection of transplanted BM; and development of prophylactic conditioning or therapeutic regimens for GVHD. Several contract awards are anticipated as a result of this announcement. It is anticipated that the awards will be made on a cost reimbursement basis over a multi-year period. Awards will be subject to DHHS regulations regarding the use of laboratory animals and/or human subjects in research. The issuance of the BAA was February 22, 1993 and proposals are due on May 10, 1993 at 4:00 p.m. INQUIRIES To receive a copy of the BAA, submit a written request along with two self-addressed mailing labels to: Rosemary McCabe Hamill, Contracting Officer Contract Management Branch National Institute of Allergy and Infectious Diseases Solar Building, Room 3C07 6003 Executive Boulevard Bethesda, MD 20892 Telephone inquiries will not be honored and all inquiries must be in writing. Any responsible offeror may submit a proposal that will be considered by the Government. This advertisement does not commit the Government to award a contract. $$R2 END ************************************************************ $$R3 BEGIN NIH-NIAID-DMID-94-13 ************************************* PNEUMOCOCCAL REFERENCE LABORATORY NIH Guide, Volume 22, Number 13, April 2, 1993 RFP AVAILABLE: NIH-NIAID-DMID-94-13 P.T. 34; K.W. 1002027, 0780005 National Institute of Allergy and Infectious Diseases The Respiratory Diseases Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID) has a requirement for a pneumococcal reference laboratory that will: (1) contribute to the development and optimization of a standardized pneumococcal antibody assay, (2) serve as a reference center through which assays will be standardized for the vaccine community, (3) prepare antigens and reagents, and (4) perform serological assays. This contract will also make available antigens and critical reagents for Hib assays. It is anticipated that one award will be made on a cost-reimbursement basis over a four-year period. The award may be subject to DHHS regulations regarding the use of laboratory animals and/or human subjects in research. INQUIRIES To receive a copy of the RFP, submit a written request along with two self-addressed mailing labels to: Rosemary McCabe Hamill, Contracting Officer Contract Management Branch National Institute of Allergy and Infectious Diseases Solar Building, Room 3C07 6003 Executive Boulevard Bethesda, MD 20892 Telephone inquiries will not be honored and all inquiries must be in writing. This RFP will be available on or about April 5, 1993 and proposals will be due in this office by 4:00 p.m. on June 30, 1993. Any responsible offeror may submit a proposal that will be considered by the Government. This advertisement does not commit the Government to award a contract. $$R3 END ************************************************************ $$R4 BEGIN OH-93-001 FULL-TEXT ************************************** CONSTRUCTION HEALTH AND SAFETY NIH Guide, Volume 22, Number 13, April 2, 1993 RFA AVAILABLE: OH-93-001 P.T. 02; K.W. 0725020 National Institute for Occupational Safety and Health Letter of Intent Receipt Date: April 30, 1993 Application Receipt Date: June 8, 1993 THE REQUEST FOR APPLICATIONS (RFA) ANNOUNCED IN THIS NOTICE CONTAINS ESSENTIAL INFORMATION FOR THE PREPARATION OF AN APPLICATION. POTENTIAL APPLICANTS MAY OBTAIN THE RFA FROM THE CONTACT NAMED IN INQUIRIES, BELOW. PURPOSE The Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), is soliciting grant applications for research and demonstration projects relating to occupational safety and health in the construction industry. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This RFA, Construction Health and Safety, is related to the priority area occupational safety and health. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Eligible applicants include domestic and foreign non-profit and for-profit organizations, universities, colleges, research institutions, and other public and private organizations, including State and local governments and small, minority and/or woman-owned businesses. Applicants for the Special Emphasis Research Career Award (SERCA) grants (K01) must be employed at a domestic institution; and be citizens or non-citizen nationals of the U.S. or its possessions or territories or must have been lawfully admitted to the U.S. for permanent residence at the time of application. Applicants for small grants (R03) must be U.S. citizens or non-citizen U.S. nationals who are predoctoral students, post-doctoral researchers (within three years following completion of doctoral degree or completion of residency or public health training), and junior faculty members (no higher than assistant professor). FUNDS AVAILABLE $1,000,000 is set aside for new projects addressing hazards in the construction industry. SERCA (K01) grants may not exceed $50,000 per year in direct costs for salary support (plus fringe benefits), technical assistance, equipment, supplies, consultant costs, domestic travel, publications, and other costs. Small grants (R03) may not exceed $25,000 per year in direct costs for salary support (plus fringe benefits), technical assistance, equipment, supplies, consultant costs, domestic travel, publications, and other costs. MECHANISMS OF SUPPORT The support mechanisms for this program are the individual research project grants (R01); demonstration project grants (R18); Special Emphasis Research Career Award (SERCA) grants (K01); and small grants (R03). A more detailed description of each of these mechanisms is given in the RFA. RESEARCH OBJECTIVES The NIOSH program priorities applicable to this RFA are occupational lung disease, musculoskeletal injuries, occupational cancers, severe occupational traumatic injuries, cardiovascular diseases, disorders of reproduction, neurotoxic disorders, noise-induced loss of hearing, dermatologic conditions, psychological disorders, control techniques, respirator research. These priority areas represent the leading diseases and injuries related to risks on the job, and NIOSH intends to support projects that facilitate progress in preventing such adverse effects among construction workers. Investigators may also apply in other areas related to construction safety and health, but the rationale for the significance of the research to construction must be developed in the application. Construction workers suffer far more serious injuries and fatalities than the general work force population. They die from work-related trauma at a rate three times the national average for workers in all industrial sectors; they suffer disproportionately from nonfatal injuries, from lung diseases, musculoskeletal disorders, hearing loss, and dermatologic conditions. For the construction industry, the national cost from lost production, medical care, workers' compensation, and related claims, is very high. Workers' compensation insurance premiums alone cost $7 billion annually. The construction industry is faced with unique safety and health problems that require special attention. Construction workers must perform work in an environment containing a variety of hazardous energy sources. They often work in the presence of excessive noise levels and with tools and equipment that produce potentially hazardous vibrations; perform repetitive, forceful motions and assume awkward working postures; frequently use a variety of toxic and volatile substances; and must cope with the complications of frequently changing work sites with multiple employers and work crews engaged in separate concurrent activities, while being self-supervised during much of the day. Construction includes not only the building of new structures, but also the destruction or renovation of existing structures. Thus, the potential hazards may be new or old, known or unknown, and simple or complex to control. A complete picture of the extent and severity of the adverse effects is not available, but a partial list of concerns is as follows: 1. Lung diseases resulting from exposure to asbestos, man-made mineral fibers, silica, and other agents that lead to cancer and chronic obstructive pulmonary disease 2. Injuries caused by falls, electricity, person- machine interactions, and environmental conditions 3. Cumulative trauma, vibration-induced disorders, and osteoarthritis 4. Skin disorders caused by irritants, allergens, and photosensitization 5. Systemic toxicity from lead, cadmium, solvents, and other "poisons" 6. Noise-induced hearing loss Potential applicants with questions concerning the acceptability of their proposed work are strongly encouraged to contact the program staff listed under INQUIRIES. STUDY POPULATIONS Applicants are required to give added attention (where feasible and appropriate) to the inclusion of minorities and/or women study populations for research into the etiology of diseases, research in behavioral and social sciences, clinical studies of treatment and treatment outcomes, research on the dynamics of health care and its impact on disease, and appropriate interventions for disease prevention and health promotion. Exceptions would be studies of diseases which exclusively affect males or where involvement of pregnant women may expose the fetus to undue risks. If minorities and/or women are not included in a given study, a clear rationale for their exclusion must be provided. LETTER OF INTENT Prospective applicants are asked to submit, by April 30, 1993, a letter of intent that includes a reference to the number and title of this RFA, a descriptive title of the proposed effort, the name and address of the Principal Investigator, the names of other key personnel, and the participating institutions. The letter of intent is requested in order to provide an indication of the number and scope of applications to be reviewed. This letter of intent does not commit the sender to submit an application, nor is it a requirement for submission of an application. The letter of intent is to be sent to Dr. Roy M. Fleming at the address listed under INQUIRIES. APPLICATION PROCEDURES Applications submitted in response to this RFA must be received on June 8, 1993. Applications are to be submitted on form PHS 398 (rev. 9/91). State and local government applicants may use form PHS 5161-1 (rev. 7/92); however, form PHS 398 is preferred. Forms are available from the contacts listed under INQUIRIES and from the Office of Grants Inquiries, Division of Research Grants, National Institutes of Health, Westwood Building, Room 449, Bethesda, MD 20892, telephone (301) 594- 7248. The RFA label available in the PHS 398 application form must be affixed to the bottom of the face page of the application. Failure to use this label could result in delayed processing of the application such that it may not reach the review committee in time for review. In addition, the RFA title and number (OH-93-001, CONSTRUCTION HEALTH AND SAFETY) must be typed on line 2a of the face page of the application form PHS 398 (or the top of the face page of the PHS 5161-1) and the YES box must be marked." The original and five copies of the PHS 398 or the original and two copies of the PHS 5161-1 application must be submitted to: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** The timetable for receiving applications and awarding grants in fiscal year 1993 is given below. Letter of Intent Receipt Date: April 30, 1993 Application Receipt Date: June 8, 1993 Initial Review: August 1993 Secondary Review September 1993 Earliest Possible Start Date: September 30, 1993 Applications must be received on the above receipt date. To guard against problems caused by carrier delays, retain a legible proof-of-mailing receipt from the carrier, dated no later than one week prior to the receipt date. Applicants must follow the guidance provided in the application package. REVIEW CONSIDERATIONS The initial (peer) review is based on scientific merit and significance of the project, competence of the proposed staff in relation to the type of research involved, feasibility of the project, likelihood of its producing meaningful results, appropriateness of the proposed project period, adequacy of the applicant's resources available for the project, and appropriateness of the budget request. AWARD CRITERIA Applicants will compete for available funds with all other approved applications assigned to NIOSH. The following will be considered in making funding decisions: o Quality of the proposed project as determined by peer review o Availability of funds o Program balance among research areas of the announcement INQUIRIES Written and telephone inquiries are encouraged. The opportunity clarify any issues or questions from potential applicants is welcome. Direct requests for the RFA, inquiries regarding programmatic issues, and address the letter of intent to: Roy M. Fleming, Sc.D. National Institute for Occupational Safety and Health Centers for Disease Control and Prevention 1600 Clifton Road, NE Building 1, Room 2053, Mail Stop D-30 Atlanta, GA 30333 Telephone: (404) 639-3343 For business information contact: Ms. Carole J. Tully Grants Management Branch National Institute for Occupational Safety and Health Centers for Disease Control and Prevention 255 E. Paces Ferry Road, NE Room 300, Mail Stop E-09 Atlanta, GA 30305 Telephone: (404) 842-6880 AUTHORITY AND REGULATIONS This program is authorized under the Public Health Service Act, as amended, Section 301 (42 U.S.C. 241); the Occupational Safety and Health Act of 1970, Section 20 (a)(29 U.S.C. 669[a]); and the Federal Mine Safety and Health Amendments Act of 1977, as amended, Section 501(30 U.S.C. 951). The applicable program regulations are in 42 CFR Part 52. Applications are not subject to review as governed by Executive Order 12372, Intergovernmental Review of Federal Programs. The Catalog of Federal Domestic Assistance number is 93.262. This program is not subject to the Public Health System Reporting Requirements. $$R4 END ************************************************************ $$R5 BEGIN RR-93-002 FULL-TEXT ************************************** NATIONAL RESOURCE FOR TRANSGENIC ANIMALS NIH Guide, Volume 22, Number 13, April 2, 1993 RFA AVAILABLE: RR-93-002 P.T. 34; K.W. 1002002, 1002019 National Center for Research Resources Application Receipt Date: June 23, 1993 THE REQUEST FOR APPLICATIONS (RFA) ANNOUNCED IN THIS NOTICE CONTAINS ESSENTIAL INFORMATION FOR THE PREPARATION OF AN APPLICATION. POTENTIAL APPLICANTS MAY OBTAIN THE RFA FROM THE CONTACT NAMED IN INQUIRIES, BELOW. PURPOSE The National Center for Research Resources (NCRR) invites applications to establish National Resource(s) for Transgenic Animals, to be awarded competitively in Fiscal Year 1993. The primary objectives of this initiative are to: (1) create a repository of embryos of transgenic rodents and lagomorphs and (2) conduct research to perfect cryopreservation methods for important animal species. This award will establish a resource center where embryos are preserved, maintained (banked), and distributed; where transgenic animals are produced at request from the maintained embryos; and where research is conducted on cryopreservation techniques. ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic, for-profit and non-profit organizations, public and private, such as universities, colleges, laboratories, hospitals, or medical centers. Applications from foreign institutions are ineligible for the P40 mechanism. Applicant institutions must demonstrate an established research and resource base in areas related to the RFA. Underrepresented minorities, persons with disabilities, and women are encouraged to apply. MECHANISM OF SUPPORT Grants awarded in response to this initiative will be via the NCRR Animal (Mammalian and Nonmammalian Model), and Animal and Biological Material Resource Grant (P40) mechanism. Responsibility for the planning, direction, and execution of the proposed project will be solely that of the applicant. Awards will be administered under Public Health Service (PHS) grants policy as stated in the PHS Grants Policy Statement and in this RFA. This RFA is a one-time solicitation. Future unsolicited competing continuation applications will compete with all investigator-initiated applications and will be reviewed according to the customary peer review procedures. The total project period for applications submitted in response to the RFA may not exceed five years and is renewable. The earliest expected award date is September 30, 1993. Applicants must limit their requests to not more than $350,000 direct costs for the initial budget period. Future budget period escalations may not exceed a four percent increase over the previous budget period. FUNDS AVAILABLE The estimated funds (total costs) available for the first year of support for this activity are approximately $1,000,000. It is anticipated that one or two awards will be made in FY 93 with an average size of approximately $500,000 total costs. However, the specific number of awards will depend upon the scientific merit and scope of the applications received and the availability of funds. RESEARCH OBJECTIVE Background The laboratory mouse is presently the most widely used, available, and economical animal model used in biomedical research and, in particular, transgenic research. In addition to the many traditional mutant mouse strains, hundreds of additional strains of mice have been created in recent years through transgenic technology. The methods presently available to preserve, maintain, and produce this proliferating number of strains include active breeding programs and embryo cryopreservation. Breeding is expensive and often duplicative. Cryopreservation of embryos is less expensive, but is technologically intensive and heavily dependent on mouse husbandry. These handicaps are clearly resulting in the loss of many strains and limiting access to other users. The development of refined technology for harvesting and successfully cryopreserving mouse sperm and reconstitution of strains through in vitro fertilization or artificial insemination and relatively simple breeding procedures offer a very promising alternative to the current situation. Objectives The objective of this RFA is to initiate a long-term, stable, integrated program for safeguarding national research animal resources of importance to research projects sponsored by the PHS. This initiative will: (1) Provide support to a limited number of centers to serve as multi- categorical research and service resources for the preservation and supply of transgenic rodent and lagomorph strains. These centers are to be regional in nature, and serve users throughout the United States. (2) Encourage applied research on the development of improved techniques for cryopreservation of eggs, sperm, and embryos of numerous rodent and lagomorph species. (3) Incorporate the resources/equipment for the freezing and maintenance of embryos, sperm, and eggs of transgenic animals, and provide, on a full cost recovery basis, live animals from the embryos. A plan will be developed that describes the cost recovery procedures to be implemented. (4) Provide a means for more extensive and long term support to maintain the embryos of those rodent and lagomorph species and models considered to be of national importance and that cannot be preserved through alternate methods. (5) Establish a national advisory committee to review, plan, and prioritize national needs for preservation of important laboratory animal resources. This committee will also act as a central point for the review and evaluation of stocks to be accepted into the repository. It is suggested that the committee be composed of no fewer than five members, with the Principal Investigator serving as the chairperson of the committee. It is encouraged that a minimum of two members be appointed from outside the institution receiving the grant. It is suggested that the committee meet formally at least twice a year during the first year, and then at least once a year thereafter. Conference calls may be held on an as-needed basis to coordinate and plan the activities of the center. (6) Establish effective cooperation with other institutions and organizations with similar interests to minimize costs and avoid duplication. (7) Establish a modern database for classification of all embryos maintained by the resource, maintenance of nomenclature for transgenic embryos being held, and tracking distribution of all embryos or animals provided to users of the resource. (8) Encourage users who have developed transgenic animals with research funds provided through the National Institutes of Health (NIH) to store constructs in these centers. (9) Encourage self-sufficiency of the centers at the end of the project period. A detailed plan will be developed that describes how self- sufficiency will be achieved. For the purposes of this RFA, users of the centers are defined as those individuals who have peer-reviewed research projects involving transgenic animals, with first priority given to those funded by the NIH, followed by those funded by other agencies of the PHS, followed by other sources of peer-reviewed research support. APPLICATION PROCEDURES Applications are to be submitted on form PHS 398 (rev. 09/91), available at most institutional offices of sponsored research and from the Office of Grants Inquiries, Division of Research Grants, National Institute of Health, 5333 Westbard Avenue, Room 449, Bethesda, MD 20892, telephone (301) 594-7248. Applicants must request a copy of the RFA for instructions regarding completion of the form PHS 398, including information on budgetary considerations. The RFA is available from the program staff contact listed under INQUIRIES. Applications must be received by close of business June 23, 1993. If an application is received after this date, it will be returned to the applicant. REVIEW CONSIDERATIONS Upon receipt, applications will be examined initially by the Division of Research Grants (DRG) for completeness. Incomplete applications will be returned to the applicant without further consideration. Evaluation of responsiveness to the program requirements and criteria stated in this RFA is an NCRR staff function. Applications that are considered complete and responsive will be evaluated in accordance with the criteria stated below by an appropriate peer review group convened by the Office of Review of NCRR. It is essential that the written application be in a form that can be reviewed on its own merit, since no site visit is anticipated. If the number of applications is large compared to the number of awards to be made, the NCRR may conduct a preliminary scientific peer review to eliminate those applications that are clearly not competitive. The NCRR will administratively withdraw from competition those applications judged to be noncompetitive, and will so notify the applicant and the institutional business official. Applications judged to be both competitive and responsive to the RFA will be evaluated further, according to the review criteria stated below. Following initial merit review, the applications will receive a second-level review by the National Advisory Research Resources Council. The review of the grant applications will focus on scientific merit, and will include the following criteria (detailed review criteria can be found in the full text RFA): o Overall Program o Administration and Planning o Scientific Expertise of Participants o Institutional Commitment Schedule Application Receipt Date: June 23, 1993 Initial Review: July/August 1993 Second Level Review: September 1993 Anticipated Award: September 1993 INQUIRIES Written and telephone inquiries concerning this RFA are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues and requests for the RFA to: Dr. Cynthia L. Pond Laboratory Animal Sciences Program National Center for Research Resources Westwood Building, Room 857 Bethesda, MD 20892 Telephone: (301) 594-7933) Direct inquiries regarding fiscal matters to: Ms. Kathy Springmann Office of Grants and Contracts Management National Center for Research Resources Westwood Building, Room 853 Bethesda, MD 20892 Telephone: (301) 594-7955) AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.306, Laboratory Animal Sciences and Primate Research. Awards will be made under authorization of the Public Health Service Act, Title III, Section 301 (Public Law 78.410, as amended; 42 USC 241) and administered under PHS grant policies and Federal Regulations 42 CFR Part 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. $$R5 END ************************************************************ ONGOING PROGRAM ANNOUNCEMENTS $$P1 BEGIN PA-93-067 ************************************************ RESEARCH SUPPLEMENTS TO PROMOTE REENTRY INTO BIOMEDICAL AND BEHAVIORAL RESEARCH CAREERS NIH Guide, Volume 22, Number 13, April 2, 1993 PA NUMBER: PA-93-067 P.T. 34; K.W. 0404000, 0710030 National Institutes of Health Application Receipt Date: June 4, 1993 PURPOSE The Office of Research on Women's Health (ORWH) and the Office of Extramural Research, National Institutes of Health (NIH) announce a program of a limited number of supplements to research grants to encourage fully trained women and men to reenter an active research career after taking time off to care for children or parents or to attend to other family responsibilities. The goal of this program is to assist fully trained individuals who have not reentered the research arena. In keeping with this goal, at the time of application a candidate may not be engaged in paid research for more than 10 hours per week. This program will provide administrative supplements to existing NIH research grants for the purpose of supporting full-time or part-time research tailored to update existing research skills and knowledge. The NIH considers the appropriate and adequate representation of women and minorities in biomedical and behavioral research careers essential. The proportion of women Principal Investigators successfully competing for NIH funds has increased steadily since 1982. In FY 1991, women accounted for about 19 percent of the NIH applications and received about 18 percent of competing Research Project Grants awards. Similarly, the proportion of NIH predoctoral and postdoctoral research training positions filled by women has increased steadily with women occupying approximately 40 percent of the research training positions supported by the NIH (see the NIH Report on Women in NIH Extramural Grant Programs, FY 1982-91, Division of Research Grants, 1992). However, the NIH recognizes that this situation can be improved. Thus, NIH encourages women and individuals from ethnic minority groups to enter research careers. Some of the reasons for the low representation of women may be in part related to the fact that women bear a preponderance of the responsibilities surrounding child and family care. As such, this program is specifically designed to offer opportunities to individuals, especially women, who have interrupted their research careers to care for children or parents, to attend to other family responsibilities. The objective of the program is for those who receive support to reestablish careers in biomedical or behavioral research. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This program announcement of Research Supplements to Promote Reentry into Biomedical and Behavioral Research Careers is related to the priority area of women's health. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy people 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Grants and Cooperative Agreements: Only the following active NIH awards at domestic institutions are eligible for Research Supplements to Promote Reentry into Biomedical and Behavioral Research Careers: R01, R10, R24, R35, R37, P01, P40, P41, P50, P51, P60, U01, U10. Principal Investigators on such awards are invited to submit a request for an administrative supplement to the awarding component of the parent grant to support an eligible candidate interested in reestablishing a research career. The parent grant must have at least two years of support remaining on September 1, 1993. The rationale underlying this policy is to provide the candidate an opportunity to accommodate her or his research during the duration of the supplement. Usually, a parent grant would support only one administrative supplement including Research Supplements for Underrepresented Minorities, Research Supplements to Promote the Recruitment of Individuals with Disabilities into Biomedical Research Careers, and the Research Supplement to Promote Reentry into Biomedical and Behavioral Research Careers. Grants most likely to support more than a single administrative supplement are multicomponent awards. Candidates: This program is to support individuals who have interrupted career development to care for children or parents, or to attend to other family responsibilities. Family responsibilities may include relocation to accommodate a family member, or retirement of the candidate's educational debt. This supplement is not intended to support graduate or postdoctoral training and is not intended to cover career changes from non-research to research careers. Candidates who have begun the reentry process through a fellowship or similar mechanism are not eligible for this program. The candidate must have a doctoral degree, such as M.D., D.D.S., Ph.D., D.V.M. or equivalent and must demonstrate evidence of excellence in research prior to the career hiatus. The duration of the hiatus in the research career may not be fewer than two or more than eight years in duration. At the time of application a candidate may not be engaged in paid research for more than 10 hours per week. The candidate must have had sufficient prior research experience to qualify for a faculty appointment at the assistant professor or equivalent level. Candidates must be citizens or noncitizen nationals or have been lawfully admitted for permanent residence (i.e., in possession of an Alien Registration Receipt Card). MECHANISM OF SUPPORT In all cases, the proposed research must be directly related to the approved ongoing research of the parent grant or cooperative agreement. The individual supported under this supplemental award, hereafter called the candidate, must be afforded the opportunity to act as a full participant in the research project and must be given an opportunity to update and enhance her or his research capabilities. This will allow the candidate to establish a career as an independent, competitive research investigator. Supplemental awards will be consistent with the goals of strengthening the existing research program and with the overall programmatic balance and priorities of the funding component of the NIH. Awards will be made according to the policies and provisions stated in this announcement and in the PHS Grants Policy Statement. Administrative supplements (S01) provided under this program may be for either part-time or full-time support for the candidate and all supported time is to be spent updating and enhancing research skills. Proposed part-time appointments may not be less than 20 hours per week. Supplemental awards may be made for up to two years and may not exceed $50,000 in direct costs per year. A maximum of $40,000 may be requested for the salary and fringe benefits for the candidate. The amount of salary requested must be consistent with the policies of the grantee institution for individuals occupying similar positions and must be related to the percent effort requested for the supplement. An additional amount up to $10,000 may be requested for supplies, travel and publication costs. Equipment may not be purchased as a part of this supplement without the prior approval of the NIH awarding component. These awards are not renewable. FUNDS AVAILABLE The ORWH estimates that approximately $1,000,000 will be available for up to 10 supplemental awards in FY 1993. APPLICATION PROCEDURES A request for this supplement must be submitted by June 4, 1993, by the grantee institution, on behalf of the Principal Investigator of the parent grant and in cooperation with the candidate to: Office of Research on Women's Health Westwood Building, Room 854 Bethesda, MD 20892** Because of the expedited review process, the original and five copies of the complete application are required. Please note that the initial step in the administrative review process will be a determination of eligibility. It is incumbent upon the applicant to submit a complete and accurate application, because there will not be an opportunity to make additions or corrections. The request for a supplemental award must include the following: 1. A completed face page (with appropriate signatures) from Grant Application Form PHS 398 (rev. 9/91). Include the title and grant number of the parent grant and "Reentry Supplement" on line 1; 2. A brief, three to four page description, prepared by the Principal Investigator of the parent grant that includes: a. A summary or abstract of the funded grant or project, b. A description of the research proposed for the candidate, c. How the supplement will expand and foster the independent research capabilities of the candidate, d. How the proposed research relates to the specific research goals and objectives of the parent grant; and e. A description of the scope and nature of the mentoring relationship between the Principal Investigator and the candidate. 3. A brief description, prepared by the candidate, that includes: a. research objectives and career goals; b. length of and reason for career hiatus; c. description of how the candidate has kept current in her/his field; and d. identification of steps taken toward reentry, (if any). 4. A biographical sketch of the candidate that includes: a. curriculum vitae; b. social security number; c. citizenship status; d. publications; and e. other evidence of scientific achievement. 5. A proposed budget entered on budget pages from the Grant Application Form PHS 398, related to the percent effort for the research proposed for the candidate during the first and future budget period(s). The amount requested for the supplement must coincide with the current period of support. Thus, if the initial budget period requested is less than 12 months, the budget must be prorated accordingly; 6. Documentation, if applicable, that the proposed research is approved by the Institutional Animal Care and Use Committee (IACUC) or human subjects Institutional Review Board (IRB) of the grantee institution; 7. Under unusual circumstances where the applicant and mentor would be at a site other than the grantee institution, an appropriately signed letter from the institution where the research is to be conducted must also be submitted. The request must be signed by the Principal Investigator, the candidate, and the appropriate institution business official. REVIEW CONSIDERATIONS An NIH review committee convened by the ORWH will review applications for eligibility according to the guidelines described in this announcement. Eligible applications will be further reviewed according to the following criteria: o qualifications of the candidate including career goals, o evidence of excellence of prior research training and experience, o evidence that the proposed research will achieve the stated objectives of the reentry supplements; o the plan for the proposed research in the supplemental request and its relationship to the parent grant; o evidence from the Principal Investigator of appropriate guidance that will enhance the research, knowledge, and/or skills of the candidate; o evidence from the Principal Investigator that the activities of the candidate will be directly related to the approved scope of the parent grant; and o evidence of effort by the candidate to initiate the reentry process, such as attending scientific meetings, keeping current with journals, etc. Funding decisions will be made by the ORWH based upon the recommendations provided by an NIH-wide review committee. These decisions will be communicated to the candidate's Principal Investigator by the Director, ORWH. Since these applications will undergo administrative review, summary statements will not be produced. This is consistent with NIH practice for other similar programs, such as those referenced in the ELIGIBILITY REQUIREMENTS section of this announcement. AWARD CRITERIA The decision to fund a supplement will take up to twelve weeks from the June 4, 1993, application receipt date. A September 1, 1993, award date is anticipated but other award dates will be considered. Second year funding for the supplement is contingent on funding of the parent grant and cannot extend beyond the current competitive segment of the parent grant. Reporting Requirements For non-competing continuation applications, the progress report for the supplement must be clearly delineated as a separate section in the progress report for the parent grant. The progress report must include information about the research accomplishments of the individual supported by the supplement, including research progress, scientific meetings attended, manuscripts in preparation or submitted or accepted for publication, other professional activities within the institution in which the recipient is involved, applications for research support that have been submitted or other evidence of successful reentry. INQUIRIES For general information about the reentry supplements, candidates and Principal Investigators should contact the program official of the appropriate awarding Institute or Center. Candidates who have not yet made contact with a Principal Investigator are encouraged to contact the program official whose institute or center is specific to the research interest. To discuss business aspects of the parent grant or the supplement, Principal Investigators should contact their grants management official. Program officials and grants management contacts and the respective awarding institutes or centers are listed below. National Cancer Institute Mrs. Toby Friedbert, Program Official or Leo Buscher, Grants Management Official Executive Plaza North, Room 636 6130 Executive Boulevard Bethesda, MD 20892 Telephone: (301) 496-3428 or (301) 496-7753 FAX: (301) 402-0275 National Eye Institute Ralph J. Helmsen, Ph.D., Program Official or Carolyn Grimes, Grants Management Official Building 31, Room 6A49 Bethesda, MD 20892 Telephone: (301) 496-5983 or (301) 496-5884 FAX: (301) 402-0528 National Heart, Lung, and Blood Institute Ronald Geller, Ph.D., Program Official or Tom Turley, Grants Management Official Westwood Building, Room 7A17 Bethesda, MD 20892 Telephone: (301) 594-7454 or (301) 594-7434 FAX: (301) 594-7424 National Institute on Aging Phyllis Eveleth, Ph.D., Program Official or Joseph Ellis, Grants Management Official 7201 Wisconsin Avenue, Room 218 Bethesda, MD 20892 Telephone: (301) 496-9322 or (301) 496-1472 FAX: (301) 402-2945 National Institute of Alcohol Abuse and Alcoholism Helen Chao, Ph.D., Program Official or Joe Weeda, Grants Management Official 5600 Fishers Lane, Room 16C-06 Rockville, MD 20857 Telephone: (301) 443-2530 or (301) 443-4703 FAX: (301) 227-8673 National Institute of Allergy and Infectious Disease Milton Hernandez, Ph.D., Program Official or Gary Thompson, Grants Management Official Solar Building, Room 4C10 Bethesda, MD 20892 Telephone: (301) 496-7291 or (301) 496-7231 FAX: (301) 402-0369 National Institute of Arthritis and Musculoskeletal and Skin Disease Julia Freeman, Ph.D., Program Official or Diane Watson, Grants Management Official 5333 Westbard Avenue Westwood Building, Room 403 Bethesda, MD 20892 Telephone: (301) 594-9961 or (301) 594-9965 FAX: (301) 480-7881 National Institute of Child Health and Human Development Ms. Hildegard Topper, Program Official or Donald Clark, Grants Management Official Building 31, Room 2A03 Bethesda, MD 20892 Telephone: (301) 496-0104 or (301) 496-5001 FAX: (301) 402-1104 National Institute of Dental Research Patricia S. Bryant, Ph.D., Program Official or Theresa Ringler, Grants Management Official 5333 Westbard Avenue Westwood Building, Room 509 Bethesda, MD 20892 Telephone: (301) 594-7648 or (301) 594-7629 FAX: (301) 402-4620 National Institute of Diabetes and Digestive and Kidney Diseases Walter S. Stolz, Ph.D., Program Official or John Garthune, Grants Management Official Westwood Building, Room 657 Bethesda, MD 20892 Telephone: (301) 594-7527 or (301) 594-7543 FAX: (301) 594-7594 National Institute on Drug Abuse Eleanor C. Friedenberg, R.N., Program Official or Shirley Denney, Grants Management Official 5600 Fishers Lane, Room 10-42 Rockville, MD 20857 Telephone: (301) 443-2755 or (301) 443-6710 FAX: (301) 443-0538 National Institute of Environmental Health Sciences Anne P. Sassaman, Ph.D., Program Official or Dave Mineo, Grants Management Official P.O. Box 12233 Research Triangle Park, NC 27709 Telephone: (919) 541-7723 or (919) 541-7628 FAX: (919) 541-2843 National Institute of General Medical Sciences Anthony Rene, Ph.D., Program Official or Carol Tippery, Grants Management Official Westwood Building, Room 925 5333 Westbard Avenue Bethesda, MD 20892 Telephone: (301) 594-7706 or (301) 594-7813 FAX: (301) 594-7701 National Institute of Mental Health Delores L. Parron, Ph.D., Program Official or Bruce Ringler, Grants Management Official Parklawn Building, Room 17C-16 5600 Fishers Lane Rockville, MD 20857 Telephone: (301) 443-2847 or (301) 443-3065 FAX: (301) 443-2578 National Institute of Neurological Disorders and Stroke Mr. Edward Donohue, Program Official or Mary Whitehead, Grants Management Official Federal Building, Room 1016 7550 Wisconsin Avenue Bethesda, MD 20892 Telephone: (301) 496-4188 or (301) 496-9231 FAX: (301) 402-4370 National Institute on Deafness and Other Communication Disorders Amy M. Donahue, Ph.D., Program Official or Sharon Hunt, Grants Management Official Executive Plaza South, Room 400B 6120 Executive Boulevard Rockville, MD 20892 Telephone: (301) 402-3458 or (301) 402-0909 FAX: (301) 402-6251 National Center for Human Genome Research Bettie Graham, Ph.D., Program Official or Jean Cahill, Grants Management Official Building 38A, Room 613 Bethesda, MD 20892 Telephone: (301) 496-7531 or (301) 402-0733 FAX: (301) 480-2770 National Center for Nursing Research Sharlene M. Weiss, Ph.D., R.N., Program Official or Sally Nichols, Grants Management Official Westwood Building, Room 757 Bethesda, MD 20892 Telephone: (301) 594-9612 or (301) 594-9615 FAX: (301) 402-2402 National Center for Research Resources Louise E. Ramm, Ph.D., Program Official or Lacey Durham, Grants Management Official Westwood Building, Room 854 Bethesda, MD 20892 Telephone: (301) 594-7906 or (301) 594-7955 FAX: (301) 594-9161 John E. Fogarty International Center David Wolff, Ph.D., Program Official or Silvia Mandes, Grants Management Official Building 31, Room B2C39 Bethesda, MD 20892 Telephone: (301) 496-1653 or (301) 496-1653 FAX: (301) 402-0779 AUTHORITY AND REGULATIONS Supplemental awards will be made under authorities applicable to the parent grant and administered under PHS grants policies and Federal Regulations 42 CFR 52 and 45 CFR Parts 74 and 92. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. $$P1 END ************************************************************ $$P2 BEGIN PA-93-068 FULL-TEXT ************************************** THE HUMAN BRAIN PROJECT: PHASE I FEASIBILITY STUDIES NIH Guide, Volume 22, Number 13, April 2, 1993 PA AVAILABLE: PA-93-068 P.T. 34; K.W. 0705010, 1002030, 1004017 National Institute of Mental Health National Institute on Drug Abuse National Science Foundation National Institute on Aging National Institute of Child Health and Human Development National Institute on Deafness and Other Communication Disorders National Center for Research Resources National Library of Medicine Office of Naval Research National Aeronautics and Space Administration Letter of Intent Receipt Date: April 19, 1993 Application Receipt Date: June 15, 1993 THE PROGRAM ANNOUNCEMENT (PA) ANNOUNCED IN THIS NOTICE CONTAINS ESSENTIAL INFORMATION FOR THE PREPARATION OF AN APPLICATION. POTENTIAL APPLICANTS MAY OBTAIN THE RFA FROM THE CONTACTS NAMED IN INQUIRIES, BELOW. PURPOSE The Human Brain Project is a broadly based federal research initiative that encourages and supports investigator-initiated basic and clinical neuroscience research and investigator-initiated research on informatics resources that could be used to facilitate neuroscience research. Particular emphasis is placed on research on computer storage and manipulation of neuroscience information, network systems, and associated tools that will give neuroscientists access to the stored information. The networks will also provide electronic channels of communication and collaboration to geographically distant laboratories. To optimize the utility of these technologies to neuroscience researchers, they will be developed in the context of specific neuroscience research. It is important to emphasize that the scientific question being addressed is as important as the technology being developed. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This program announcement, The Human Brain Project: Phase I Feasibility Studies, is related to the priority area of mental health and mental disorders. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3228). ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic and foreign, public and private, non-profit and for-profit organizations such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal government. Women and minority investigators are encouraged to apply. MECHANISMS OF SUPPORT This program will use research project grant (R01) and exploratory grant (P20) mechanisms. The R01 mechanism will be used for research project grants, which will allow investigators to work on highly focused projects related to the integration of neuroscience and informatics research. R01 mechanisms can be used for collaborative research initiation grants that will be directed towards fostering the interactions of computer and mathematical scientists or engineers and neuroscientists to design and implement novel technological solutions to particular neuroscience questions. Applications may include support for expenses for travel and per diem expenses to several laboratories to initiate or to explore the possibility of setting up a collaboration. It is essential that the scientific questions to be pursued and the unique contribution of each potential group member should be explicitly stated. The Exploratory Grant (P20) mechanism will provide the opportunity for several investigators using different approaches to focus on a common problem, and will facilitate coordinated communication across disciplinary and geographic boundaries. Anticipated maximum annual budgets (direct and indirect costs) at time of award are $230,000 for the R01 mechanism and $1.1 million for the P20 mechanism. Support may be requested for a period of up to 5 years for R01 and P20 grant mechanisms (foreign grants are limited to 3 years duration). Applicants are strongly encouraged to contact the appropriate individual listed at the end of this announcement for information on specific grant mechanisms. RESEARCH OBJECTIVES Neuroscience is a vigorous, multidisciplinary field that has grown tremendously in the last two decades. This progress has, to a large extent, been fueled by information from many disciplines and across many levels of neural organization. An explosion of information at each of these levels, from gene to behavior, makes it increasingly difficult for individual neuroscientists to keep up with developments in their own circumscribed areas of interest. It is more difficult still for investigators to relate their findings to an integrated understanding of the nervous system. Yet it is precisely such integration that is necessary for the generation of meaningful hypotheses and continued rapid scientific progress. Phase I of the Human Brain Project will support the research related to the development, storage, management, analysis, integration and dissemination of neuroscience information. This initiative will incorporate cutting-edge informatics research with neuroscience research in order to facilitate the integration of neuroscience information and to promote communication and collaboration across scientific disciplines and geographic locations. Broad research objectives appropriate to the Human Brain Project are described in the program announcement. STUDY POPULATIONS SPECIAL INSTRUCTIONS FOR INCLUSION OF WOMEN AND MINORITIES IN CLINICAL RESEARCH STUDIES For projects involving clinical research, NIH requires applicants to give special attention to the inclusion of women and minorities in study populations. If women or minorities are not included in the study populations for clinical studies, a specific justification for this exclusion must be provided. Applications without such documentation will not be accepted for review. LETTER OF INTENT It may be beneficial for applicants to contact the appropriate program official(s) listed below and submit a letter of intent. The letter should include a descriptive title of the proposed research, the name, address, and telephone number of the Principal Investigator (or Director) the identities of other key personnel, and participating institutions. Although a letter of intent is not required, is not binding, and does not enter into the review of subsequent applications, the information that it contains is helpful in planning for the review of applications. The letter is to be submitted to Dr. Michael F. Huerta at the address listed under INQUIRIES. Each letter of intent will be distributed to all of the sponsoring agencies, institutes and centers. APPLICATION PROCEDURES Applicants are to use the grant application form PHS 398 (rev. 9/91). The number and title of the program announcement, "PA-93-068 THE HUMAN BRAIN PROJECT: PHASE I" must be typed in item number 2a on the face page of the PHS 398 application form. The mechanism, either R01 or P20, should be typed in item 2b on the face page of the PHS 398 application form. When applicable, consultant/collaborator information should be provided in section 7, and consortium/contractual arrangements should be provided in section 8 of the PHS 398 application form. This form may be obtained from business offices or offices of sponsored research at most universities, colleges, medical schools, and other major research facilities; from the Office of Grants Inquiries, Division of Research Grants, National Institutes of Health, Westwood Building, Room 449, Bethesda, MD, telephone 301/594-7248; and from the program officials listed under INQUIRIES. Applications must be received by June 15, 1993. For the R01 mechanism, applicants must follow the instructions provided in grant application form PHS 398 (rev. 9/91). Each application for the P20 mechanism must have a director with a demonstrated ability to organize, administer, and direct the group of constituent projects. The director must commit at least 25 percent effort to the P20 Exploratory Grant and be Principal Investigator on one of the projects. It is expected that all of the Principal Investigators of projects funded with the P20 mechanism will be leaders in their fields. Applicants intending to submit an application for a P20 Exploratory Grant are advised to contact a project officer listed under INQUIRIES for more information. Dates for the submission of Phase I Human Brain Project applications for Fiscal Year 1993 and review cycles are: Letter of Intent Receipt Date: April 19, 1993 Application Receipt Date: June 15, 1993 Administrative Review: June 1993 Scientific Review: July/August 1993 Advisory Council Review: September 1993 Earliest Starting Date: September 1993 In subsequent years, the dates for the submission of Phase I Human Brain Project applications and review cycles will be: Letter of Intent Receipt Date: July 1 Application Receipt Date: October 15 Administrative Review: October Scientific Review: February/March Advisory Council Review: May/June Earliest Starting Date: July REVIEW CONSIDERATIONS Applications will be assigned to the appropriate agencies, institutes and center according to their goals and designs and in accordance with standard referral guidelines. Those deemed by the Division of Research Grants to be appropriate for this program announcement will be reviewed for scientific and technical merit by a special review committee (SRC) composed primarily of non-Federal scientists. The members of this committee will be determined by the participating agencies, institutes, and centers. Summaries of SRC recommendations will be sent to applicants as soon as possible after the meeting of the SRC. Subsequent processing of the application will follow the procedures of the respective agency, institute and/or center to which it has been assigned. For applications assigned to a Public Health Service (PHS) institute or center, the application will receive further review by the appropriate National Advisory Council. AWARD CRITERIA Criteria for grant awards include the scientific merit of the proposed research as determined during the review process, responsiveness to the objectives outlined in this announcement and relevance of the research to the mission of the Human Brain Project, availability of the research funds, and the competing demands of other research funding requirements. INQUIRIES The following representatives from each of the participating agencies, institutes, and center can be contacted for further information or clarification. Potential applicants are strongly encouraged to contact the agency or institute representative to discuss their plans prior to preparing an application, and to obtain the full length program announcement for the Human Brain Project. Michael F. Huerta, Ph.D. National Institute of Mental Health 5600 Fishers Lane, Room 11-95 Rockville, MD 20857 Telephone: (301) 443-3948 FAX: (301) 443-4822 E-mail: HMI@CU.NIH.GOV Christine R. Hartel, Ph.D. National Institute on Drug Abuse 5600 Fishers Lane, Room 10A-31 Rockville, MD 20857 Telephone: (301) 443-1887 FAX: (301) 227-6043 E-mail: CHARTEL@AOADA.SSW.DHHS.GOV Christiana Leonard, Ph.D. National Science Foundation 1800 G Street, NW, Room 321 Washington, DC 20550 Telephone: (202) 357-7041 FAX: (202) 357-7846 E-mail: CMLEONAR@NSF.GOV Deborah Claman, Ph.D. National Institute on Aging Gateway Building, Room 3C307 7201 Wisconsin Avenue Bethesda, MD 20872 Telephone: (301) 496-9350 FAX: (301) 496-1494 E-mail: CLAMAN@NIHNIAGW Norman Krasnegor, Ph.D. National Institute of Child Health and Human Development 6100 Building, Room 4B05 Bethesda, MD 20892 From owner-sci-resources@net.bio.net Wed Apr 07 23:00:00 1993 Path: biosci!NET.BIO.NET!kristoff From: kristoff@NET.BIO.NET (Dave Kristofferson) Newsgroups: bionet.sci-resources Subject: NIH Guide, vol. 22, no. 13, pt. 2, 2 April 1993 Message-ID: Date: 8 Apr 93 20:24:11 GMT Sender: kristoff@net.bio.net Distribution: bionet Lines: 1962 $$XID NIHGUIDE 19930402 V22N13 P2O2 ************************************ Telephone: (301) 496-6591 FAX: (301) 402-2085 Judith Cooper, Ph.D. National Institute on Deafness and Other Communication Disorders Executive Plaza South, Room 400B 6120 Executive Boulevard Rockville, MD 20852 Telephone: (301) 496-5061 FAX: (301) 402-6251 Charles L. Coulter, Ph.D. National Center for Research Resources Westwood Building, Room 8A15 Bethesda, MD 20892 Telephone: (301) 594-7934 FAX: (301) 594-9187 E-mail: CCO@CU.NIH.GOV Peter A. Clepper National Library of Medicine Building 38A, Room 5S518 Bethesda, MD 20894 Telephone: (301) 496-4221 FAX: (301) 402-0421 E-mail: CLEPPER@NLM.NIH.GOV Terry Allard, Ph.D. Office of Naval Research 800 N. Quincy Street, Room 1142 Arlington, VA 22217-5660 Telephone: (703) 696-4502 FAX: (703) 696-1212 E-mail: TERRY@TOMCAT.ONR.NAVY.MIL Frank M. Sulzman, Ph.D. National Aeronautics and Space Administration Code SBM, NASA Headquarters Washington, DC 20546 Telephone: (202) 358-2359 FAX: (202) 358-4168 E-mail: FSULZMAN@SMTPGMGW.OSSA.HQ.NASA.GOV Direct inquiries regarding fiscal matters to: Diana Trunnell Assistant Chief, Grants Management Branch National Institute of Mental Health 5600 Fishers Lane, Room 7C-23 Rockville, MD 20857 Telephone: (301) 443-3065 Shirley Denney Chief, Grants Management Branch National Institute on Drug Abuse 5600 Fishers Lane, Room 8A54 Rockville, MD 20857 Telephone: (301) 443-6710 Jean Feldman, Policy Officer Division of Grants and Contracts Policy Office National Science Foundation 1800 G Street, NW, Room 1140 Washington, DC 20550 Telephone: (202) 357-7880 Joseph Ellis Office of Extramural Affairs National Institute on Aging Gateway Building, Room 2N210 7201 Wisconsin Avenue Bethesda, MD 20872 Telephone: (301) 496-1472 Doug Shawver Office of Grants and Contracts National Institute of Child Health and Human Development 6100 Executive Boulevard, Room 8A17 Rockville, MD 20852 Telephone: (301) 496-1303 Sharon Hunt Division of Extramural Activities National Institute on Deafness and Other Communication Disorders 6120 Executive Boulevard, Room 400-B Rockville, MD 20852 Telephone: (301) 402-0909 Paul Karadbil Office of Grants and Contracts Management National Center for Research Resources Westwood Building, Room 849 5333 Westbard Avenue Bethesda, MD 20892 Telephone: (301) 594-7955 Shelly Carow Office of Extramural Programs National Library Medicine Building 38A, Room 5N517 Bethesda, MD 20894 Telephone: (301) 496-4195 Willard Vaughan, Ph.D. Cognitive and Neural Sciences Division Office of Naval Research 800 N. Quincy Street, Room 823 Arlington, VA 22217-5660 Telephone: (703) 696-4505 The National Institute of Neurological Disorders and Stroke (NINDS) and the National Eye Institute (NEI), while not cosponsors of this Program Announcement, have continuing interest in the scientific areas related to the Human Brain Project. NINDS and NEI will continue to fund research on these topics through applications received through the regular receipt and referral processes of the Division of Research Grants. Applicants should contact the relevant NINDS or NEI program staff for further information. AUTHORITY AND REGULATIONS This program is described in the Catalogue of Federal Domestic Assistance Nos. 93.242 (NIMH), 93.279 (NIDA), 47.074 (NSF), 93.866 (NIA), 93.865 (NICHD), 93.173 (NIDCD), 93.371 (NCRR), 93.879 (NLM) and 12.300 (ONR). Awards are made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grants policies and Federal regulations 42 CFR 52 and 45 CFR part 74. Applications submitted in response to this announcement are not subject to the intergovernmental review requirements of Executive Order 12372 as implemented through Department of Health and Human Services regulations at 45 CFR part 100 or Health Systems Agency review. $$P2 END ************************************************************ $$XID RFA OH93001 OH-93-001 P1O1 *************************************** CONSTRUCTION HEALTH AND SAFETY NIH Guide, Volume 22, Number 13, April 2, 1993 RFA: OH-93-001 P.T. 02; K.W. 0725020 National Institute for Occupational Safety and Health Letter of Intent Receipt Date: April 30, 1993 Application Receipt Date: June 8, 1993 PURPOSE The Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), is soliciting grant applications for research and demonstration projects relating to occupational safety and health in the construction industry. The purpose of this Request for Applications (RFA) is to develop knowledge that can be used in preventing occupational diseases and injuries. The NIOSH will support the following types of applied research projects: causal research to identify and investigate the relationships between hazardous working conditions and associated occupational diseases and injuries; methods research to develop more sensitive means of evaluating hazards at work sites, as well as methods for measuring early markers of adverse health effects and injuries; control research to develop new protective equipment, engineering control technology, and work practices to reduce the risks of occupational hazards; and demonstrations to evaluate the technical feasibility or application of a new or improved occupational safety and health procedure, method, technique, or system. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This RFA, Construction Health and Safety, is related to the priority area of occupational safety and health. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Eligible applicants include domestic and foreign non-profit and for-profit organizations, universities, colleges, research institutions, and other public and private organizations, including State and local governments and small, minority and/or woman-owned businesses. FUNDS AVAILABLE $1,000,000 is set aside for new projects addressing hazards in the construction industry. MECHANISMS OF SUPPORT The types of grants NIOSH supports are described below. Applications responding to this announcement will be reviewed by staff for their responsiveness to the following program requirements. Grants are funded for 12-month budget periods in project periods up to five years for research project grants and demonstration project grants; three years for SERCA grants; and up to two years for small grants. Continuation awards within the project period are made on the basis of satisfactory progress and on the availability of funds. Research Project Grants (R01). A research project grant application should be designed to establish, discover, develop, elucidate, or confirm information relating to occupational safety and health, including innovative methods, techniques, and approaches for dealing with occupational safety and health problems. These studies may generate information that is readily available to solve problems or contribute to a better understanding of underlying causes of diseases and injuries. Demonstration Project Grants (R18). A demonstration project grant application should address, either on a pilot or full-scale basis, the technical or economic feasibility of implementing a new/improved innovative procedure, method, technique, or system, for preventing occupational safety or health problems. The project should be conducted in an actual workplace where a baseline measure of the occupational problem will be defined, the new/improved approach will be implemented, a follow-up measure of the problem will be documented, and an evaluation of the benefits will be conducted. Special Emphasis Research Career Award (SERCA) Grants (K01). The SERCA grant is intended to provide opportunities for individuals to acquire experience and skills essential to the study of work-related hazards, and in so doing create a pool of highly qualified investigators who can make future contributions to research in the area of occupational safety and health. SERCA grants are not intended either for individuals without research experience or for productive, independent investigators with a significant number of publications and of senior academic rank. Moreover, the award is not intended to substitute one source of salary support for another for an individual who is already conducting full-time research; nor is it intended to be a mechanism for providing institutional support. Candidates must: (1) hold a doctoral degree; (2) have research experience at or above the doctoral level; (3) not be above the rank of associate professor; (4) be employed at a domestic institution; and (5) be citizens or non-citizen nationals of the U.S. or its possessions or territories or must have been lawfully admitted to the U.S. for permanent residence at the time of application. This non-renewable award provides support for a three-year period for individuals engaged in full-time research and related activities. Awards will not exceed $50,000 per year in direct costs for salary support (plus fringe benefits), technical assistance, equipment, supplies, consultant costs, domestic travel, publications, and other costs. The indirect cost rate applied is limited to 8 percent of the direct costs, excluding tuition and related fees and equipment expenses, or to the actual indirect cost rate, whichever results in the lesser amount. A minimum of 60 percent time must be committed to the proposed research project, although full-time is desirable. Other work in the area of occupational safety and health will enhance the candidate's qualifications but is not a substitute for this requirement. Related activities may include research career development activities as well as involvement in patient care to the extent that it will strengthen research skills. Fundamental/basic research will not be supported unless the project will make an original contribution for applied technical knowledge in the identification, evaluation, and/or control of occupational safety and health hazards (e.g., development of a diagnostic technique for early detection of an occupational disease). Research project proposals must be of the applicants' own design and of such scope that independent investigative capability will be evident within three years. At the completion of this three-year award, it is intended that awardees should be better able to compete for individual research project grants awarded by NIOSH. SERCA grant applications should be identified as such on the application form. Section 2 of the application (the Research Plan) should include a statement regarding the applicant's career plans and how the proposed research will contribute to a career in occupational safety and health research. This section should also include a letter of recommendation from the proposed advisor(s). Small Grants (R03). The small grant program is intended to stimulate applications from individuals who are considering a research career in occupational safety and health; as such, the minimum time commitment is 10 percent. It is expected that a recipient would subsequently compete for a career development grant (K01) or for a traditional research project grant (R01) related to occupational safety and health. The award is not intended to supplement ongoing or other proposed research; nor is it intended to be a mechanism for providing institutional support. The small grant investigators must be U.S. citizens or non-citizen nationals who are predoctoral students, post-doctoral researchers (within 3 years following completion of doctoral degree or completion of residency or public health training), or junior faculty members (no higher than assistant professor). If university policy requires that a more senior person be listed as Principal Investigator, it should be clear in the application which person is the small grant investigator. Except for applicants who are assistant professors, there must be one or more named mentors to assist with the project. A biographical sketch is required for the small grant investigator, as well as for the supervisor and other key consultants, as appropriate. This non-renewable award provides support for project periods of up to two years to carry out exploratory or pilot studies, to develop or test new techniques or methods, or to analyze data previously collected. Awards will not exceed $25,000 per year in direct costs for salary support (plus fringe benefits), technical assistance, equipment, supplies, consultant costs, domestic travel, publications, and other costs. The indirect costs will be based upon the negotiated indirect cost rate of the applicant organization. An individual may not receive more than two small grant awards, and then, only if the awards are at different stages of development (e.g., doctoral student, post-doctoral researcher, or junior faculty member). RESEARCH OBJECTIVES The NIOSH program priorities applicable to this RFA are occupational lung disease, musculoskeletal injuries, occupational cancers, severe occupational traumatic injuries, cardiovascular diseases, disorders of reproduction, neurotoxic disorders, noise-induced loss of hearing, dermatologic conditions, psychological disorders, control techniques, respirator research. These priority areas represent the leading diseases and injuries related to risks on the job, and NIOSH intends to support projects that facilitate progress in preventing such adverse effects among workers. Investigators may also apply in other areas related to the occupational safety and health of construction workers, but the rationale for the significance of the research to the field of occupational safety and health must be developed in the application. Construction workers suffer far more serious injuries and fatalities than the general work force population. They die from work-related trauma at a rate three times the national average for workers in all industrial sectors; they suffer disproportionately from nonfatal injuries, from lung diseases, musculoskeletal disorders, hearing loss, and dermatologic conditions. For the construction industry, the national cost from lost production, medical care, workers' compensation, and related claims, is very high. Workers' compensation insurance premiums alone cost $7 billion annually. The construction industry is faced with unique safety and health problems that require special attention. Construction workers must perform work in an environment containing a variety of hazardous energy sources. They often work in the presence of excessive noise levels and with tools and equipment that produce potentially hazardous vibrations; perform repetitive, forceful motions and assume awkward working postures; frequently use a variety of toxic and volatile substances; and must cope with the complications of frequently changing work sites with several employers and work crews engaged in separate concurrent activities, while being self-supervised during much of the day. Construction includes not only the building of new structures, but also the destruction or renovation of existing structures. Thus, the potential hazards may be new or old, known or unknown, and simple or complex to control. A complete picture of the extent and severity of the adverse effects is not available, but a partial list of concerns is as follows: 1. Lung diseases resulting from exposure to asbestos, man-made mineral fibers, silica, and other agents that lead to cancer and chronic obstructive pulmonary disease 2. Injuries caused by falls, electricity, person-machine interactions, and environmental conditions 3. Cumulative trauma, vibration-induced disorders, and osteoarthritis 4. Skin disorders caused by irritants, allergens, and photosensitization 5. Systemic toxicity from lead, cadmium, solvents, and other "poisons" 6. Noise-induced hearing loss Priorities The NIOSH program priorities listed below are applicable to all of the support mechanisms listed in this RFA. These priority areas represent the leading diseases and injuries related to risks on the job, and NIOSH intends to support projects that facilitate progress in preventing such adverse effects among workers. The conditions or examples listed under each category are selected examples, not comprehensive definitions of the category. The NIOSH Program Priorities are: o Occupational lung disease: asbestosis, byssinosis, silicosis, coal workers' pneumoconiosis, lung cancer, occupational asthma o Musculoskeletal injuries: disorders of the back, trunk, upper extremity, neck, lower extremity: traumatically induced Raynaud's phenomenon o Occupational cancers (other than lung): leukemia, mesothelioma, cancers of the bladder, nose and liver o Severe occupational traumatic injuries: amputations, fractures, eye loss, and lacerations o Cardiovascular diseases: hypertension, coronary artery disease, acute myocardial infraction Disorders of reproduction: infertility, spontaneous abortion, teratogenesis o Neurotoxic disorders: peripheral neuropathy, toxic encephalitis, neuroses, extreme personality changes (exposure-related) o Noise-induced loss of hearing o Dermatologic conditions: dermatoses, burns (scalding), chemical burns, contusions (abrasions) o Psychological disorders: affective disturbances such as anxiety, depression and job dissatisfaction; mal-adaptive behavior and lifestyle patterns; aggression; stress and post traumatic stress disorders; substance abuse o Control Techniques: new technology performance evaluation, preconstruction review, equipment redesign, containment of hazards at the source, fundamental dust generation mechanisms, machine guarding/avoidance methods, explosion control, removal of emissions after generation, dispersion models, monitoring and warning techniques, technology transfer o Respirator research: new and innovative respiratory protective devices, techniques to predict performance, effectiveness of respirator programs, physiologic and ergonomic factors, medical surveillance strategies, psychological and motivational aspects, effectiveness of sorbents and filters, including chemical and physical properties STUDY POPULATIONS SPECIAL INSTRUCTIONS TO APPLICANTS REGARDING IMPLEMENTATION OF NIH POLICIES CONCERNING INCLUSION OF WOMEN AND MINORITIES IN CLINICAL RESEARCH STUDY POPULATIONS NIH policy is that applicants for NIH clinical research grants and cooperative agreements will be required to include minorities and women in study populations so that research findings can be of benefit to all persons at risk of the disease, disorder or condition under study; special emphasis should be placed on the need for inclusion of minorities and women in studies of diseases, disorders and conditions which disproportionately affect them. This policy is intended to apply to males and females of all ages. If women or minorities are excluded or inadequately represented in clinical research, particularly in proposed population-based studies, a clear compelling rationale should be provided. The composition of the proposed study population must be described in terms of gender and racial/ethnic group. In addition, gender and racial/ethnic issues should be addressed in developing a research design and sample size appropriate for the scientific objectives of the study. This information should be included in the form PHS 398 in Sections 1-4 of the Research Plan AND summarized in Section 5, Human Subjects. Applicants are urged to assess carefully the feasibility of including the broadest possible representation of minority groups. However, NIH recognizes that it may not be feasible or appropriate in all research projects to include representation of the full array of United States racial/ethnic minority populations (i.e., Native Americans (including American Indians or Alaskan Natives), Asian/Pacific Islanders, Blacks, Hispanics). The rationale for studies on single minority population groups should be provided. For the purpose of this policy, clinical research includes human biomedical and behavioral studies of etiology, epidemiology, prevention (and preventive strategies), diagnosis, or treatment of diseases, disorders or conditions, including but not limited to clinical trials. The usual NIH policies concerning research on human subjects also apply. Basic research or clinical studies in which human tissues cannot be identified or linked to individuals are excluded. However, every effort should be made to include human tissues from women and racial/ethnic minorities when it is important to apply the results of the study broadly, and this should be addressed by applicants. For foreign awards, the policy on inclusion of women applies fully; since the definition of minority differs in other countries, the applicant must discuss the relevance of research involving foreign population groups to the United States' populations, including minorities. If the required information is not contained within the application, the application will be returned. Peer reviewers will address specifically whether the research plan in the application conforms to these policies. If the representation of women or minorities in a study design is inadequate to answer the scientific question(s) addressed AND the justification for the selected study population is inadequate, it will be considered a scientific weakness or deficiency in the study design and will be reflected in assigning the priority score to the application. All applications for clinical research submitted to NIH are required to address these policies. NIH funding components will not award grants or cooperative agreements that do not comply with these policies. LETTER OF INTENT Prospective applicants are asked to submit, by April 30, 1993, a letter of intent that includes a reference to the number and title of this RFA, a descriptive title of the proposed effort, the name and address of the Principal Investigator, the names of other key personnel, and the participating institutions. The letter of intent is requested in order to provide an indication of the number and scope of applications to be reviewed. This letter of intent does not commit the sender to submit an application, nor is it a requirement for submission of an application. The letter of intent is to be sent to Dr. Fleming at the address listed under INQUIRIES. APPLICATION PROCEDURES Applications submitted in response to this RFA must be received on June 8, 1993. Applications are to be submitted on form PHS 398 (rev. 9/91). State and local government applicants may use form PHS 5161-1 (rev. 7/92); however, form PHS 398 is preferred. Forms are available from the contacts listed under INQUIRIES and from the Office of Grants Inquiries, Division of Research Grants, National Institutes of Health, Westwood Building, Room 449, Bethesda, MD 20892, telephone (301) 594- 7248. The RFA label available in the PHS 398 application form must be affixed to the bottom of the face page of the application. Failure to use this label could result in delayed processing of the application such that it may not reach the review committee in time for review. In addition, the RFA title and number (OH-93-001, CONSTRUCTION HEALTH AND SAFETY) must be typed on line 2a of the face page of the application form PHS 398 (or the top of the face page of the PHS 5161-1) and the YES box must be marked." The original and five copies of the PHS 398 or the original and two copies of the PHS 5161-1 application must be submitted to: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** The timetable for receiving applications and awarding grants in fiscal year 1993 is given below. Letter of Intent Receipt Date: April 30, 1993 Application Receipt Date: June 8, 1993 Initial Review: August 1993 Secondary Review September 1993 Earliest Possible Start Date: September 30, 1993 Applications must be received on the above receipt date. To guard against problems caused by carrier delays, retain a legible proof-of-mailing receipt from the carrier, dated no later than one week prior to the receipt date. Applicants must follow the guidance provided in the application package. REVIEW CONSIDERATIONS Applications received under this RFA will be assigned to an Initial Review Group (IRG). The IRGs, consisting primarily of non-Federal scientific and technical experts, will review the applications for scientific and technical merit. Notification of the review recommendations will be sent to the applicants after the initial review. Applications will also be reviewed for programmatic importance by NIOSH. Awards will be made based on results of the initial and secondary reviews, as well as availability of funds. The initial (peer) review is based on scientific merit and significance of the project, competence of the proposed staff in relation to the type of research involved, feasibility of the project, likelihood of its producing meaningful results, appropriateness of the proposed project period, adequacy of the applicant's resources available for the project, and appropriateness of the budget request. Demonstration grant applications will be reviewed additionally on the basis of the following criteria: o Degree to which project objectives are clearly established, obtainable, and for which progress toward attainment can and will be measured. o Availability, adequacy, and competence of personnel, facilities, and other resources needed to carry out the project. o Degree to which the project can be expected to yield or demonstrate results that will be useful and desirable on a national or regional basis. o Documentation of cooperation from industry, unions, or other participants in the project, where applicable. SERCA grant applications will be reviewed additionally on the basis of the following criteria: o The review process will consider the applicant's scientific achievements, the applicant's research career plan in occupational safety and health, and the degree to which the applicant's institution offers a superior research environment (supportive nature, including letter(s) of reference from advisor(s), which should accompany the application). Small grant applications will be reviewed additionally on the basis of the following criteria: o The review process will take into consideration the fact that the applicants do not have extensive experience with the grant process. AWARD CRITERIA In the secondary review, the following factors will be considered: o The results of the initial review. o The significance of the proposed study to the mission of NIOSH. o Relevance to occupational safety and health, by contributing to achievement of the research objectives specified in Section 20(a) of the Occupational Safety and Health Act of 1970 and Section 501 of the Federal Mine Safety and Health Amendments Act of 1977, o Magnitude of the problem in terms of numbers of workers affected, o Severity of the disease or injury in the worker population, o Potential contribution to applied technical knowledge in the identification, evaluation, and/or control of occupational safety and health hazards, and o Program balance, and o Policy and budgetary considerations. Questions regarding the above criteria may be addressed to the program staff listed under INQUIRIES. INQUIRIES Written and telephone inquiries are encouraged. The opportunity clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues, questions concerning the acceptability of a proposed project, and address the letter of intent to: Roy M. Fleming, Sc.D. National Institute for Occupational Safety and Health Centers for Disease Control and Prevention 1600 Clifton Road, NE Building 1, Room 2053, Mail Stop D-30 Atlanta, GA 30333 Telephone: (404) 639-3343 For business information contact: Ms. Carole J. Tully Grants Management Branch National Institute for Occupational Safety and Health Centers for Disease Control and Prevention 255 E. Paces Ferry Road, NE Room 300, Mail Stop E-09 Atlanta, GA 30305 Telephone: (404) 842-6880 AUTHORITY AND REGULATIONS This program is authorized under the Public Health Service Act, as amended, Section 301 (42 U.S.C. 241); the Occupational Safety and Health Act of 1970, Section 20 (a)(29 U.S.C. 669[a]); and the Federal Mine Safety and Health Amendments Act of 1977, as amended, Section 501(30 U.S.C. 951). The applicable program regulations are in 42 CFR Part 52. Applications are not subject to review as governed by Executive Order 12372, Intergovernmental Review of Federal Programs. The Catalog of Federal Domestic Assistance number is 93.262. This program is not subject to the Public Health System Reporting Requirements. $$XID RFA RR93002 RR-93-002 P1O1 *************************************** NATIONAL RESOURCE FOR TRANSGENIC ANIMALS NIH Guide, Volume 22, Number 13, April 2, 1993 RFA: RR-93-002 P.T. 34; K.W. 1002002, 1002019 National Center for Research Resources Application Receipt Date: June 23, 1993 PURPOSE The National Center for Research Resources (NCRR) invites applications to establish National Resource(s) for Transgenic Animals, to be awarded competitively in Fiscal Year 1993. The primary objectives of this initiative are to: (1) create a repository of embryos of transgenic rodents and lagomorphs, and (2) conduct research to perfect cryopreservation methods for important animal species. This award will establish a resource center where embryos are preserved, maintained (banked), and distributed; where transgenic animals are produced at request from the maintained embryos; and where research is conducted on cryopreservation techniques. ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic, for-profit and non-profit organizations, public and private, such as universities, colleges, laboratories, hospitals, or medical centers. Applications from foreign institutions are ineligible for the P40 mechanism. Applicant institutions must demonstrate an established research and resource base in areas related to the Request for Applications (RFA). Underrepresented minorities, persons with disabilities, and women are encouraged to apply. MECHANISM OF SUPPORT Grants awarded in response to this initiative will be via the NCRR Animal (Mammalian and Nonmammalian Model), and Animal and Biological Material Resource Grant (P40) mechanism. Responsibility for the planning, direction, and execution of the proposed project will be solely that of the applicant. Awards will be administered under Public Health Service (PHS) grants policy as stated in the PHS Grants Policy Statement and in this RFA. The total project period for applications submitted in response to the RFA may not exceed five years and is renewable. The earliest expected award date is September 30, 1993. Applicants must limit their requests to not more than $350,000 direct costs for the initial budget period. Future budget period escalations may not exceed a four percent increase over the previous budget period. This RFA is a one-time solicitation. Future unsolicited competing continuation applications will compete with all investigator-initiated applications and will be reviewed according to the customary peer review procedures. FUNDS AVAILABLE The estimated funds (total costs) available for the first year of support for this activity are approximately $1,000,000. It is anticipated that one or two awards will be made in FY 93 with an average size of approximately $500,000 total costs. However, the specific number of awards will depend upon the scientific merit and scope of the applications received and the availability of funds. RESEARCH OBJECTIVE Background The laboratory mouse is presently the most widely used, available, and economical animal model used in biomedical research and, in particular, transgenic research. In addition to the many traditional mutant mouse strains, hundreds of additional strains of mice have been created in recent years through transgenic technology. The methods presently available to preserve, maintain, and produce this proliferating number of strains include active breeding programs and embryo cryopreservation. Breeding is expensive and often duplicative. Cryopreservation of embryos is less expensive, but is technologically intensive and heavily dependent on mouse husbandry. These handicaps are clearly resulting in the loss of many strains and limiting access to other users. The development of refined technology for harvesting and successfully cryopreserving mouse sperm and reconstitution of strains through in vitro fertilization or artificial insemination and relatively simple breeding procedures offer a very promising alternative to the current situation. An NCRR-sponsored conference on Development of Transgenic Animal Model Resources was held in November 1990. This conference recommended the development of transgenic technology and cryopreservation of transgenic embryos and sperm. Improved preservation of animal genetic resources through cryopreservation was also recommended in the 1990 Report of the Committee on Preservation of Laboratory Animal Resources, Institute of Laboratory Animal Resources, Commission of Life Sciences, National Research Council. Objectives The objective of this RFA is to initiate a long-term, stable, integrated program for safeguarding national research animal resources of importance to research projects sponsored by the PHS. This initiative will: 1) Provide support to a limited number of centers to serve as multi-categorical research and service resources for the preservation and supply of transgenic rodent and lagomorph strains. These centers are to be regional in nature, and serve users throughout the United States. 2) Encourage applied research on the development of improved techniques for cryopreservation of eggs, sperm, and embryos of numerous rodent and lagomorph species. 3) Incorporate the resources/equipment for the freezing and maintenance of embryos, sperm, and eggs of transgenic animals, and provide, on a full cost recovery basis, live animals from the embryos. A plan will be developed that describes the cost recovery procedures to be implemented. 4) Provide a means for more extensive and long term support to maintain the embryos of those rodent and lagomorph species and models considered to be of national importance and that cannot be preserved through alternate methods. 5) Establish a national advisory committee to review, plan, and prioritize national needs for preservation of important laboratory animal resources. This committee will also act as a central point for the review and evaluation of stocks to be accepted into the repository. It is suggested that the committee be composed of no fewer than five members, with the Principal Investigator serving as the chairperson of the committee. It is encouraged that a minimum of two members be appointed from outside the institution receiving the grant. It is suggested that the committee meet formally at least twice a year during the first year, and then at least once a year thereafter. Conference calls may be held on an as-needed basis to coordinate and plan the activities of the center. 6) Establish effective cooperation with other institutions and organizations with similar interests to minimize costs and avoid duplication. 7) Establish a modern database for classification of all embryos maintained by the resource, maintenance of nomenclature for transgenic embryos being held, and tracking distribution of all embryos or animals provided to users of the resource. 8) Encourage users who have developed transgenic animals with research funds provided through the National Institutes of Health (NIH) to store constructs in these centers. 9) Encourage self-sufficiency of the centers at the end of the project period. A detailed plan will be developed that describes how self-sufficiency will be achieved. For the purposes of this RFA, users of the centers are defined as those individuals who have peer-reviewed research projects involving transgenic animals, with first priority given to those funded by the NIH, followed by those funded by other agencies of the PHS, followed by other sources of peer-reviewed research support. APPLICATION PROCEDURES Applications are to be submitted on form PHS 398 (rev. 09/91), available at most institutional offices of sponsored research and from the Office of Grants Inquiries, Division of Research Grants, National Institute of Health, 5333 Westbard Avenue, Room 449, Bethesda, MD 20892, telephone (301) 594-7248. For item 2a of the face page of the application, applicants must enter RFA: National Resource for Transgenic Animals, RFA RR-93-002. The RFA label available in the form PHS 398 must be affixed to the bottom of the face page. Failure to use this label could result in delayed processing of the application to the extent that it may not reach the review committee in time for review. Applications must be received by close of business June 23, 1993. If an application is received after this date, it will be returned to the applicant. Submit a signed, typewritten original and three signed photocopies of the application to: Application Receipt Office Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** At the time of submission, two additional copies of the application must also be sent to: Dr. Bernadette Tyree Office of Review National Center for Research Resources Westwood Building, Room 10A16 Bethesda, MD 20892 The Division of Research Grants (DRG) will not accept any application in response to this RFA that is essentially the same as one currently pending initial review, unless the applicant withdraws the pending application. Nor will the DRG accept any application that is essentially the same as one already reviewed. This does not preclude the submission of substantial revisions of applications already reviewed, but such applications must include an introduction addressing the previous critique. Budgetary Considerations - Allowable Costs Unless otherwise indicated, allowable costs and policies governing the research grant programs of the NIH will prevail. Overlapping support between the grant and other NIH grants and contracts to the applicant institution will be administratively reviewed and, if appropriate, will be adjusted to avoid duplication of funding. Support may be requested for salaries of professional, technical, and support personnel who contribute to allowable activities under the grant. The salaries derived from the grant will depend on the effort provided and institutional salary policies. Stipends for research fellows/trainees are not allowable. No overlap of time or effort between the grant and other separately funded projects is permitted. Support for secretarial and administrative staff may be provided to the extent that their activities relate to administrative management of the grant activities, providing these costs have not been included in the institution's indirect cost pool. It is expected that most major equipment necessary to carry out this work will already be available. However, requests for major equipment under this RFA will be considered; this would include, but not be limited to, equipment for producing and maintaining (freezing) transgenic embryos, ova, and sperm. General purpose equipment needs may be included and justified only after surveying the availability of such items within the institution. While costs of animal maintenance (i.e., per diem charges) for research animals are allowable, it is expected that the costs of production of live animals from transgenic embryos will be recovered from the users through a cost recovery system. Applicants should separately identify all costs related to the maintenance of research animals and to animal production. Costs of domestic travel for grant personnel and advisory committee members are allowable. Foreign travel will not be allowed except under unusual and compelling circumstances, and will require prior approval by the awarding agency. Costs for consultant services (consultation fees, per diem, travel) may be included. Costs associated with consultation or scientific or technical assistance, evaluation of planning activities, and development of new techniques are allowable. Costs for telephone, facsimile transmissions, photocopying, and computer time that are directly related to the grant are permitted. REVIEW CONSIDERATIONS Upon receipt, applications will be examined initially by DRG for completeness. Incomplete applications will be returned to the applicant without further consideration. Evaluation of responsiveness to the program requirements and criteria stated in this RFA is an NCRR staff function. Applications that are considered complete and responsive will be evaluated in accordance with the criteria stated below by an appropriate peer review group convened by the Office of Review of NCRR. It is essential that the written application be in a form that can be reviewed on its own merit, since no site visit is anticipated. If the number of applications is large compared to the number of awards to be made, the NCRR may conduct a preliminary scientific peer review to eliminate those applications that are clearly not competitive. The NCRR will administratively withdraw from competition those applications judged to be noncompetitive, and will so notify the applicant and the institutional business official. Applications judged to be both competitive and responsive to the RFA will be evaluated further, according to the review criteria stated below. Following initial merit review, the applications will receive a second-level review by the National Advisory Research Resources Council. The review of the grant applications will focus on scientific merit. The evaluation will include the following review criteria: 1. Overall Program o The potential of the center, as proposed, to meet the objectives stated in this RFA. o The scientific merit of the program as a whole, including the significance of the overall program goals and the development of a well-defined central focus. o The potential of the identified participants to develop research programs of high merit as evidenced by previous accomplishments. 2. Administration and Planning o The scientific and administrative leadership ability and experience of the grant's Principal Investigator and his/her commitment and ability to devote adequate time to the effective management of the center. o The composition of the advisory committee, and how the national needs for preservation of the laboratory animal resources will be reviewed, planned, and prioritized. o Maintenance of internal communication and cooperation among the investigators involved in the center, and adequacy of plans for such collaboration. o Appropriateness of the budget for the various components of the grant. o Appropriateness of the plan that details full cost recovery for production of live animals from embryos. o Appropriateness of the plan that describes how the resource will become self-sufficient by the end of the project period. o Quality of the plan to develop a database that will classify all embryos maintained by the resource; maintain nomenclature for transgenic embryos being held; and track distribution of all embryos or animals sent to users of the resource. 3. Scientific Expertise of Participants o Quality and appropriateness of expertise available at the applicant institution for research on the development of improved cryopreservation techniques, maintenance of animals, and development of the database. o Nature and degree of interdisciplinary approach proposed to promote the collaboration of scientists with expertise in transgenic animal methodology. o Qualifications, experience, and evidence of commitment of the investigators within the applicant institution, and their willingness to interrelate with other elements proposed for the center. 4. Institutional Commitment o The institutional commitment to the program, including lines of responsibility for the proposed center and the institution's contribution to the management capabilities of the center. o The degree of institutional contributions for administrative and planning activities. o The research environment and the availability of expertise, resources, equipment, and space for the freezing and maintenance of embryos, sperm, and eggs of transgenic animals. o The availability of expertise and resources required to provide users with live animals from embryos at their request. o The potential for interaction with scientists from other departments and institutions to minimize costs and avoid duplication. o The institutional commitment to any newly-recruited individuals responsible for conducting essential grant functions and activities. AWARD CRITERIA Applications will compete for available funds with all other applications submitted in response to this RFA and recommended by peer review. The following will be considered in making funding decisions: o Quality of the application as determined by peer review o Availability of funds o Overall program balance and geographic distribution represented by the applications recommended by peer review Schedule Application Receipt Date: June 23, 1993 Initial Review: July/August 1993 Second Level Review: September 1993 Anticipated Award: September 1993 INQUIRIES Written and telephone inquiries concerning this RFA are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues to: Dr. Cynthia L. Pond Laboratory Animal Sciences Program National Center for Research Resources Westwood Building, Room 857 5333 Westbard Avenue Bethesda, MD 20892 Telephone: (301) 594-7933 Direct inquiries regarding fiscal matters to: Ms. Kathy Springmann Office of Grants and Contracts Management National Center for Research Resources Westwood Building, Room 853 Bethesda, MD 20892 Telephone: (301) 594-7955 AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.306, Laboratory Animal Sciences and Primate Research. Awards will be made under authorization of the Public Health Service Act, Title III, Section 301 (Public Law 78.410, as amended; 42 USC 241) and administered under PHS grant policies and Federal Regulations 42 CFR Part 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. $$XID RFA PA93068 PA-93-068 P1O1 *************************************** THE HUMAN BRAIN PROJECT: PHASE I FEASIBILITY STUDIES NIH Guide, Volume 22, Number 13, April 2, 1993 PA NUMBER: PA-93-068 P.T. 34; K.W. 0705010, 1002030, 1004017 National Institute of Mental Health National Institute on Drug Abuse National Science Foundation National Institute on Aging National Institute of Child Health and Human Development National Institute on Deafness and Other Communication Disorders National Center for Research Resources National Library of Medicine Office of Naval Research National Aeronautics and Space Administration Letter of Intent Receipt Date: April 19, 1993 Application Receipt Date: June 15, 1993 PURPOSE The Human Brain Project is a broadly based federal research initiative, supported by the National Institute of Mental Health (NIMH), the National Institute on Drug Abuse (NIDA), the National Science Foundation (NSF), the National Institute of Child Health and Human Development (NICHD), the National Institute on Aging (NIA), the National Institute on Deafness and Other Communication Disorders (NIDCD), the National Center for Research Resources (NCRR), the National Library of Medicine (NLM), and the Office of Naval Research (ONR). In addition, the National Aeronautics and Space Administration (NASA) will make available to Human Brain Project research its supercomputer and other resources of the Biocomputation Center. The general purpose of this initiative is to encourage and support investigator-initiated basic and clinical neuroscience research and investigator-initiated research on informatics resources that could be used to facilitate neuroscience research. Particular emphasis is placed on research on computer storage and manipulation of neuroscience information, network systems, and associated tools that will give neuroscientists access to the stored information. The networks will also provide electronic channels of communication and collaboration to geographically distant laboratories. Emphasis will also be placed on collaborations that result in new experimental technologies or new mathematical paradigms linked to empirical research. To optimize the utility of these technologies to neuroscience researchers, they will be developed in the context of specific neuroscience research. It is important to emphasize that the scientific question being addressed is as important as the technology being developed. Neuroscience is a vigorous, multidisciplinary field that has grown tremendously in the last two decades. This progress has, to a large extent, been fueled by information from many disciplines and across many levels of neural organization. An explosion of information at each of these levels, from gene to behavior, makes it increasingly difficult for individual neuroscientists to keep up with developments in their own circumscribed areas of interest. It is more difficult still for investigators to relate their findings to an integrated understanding of the nervous system. Yet it is precisely such integration that is necessary for the generation of meaningful hypotheses and continued rapid scientific progress. Limitations in the ability of scientists to manage and integrate information are forcing a return to the fragmented view of neuroscience that existed 30 years ago. Fortunately, computer, information, and telecommunication sciences offer solutions to this problem. The Human Brain Project will research these informatics solutions in the context of neuroscience research projects. Human Brain Project research will thus augment the ability of neuroscientists to integrate and synthesize information across disciplinary and geographic boundaries. In 1989, NIMH, NIDA and NSF requested the National Academy of Science's Institute of Medicine (IOM) to establish a Committee on a National Neural Circuitry Database. The Committee's charge was to consider the desirability, feasibility, and possible ways of implementing a family of resources, both electronic (e.g., computer networks) and digital (e.g., databases), for the enhancement of neuroscience research. After deliberations spanning almost two years and involving more than 150 scientific consultants, the IOM endorsed the concept of mapping the brain and its functions and issued several specific recommendations (Mapping the Brain and Its Functions: Integrating Enabling Technologies into Neuroscience Research, 1991, Institute of Medicine, National Academy Press). Among these recommendations is that this initiative should be implemented in several phases by the research community. Phase I will consist of research feasibility studies that researchers will then refine and extend in Phase II. The participating agencies, institutes and center are requesting research grant applications for Phase I of the Human Brain Project. This ongoing program announcement pertains only to Phase I activities. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of Healthy People 2000, a PHS-led national activity for setting priority areas. This program announcement, The Human Brain Project: Phase I Feasibility Studies, is related to the priority area of mental health and mental disorders. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3228). ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic and foreign, public and private, non-profit and for-profit organizations such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal government. Women and minority investigators are encouraged to apply. MECHANISMS OF SUPPORT Anticipated maximum annual budgets (direct and indirect costs) at time of award are $230,000 for the R01 mechanism and $1.1 million for the P20 mechanism. Support may be requested for a period of up to five years for R01 and P20 grant mechanisms (foreign grants are limited to three years duration). It is estimated that approximately $4 to 5 million will be available to support new grants under this announcement in fiscal year 1993. The exact amount of funding available will depend on appropriated funds, the quality of applications, and program priorities at the time of award. This program will use research project grant (R01) and Exploratory Grant (P20) mechanisms. Listed below are opportunities and requirements which differ between these grant mechanisms: Research Project Grants (R01). The R01 mechanism will be used for research project grants, which will allow investigators to work on highly focused projects related to the integration of neuroscience and informatics research. The R01 mechanism can be used for collaborative research initiation grants that will be directed towards fostering the interactions of computer and mathematical scientists or engineers and neuroscientists to design and implement novel technological solutions to particular neuroscience questions. Applications may include support for expenses for travel and per diem expenses to several laboratories to initiate or to explore the possibility of setting up a collaboration. It is essential that the scientific questions to be pursued and the unique contribution of each potential group member should be explicitly stated. Exploratory Grants (P20). These awards will provide the opportunity for several investigators using different approaches to focus on a common problem. Exploratory Grants (P20) will facilitate coordinated communication across disciplinary and geographic boundaries. o Director. Each Exploratory Grant (P20) will have a Director with a demonstrated ability to organize, administer, and direct the grant. The Director must commit at least 25 percent effort to the grant and be Principal Investigator on one of the projects. o Focus of research. The Exploratory Grants (P20) will combine informatics and neuroscience research components in an effort to develop novel approaches for managing and distributing neuroscience information. Each Exploratory Grant (P20) will focus on a specific research issue in neuroscience and will include investigations at several levels of neural organization (e.g., molecular, cellular, and systems levels) and/or using different methodological approaches (e.g., electrophysiological, anatomical and behavioral), thereby facilitating the integration of different types of neuroscience information. Exploratory Grants (P20) are characterized by the synergy of their constituent projects. Each such grant application must, therefore, not only demonstrate the interrelationship of its constituent projects but also indicate how the inclusion of each project will enhance the overall goals of the grant. o Group members. Each Exploratory Grant (P20) will comprise several, probably from three to five, laboratories or projects. It is expected that the Principal Investigators of the constituent laboratories or projects will be regarded as leaders in their respective fields. o Information sharing. In research funded by this mechanism, digital and electronic communication, especially via computer networks, will be established among different laboratories or projects within a given Exploratory Grant (P20) group. An important goal of each Exploratory Grant (P20) will be to develop the technology that will allow databases and computer network systems to handle and integrate data generated by all of the laboratories or projects supported by that grant. Communication among different Exploratory Grant (P20) groups will promote the compatibility of the various technologies developed by each group. Therefore, digital communication, especially via computer networks, will be encouraged among different such groups. Investigators working on problems at the same level of neural organization, or using the same methodologies, are prime candidates for such interaction. Additionally, because of the pivotal role that computer networks will play in this initiative, laboratories participating in a given Exploratory Grant (P20) group need not all be at the same geographic location. RESEARCH OBJECTIVES Phase I of the Human Brain Project will support the research related to the development, storage, management, analysis, integration and dissemination of neuroscience information. This initiative will incorporate cutting-edge informatics research with neuroscience research in order to facilitate the integration of neuroscience information and to promote communication and collaboration across scientific disciplines and geographic locations. Consistent with the goal to integrate neuroscience information, the Human Brain Project research will lead to three-dimensional computerized maps and models of the structures, functions, connectivity, physiology, pharmacology, biochemistry, and molecular biology of human, monkey, and rat brains. Other mammalian, as well as nonmammalian vertebrate and invertebrate species, are also appropriate for study. It is expected that these maps and models will ultimately: span different developmental stages of organisms; reflect both normal and disease states; include numeric, textual, graphic, and image data; and be available via computer networks. Broad research objectives appropriate to the Human Brain Project include, but are not limited to, the following: o Storage and manipulation of neuroanatomical, neurochemical, neurophysiological, and other data that are portable at the source code, user interface, and platform levels o Network transmission of neuroscience data at varying levels of confidentiality o Ways to integrate neuroanatomical data, neurochemical data, neurophysiological data, and behavioral data o Approaches that permit access to and integration of information related to different areas of neuroscience (e.g., molecular biology, electrophysiology, and behavior) o Visualization of data related to the structure and function of the nervous system o Approaches for the intelligent navigation through a range of types of neuroscience information in heterogeneous environments over networks o Probabilistic, population-based anatomic atlases of brain images of normal subjects matched for handedness, age, and gender. o Approaches for the analysis of intersubject variability of structural and functional image data for circumscribed subject populations o Approaches for compression of neuroimaging data o Shared data resources and repositories for neuroscience data generated by the Human Brain Project o Ways to provide interactions between the Human Brain Project neuroscience information and pertinent national informational resources, such as those associated with the Human Genome Project o Approaches for electronic collaboration of neuroscientists o Assessment of behavior and ontogenetic brain changes in infants, children, and adolescents, particularly in populations at risk for consequently developing specific medical or behavioral disorders o Analysis and display techniques for optimizing functional brain imaging by integrating images from several modalities, e.g., EEG, MRI, PET, functional MRI o Ways to use neurobiologically realistic information and algorithms to guide implementation of Very Large Scale Integrated chip technologies o Use of intelligent control or neuroengineering paradigms to explain neurobiological results o Interactive graphics systems to facilitate real-time imaging o Approaches to allow interaction with stored neurobiological information to provide biological constraints on computational models o Qualitatively new types of biological sensors and sensor data processing systems o Massively parallel virtual supercomputing based on networks of small computers in multiple geographic locations to facilitate modeling of information processing in neurobiological systems. o Ways to interface humans with computers o Computerized search strategies for stored neuroscience information This list of broad objectives is meant to be illustrative and is not exclusive of other objectives appropriate to Phase I of this initiative. The Human Brain Project encourages informatics research carried out in concert with neuroscience research. This initiative will provide support either for an informatics component that is carried out with ongoing peer-reviewed neuroscience research or for both the informatics and the neuroscience components. In the former case, the funding of the neuroscience component may come from any source. Each project will be accountable for the attainment of proposed specific aims through progress reports and the timely publication and dissemination of results, including software, database designs, and source codes. Phase I projects will be investigator-initiated and can use the R01 or P20 mechanism, explained below. As Phase I evolves, digital and electronic communication among projects will be supported. Supplemental funds may be competitively awarded to projects to support such interactions after they have been in existence for 3 years and have demonstrated the requisite capabilities within their own projects. A listing of investigators participating in Phase I, and the types of data, software, or other information that is available from or through them will be created to minimize scientifically unnecessary duplication of effort in Phase I. This list will indicate from whom particular data might be obtained. Grantees will be invited to contribute to this list and to participate in semiannual meetings of Human Brain Project investigators. These meetings will promote communication among different groups of investigators. Availability of Computational Resources The choice of computational resources to be used in Human Brain Project research is entirely that of the applicant, and the range of appropriate resources extends across the entire spectrum of computer technology. Nevertheless, some investigators may be interested in using, or collaborating with those using, supercomputers, massively parallel computers, and other advanced technology that may not be available at their institution. To facilitate such use and collaboration, the following information is provided. o The NSF supports High Performance Computer Centers and Science and Technology Centers. Individuals considering applications for supercomputer use should contact these centers early in the proposal development process. Linda Callahan Cornell Theory Center 514 Engineering and Theory Center Building Ithaca, NY 14853-3801 Telephone: (607) 254-8610 Internet: cal@theory.tc.cornell.edu Bitnet: cal@CRNLTHRY National Center for Atmospheric Research, Scientific Computing Division Visitor/User Information P.O. Box 3000 Boulder, CO 80307 Telephone: (303) 497-1225 Internet: scdinfo@ncar.ucar.edu Bitnet: scdinfo@ncario Scott Lathrop National Center for Supercomputing Applications 605 East Springfield Avenue Champaign, IL 61820-5518 Telephone: (217) 244-1099 Internet: slathrop@ncsa.uiuc.edu Bitnet: ul3006@ncsagate Robert B. Stock Pittsburgh Supercomputing Center 4400 Fifth Avenue Pittsburgh, PA 15213 Telephone: (412) 268-4960 Internet: stock@psc.edu Bitnet: stock@cpwpsca Mark Sheddon San Diego Supercomputer Center P.O. Box 85608 San Diego, CA 92186-9784 Telephone: (619) 534-5130 Internet: sheddon@sdse.edu Bitnet: sheddon@sdsc o The ONR also supports a variety of supercomputer facilities. Those interested in these resources for Human Brain Project Research should contact the ONR contact listed at the end of this announcement early in the process of application development. o In addition, NASA will make available computational resources of the Biocomputation Center (BC) at Ames Research Center, Moffett Field, California. These resources include computer-controlled transmission electron microscopy for semiautomated 3 dimensional reconstruction of neural tissue, virtual environments, high-performance workstations, supercomputers, and massively parallel computers. A scientist interested in using the BC as part of Human Brain Project research will submit a written request for facility use to the BC Director prior to submitting an application to the Public Health Service. This request will state the objectives of the intended work and the approaches to be used. This request will also provide enough information to allow BC staff to assess whether or not the intended use is within the capability of the BC. In addition, this request will provide information necessary to allow BC staff to determine the amount of time the proposed work will require. On review of the request for BC use, the BC staff will provide the inquiring scientist with an itemized estimate of the costs for BC resources needed to achieve the stated objectives. The scientist will use this estimate as part of the budget justification in the Public Health Service application for funds to support the Human Brain Project research. Requests for BC use are to be sent to: Dr. Muriel Ross Director, Biocomputation Center MS 261-2 Ames Research Center Moffett Field, CA 94035-1000 STUDY POPULATIONS SPECIAL INSTRUCTIONS TO APPLICANTS REGARDING IMPLEMENTATION OF NIH POLICIES CONCERNING INCLUSION OF WOMEN AND MINORITIES IN CLINICAL RESEARCH STUDY POPULATIONS Applications for grants that involve human subjects are required to include minorities and both genders in study populations so that research findings can be of benefit to all persons at risk of the disease, disorder or condition under study; special emphasis should be placed on the need for inclusion of minorities and women in studies of diseases, disorders and conditions which disproportionately affect them. This policy applies to all research involving human subjects and human materials, and applies to males and females of all ages. If one gender and/or minorities are excluded or are inadequately represented in this research, particularly in proposed population-based studies, a clear compelling rationale for exclusion or inadequate representation should be provided. The composition of the proposed study population must be described in terms of gender and racial/ethnic group, together with a rationale for its choice. In addition, gender and racial/ethnic issues should be addressed in developing a research design and sample size appropriate for the scientific objectives of the study. Applicants are urged to assess carefully the feasibility of including the broadest possible representation of minority groups. However, it is recognized that it may not be feasible or appropriate in all research projects to include representation of the full array of United States racial/ethnic minority populations (i.e., American Indians or Alaskans Natives, Asians or Pacific Islanders, Blacks and Hispanics). Investigators must provide the rationale for studies on single minority population groups. Applications for support of research involving human subjects must employ a study design with minority and/or gender representation (by age distribution, risk factors, incidence/prevalence, etc.) appropriate to the scientific objectives of the research. It is not an automatic requirement for the study design to provide statistical power to answer the questions posed for men and women and racial/ethnic groups separately; however, whenever there are scientific reasons to anticipate differences between men and women, and racial/ethnic groups, with regard to the hypothesis under investigation, applicants should include an evaluation of these gender and minority group differences in the proposed study. If adequate inclusion of one gender and/or minorities is impossible or inappropriate with respect to the purpose of the research, because of the health of the subjects, or other reasons, or if in the only study population available, there is a disproportionate representation of one gender or minority/majority group, the rationale for the study population must be well explained and justified. The funding components will not make awards of grants, cooperative agreements or contracts that do not comply with this policy. For research awards which are covered by this policy, awardees will report annually on enrollment of women and men, and on the race and ethnicity of subjects. Protection of Human Subjects The Department of Health and Human Services has regulations for the protection of human subjects and has developed additional regulations for the protection of children. A copy of these regulations (45 CFR 46, Protection of Human Subjects) and those pertaining specifically to children are available from the Office of Protection from Research Risks, National Institutes of Health, Bethesda, Maryland 20892, telephone (301) 496-7041. Specific questions concerning protection of human subjects in research may be directed to NIMH staff listed under INQUIRIES. LETTER OF INTENT It may be beneficial for applicants to contact the appropriate program official(s) listed below and submit a letter of intent. The letter should include a descriptive title of the proposed research, the name, address, and telephone number of the Principal Investigator (or Director), names of other key personnel, and participating institutions. Although a letter of intent is not required, is not binding, and does not enter into the review of subsequent applications, the information that it contains is helpful in planning for the review of applications. The letter is to be submitted to Dr. Michael F. Huerta at the address listed under Inquiries. Each letter of intent will be distributed to all of the sponsoring agencies, institutes and center. APPLICATION PROCEDURES Applicants are to use the grant application form PHS 398 (rev. 9/91). The number and title of the program announcement, "PA-93-068 THE HUMAN BRAIN PROJECT: PHASE I" must be typed in item number 2a on the face page of the PHS 398 application form. The mechanism, either R01 or P20, must be typed in item 2b on the face page of the PHS 398 application form. When applicable, consultant/collaborator information should be provided in section 7, and consortium/contractual arrangements should be provided in section 8 of the PHS 398 application form. This form may be obtained from business offices or offices of sponsored research at most universities, colleges, medical schools, and other major research facilities; from the Office of Grants Inquiries, Division of Research Grants, National Institutes of Health, Westwood Building, Room 449, Bethesda, MD, telephone 301/594-7248; and from the program officials listed under INQUIRIES. Applications must be received by June 15, 1993. Research Project Grants (R01). For the R01 mechanism, applicants must follow the instructions provided in grant application form PHS 398 (rev. 9/91). Exploratory Grants (P20). The application must describe the specific research hypotheses to be tested and how they relate to the overall research issue addressed by the grant. In addition, the application should clearly articulate the manner in which technological components relate to neuroscience components. For the Exploratory Grant (P20) applications only, the Research Plan Section of form PHS 398 (Specific Aims, Background and Significance, Progress Report/Preliminary Studies, and Research Design and Methods) should be replaced by the following. o General Description of the Overall Project (Not to exceed 10 pages). The applicant must provide an overview of the overall proposed project and its central theme and goals, describe the general objectives, and explain the proposed contribution of each of the individual projects and cores in achieving these objectives. Furthermore, the administrative arrangements and support necessary to effect the research should be carefully described in the application. In particular, when multiple institutional sites are involved, a detailed description and supporting documentation for the administrative arrangements should be included. Detailed information on collaborations, recruitment, facilities, and resources should also be provided. o Cores (Not to exceed 5 pages for any one core). The applicant must describe how each core will contribute to the goals of the overall project as well as how each individual project will draw upon a particular core. The description of each core should clearly indicate the facilities, resources, services and professional skills that the facility will provide. o Individual Projects (Not to exceed 15 pages for any one project). The applicant must describe the major objectives and goals of each individual project and its relationship to the effort of the entire group of constituent projects. In addition, detailed descriptions should be provided on the following: o Research Plan: The questions to be addressed and the hypotheses to be tested by the proposed research should be highly focused and fully explained. Full discussion is required on the status of current research efforts, the limitations of existing approaches, and how the research questions posed relate to the objectives of the Human Brain Project. In addition, the relationship between the neuroscience and the technological components should be made explicit. o Experimental Plan: The description of the experimental design should provide the specific strategies proposed to accomplish the specific aims of the project and should include a discussion of the innovative aspects of the approach. Nevertheless, the experimental procedures need not be spelled out in great detail if those procedures have already been extensively published and accepted by the scientific community. New methodology and its advantage over existing methodologies should, however, be fully described. Furthermore, the feasibility of the proposed experiments, the potential pitfalls, alternative approaches, and relevance to the goals of the project as a whole should be fully discussed. The methods to be used should be cited and referenced. It should be emphasized that these reduced requirements necessitate the inclusion of investigators that are considered to be leaders in their fields. o Operational Plan: A description of the resources and working arrangements required to implement the research plan should be fully elaborated. If a project includes a clinical component, attention should be devoted to a description of the clinical populations, tissue resources, etc. A distinction must be made between those resources that are already in place (including staff) and those resources which must be added to carry out the proposed research. The signed original and five legible copies of the completed application must be sent to: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** Dates for the submission of Phase I Human Brain Project applications for Fiscal Year 1993 and review cycles are: Letter of Intent Receipt Date: April 19, 1993 Application Receipt Date: June 15, 1993 Administrative Review: June 1993 Scientific Review: July/August 1993 Advisory Council Review: September 1993 Earliest Starting Date: September 1993 In subsequent years, the dates for the submission of Phase I Human Brain Project applications and review cycles will be: Letter of Intent Receipt Date: July 1 Application Receipt Date: October 15 Administrative Review: October Scientific Review: February/March Advisory Council Review: May/June Earliest Starting Date: July REVIEW CONSIDERATIONS Applications will be assigned to the appropriate agencies, institutes and centers according to their goals and designs and in accordance with standard referral guidelines. Those deemed by the Division of Research Grants to be appropriate for this program announcement will be reviewed for scientific and technical merit by a special review committee (SRC) composed primarily of non-Federal scientists. The members of this committee will be determined by the participating agencies, institutes, and centers. Summaries of SRC recommendations will be sent to applicants as soon as possible after the meeting of the SRC. Subsequent processing of the application will follow the procedures of the respective agency, institute and/or center to which it has been assigned. For applications assigned to a Public Health Service (PHS) institute or center, the application will receive further review by the appropriate National Advisory Council. By law, only projects recommended for approval by Council may be considered for PHS funding. All successful projects will be identified as "A Unit of the NIH/NSF/ONR/NASA Human Brain Project." Criteria for review of applications will include the following: o Scientific, technical, or medical significance and originality of proposed research o Appropriateness and adequacy of the experimental approach and methodology proposed to carry out the research o Qualifications and research experience of the Principal Investigator and staff, particularly but not exclusively in the area of the proposed research o Availability of resources necessary to perform the research o Appropriateness of the proposed budget and duration in relation to the proposed research o Likelihood that the work will lead to significant integration of informatics and neuroscience research, to new discoveries, and/or to new technological developments o Feasibility and adequacy of the organizational and administrative plans o Mechanisms to evaluate the progress of the project o Adequacy of the project's plans for the protection of human and animal subjects AWARD CRITERIA Criteria for grant awards include the following: o Intrinsic interest of the neuroscience problem o Scientific merit of the proposed research o Responsiveness to the objectives outlined in this announcement and relevance of the research to the mission of the Human Brain Project o Availability of research funds and competing demands of other research funding requirements Annual awards will be made subject to continued availability of funds and progress achieved. A competing supplemental application may be submitted during an approved period of support to expand the scope of a project during the approved period. A competing continuation (i.e., renewal) application may be submitted before the end of an approved period of support to continue a project. INQUIRIES The following representatives from each of the participating agencies, institutes and center can be contacted for further information or clarification. Potential applicants are strongly encouraged to contact the agency or institute representative to discuss their plans prior to preparing an application. Michael F. Huerta, Ph.D. National Institute of Mental Health 5600 Fishers Lane, Room 11-95 Rockville, MD 20857 Telephone: (301) 443-3948 FAX: (301) 443-4822 E-mail: HMI@CU.NIH.GOV Christine R. Hartel, Ph.D. National Institute on Drug Abuse 5600 Fishers Lane, Room 10A-31 Rockville, MD 20857 Telephone: (301) 443-1887 FAX: (301) 227-6043 E-mail: CHARTEL@AOADA.SSW.DHHS.GOV Christiana Leonard, Ph.D. National Science Foundation 1800 G Street, NW, Room 321 Washington, DC 20550 Telephone: (202) 357-7041 FAX: (202) 357-7846 E-mail: CMLEONAR@NSF.GOV Deborah Claman, Ph.D. National Institute on Aging Gateway Building, Room 3C307 7201 Wisconsin Avenue Bethesda, MD 20872 Telephone: (301) 496-9350 FAX: (301) 496-1494 E-mail: CLAMAN@NIHNIAGW Norman Krasnegor, Ph.D. National Institute of Child Health and Human Development 6100 Building, Room 4B05 Bethesda, MD 20892 Telephone: (301) 496-6591 FAX: (301) 402-2085 Judith Cooper, Ph.D. National Institute on Deafness and Other Communication Disorders Executive Plaza South, Room 400B 6120 Executive Boulevard Rockville, MD 20852 Telephone: (301) 496-5061 FAX: (301) 402-6251 Charles L. Coulter, Ph.D. National Center for Research Resources Westwood Building, Room 8A15 Bethesda, MD 20892 Telephone: (301) 594-7934 FAX: (301) 594-9187 E-mail: CCO@CU.NIH.GOV Peter A. Clepper National Library of Medicine Building 38A, Room 5S518 Bethesda, MD 20894 Telephone: (301) 496-4221 FAX: (301) 402-0421 E-mail: CLEPPER@NLM.NIH.GOV Terry Allard, Ph.D. Office of Naval Research 800 N. Quincy Street, Room 1142 Arlington, VA 22217-5660 Telephone: (703) 696-4502 FAX: (703) 696-1212 E-mail: TERRY@TOMCAT.ONR.NAVY.MIL Frank M. Sulzman, Ph.D. National Aeronautics and Space Administration Code SBM, NASA Headquarters Washington, DC 20546 Telephone: (202) 358-2359 FAX: (202) 358-4168 E-mail: FSULZMAN@SMTPGMGW.OSSA.HQ.NASA.GOV Direct inquiries regarding fiscal matters to: Diana Trunnell Assistant Chief, Grants Management Branch National Institute of Mental Health 5600 Fishers Lane, Room 7C-23 Rockville, MD 20857 Telephone: (301) 443-3065 Shirley Denney Chief, Grants Management Branch National Institute on Drug Abuse 5600 Fishers Lane, Room 8A54 Rockville, MD 20857 Telephone: (301) 443-6710 Jean Feldman, Policy Officer Division of Grants and Contracts Policy Office National Science Foundation 1800 G Street, NW, Room 1140 Washington, DC 20550 Telephone: (202) 357-7880 Joseph Ellis Office of Extramural Affairs National Institute on Aging Gateway Building, Room 2N210 7201 Wisconsin Avenue Bethesda, MD 20872 Telephone: (301) 496-1472 Doug Shawver Office of Grants and Contracts National Institute of Child Health and Human Development 6100 Executive Boulevard, Room 8A17 Rockville, MD 20852 Telephone: (301) 496-1303 Sharon Hunt Division of Extramural Activities National Institute on Deafness and Other Communication Disorders 6120 Executive Boulevard, Room 400-B Rockville, MD 20852 Telephone: (301) 402-0909 Paul Karadbil Office of Grants and Contracts Management National Center for Research Resources Westwood Building, Room 849 5333 Westbard Avenue Bethesda, MD 20892 Telephone: (301) 594-7955 Shelly Carow Office of Extramural Programs National Library Medicine Building 38A, Room 5N517 Bethesda, MD 20894 Telephone: (301) 496-4195 Willard Vaughan, Ph.D. Cognitive and Neural Sciences Division Office of Naval Research 800 N. Quincy Street, Room 823 Arlington, VA 22217-5660 Telephone: (703) 696-4505 The National Institute of Neurological Disorders and Stroke (NINDS) and the National Eye Institute (NEI), while not cosponsors of this Program Announcement, have continuing interest in the scientific areas related to the Human Brain Project. NINDS and NEI will continue to fund research on these topics through applications received through the regular receipt and referral processes of the Division of Research Grants. Applicants should contact the relevant NINDS or NEI program staff for further information. AUTHORITY AND REGULATIONS This program is described in the Catalogue of Federal Domestic Assistance Nos. 93.242 (NIMH), 93.279 (NIDA), 47.074 (NSF), 93.866 (NIA), 93.865 (NICHD), 93.173 (NIDCD), 93.371 (NCRR), 93.879 (NLM) and 12.300 (ONR). Awards are made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grants policies and Federal regulations 42 CFR 52 and 45 CFR part 74. Applications submitted in response to this announcement are not subject to the intergovernmental review requirements of Executive Order 12372 as implemented through Department of Health and Human Services regulations at 45 CFR part 100 or Health Systems Agency Review. From owner-sci-resources@net.bio.net Thu Apr 08 23:00:00 1993 Path: biosci!kristoff From: kristoff@net.bio.net (David Kristofferson) Newsgroups: bionet.announce,bionet.general,bionet.sci-resources,bionet.journals.contents Subject: Taking steps to moderate BIO-JOURNALS and SCIENCE-RESOURCES Message-ID: Date: 9 Apr 93 22:23:33 GMT Organization: BIOSCI International Newsgroups for Biology Lines: 20 Approved: bionews-moderator@net.bio.net Xref: biosci bionet.announce:459 bionet.general:4530 bionet.sci-resources:697 bionet.journals.contents:772 Having received no negative feedback on the idea, I have asked Kenton to take the appropriate steps to register BIO-JOURNALS/bionet.journals.contents and SCIENCE-RESOURCES/bionet.sci-resources as moderated newsgroups. I will serve as the moderator on these two groups. This will prevent extraneous postings to the newsgroups without prior approval. This action will take a few weeks to go into effect and an announcement will be made when appropriate. Sincerely, Dave Kristofferson BIOSCI/bionet Manager kristoff@net.bio.net From owner-sci-resources@net.bio.net Fri Apr 09 23:00:00 1993 Path: biosci!NET.BIO.NET!kristoff From: kristoff@NET.BIO.NET (Dave Kristofferson) Newsgroups: bionet.sci-resources Subject: NIH Guide, vol. 22, no. 14, pt. 3, 9 April 1993 Message-ID: Date: 10 Apr 93 01:46:13 GMT Sender: kristoff@net.bio.net Distribution: bionet Lines: 1023 $$XID RFA DK93020 DK-93-020 P1O1 *************************************** CORE GRANTS FOR CLINICAL NUTRITION RESEARCH UNITS NIH Guide, Volume 22, Number 14, April 9, 1993 RFA: DK-93-020 P.T. 34; K.W. 0710095, 0715145, 0710030 National Institute of Diabetes and Digestive and Kidney Diseases Letter of Intent Receipt Date: October 8, 1993 Application Receipt Date: November 18, 1993 PURPOSE The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) invites applications for funding of three Clinical Nutrition Research Unit (CNRU) grants to be competitively awarded in Fiscal Year 1995. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This Request for Applications (RFA), Core Grants for Clinical Nutrition Research Units, is related to the priority areas of nutrition, physical activity and fitness, heart disease and stroke, cancer, diabetes and chronic disabling conditions. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal government. There must be in existence at the applicant's institution an ongoing program of excellence in biomedical basic and clinical research related to the nutritional sciences, obesity, eating disorders and energy regulation. The quality of the programs must be evident from the fact that they have been awarded support through peer review competition. Minority individuals and women are encouraged to submit as principal investigators. Foreign institutions are not eligible to apply. MECHANISM OF SUPPORT Support of this program will be through the NIH core center grant (P30). Responsibility for the planning, direction, and execution of the proposed project will be solely that of the applicant. Except as otherwise stated in this announcement, awards will be administered under PHS grants policy as stated in the PHS Grants Policy Statement. The receipt of three competing continuation applications is anticipated, which will be in competition together with other applications received in response to this announcement. The anticipated awards will be for five years and will be contingent upon the availability of appropriated funds. Requests for support must be limited to no more than $700,000 in direct costs per year. It is anticipated that awards will average approximately $750,000 total costs for the first budget period. FUNDS AVAILABLE Approximately $2,250,000 has been set-aside for grants awarded under this RFA. NIDDK anticipates awarding three CNRU Grants in Fiscal Year 1995 on a competitive basis. RESEARCH OBJECTIVES The NIDDK-supported CNRUs are part of an integrated program of nutrition and obesity-research support provided by NIDDK. These centers have provided a focus for increasing collaboration and cost effectiveness among groups of successful investigators at institutions with established comprehensive nutritional sciences and obesity research bases. A CNRU, at a minimum, must comprise the following seven components and also include other sources of support such as an NIH research project grant (R01), NIH FIRST Award (R29), NIH Program Project (P01), NIH Individual Fellowship (F32), and the NIH Institutional National Research Service Award (T32) or other Federal and non-federal sources: 1. Research with human subjects and populations; 2. Laboratory investigations; 3. Research training (funds to be derived from other sources*); 4. Shared facilities and research services; 5. Education programs for medical students, house staff, practicing physicians, amd allied health personnel (funds to be derived from other sources*); 6. Research components of nutritional support services; and 7. Public information activities (funds to be derived from other sources*). * Funds to support these components may not be requested as part of an application in response to this announcement. The objectives of the CNRUs are to bring together investigators from relevant disciplines in a manner that will enhance and extend the effectiveness of research related to nutritional sciences, obesity and related disorders. A CNRU must be an identifiable unit within a single university medical center or a consortium of cooperating institutions, including an affiliated university. The overall goal of the CNRU is to bring together on a cooperative basis, clinical and basic science investigators in a manner that will enrich the effectiveness of nutrition and obesity research. An existing program of excellence in biomedical research in the area of nutritional sciences, obesity, and related disorders is required. This research should be in the form of NIH-funded research projects, program projects, or other peer-reviewed research that is in existence at the time of submission of a center application. Close cooperation, communication, and collaboration among all involved personnel of all professional disciplines are ultimate objectives. Applicants should consult with NIDDK staff concerning plans for the development of the center. The CNRUs are based on the core center concept. Cores are defined as shared resources that enhance productivity or in other ways benefit a group of investigators working in nutrition and obesity related areas to accomplish the stated goals of the center. Two other types of activities may also be supported with center funding--a pilot and feasibility program and an enrichment program. The pilot and feasibility program provides modest support for new initiatives or feasibility research studies. This program is directed at new investigators or established investigators in other research disciplines where their expertise may be applied to nutrition and obesity research. The center grant may also include limited funds for program enrichment such as seminars, visiting scientists, consultants, workshops, etc. Applicants from institutions that have a General Clinical Research Center (GCRC) funded by the NIH National Center for Research Resources may wish to identify the GCRC as a resource for conducting the proposed research. If so, a letter of agreement from either the GCRC program director or Principal Investigator should be included with the application. STUDY POPULATIONS SPECIAL INSTRUCTIONS TO APPLICANTS REGARDING IMPLEMENTATION OF NIH POLICIES CONCERNING INCLUSION OF WOMEN AND MINORITIES IN CLINICAL RESEARCH STUDY POPULATIONS NIH policy is that applicants for NIH clinical research grants and cooperative agreements are required to include minorities and women in study populations so that research findings can be of benefit to all persons at risk of the disease, disorder or condition under study; special emphasis must be placed on the need for inclusion of minorities and women in studies of diseases, disorders and conditions which disproportionately affect them. This policy is intended to apply to males and females of all ages. If women or minorities are excluded or inadequately represented in clinical research, particularly in proposed population-based studies, a clear compelling rationale must be provided. This policy is applicable for every individual study or project proposed in the application. The composition of the proposed study population must be described in terms of gender and racial/ethnic group. In addition, gender and racial/ethnic issues must be addressed in developing a research design and sample size appropriate for the scientific objectives of the study. This information must be included in the form PHS 398 (Rev. 09/91) in Item 4 (Research Design and Methods) of the Research Plan AND summarized in Item 5, Human Subjects. Applicants are urged to assess carefully the feasibility of including the broadest possible representation of minority groups. However, NIH recognizes that it may not be feasible or appropriate in all research projects to include representation of the full array of United States racial/ethnic minority populations; i.e., Native Americans (including American Indians or Alaskan Natives), Asian/Pacific Islanders, Blacks, Hispanics. The rationale for studies on single minority population groups should be provided. For the purpose of this policy, clinical research is defined as human biomedical and behavioral studies of etiology, epidemiology, prevention [and preventive strategies], diagnosis, or treatment of diseases, disorders or conditions, including but not limited to clinical trials. The usual NIH policies concerning research on human subjects also apply. Basic research or clinical studies in which human tissues cannot be identified or linked to individuals are excluded. However, every effort should be made to include human tissues from women and racial/ethnic minorities when it is important to apply the results of the study broadly, and this should be addressed by applicants. If the required information is not contained within the application, the application will be returned without review. LETTER OF INTENT Potential applicants are strongly encouraged to submit a letter of intent no later than October 8, 1993. The letter of intent is to include: (1) names of the Principal Investigator/program director and principal collaborators, (2) descriptive title of the potential application, (3) identification of the organization(s) involved, and (4) reference to the RFA number "DK-93-020." The letter of intent is to be sent to the Chief, Review Branch, NIDDK at the address listed under INQUIRIES. Although a letter of intent is not required, is not binding, and does not enter into the review of subsequent applications, the information that it contains is helpful in planning the review of applications. It allows NIDDK staff to estimate the potential review workload and to avoid conflict of interest in the review. APPLICATION PROCEDURES Applications are to be submitted on the form PHS 398 (rev. 09/91) available at most institutional offices of sponsored research and from the Office of Grants Inquiries, Division of Research Grants, National Institutes of Health, Westwood Building, Room 449, Bethesda, MD, telephone (301) 594-7248. On item 2a of the face page of the application, applicants must enter: "RFA: Core Grants for Clinical Nutrition Research Units, RFA number DK-93-020." The RFA label available in the application form PHS 398 must be affixed to the bottom of the face page. Failure to use this label could result in delayed processing of the application to the extent that it may not reach the review committee in time for review. Applications must be received by November 18, 1993, the original and three copies of the application must be sent or delivered to: Application Receipt Office Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** Two additional copies of the application under separate cover must be sent to: Review Branch National Institute of Diabetes and Digestive and Kidney Diseases Westwood Building, Room 603 Bethesda, MD 20892 REVIEW CONSIDERATIONS Upon receipt, applications will be initially reviewed by the Division of Research Grants (DRG) for completeness. Incomplete applications will be returned to the applicant without further consideration. Evaluation of responsiveness to the program requirements and criteria stated in this RFA is an NIDDK staff function. Those applications that are complete and responsive will be evaluated in national competition in accordance with the criteria stated below and in the CNRU Guidelines for Scientific/technical merit by an appropriate peer review group convened by the NIDDK. It is essential that the written application be in a form to be reviewed on its own merit, since no site-visit is anticipated. Applications may be subjected to triage by an NIDDK peer review group to determine scientific merit relative to other applications received in response to this RFA. If the number of applications submitted is large compared to the number of awards to be made, a preliminary scientific peer review may be conducted and applications withdrawn from further competition if not competitive for the award. The initial review group will review each application using the criteria stated below: A. Biomedical Research o The scientific excellence of the Center's research base (its strengths, breadth, and depth) as well as the relevance and interrelation of these separately funded projects to the central themes of the Center and the likelihood for meaningful collaboration among Center investigators. The existence of a base of established, independently sponsored biomedical research of high quality is a prerequisite for the establishment of a Center and is the most important component of the review. o The qualifications, experience, and commitment of the Center investigators responsible for the individual research projects and their willingness to interrelate with each other and contribute to the overall objectives of the Center. o The appropriateness and relevance of the proposed cores and their modes of operation, facilities, and potential for contribution to ongoing research. Renewal applications must include the use, utility, quality control, cost effectiveness, and demonstrated progress of any developmental research in the shared resources. o For new applications, the proposed management of the P/F program and the scientific and technical merit of the P/F projects for which funds are requested from the Center grant. In competitive renewal applications, emphasis is accorded to the program as a whole, including past track record and management of the program. B. Enrichment o Efficient and effective use and/or planned use of these limited funds, including the contribution of these activities to enhancing the objectives of the Center. C. Administration o The scientific and administrative leadership abilities of the proposed Center director and associate director and their commitment and ability to devote adequate time to the effective management of the program. o The administrative organization proposed for the following: a. Coordination of ongoing research between the separately funded projects and the Center, including mechanisms for internal monitoring. b. Establishment and maintenance of internal communication and cooperation among the Center investigators. c. Mechanism for selecting and replacing professional or technical personnel within the Center. d. Mechanism for reviewing and administering funds for the P/F program. e. Management capabilities, including fiscal administration, procurement, property and personnel management, planning, and budgeting. C. Budget o The appropriateness of the budgets for the proposed work to be done in core facilities, for P/F studies, and for enrichment in relation to the total Center program. D. Institutional Commitment o The institutional commitment to the program, including lines of accountability for management of the Center grant and the institution's contribution to the management capabilities of the Center. o The academic environment and resources in which the activities will be conducted, including the availability of space, equipment, facilities, and the potential for interaction with scientists from other departments and schools within the institution. o The institutional commitment to new individuals responsible for conducting essential Center functions. o The institutional commitment to establishing new positions specifically to enhance the operation of the Center. Applications determined in the initial review process to have sufficient merit for further consideration will be given a second level review by the National Diabetes and Digestive and Kidney Diseases Advisory Council. AWARD CRITERIA Applications will compete for available funds with all other applications submitted in response to this RFA and recommended by peer review. The following will be considered in making funding decisions: o Quality of the proposed center as determined by peer review. o Availability of funds. o Overall balance in the CNRU program. INQUIRIES Applicants should request a copy of "Guidelines for Clinical Nutrition Research Units". These guidelines contain important additional information of the format, content and review criteria. These documents and information about programmatic issues may be obtained from: Van S. Hubbard, M.D., Ph.D. Division of Digestive Diseases and Nutrition National Institute of Diabetes and Digestive and Kidney Diseases Westwood Building, Room 3A18B Bethesda, MD 20892 Telephone: (301) 594-7573 FAX: (301) 594-7504 Inquiries regarding fiscal matters may be directed to: Ms. Nancy Dixon Division of Extramural Activities National Institute of Diabetes and Digestive and Kidney Diseases Westwood Building, Room 637A Bethesda, MD 20892 Telephone: (301) 594-7543 Schedule Letter of Intent Receipt Date: October 8, 1993 Application Receipt Date: November 18, 1993 Initial Review: March-April 1994 Second Level Review: May-June 1994 Anticipated Date of Award: December 1, 1994 AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.847. Awards are made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grants policies and Federal Regulations 42 CFR 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. $$XID RFA DE93001 DE-93-001 P1O1 *************************************** SPECIALIZED MATERIALS SCIENCE RESEARCH CENTERS NIH Guide, Volume 22, Number 14, April 9, 1993 RFA: DE-93-001 P.T. 34; K.W. 0750005, 1009007 National Institute of Dental Research Letter of Intent Receipt Date: September 24, 1993 Application Receipt Date: October 21, 1993 PURPOSE The National Institute of Dental Research (NIDR) invites applications from domestic institutions for the support of Specialized Materials Science Research Centers. The primary goal of these centers is to conduct research leading to the development of new or improved biocompatible dental restorative materials as alternatives to dental amalgam. The centers are intended to provide an environment that strengthens and increases productivity in basic and clinical materials research leading to the development of novel materials and of innovative materials processing strategies through multidisciplinary collaborative efforts. It is important to focus on a collaboration between basic and clinical sciences to achieve the proposed goals. Applications in response to this Request for Applications (RFA) may not include research on maxillofacial and implant materials. The overall intent of this RFA is to attract outstanding materials science and engineering investigators, including those with no prior experience in dental research, to the field of restorative dental materials science and to encourage collaboration between basic materials scientists, dental materials scientists, engineers, toxicologists, and clinical researchers. The research will focus on new approaches to materials development and methodologies and allow for correlation of new laboratory findings with clinical performance. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This RFA, Specialized Materials Science Research Centers, is related to the priority area of oral health. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic for-profit and non-profit organizations, public and private, such as universities, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal government. Foreign organizations are not eligible to apply. However, domestic applications may include international components. Applications from minority individuals and women are encouraged. Although an application must be submitted from a single institution, it may include consortia arrangements with other institutions provided these arrangements are clearly delineated and confirmed by signed statements from the responsible officials of each institution. To be eligible for a center grant under this program, the potential applicant institution must have ongoing, independently supported research in materials science and must propose new research in the area with the ultimate goal of developing new or improved dental restorative materials and methods. MECHANISM OF SUPPORT This RFA will use the National Institutes of Health Specialized Center grant (P50). This RFA is a one-time solicitation. Subsequent support will be contingent upon program needs and availability of funds. Responsibility for planning, direction, and execution of the proposed project will be solely that of the applicant institution. However, periodic consultation with NIDR staff will be expected. This may take the form of site visits. Applicants may request up to $500,000 in direct costs for the first year. Where indirect costs are assigned to a subcontract and counted as direct costs on the parent grant, the allowable direct cost maximum of $500,000 may be exceeded by the amount of indirect costs assigned to the subcontract. Applications that exceed these limits will be returned without review. Budget increases of no more than four percent per year may be requested for each of the subsequent four years. Applicants are encouraged to seek support from other public sources and private sector sources, including foundations and industrial concerns, for studies that will complement and expand the research supported by the Specialized Materials Science Research Centers. A summary of the objectives and financial support for such studies must be included in the application. FUNDS AVAILABLE It is anticipated that two or three awards will be made and $1.5 to $2.25 million in total cost will be committed for the first year of support for the entire program, if a sufficient number of applications of high scientific merit are received. Although this program is included in the financial plans of the NIDR, the award of grants pursuant to this RFA is also contingent upon availability of funds for this purpose. RESEARCH OBJECTIVES Background The NIDR national survey of dental health of American adults, conducted over one year and ending in March 1986, revealed that four percent of the employed adults surveyed were missing all their teeth, and one half had lost at least one tooth. However, among Americans aged 65 and older, forty-two percent were missing all their teeth, and only two percent still had all 28 permanent teeth. The survey also showed that both younger and older adults continued to suffer from tooth decay. Employed adults had an average of 23 decayed or filled coronal surfaces, and seniors had an average of 20. Root caries was found in 21 percent of the employed adults and in 63 percent of the seniors. These statistics indicate that a considerable need still exists for dental restorative treatment. Current dental restorative materials have several shortcomings. Longevity of restorations is to a large extent material dependent. Amalgam is the most widely used posterior material. Amalgam requires removal of sound tooth structure beyond the decay in order to secure the restoration in place, and it exhibits deficiencies such as poor esthetic appearance and discoloration of tooth structure. Only minor changes occurred in the composition of amalgams until about 20 years ago when non-gamma-2 amalgams were developed. Since then no major development has occurred. Resin-based composite materials were initially developed for anterior restorations, but materials suitable for use in small posterior restorations also have been marketed. Resin-based composite materials have limited clinical applicability due to material degradation and wear, color changes and plaque adhesion leading to recurrent caries. Existing types of resin-based materials are not considered suitable alternatives to amalgam, especially for large restorations. No major improvement has occurred to make these materials suitable for large posterior restorations; i.e., as materials suitable for replacement of amalgam. Gold inlays have been used successfully for decades. Glass ionomer materials do not have the physical properties required for stress bearing areas. They also tend to disintegrate in vivo. Indirectly manufactured restorations such as those made from gold and ceramic materials require extensive removal of sound tooth tissues during cavity preparation. Such restorations are relatively expensive. Ceramic materials also fracture easily. Recently, a number of ceramic inlay materials have been developed for indirect restorations, including CAD-CAM restorations, which can be completed at the same appointment as the cavity preparation. Secondary caries is a major reason for replacement of all types of restorations, except glass ionomer materials, because of the leachable fluoride components. The development of alternative materials, therefore, should pay particular attention to possible anticariogenic properties. The existence of materials or agents that bond permanently to enamel and dentin would eliminate marginal leakage and thus reduce the risk of secondary caries and enhance the longevity of restorations, but surface characteristics are also important for plaque adhesion. The 1991 NIH-sponsored Technology Assessment Conference on Effects and Side Effects of Dental Restorative Materials also emphasized the need for continued research on materials used for permanent restorations in order to provide supporting data to ascertain that existing and future materials are safe and effective. Clinical studies have shown that gold inlays are much more durable than are any of the other current restorative materials. The median longevity of amalgam restorations is about 8 to 10 years, while that for posterior composites in stress bearing areas is considerably less. Few data are available on the longevity of other posterior restorations, but it is generally agreed that durability is of paramount importance for the efficacy of restorations. Biological reactions and side effects of different restorative materials have received much attention during the last two decades. The incidence of biological side effects to amalgam and composite materials is similar. Reports on side effects for glass ionomer materials are scarce, but these materials have not been in extensive use. However, biological side effects to gold and ceramic materials are extremely rare. Despite the low incidence of side effects to all types of dental restorative materials, the focus on the possible toxic effects of mercury in dental amalgam has resulted in a need for the development of alternative restorative materials. Thus, it is important to ensure that improved or newly developed materials are not only effective, but also safe. Center Goals The Specialized Materials Science Research Center program's primary goal is to provide support for interrelated, multidisciplinary, basic and clinical research leading to the development of new or improved restorative dental materials and methodologies as well as to facilitate and establish collaboration among basic materials scientists, biomedical engineers, clinical dental researchers, and industrial researchers. A secondary goal is to create an environment in which these researchers can interact to conduct studies aimed at providing an understanding of the physical, chemical, clinical, and biological characteristics of novel materials and technologies. Although funds are not provided for training, centers are expected to provide a focus for training of scientists dedicated to the pursuit of careers in dental materials research. The development of the new restorative materials should be accompanied by development of procedures and guidelines for their optimal use. Some examples of research on materials that satisfy the criteria for the ideal restorative material might include, but are not limited to, the development of: o Molecular and structural models of monomer/polymer based restorative systems. o Materials based on biotechnological processes for the reconstruction of carious defects; e.g., collagen-hydroxyapatite complexes that mimic biological materials. o New ceramic and titanium-based alloy restorative materials. o New non-mercury-containing metallic direct restorative materials. o New materials that enhance preventive properties through materials design, such as slow-release systems, and adhesive, anticariogenic restorative materials, coatings or cements that will increase the resistance of the tooth to acid dissolution or prevent attachment of oral bacteria to the surface of the tooth or the restoration. o New methods for assessing surface characteristics and surface modifications of existing materials including effects of pellicle and plaque formation on different materials. o Coatings that will protect exposed dentin and the underlying pulp from chemical and physical damage while providing stable bonds with both the dentin and the restorative material. o Cost effective technologies such as computer-controlled milling or other new technologies for both new and existing materials that cannot be processed by conventional approaches. o New methods for assessing the function, durability, and biocompatibility of promising materials. Center Characteristics Each Materials Science Research Center is envisioned as an identifiable organizational unit within one institution with established bases of ongoing materials science or as a collaborative unit bringing together materials science experts with dental restorative materials science experts. The center will consist of a cluster of related research projects, some of which will be fundamental and others will involve clinical studies. These various projects should not constitute a collection of individual, unrelated investigations more appropriately supported by individual research project or small grants. Core resources, such as computer services and equipment to be shared by investigators, will be provided, although budgetary constraints preclude expenditures for very expensive items of equipment or major renovations. Pilot projects and feasibility studies may be included in the core. Pre-clinical and clinical assessments of developments are envisioned as part of this five-year funding period. The center director should be an established scientist who can provide both scientific and administrative leadership. The director and co-director will be responsible for organizing and operating the center and for communicating with the NIDR on scientific and operational matters. It is anticipated that each center will facilitate cooperation between its own scientists, foster collaboration and communication with researchers from other institutions and industry, and also provide a training environment for young investigators. An internal review board consisting of staff members of the center and other non-member expert consultants should be established. This board will conduct initial reviews of proposed projects, assess scientific progress, and provide general advice on organizational developments and program planning. In addition, an external advisory committee consisting of members who are not associated with the applicant institution, who will advise the director on the merits of new projects and the progress of existing projects, should be established. Some funds, not to exceed $25,000 in direct costs, may be used to support pilot projects. Although the center mechanism does not provide funds for training, it is expected that the centers will provide a training environment for young investigators supported by other public or private funds. Scientists who wish to broaden their range of activities during the award period will be expected to obtain additional research support from sources other than the center grant. Center grant funds should not be used to provide 100 percent of the salary support for investigators. Funding for a five-year project period, with a possibility of renewal, should provide a more stable environment than is usually encountered when investigators are supported entirely by individual research project grants. Site visits to review the performance of the centers and provide guidance to the director may be conducted periodically by NIDR staff and nongovernment expert consultants. Annual meetings with the center directors and NIDR staff may be held at the AADR meetings or at the NIH to encourage exchange of information and to stimulate collaboration among the centers. Expenses for these meetings are the responsibility of the centers. STUDY POPULATIONS SPECIAL INSTRUCTIONS TO APPLICANTS REGARDING IMPLEMENTATION OF NIH POLICIES CONCERNING INCLUSION OF WOMEN AND MINORITIES IN CLINICAL RESEARCH STUDY POPULATIONS NIH policy is that applicants for clinical research grants and cooperative agreements are required to include minorities and women in study populations so that research findings can be of benefit to all persons at risk of the disease, disorder or condition under study; special emphasis should be placed on the need for inclusion of minorities and women in studies of diseases, disorders and conditions which disproportionately affect them. This policy is intended to apply to males and females of all ages. If women or minorities are excluded or inadequately represented in clinical research, particularly in proposed population-based studies, a clear compelling rationale must be provided. The composition of the proposed study population must be described in terms of gender and racial/ethnic group. In addition, gender and racial/ethnic issues should be addressed in developing a research design and sample site appropriate for the scientific objectives of the study. This information should be included in form PHS 398 (rev. 9/91) in items l-4 of the Research Plan and summarized in item 5, Human Subjects. Applicants are urged to carefully assess the feasibility of including the broadest possible representation of minority groups. However, NIH recognizes that it may not be feasible or appropriate in all such projects to include representation of the full array of United States racial, ethnic minority populations (i.e., Native Americans [including American Indians or Alaskan Natives], Asian/Pacific Islanders, Blacks, Hispanics). The rationale for studies on single minority population groups should be provided. For the purpose of this policy, clinical research is defined as human biomedical and behavioral studies of etiology, epidemiology, prevention (and preventive strategies), diagnosis, or treatment of diseases, disorders or conditions, including but not limited to clinical trials. The usual NIH policies concerning research on human subjects also apply. Basic research or clinical studies in which human tissues cannot be identified or linked to individuals are excluded. However, every effort should be made to include human tissues from women and racial/ethnic minorities when it is important to apply the results of the study broadly, and this should be addressed by applicants. If the required information is not contained within the application, the application will be returned. Peer reviewers will address specifically whether the research plan in the application conforms to these policies. If the representation of women or minorities in a study design is inadequate to answer the scientific question(s) addressed the justification for the selected study population is inadequate, it will be considered a scientific weakness or deficiency in the study design and will be reflected in assigning the priority score to the application. All applications for clinical research submitted to the NIH are required to address these policies. NIH funding components will not award grants or cooperative agreements that do not comply with these policies. LETTER OF INTENT Prospective applicants are asked to submit, by September 24, 1993, a letter of intent that includes a descriptive title of the proposed or existing center, the name, address and telephone number of the center director, the identities of other key personnel and the participating institution(s) and a descriptive title of each subproject, and the number and title of the RFA in response to which the application may be submitted. Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains is helpful to the NIDR staff in planning for timely review of applications. It allows Institute staff to estimate the potential workload and to avoid possible conflict of interest in review. The letter of intent is to be addressed to Dr. Joyce A. Reese at the address listed under INQUIRIES. APPLICATION PROCEDURES Prospective applicants are advised to communicate with program and grants management staff of the NIDR Extramural Program as early as possible in the planning phase of application preparation. NIDR staff is available to assist applicants to ensure that the objectives, structure, and the budget format for the proposed center are acceptable. The research grant application form PHS-398 (rev. 9/91) is to be used in applying for these grants. These forms are available at most institutional offices of sponsored research; from the Office of Grant Inquiries, Division of Research Grants, National Institutes of Health, 5333 Westbard Avenue, Room 449, Bethesda, MD 20892, telephone 301/594- 7248; and from the program administrator listed under INQUIRIES. To identify the application as a response to this RFA, check "yes" on item 2a of face page AA of the application and enter RFA: DE-93-001, Specialized Materials Science Research Centers. The RFA label available in the form PHS 398 must be affixed to the bottom of the face page of the original application. Failure to use this label could result in delayed processing of an application such that it may not reach the review committee in time for review. The instructions accompanying form PHS-398 must be followed as far as possible, but some modifications will be necessary. For example, a new Table of Contents must be prepared giving page numbers for all items in the application. Pagination must be consecutive throughout the application. Each project and core must be identified by number and investigator. A consolidated budget for the complete center, for all years of support, should be included (use pages DD-EE, form PHS 398). Separate detailed annual and total budgets for the entire project period for each project and core must be presented (use pages DD-EE, form PHS 398). Direct and indirect costs estimates are to be given. Funds may be requested for professional, technical, and administrative personnel, consultant services, equipment, supplies, travel, patient costs directly related to the research, minor renovations and other costs. Detailed justification of the budget requests will be required. Provide a summary of financial support from non-NIDR sources for studies that will complement and expand the program supported by the NIDR. Explain how these studies will further the goals of the center and make it more cost effective. Awardees will be expected to update this information on an annual basis. Under Research Plan, describe the goals of the center and discuss the background and significance of the topics being addressed. Explain how each project will contribute to achieving those goals. Describe the administrative structure, the responsibilities of the center director, individual investigators, advisory groups and the proposed mechanisms for monitoring scientific progress. Describe the relationship of all existing and pending institutional research projects that may be relevant to the center regardless of funding source. Throughout the application, provide sufficient but concise information to facilitate an effective evaluation. Brevity and clarity in the presentation of the research plans and in the description of the organizational structure, including the cores, may be considered a reflection of the applicant's ability to achieve the objectives of the center. Each research project should be presented as in a research project grant application. That is, the instruction on pages 19-24 of form PHS 398 should be followed. Each project must be described within the 25-page limitation which applies to research project grant applications and each pilot project must be presented in no more than 10 pages. Describe each core in no more than 25 pages and explain how it will relate to the projects that will utilize its resources. Abstracts (page BB, form PHS 398) must be completed for the core resources, each subproject, pilot project, and for the entire application. Submit a signed, typewritten original of the application, including the Checklist, and three signed photocopies, in one package to: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** At the time of submission, two additional copies of the application must be sent to: H. George Hausch, Ph.D. Scientific Review Office National Institute of Dental Research Westwood Building, Room 519 Bethesda, MD 20892 Applications must be received by October 21, 1993. If an application is received after that date, it will be returned to the applicant without review. REVIEW CONSIDERATIONS Applications will be evaluated initially for scientific and technical merit by a special review committee convened by the NIDR Scientific Review Office. Prior to the initial review, a triage mechanism may be employed to screen out applications that are noncompetitive or nonresponsive to the RFA. An applicant interview or site visit may be included. Secondary review will be conducted by the National Advisory Dental Research Council. Non-competitive or nonresponsive applications and those received after October 21, 1993, or that exceed the first year budget limit of $500,000 in direct costs will be returned to the applicant. Waivers of the receipt deadline and budget limitation will not be granted. Major factors to be considered in the evaluation of applications include: o The extent to which the center will promote advances toward the development of novel restorative dental materials and methodologies which could not be achieved or which would be achieved more slowly if the component projects were funded separately. o The extent to which the various research and pilot projects and the cores have been combined into an effective and cohesive program, and the adequacy of plans to ensure efficient collaboration, interaction, and dissemination of information among investigators. o The scientific and administrative qualifications, experience, and commitment of the director, including the ability to provide effective leadership. The provisions for selection of a replacement director, if it should be necessary. o The competence of the center investigators and their commitment to the accomplishment of the proposed research goals. o The scientific merit of each proposed project, including its significance, originality, feasibility, experimental design, and methods, including those for data management and analysis. o The institutional environment, including its commitment to the proposed center, and to multidisciplinary, collaborative research of the highest quality. o The adequacy of laboratory, clinical and animal facilities to meet the needs of the proposed studies. o The plans for establishing and developing the center including collaborative efforts, for monitoring research, for reviewing changes in research directions, and for the use of scientific advisory processes. o The availability and appropriateness of study populations. o The scientific, technical merit and justification for requested core resources. o The appropriateness of the budget and period of support for research and pilot projects, cores, and for the entire center. o For competitive renewal applications, the extent to which the goals and specific aims of the previous application have been achieved. The inclusion of projects that are deemed to have little or no scientific merit or that are deemed peripheral to the center's objectives may be considered a reflection of the director's judgement and may adversely affect the rating. Component projects that are not deemed essential to the success of the center, will be recommended for deletion. AWARD CRITERIA The anticipated date of award is September 29, 1994. Applicants should be aware that, in addition to scientific merit, program priorities and program balance, the total cost of the Specialized Materials Science Research Centers to the NIDR will be considered by NlDR staff and the Council in making funding recommendations. An additional consideration will be the extent to which complementary projects, supported from non-NIDR funds, will contribute to the cost-effectiveness of the proposed Specialized Materials Science Research Centers. Once funded, a center may undergo an interim review by the NIDR to evaluate progress. The funding for subsequent years may be contingent on a successful outcome of this review. Amended Applications In the past, it has been common practice for applicants responding to RFAs issued by the NIDR for specialized research centers grants (P50) to amend unfunded applications and submit them as unsolicited program project grant (P01) applications. Alternatively, sub-projects from unfunded P50 grant applications have been amended and submitted as applications for other support mechanisms such as research project grants (R01) or small grants (R03). Applicants responding to the current RFA should be aware that, because of fiscal constraints, it is unlikely that the NIDR will be able to fund P01 grant applications resulting from the amendment of unfunded applications. Thus, submission of program project applications with goals similar to those included in this RFA is discouraged. However, applicants are encouraged to amend promising sub-projects from unfunded P50 applications and apply for support under other grant mechanisms. INQUIRIES Written and telephone inquiries concerning this RFA are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues to: Joyce A. Reese, D.D.S., M.P.H. Biomaterials, Pulp Biology and Dental Implants Program National Institute of Dental Research Westwood Building, Room 509 Bethesda, MD 20892 Telephone: (301) 594-7648 FAX: (301) 402-4620 Inquiries regarding fiscal matters may be directed to: Ms. Theresa Ringler Grants Management Office National Institute of Dental Research Westwood Building, Room 510 Bethesda, MD 20892 Telephone: (301) 594-7629 FAX: (301) 594-7600 AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.121. Awards are made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78- 410, as amended by Public Law 99-158,42 USC 241 and 285) and administered under PHS grants policies and Federal Regulations 42 CFR 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. From owner-sci-resources@net.bio.net Fri Apr 09 23:00:00 1993 Path: biosci!NET.BIO.NET!kristoff From: kristoff@NET.BIO.NET (Dave Kristofferson) Newsgroups: bionet.sci-resources Subject: NIH Guide, vol. 22, no. 14, pt. 2, 9 April 1993 Message-ID: Date: 10 Apr 93 01:45:00 GMT Sender: kristoff@net.bio.net Distribution: bionet Lines: 1052 $$XID NIHGUIDE 19930409 V22N14 P2O2 ************************************ provide each trainee with a mentor who is recognized as an accomplished investigator in cardiovascular, pulmonary, or hematologic research and who will assist the advisor at the minority institution in the trainee's development and research plan. Trainees either must be training at the post-baccalaureate level in a relevant biomedical or behavioral science and have made a strong commitment to completing a doctoral degree, be enrolled in a minority health professional school, or have a doctoral degree or equivalent in a biomedical or behavioral science. MECHANISM OF SUPPORT The mechanism of support is the Institutional National Research Service Award (T32). Institutions may request up to five years of support. Training programs may support predoctoral students, postdoctoral trainees, and short-term trainees in health professional schools. Stipend levels for predoctoral and short-term trainees are $8,800 per year and stipend levels for postdoctoral trainees range from $18,600 to $32,300 per year. Stipends may be supplemented from non-Federal sources. Training related expenses, tuition and fees, and travel expenses may also be requested for trainees, although the levels may vary depending on the type of training to be supported. The trainees may be appointed for 9-12 months (for short-term trainees, the period of appointment may be of 2 to 3 months duration) at any time during the course of the budget period after he/she has been accepted as a full-time student. A strong interest in a cardiovascular, pulmonary, or hematologic research career must be evident. Indirect costs will be awarded based on eight percent of total direct costs with no exclusions from the base for training-related expenses. RESEARCH OBJECTIVES The Minority Institutional Research Training Program is designed to offer research training grant awards in cardiovascular, pulmonary, and hematologic research to minority schools to enable qualified graduate students, health professional students, and postdoctoral students to participate in research programs. It is expected to attract students in the developmental stages, increase awareness of these diseases, and to acquaint them with career opportunities in research. The Minority Institutional Research Training Program is intended to: o Train graduate students, health professional students, and postdoctoral students at minority schools that have the potential to develop a meritorious program in cardiovascular, pulmonary, or hematologic research for research careers in areas relevant to these diseases. o Stimulate cardiovascular, pulmonary, and hematologic diseases and hematologic resources research, prevention, control, and education by offering minority school graduate students, health professional students, and postdoctoral students the opportunity to enhance their research capabilities in these areas. APPLICATION PROCEDURES Applications are to be submitted on the grant application form PHS 398 (rev. 9/91). Application kits are available at most institutional offices of sponsored research and may be obtained from the Office of Grants Inquiries, Division of Research Grants, National Institutes of Health, Westwood Building, Room 449, Bethesda, MD 20892, telephone (301) 594-7248. The title and number of the announcement must be typed in section 2a on the face page of the application. The completed original application and three legible copies must be sent or delivered to: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** Two additional copies of the application must be sent to: Scientific Review Administrator Division of Extramural Affairs National Heart, Lung, and Blood Institute Westwood Building, Room 550 Bethesda, MD 20892 Applications must be received by August 27, 1993. REVIEW PROCEDURES All applications responding to this announcement will be reviewed for scientific and technical merit by the Research Training Review Committee of the Division of Extramural Affairs, NHLBI, followed by a second level review by the National Heart, Lung, and Blood Advisory Council. The factors to be considered in the evaluation of the proposed training program are: o Adequacy of faculty, facilities, and resources for the proposed research training, both at the minority institution and the research center; o Adequacy of the cooperative arrangements between the minority institution and the research program; o Commitment of the relevant faculty and the two institutions to the goals of the training program; o Procedures for evaluation of the impact of the program on the trainees involved. AWARD CRITERIA Applications will compete for available funds with other approved applications assigned to the National Heart, Lung, and Blood Institute. The following will be considered in making funding decisions: o Scientific and technical merit of the application as determined by peer review o Availability of funds o Program balance among the research areas of the announcement INQUIRIES Written and telephone inquires are encouraged. Guidelines for this program may be obtained from any of the following: John Fakunding, Ph.D. Division of Heart and Vascular Diseases National Heart, Lung, and Blood Institute Federal Building, Room 3C04 Bethesda, MD 20892 Telephone: (301) 496-1724 Fann Harding, Ph.D. Division of Blood Diseases and Resources National Heart, Lung, and Blood Institute Federal Building, Room 5A08 Bethesda, MD 20892 Telephone: (301) 496-1817 Mary Reilly, M.S. Division of Lung Diseases National Heart, Lung, and Blood Institute Westwood Building, Room 640A Bethesda, MD 20892 Telephone: (301) 594-7466 For fiscal and administrative matters, contact: Grants Operations Branch Division of Extramural Affairs National Heart, Lung, and Blood Institute Westwood Building, Room 4A15C Bethesda, MD 20892 Telephone: (301) 594-7434 AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance Nos. 93.837, 93.838, and 93.839. Awards will be made under the authority of the Public Health Service Act, Title III, Section 301 (Public Law 78-410, as amended; 42 USC 241) and administered under PHS grants policies and Federal Regulations at 42 CFR Part 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. $$P4 END ************************************************************ $$P5 BEGIN PAR-93-073 *********************************************** RESEARCH DEVELOPMENT AWARD FOR MINORITY FACULTY NIH Guide, Volume 22, Number 14, April 9, 1993 PAR NUMBER: PAR-93-073 P.T. 34, FF; K.W. 0720005, 0715032, 0715040, 0715165 National Heart, Lung, and Blood Institute Application Receipt Date: August 27, 1993 PURPOSE The National Heart, Lung, and Blood Institute (NHLBI) announces a program directed at developing the research capabilities of minority faculty investigators in areas relevant to cardiovascular, pulmonary, and hematologic* diseases and resources. The purpose of the award is to encourage the enhancement of research skills in the areas of interest to the NHLBI by minority* faculty members at domestic institutions and to increase the number of minority individuals involved in research endeavors. * Within the NHLBI, the term "hematologic" covers research on thrombosis and hemostasis, immunohematology, blood cell disorders, hematopoiesis, thalassemia, sickle cell disease, transfusion medicine including blood component and derivative therapy, blood substitutes and blood resource management, aspects of AIDS-products in AIDS prevention and treatment, and AIDS-related bone marrow and hematologic disorders. Other Institutes of the NIH are responsible for research on disorders of white cells, including the leukemias and other blood malignancies, and basic immunology related to the lymphoid system. Therefore, the NHLBI cannot provide support for such studies. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This program announcement, Research Development Award for Minority Faculty, is related to the priority area of heart disease and stroke. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Awards in this program will be made to domestic institutions or organizations on behalf of awardees. Individuals for this program must have been awarded a doctoral degree (a Ph.D., M.D., D.V.M. or D.O., degree or its equivalent) and have a faculty appointment at an accredited college or university at the time of award. Applicants for this award must be either citizens or noncitizen nationals of the United States or have been lawfully admitted to the United States for permanent residence. An individual lawfully admitted for permanent residence must submit, with the application, a notarized statement indicating possession of the Alien Registration Receipt Card (I-151 or I-551). Individuals on temporary or student visas are not eligible. Candidates must be nominated by an institution on the basis of qualifications, interests, accomplishments, motivation, and potential for performing quality research. The candidate's academic background, previous experience, and career goals should determine both the necessary length and the kind of program that is appropriate. Each candidate must identify a sponsor(s) who is an accomplished investigator in the research area proposed and has experience in developing independent investigators. The sponsor is not required to be affiliated with the applicant institution. For the purpose of this program, underrepresented minority faculty members are defined as individuals belonging to a particular ethnic or racial group that has been determined by the grantee institution to be underrepresented in biomedical or behavioral research. In making grant awards under this program, the NHLBI will give priority to projects involving Black, Hispanic, Native American, Pacific Islander and other ethnic or racial group members who have been found to be underrepresented in biomedical or behavioral research nationally. MECHANISM OF SUPPORT The mechanism of support is the career development award (K14). Awards will be made to the institution on behalf of the awardee. Each award will have a duration of three to five years and is non-renewable. Funding beyond the first year of the grant is contingent upon satisfactory progress during the preceding year. Substitution of another sponsor and/or a change of institution may be permitted with the prior approval of the NHLBI. The awardee may receive salary support up to a maximum of $50,000 plus fringe benefits per year for five years. All funds must be used to support the awardee. A minimum of 80 percent effort must be devoted to the research program. The remainder may be devoted to other clinical and teaching pursuits that are consistent with the program goals, i.e., the candidate's development into an independent biomedical scientist or the maintenance of the teaching and clinical skills needed for an academic research career. In addition to the salary request for the candidate, support for up to five percent of the sponsor's salary may be requested. Up to $30,000 per year will be provided for research support. RESEARCH OBJECTIVES The Research Development Award for Minority Faculty is intended to: o encourage research-oriented minority faculty to develop independent research skills and gain experience in advanced methods and experimental approaches in the basic and applied sciences relevant to heart, blood vessel, lung, blood diseases, and transfusion medicine. o increase the pool of highly trained minority investigators who can use advanced technologies to address the major problems in heart, blood vessel, lung, blood diseases, and transfusion medicine. STUDY POPULATIONS SPECIAL INSTRUCTIONS TO APPLICANTS REGARDING IMPLEMENTATION OF NIH POLICIES CONCERNING INCLUSION OF WOMEN AND MINORITIES IN CLINICAL RESEARCH STUDY POPULATIONS NIH policy is that applicants for NIH clinical research grants and cooperative agreements are required to include minorities and women is study populations so that research finds can be of benefits to all persons at risk of the disease, disorder or condition under study; special emphasis must be placed on the need for inclusion of minorities and women in studies of diseases, disorders and conditions which disproportionately affect them. This policy is intended to apply to males and females of all ages. If women or minorities are excluded or inadequately represented in clinical research, particularly in proposed population-based studies, a clear compelling rationale must be provided. The composition of the proposed study population must be described in terms of gender and racial/ethnic group. In addition, gender and racial/ethnic issues should be addressed in developing a research design and sample size appropriate for the scientific objectives of the study. This information must be included in the form PHS 398 in sections 1-4 of the Research Plan AND summarized in Section 5, Human Subjects. Applicants are urged to assess carefully the feasibility of including the broadest possible representation of minority groups. However, NIH recognizes that it may not be feasible or appropriate in all research projects to include representation of the full array of United States racial/ethnic minority populations (i.e., Native American (including American Indians or Alaskan Natives), Asian/Pacific Islanders, Blacks, Hispanics). The rationale for studies on single minority population groups must be provided. For the purpose of this policy, clinical research is defined as human biomedical and behavioral studies of etiology, epidemiology, prevention (and preventive strategies), diagnosis, or treatment of diseases, disorders or conditions, including but not limited to clinical trials. The usual NIH policies concerning research on human subjects also apply. Basic research or clinical studies in which human tissues cannot be identified or linked to individuals are excluded. However, every effort should be made to include human tissues from women and racial/ethnic minorities when it is important to apply the results of the study broadly, and this should be addressed by applicants. If the required information is not contained within the application, the review will be deferred until the information is provided. Peer reviewers will address specifically whether the research plan in the application conforms to these policies. If the representation of women or minorities in a study design is inadequate to answer the scientific question(s) addressed AND the justification for the selected study population is inadequate, it will be considered a scientific weakness or deficiency in the study design and will be reflected in assigning the priority score to the application. All applications for clinical research submitted to NIH are required to address these policies. NIH funding components will not award grants or cooperative agreements that do not comply with these policies. APPLICATION PROCEDURES Applications must be received by August 27, 1993. Applications are to be submitted on the grant application form PHS 398 (rev. 9/91). Application kits are available at most institutional offices of sponsored research and may be obtained from the Office of Grants Inquires, Division of Research Grants, National Institutes of Health, Westwood Building, Room 449, Bethesda, MD 20892, telephone 301-594-7248. The title and number of the announcement must be typed in section 2a on the face page of the application. The completed original application and three legible copies must be sent or delivered to: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** Two additional copies of the application must be sent to: Scientific Review Administrator Division of Extramural Affairs National Heart, Lung, and Blood Institute Westwood Building, Room 550 Bethesda, MD 20892 REVIEW PROCEDURES All applications will be reviewed for scientific and technical merit by the Research Training Review Committee of the Division of Extramural Affairs, NHLBI, followed by a second level review by the National Heart, Lung, and Blood Advisory Council. The criteria for initial review of applications include: 1. Candidate -- The candidate's overall competence as demonstrated by academic record and performance, potential for a career in independent research, and commitment or interest in pursuing an academic research career. 2. Sponsor(s) -- The sponsor's accomplishments in the scientific research area(s) proposed, experience and track record in training investigators, and commitment for the duration of a candidate's research development. A curriculum vitae with relevant publications and a list of current and pending research support must be included for all sponsors. Sponsors should also include a list of current and past research trainees (not more than the last 10 years) with information on their current positions. 3. Environment -- The applicant institution's ability to provide adequate facilities, resources, and opportunities necessary for the candidate's training, and the institutional commitment to the candidate. If different from the applicant institution, the quality and extent of interaction of the faculty in the basic and clinical sciences, and the quality of the research and research training programs at the sponsor's institution. 4. Career Development Plan -- The adequacy of the research career development plan, based on the candidate's past research experience, training, and career goals. 5. Research Project -- Scientific merit of the proposed research project and its appropriateness as a vehicle for developing the candidate's research skills. AWARD CRITERIA Applications will compete for available funds with other approved career development award applications assigned to the National Heart, Lung, and Blood Institute. The following will be considered in making funding decisions: o Technical merit of the application as determined by peer review o Availability of funds o Program balance among the research areas of the announcement INQUIRIES Written and telephone inquires are encouraged. Guidelines for this program may be obtained from any of the following: John Fakunding, Ph.D. Division of Heart and Vascular Diseases National Heart, Lung and Blood Institute Federal Building, Room 3C04 Bethesda, MD 20892 Telephone: (301) 496-1724 Helena O. Mishoe, Ph.D. Division of Blood Diseases and Resources National Heart, Lung and Blood Institute Federal Building, Room 5A12 Bethesda, MD 20892 Telephone: (301) 496-5911 Mary Reilly, M.S. Division of Lung Diseases National Heart, Lung, and Blood Institute Westwood Building, Room 640A Bethesda, MD 20892 Telephone: (301) 594-7466 For fiscal and administrative matters, contact: Jane Davis Division of Extramural Affairs National Heart, Lung, and Blood Institute Westwood Building, Room 4A15C Bethesda, MD 20892 Telephone: (301) 594-7436 AUTHORITY AND REGULATION This program is described in the Catalog of Federal Domestic Assistance numbers 93.837, 93.838, and 93.839. Awards will be made under the authority of the Public Health Service Act, Title III, Section 301 (Public Law 78-410, as amended; 42 USC 241) and administered under PHS grants policies and Federal Regulations at 42 CFR Part 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. $$P5 END ************************************************************ $$P6 BEGIN PAR-93-074 *********************************************** SHORT-TERM TRAINING FOR MINORITY STUDENTS PROGRAM NIH Guide, Volume 22, Number 14, April 9, 1993 PAR NUMBER: PAR-93-074 P.T. 44, FF; K.W. 0720005, 0715032, 0715040, 0715165 National Heart, Lung and Blood Institute Application Receipt Date: August 27, 1993 The National Heart, Lung, and Blood Institute (NHLBI) announces a program to support short-term research training experiences for minority undergraduate, graduate, and health professional students in areas related to cardiovascular, pulmonary, and hematologic* diseases. The purpose of the award is to encourage institutions to provide opportunities for underrepresented minority students at the undergraduate and graduate level to become exposed to biomedical research in areas relevant to cardiovascular, pulmonary, and hematologic diseases through a short-term research experience. * Within the NHLBI, the term "hematologic" covers research on thrombosis and hemostasis, immunohematology, blood cell disorders, sickle cell disease, blood resources, including blood component and derivative therapy, blood substitutes and blood resource management, aspects of AIDS products in AIDS prevention and treatment, and AIDS-related bone marrow and hematologic disorders. Other Institutes of the NIH are responsible for research on disorders of white cells, including the leukemias, and other blood malignancies, and basic immunology related to the lymphoid system. Therefore, the NHLBI does not provide support for such studies. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This program announcement, Short-term Training for Minority Students Program, is related to the priority area of heart disease and stroke. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Awards in this program will be made to domestic institutions or organizations, including minority institutions, engaged in health related-research in areas related to heart, lung or blood disorders. These grants will support short-term research training experiences of two to three months duration for minority undergraduate students, minority students in health professional schools and minority graduate students. Trainees appointed to the program need not be from the grantee institution, but may include a number of minority students from other institutions, schools, colleges or universities. The grantee institution will be responsible for the selection and appointment of trainees. Special attention should be given to the recruitment of individuals from minority groups that are underrepresented nationally in the biomedical and behavioral sciences, i.e., Blacks, Hispanics, Native Americans, Alaskan Americans and Pacific Islanders. Trainees should have successfully completed at least one undergraduate year at an accredited school or university or have successfully completed one semester at a school of medicine, optometry, osteopathy, dentistry, veterinary medicine, pharmacy or public health or an institution with an accredited graduate program, prior to participating in the program. These grants are intended to introduce students to research that would not otherwise be available through their regular course of studies. For graduate students, this may include graduate students in programs, such as mathematics, where they would not normally be exposed to biomedical research or minority graduate students who may need a specialized research experience to supplement their normal graduate education. Individuals holding Ph.D., M.D., D.V.M. or equivalent doctoral degrees in the health sciences are not eligible for participation in the program. MECHANISMS OF SUPPORT The mechanism of support is the institutional National Research Service Award for Short-Term Training Students in Health Professional Schools (T35). Institutions may request up to five years of support for short-term training programs for at least 4 but not more than 24 trainees per year. The stipend level for trainees is $733 per month. Stipends may be supplemented from non-federal funds. Training-related expenses up to $125 per month per trainee may be requested. In addition, up to $500 per trainee may be requested to cover domestic travel to and from the training site and up to $250 per month per trainee may be requested to cover the cost of housing at the training site. Trainee tuition and fees, where necessary to the research training, must be covered by the Training Related Expenses. Indirect costs will be awarded based on 8 percent of total direct costs, exclusive of tuition and fees. RESEARCH OBJECTIVES The Short-Term Training for Minority Students program is designed to offer short-term training grant awards to qualified institutions to enable minority undergraduate students, graduate students, and health professional students to become exposed to research career opportunities in biomedical or behavioral research. These awards are expected to attract students to biomedical science in their developmental stages, increase awareness of biomedical research, and to acquaint students with career opportunities in research. Awards under the Short-Term Training Program for Minority Students are intended to: o Expose minority undergraduate students, graduate students, and students in health professional schools to opportunities inherent in research careers in areas relevant to cardiovascular, pulmonary, and hematologic diseases; o Attract highly qualified minority students into biomedical and behavioral research careers, and; o Alleviate the deficit of minority investigators. APPLICATION PROCEDURES Applications must be received by August 27, 1993. Applications are to be submitted on the grant application form PHS 398 (rev. 9/91). Application kits are available at most institutional offices of sponsored research and may be obtained from the Office of Grants Inquires, Division of Research Grants, National Institutes of Health, Westwood Building, Room 449, Bethesda, MD 20892, telephone 301-594-7248. The title and number of this announcement must be typed in section 2a on the face page of the application. The completed original application and three legible copies must be sent or delivered to: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** Two additional copies of the application must be sent to: Scientific Review Administrator Division of Extramural Affairs National Heart, Lung, and Blood Institute Westwood Building, Room 550 Bethesda, MD 20892 REVIEW PROCEDURES All applications responding to this announcement will be reviewed for scientific and technical merit by the Research Training Review Committee of the Division of Extramural Affairs, NHLBI, followed by a second level review by the National Heart, Lung, and Blood Advisory Council. The factors to be considered in the evaluation of the proposed training program are: o Design of the proposed training program; o Qualifications and previous training record of the program director and participating faculty; o Adequacy of facilities, environment, and resources for the proposed research training; o Methods of recruiting, selecting and assigning minority students; o Commitment of the institution and participating faculty to the goals of the training program; o Procedures for evaluation of the effectiveness of the program and the impact of the program on the students involved. AWARD CRITERIA Applications will compete for available funds with other approved career development award applications assigned to the National Heart, Lung, and Blood Institute. The following will be considered in making funding decisions: o Technical merit of the application as determined by peer review o Availability of funds o Program balance among the research areas of the announcement INQUIRIES Written and telephone inquires are encouraged. Guidelines for this program may be obtained from any of the following: John Fakunding, Ph.D. Division of Heart and Vascular Diseases National Heart, Lung, and Blood Institute Federal Building, Room 3C04 Bethesda, MD 20892 Telephone: (301) 496-1724 Fann Harding, Ph.D. Division of Blood Diseases and Resources National Heart, Lung, and Blood Institute Federal Building, Room 5A08 Bethesda, MD 20892 Telephone: (301) 496-1817 Mary Reilly, M.S. Division of Lung Diseases National Heart, Lung, and Blood Institute Westwood Building, Room 640A Bethesda, MD 20892 Telephone: (301) 594-7466 For fiscal and administrative matters contact: Grants Operations Branch Division of Extramural Affairs National Heart, Lung, and Blood Institute Westwood Building, Room 4A15C Bethesda, MD 20892 Telephone: (301) 594-7434 AUTHORITY AND REGULATION This program is described in the Catalog of Federal Domestic Assistance numbers 93.837, 93.838, and 93.839. Awards will be made under the authority of the Public Health Service Act, Title III, Section 301 (Public Law 78-410, as amended; 42 USC 241) and administered under PHS grants policies and Federal Regulations at 42 CFR Part 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. $$P6 END ************************************************************ ERRATUM $$E1 BEGIN R6 19930205 APPEND RFA CA-93-009 BOTH *********************** PHASE II TRIALS OF NEW ANTI-CANCER AGENTS NIH Guide, Volume 22, Number 14, April 9, 1993 RFA: CA-93-009 P.T. 34; K.W. 0755015, 0715035, 0740020, 0710100 National Cancer Institute Letter of Intent Receipt Date: April 1, 1993 Application Receipt Date: June 10, 1993 The Division of Cancer Treatment of the National Cancer Institute (NCI) would like to clarify Request for Applications (RFA) CA-93-09, published in the NIH Guide, Vol. 22, No. 5, February 5, 1993 as follows: The section entitled SPECIAL REQUIREMENTS is modified as follows: 2. The applicant must demonstrate in the application the ability to meet the following requirements: a. documented numbers of eligible patients with a history of adequate accrual to complete on average two to three Phase II trials annually. 1) information should be provided on the numbers of eligible patients in each disease category, particularly in, but not limited to, tumors of special interest such as breast, ovarian, lung and urologic cancers, that would be available for inclusion in Phase II clinical trials. 2) it is desirable for applications to indicate the relative emphasis of the proposed projects to each of these disease categories. The section entitled AWARD CRITERIA is modified as follows: AWARD CRITERIA The anticipated date of award is June 10, 1994. In addition to the technical merit of the application, NCI will consider how well the applicant institution met the goals and objectives of the program as described in the RFA, availability of resources, and balance of study populations. While applications may include any malignancy, it should be noted that those applications that involve anti-cancer agents particularly relevant to breast cancer and the ability to conduct Phase II trials in breast cancer will be given a high priority for funding should additional dedicated funds become available for this purpose. $$E1 END ************************************************************ $$XID RFA HL93014 HL-93-014 P1O1 *************************************** IN UTERO STEM CELL TRANSPLANTATION FOR GENETIC DISEASES NIH Guide, Volume 22, Number 14, April 9, 1993 RFA: HL-93-014 P.T. 34; K.W. 0715032, 0745065, 0755020 National Heart, Lung, and Blood Institute Letter of Intent Receipt Date: October 1, 1993 Application Receipt Date: November 17, 1993 PURPOSE The Cellular Hematology Branch, Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute (NHLBI), invites applications for studies that may contribute to the development of methodologies to perform in utero hematopoietic stem cell transplants to cure genetic blood diseases that can both be diagnosed in utero and are curable by postnatal marrow transplantation. The specific focus will be on animal models, but human studies will also be considered. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This Request for Applications (RFA), In Utero Stem Cell Transplantation for Genetic Diseases, is related to the priority areas of Cooley's anemia, sickle cell anemia, other genetic blood diseases, and hematopoietic stem cell transplantation. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-782-3238). ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic and foreign for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal government. Awards in response to this RFA will be made to foreign institutions only for research of very unusual merit, need, and promise, and in accordance with PHS policy governing such awards. Foreign institutions are not eligible for First Independent Research Support and Transition (FIRST) (R29) awards. Applications from minority individuals and women are encouraged. MECHANISM OF SUPPORT This RFA will use the National Institutes of Health (NIH) individual research grant (R01) and FIRST (R29) awards and is a one-time solicitation. Applicants, who will plan and execute their own research programs, are requested to furnish their own estimates of the time required to achieve the objectives of the proposed research project. Up to five years of support may be requested. Applicants for FIRST awards must request five years of support. At the end of the official award period, renewal applications may be submitted for peer review and competition for support through the regular grant program of the NHLBI. It is anticipated that support for the present program will begin in July 1994. Administrative adjustments in project period and/or amount of support may be required at the time of the award. All current policies and requirements that govern the research grant programs of the National Institutes of Health will apply to grants awarded in connection with this RFA. Since a variety of approaches would represent valid responses to this announcement, it is anticipated that there will be a range of costs among individual grants awarded. FUNDS AVAILABLE Although the financial plans for fiscal year 1994 include $1.5 million for this program, award of grants pursuant to this RFA is contingent upon receipt of funds for this purpose. It is anticipated that about six new grants will be awarded under this program. The specific amount to be funded will, however, depend on the merit and scope of the applications received and on the availability of funds. If collaborative arrangements involve sub-contracts with other institutions, the NHLBI Grants Operations Branch (telephone 301-594-7436) should be consulted regarding procedures to be followed. RESEARCH OBJECTIVES In the past twenty years, allogeneic bone marrow transplantation increasingly has become used as a cure for a variety of genetic defects of the hematopoietic and immune systems and for lysosomal storage diseases. Genetic diseases that have been successfully cured by bone marrow transplantation include Cooley's anemia, sickle cell anemia, Fanconi anemia, Blackfan-Diamond anemia, severe combined immunodeficiency, Wiskott-Aldrich syndrome, ataxia telangiectasia, infantile agranulocytosis, Chediak-Higashi disease, chronic mucocutaneous candidiasis, mucopolysaccharidosis, cartilage-hair hypoplasia, Gaucher's and other storage diseases. Some of these diseases, such as Cooley's anemia (beta-thalassemia) and sickle cell anemia, are major worldwide public health problems. Others are devastating orphan diseases that are extremely costly to treat. Genetic diseases that cause death in utero, such as homozygous alpha-thalassemia, may also possibly be cured by in utero stem cell transplantation. Collectively, these diseases occur in tens-of-thousands of births per year. However, conventional bone marrow transplantation has several drawbacks: (1) only about 35 percent of transplant candidates will have a suitably matched marrow donor; (2) the long-term effects of the preparative regimen of lethal doses of irradiation and/or cytotoxic drugs are not known; (3) post-transplant complications such as infection and graft-versus-host disease are significant and contribute to the morbidity and mortality of the procedure; (4) for some diseases, the disease process has caused irreversible damage prior to the transplant; and (5) the significant cost of the procedure which could be as much as $250,000, not including the possible long-term care for chronic graft-versus-host disease. In the sheep and monkey animal models, recent progress seems to indicate that donor fetal liver hematopoietic stem cells can be successfully transplanted into an unrelated pre-immune recipient fetus. After birth, the chimeric animals still appear healthy and normal up to five years post-transplant. This procedure has been performed without the need for tissue matching, without marrow ablation, without immunosuppressive drugs, and without the development of graft-versus-host disease. This suggests that the fetus is both an ideal recipient and donor of hematopoietic stem cells, as has recently been demonstrated by the long-term engraftment and expression of human stem cells in preimmune sheep fetuses. In a number of diseases (e.g., storage diseases), an early expression of donor cells activity (i.e., soon after transplant and before birth) is a critical requirement since even at birth significant clinical disease exists. In diseases such as Cooley's anemia and other hemoglobinopathies, a higher level of donor cell engraftment is needed to be of therapeutic benefit. In this regard, recent findings of improved donor hematopoietic stem cell engraftment as the result of homing receptor manipulations by growth factors are promising. The technical and quality control issues that are involved when fetal donor stem cells are used may limit the applicability of this source of stem cells. Although in animal studies and in limited clinical studies, T-depleted adult stem cells have failed to engraft adequately in utero. The significant progress in stem cell purification and characterization provides for new sources of donor stem cells. Moreover, the possibility of employing in vitro expanded fetal or adult stem cells for use in in utero transplants has not been explored. The possibility now exists for correcting genetic diseases in utero, without the significant problems that were described above for bone marrow transplantation. Therefore, this initiative is for the development of methodologies to perform in to perform in to ppero hematopoietic stem cell transplants to cure genetic diseases that can be diagnosed in utero and that are curable by postnatal marrow transplantation. Examples of Areas of Interest The following are only examples and prospective applicants are urged to use their own ideas as to the area of research on which to focus. The major areas that need further investigation before the procedure can be applied in clinical practice include, among others: (a) improved donor cell engraftment; (b) en oy expresssf donor cell activity; (c) the use of alternate sources of donor stem cells, such as fetal liver, adult peripheral blood, adult bone marrow, and hematopoietic stem cells that have been expanded in culture; and (d) quality control issues regarding the collection, processing, storage and use of donor hematopoietic stem cells. Disciplines and Expertise Among the disciplines and expertise that may be appropriate for this program are hematology, immunology, cell biology, medicine, and neonatology. ith no exclusions from the base for training-related expenses. RESEARCH OBJECTIVES The Minority Institutional Research Training Program is designed to offer research training grant awards in cardiovascular, pulmonary, and hematologic research to minority schools to enable qualified graduate students, health professional students, and postdoctoral students to participate in research programs. It is expected to attract students in the developmental stages, increase awareness of these diseases, and to acquaint them with career opportunities in research. The Minority Institutional Research Training Program is intended to: o Train graduate students, health professional students, and postdoctoral students at minority schools that have the potential to develop a meritorious program in cardiovascular, pulmonary, or hematologic research for research careers in areas relevant to these diseases. o Stimulate cardiovascular, pulmonary, and hematologic diseases and hematologic resources research, prevention, control, and education by offering minority school graduate students, health professional students, and postdoctoral students the opportunity to enhance their research capabilities in these areas. APPLICATION PROCEDURES Applications are to be submitted on the grant application form PHS 398 (rev. 9/91). Application kits are available at most institutional offices of sponsored research and may be obtained from the Office of Grants Inquiries, Division of Research Grants, National Institutes of Health, Westwood Building, Room 449, Bethesda, MD 20892, telephone (301) 594-7248. The title and number of the RFA must be typed in section 2a on the face page of the application. The completed original application and three legible copies must be sent or delivered to: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** Two additional copies of the application must be sent to: Scientific Review Administrator Division of Extramural Affairs National Heart, Lung, and Blood Institute Westwood Building, Room 550 Bethesda, MD 20892 Applications must be received by November 17, 1993. REVIEW PROCEDURES All applications responding to this announcement will be reviewed for scientific and technical merit by the Research Training Review Committee of the Division of Extramural Affairs, NHLBI, followed by a second level review by the National Heart, Lung, and Blood Advisory Council. The factors to be considered in the evaluation of the proposed training program are: o Adequacy of faculty, facilities, and resources for the proposed research training, both at the minority institution and the research center; o Adequacy of the cooperative arrangements between the minority institution and the research program; o Commitment of the relevant faculty and the two institutions to the goals of the training program; o Procedures for evaluation of the impact of the program on the trainees involved. AWARD CRITERIA Applications will compete for available funds with other approved applications assigned to the National Heart, Lung, and Blood Institute. The following will be considered in making funding decisions: o Scientific and technical merit of the application as determined by peer review o Availability of funds o Program balance among the research areas of the announcement INQUIRIES Written and telephone inquires are encouraged. Guidelines for this program may be obtained from any of the following: John Fakunding, Ph.D. Division of Heart and Vascular Diseases National Heart, Lung, and Blood Institute Federal Building, Room 3C04 Bethesda, MD 20892 Telephone: (301) 496-1724 Fann Harding, Ph.D. Division of Blood Diseases and Resources National Heart, Lung, and Blood Institute Federal Building, Room 5A08 Bethesda, MD 20892 Telephone: (301) 496-1817 Mary Reilly, M.S. Division of Lung Diseases National Heart, Lung, and Blood Institute Westwood Building, Room 640A Bethesda, MD 20892 Telephone: (301) 594-7466 For fiscal and administrative matters, contact: Grants Operations Branch Division of Extramural Affairs National Heart, Lung, and Blood Institute Westwood Building, Room 4A15C Bethesda, MD 20892 Telephone: (301) 594-7434 AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance Nos. 93.837, 93.838, and 93.839. Awards will be made under the authority of the Public Health Service Act, Title III, Section 301 (Public Law 78-410, as amended; 42 USC 241) and administered under PHS grants policies and Federal Regulations at 42 CFR Part 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. From owner-sci-resources@net.bio.net Fri Apr 09 23:00:00 1993 Path: biosci!agate!howland.reston.ans.net!wupost!tulane!ukma!rutgers!mcclb0.med.nyu.edu!sci.wfeb.edu!macrides From: macrides@sci.wfeb.edu Newsgroups: bionet.sci-resources Subject: Re: listing opportunities one at a time NIH/USNAval Research etc Message-ID: <1993Apr8.102606.108@wfeb2> Date: 8 Apr 93 14:26:05 GMT References: <1ps8cj$7n2@usenet.INS.CWRU.Edu> Organization: Worcester Fndn. for Exptl. Biol. Lines: 97 In article <1ps8cj$7n2@usenet.INS.CWRU.Edu>, dd544@cleveland.Freenet.Edu (Paul F. Lehmann Ph.d.) writes: > > It is hard to wade through NIH Guide the way it is posted. > Could the NIH and other gencies put each opportunity into a > different message? Then I wouldn't have to read about things > of no significance to my resera research in the hope that > some gold mine lies further on! > > Paul F. Lehmann > lehmann%opus@mcoiarc.bitnet Paul, The NIH Guide posted here is a "public service" re-posting by Dave Kristofferson of the "offical" Eguide distributed via subscriptions to NIHGDE-L at LISTSERV@JHUVM.BITNET. The various sections of each week's Eguide are preceded by "delimiter" lines developed for parsing by software to create a database that can be read and seached via a browser. To my knowledge, publiclly distributed software of this sort has been developed only for VMS systems. A posting about it and how to get it is appended. If you're not on a VMS system, the NIH has recently set up access to the Eguide via it's gopher server (gopher.nih.gov 70). Though this is not quite as fancy and powerful as the VMS-based database and browser, it does provide basic search capabilities and the ability to select items from a menu (i.e., it's much better than "plowing" through the "raw" distribution). Here's the link info for the Eguide itself, should you want to put it in your gopher bookmark file: Name=NIH Guide to Grants and Contracts Type=1 Port=70 Path=1/nih/nihguide Host=helix.nih.gov Fote ========================================================================= Foteos Macrides Worcester Foundation for Experimental Biology MACRIDES@SCI.WFEB.EDU 222 Maple Avenue, Shrewsbury, MA 01545 ========================================================================= From: IN%"SMITH@NYUMED.BITNET" 12-JAN-1993 10:54:35.69 To: IN%"nih-reader@MCCLB0.MED.NYU.EDU" Subj: Announcing V1.2 of the NIH-Guide Reader (Pre-release) Announcing V1.2 of the NIH-Guide Reading Program (Pre-release) ================================================ We have recently revised our NIH-Guide reading program for OpenVMS. Its purpose is to provide a user-friendly tool to browse and search the NIH-Guide for Grants and Contracts, as distributed electronically via BITNET. It is designed to allow the NIH-Guide database to be updated automatically as new Guide information is distributed, allowing administrative overhead for database management to be significantly reduced. A major administrativer change is that the software is now owned by New York University, to whom we (Ross Smith and Suzy Gottesman) have transferred the copyright, all rights and title. The major functional changes since V1.1 are: - The program has been ported to OpenVMS/AXP: it is now Alpha-ready! - The program can now process more than one guide at a time: if you miss collecting the guide one week, you do not need to untangle the two intermixed guides (this has already been distributed as part of V1.1 in November, 1991). - A major bug has been fixed which caused problems if there were more than 99 guides to display. The software is available free of charge from our MAILSERVer. To get it, send mail to MAILSERV@MCCLB0.MED.NYU.EDU with the following lines in the body of the message: the distribtion is in ten parts. SEND NIH-GUIDE.01-OF-10 ..etc.. SEND NIH-GUIDE.10-OF-10 You may find it more reliable to request the software in two blocks: 1-5 and 6-10. The distribution will be mailed to you. Follow the instructions at the begining of the first mailed message: the distribution is in a VMS_SHARE archive. Note that this program superceds the V1.1 version of this package but does not reqire a new format for the databases, provided you are running the latest version: V1.1. If you would like to test the package before installing it, AND you have access to TELNET, please contact us and we will tell you how to log in to our VAX to run the program. The development of these programs owes much to the help of people who called or mailed comments on what they saw during the testing phase of development: particular thanks to Foteos Macrides for many detailed reports which were key to resolving significant problems. Contacts: smith@mcclb0.med.nyu.edu SMITH@NYUMED.BITNET gottesman@mcclb0.med.nyu.edu GOTTESMAN@NYUMED.BITNET From owner-sci-resources@net.bio.net Fri Apr 09 23:00:00 1993 Path: biosci!NET.BIO.NET!kristoff From: kristoff@NET.BIO.NET (Dave Kristofferson) Newsgroups: bionet.sci-resources Subject: NSF - Summary of new documents on STIS - 4 April 1993 Message-ID: Date: 10 Apr 93 02:47:49 GMT Sender: kristoff@net.bio.net Distribution: bionet Lines: 131 ** NEW DOCUMENTS ON STIS ** Document Type: Dir of Awards Title: FY93 Minority Graduate Fellowship Awards File size (bytes): 17898 STIS Filename: gf93mawd Also available: gf93mawd.dlm Title: FY93 Minority Graduate Fellowship Honorable Mention File size (bytes): 45968 STIS Filename: gf93mhm Also available: gf93mhm.dlm Title: FY93 Graduate Fellowship Awards File size (bytes): 106141 STIS Filename: gf93rawd Also available: gf93rawd.dlm Title: FY93 Graduate Fellowship Awards Honorable Mention File size (bytes): 251930 STIS Filename: gf93rhm Also available: gf93rhm.dlm Document Type: Press Release Title: NSF Welcomes Role in President's Defense Conversion File size (bytes): 7097 STIS Filename: pr9329 Title: Education Leaders Seek Solutions at NSF Conference File size (bytes): 6784 STIS Filename: pr9330 Title: NSF Halts Incinerator at McMurdo Station File size (bytes): 3608 STIS Filename: pr9331 Title: President Proposes Substantial Increase for NSF in FY94 File size (bytes): 6235 STIS Filename: pr9333 Document Type: Program Guideline Title: NSF 9342 File size (bytes): 10198 STIS Filename: nsf9342 ------------------------------------------------------------------------ ** UPDATES TO EXISTING STIS DOCUMENTS ** Document Type: Committees Title: NSF Advisory Committee Meetings File size (bytes): 4390 STIS Filename: cmpublic Document Type: Dir of Awards Title: FY93 Minority Graduate Fellowship Awards File size (bytes): 17898 STIS Filename: gf93mawd Also available: gf93mawd.dlm Title: FY93 Minority Graduate Fellowship Honorable Mention File size (bytes): 45968 STIS Filename: gf93mhm Also available: gf93mhm.dlm Title: FY93 Graduate Fellowship Awards File size (bytes): 106141 STIS Filename: gf93rawd Also available: gf93rawd.dlm Title: FY93 Graduate Fellowship Awards Honorable Mention File size (bytes): 251930 STIS Filename: gf93rhm Also available: gf93rhm.dlm Document Type: Phone Book Title: NSF Alphabetical Listing File size (bytes): 83881 STIS Filename: phnalpha Title: NSF Organizational Directory File size (bytes): 92910 STIS Filename: phnorg ------------------------------------------------------------------------ ** FOR YOUR REFERENCE ** ------------------------------------------------------------------------ HOW TO OBTAIN DOCUMENTS The above files can be retrieved in electronic form using the STIS system. If you don't know how to use STIS, send an E-mail message to stisinfo@nsf.gov (Internet) or stisinfo@NSF (BITNET). You will receive a copy of the STIS flyer via E-mail. If you are already using STIS, you can use the information above to retrieve these files: Documents via E-mail: Send a message to stisserv@nsf.gov (Internet) or stisserv@NSF (BITNET). Use the "STIS Filename" shown above in the "get" command. For example, to retrieve phnorg, the text of your message should be as follows: get phnorg Anonymous FTP: FTP to stis.nsf.gov. Use the "STIS Filename" shown above to retrieve a file. For example, to retrieve phnorg, you would enter: ftp> get phnorg WAIS or Gopher: Do a word search on the filename as shown in the summary. If you want a *printed* copy of a document: Send your name and postal mailing address, and the document title and number to "firstop@nsf.gov" (Internet) or "firstop@nsf" (BITNET). If you have problems with the above procedures: Send a message to "stis@nsf.gov" (Internet) or "stis@NSF" (BITNET). From owner-sci-resources@net.bio.net Fri Apr 09 23:00:00 1993 Path: biosci!NET.BIO.NET!kristoff From: kristoff@NET.BIO.NET (Dave Kristofferson) Newsgroups: bionet.sci-resources Subject: NIH Guide, vol. 22, no. 14, pt. 1, 9 April 1993 Message-ID: Date: 10 Apr 93 01:43:35 GMT Sender: kristoff@net.bio.net Distribution: bionet Lines: 1506 NOTE: The NIH Guide may be split into more than one mail message to avoid truncation during e-mail distribution. The first message always begins with the RFP/RFA summary sections followed by the appended texts of the full RFP/RFAs. ---------------------------------------------------------------------- $$XID NIHGUIDE 19930409 V22N14 P1O2 ************************************ X-comment: RFAs described: DE-93-001, HL-93-014, DK-93-020 NIH GUIDE - Vol. 22, No. 14 - April 9, 1993 $$INDEX BEGIN ******************************************************* NOTICES $$INDEX N1 ********************************************************** REVISED GUIDELINES FOR INVESTIGATOR-INITIATED CLINICAL TRIALS National Heart, Lung, and Blood Institute INDEX: HEART, LUNG, BLOOD NOTICES OF AVAILABILITY (RFPs AND RFAs) $$INDEX R1 10/21/93 ************************************************* SPECIALIZED MATERIALS SCIENCE RESEARCH CENTERS (RFA DE-93-001) National Institute of Dental Research INDEX: DENTAL RESEARCH $$INDEX R2 11/17/93 ************************************************* IN UTERO STEM CELL TRANSPLANTATION FOR GENETIC DISEASES (RFA HL-93-014) National Heart, Lung, and Blood Institute INDEX: HEART, LUNG, BLOOD $$INDEX R3 11/18/93 ************************************************* CORE GRANTS FOR CLINICAL NUTRITION RESEARCH UNITS (RFA DK-93-020) National Institute of Diabetes and Digestive and Kidney Diseases INDEX: DIABETES, DIGESTIVE, KIDNEY ONGOING PROGRAM ANNOUNCEMENTS $$INDEX P1 06/01/93 ************************************************* ACADEMIC AWARD IN ENVIRONMENTAL/OCCUPATIONAL MEDICINE (PAR-93-069) National Institute of Environmental Health Sciences INDEX: ENVIRONMENTAL HEALTH SCIENCES $$INDEX P2 ********************************************************** CANCER PREVENTION AND CONTROL RESEARCH SMALL GRANT PROGRAM (PA-93-070) National Cancer Institute INDEX: CANCER $$INDEX P3 08/27/93 ************************************************* MINORITY SCHOOL FACULTY DEVELOPMENT AWARD (PAR-93-071) National Heart, Lung, and Blood Institute INDEX: HEART, LUNG, BLOOD $$INDEX P4 08/27/93 ************************************************* MINORITY INSTITUTIONAL RESEARCH TRAINING PROGRAM (PAR-93-072) National Heart, Lung, and Blood Institute INDEX: HEART, LUNG, BLOOD $$INDEX P5 08/27/93 ************************************************* RESEARCH DEVELOPMENT AWARD FOR MINORITY FACULTY (PAR-93-073) National Heart, Lung, and Blood Institute INDEX: HEART, LUNG, BLOOD $$INDEX P6 08/27/93 ************************************************* SHORT-TERM TRAINING FOR MINORITY STUDENTS PROGRAM (PAR-93-074) National Heart, Lung and Blood Institute INDEX: HEART, LUNG, BLOOD ERRATUM $$INDEX E1 ********************************************************** PHASE II TRIALS OF NEW ANTI-CANCER AGENTS (RFA CA-93-09) National Cancer Institute INDEX: CANCER This publication is also available electronically to institutions via BITNET or INTERNET. Alternative access is through the NIH Grant Line using a personal computer (data line 301/402-2221). Contact Dr. John James at 301/594-7270 for details, or send an E-mail message to ZNS@NIHCU. $$INDEX END ********************************************************* NOTICES $$N1 BEGIN ********************************************************** REVISED GUIDELINES FOR INVESTIGATOR-INITIATED CLINICAL TRIALS NIH Guide, Volume 22, Number 14, April 9, 1993 P.T. 34; K.W. 0715040, 0755015 National Heart, Lung, and Blood Institute Revised guidelines for Investigator-Initiated Clinical Trials and updated instructions for the preparation of trial applications for submission to the National Heart, Lung, and Blood Institute (NHLBI) are available. All applicants who plan to submit applications for Investigator-Initiated Clinical Trial grants to NHLBI should obtain a copy by calling the Review Administrator for the Clinical Trials Review Committee, Review Branch, NHLBI (301 594-7450). $$N1 END ************************************************************ NOTICES OF AVAILABILITY (RFPs AND RFAs) $$R1 BEGIN DE-93-001 FULL-TEXT ************************************** SPECIALIZED MATERIALS SCIENCE RESEARCH CENTERS NIH Guide, Volume 22, Number 14, April 9, 1993 RFA AVAILABLE: DE-93-001 P.T. 34; K.W. 0750005, 1009007 National Institute of Dental Research Letter of Intent Receipt Date: September 24, 1993 Application Receipt Date: October 21, 1993 THE REQUEST FOR APPLICATIONS (RFA) ANNOUNCED IN THIS NOTICE CONTAINS ESSENTIAL INFORMATION FOR THE PREPARATION OF AN APPLICATION. POTENTIAL APPLICANTS MAY OBTAIN THE RFA FROM THE CONTACT NAMED IN INQUIRIES, BELOW. PURPOSE The National Institute of Dental Research (NIDR) invites applications from domestic institutions for the support of Specialized Materials Science Research Centers. The primary goal of these centers is to conduct research leading to the development of new and improved biocompatible dental restorative materials as alternatives to dental amalgam. The centers are intended to provide an environment that strengthens and increases productivity in basic and clinical materials research leading to the development of novel materials and of innovative materials processing strategies through multidisciplinary collaborative efforts. It is important to focus on a collaboration between basic and clinical sciences to achieve the proposed goals. Applications in response to this RFA may not include research on maxillofacial and implant materials. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This RFA, Specialized Materials Science Research Centers, is related to the priority area of oral health. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal government. Foreign organizations are not eligible to apply. However,domestic applications may include international components. Only one application will be allowed under this program from each U.S. institution. Applications from minority individuals and women are encouraged. Although an application must be submitted from a single institution, it may include consortia arrangements with other institutions provided these arrangements are clearly delineated and confirmed by signed statements from the responsible officials of each institution. To be eligible for a center grant under this program, the potential applicant institution must have ongoing, independently supported research in materials science and must propose new research in the area with the ultimate goal of developing new or improved dental restorative materials and methods. MECHANISM OF SUPPORT This RFA will use the National Institutes of Health (NIH) Specialized Center grant (P50). Responsibility for the planning, direction, and execution of the proposed project will be solely that of the applicant. The total project period for applications submitted in response to this RFA may not exceed five years. The anticipated award date is September 29, 1994. This RFA is a one-time solicitation. It is anticipated that each award will be approximately $500,000 direct costs for the first year. A standard escalation factor may be used for subsequent budget periods. FUNDS AVAILABLE The estimated funds for the first year of support for the entire program will be $1.5 to $2.25 million. It is anticipated that two or three grants will be awarded. This funding level is dependent on the receipt of a sufficient number of applications of high scientific merit. Although this program is included in the financial plans of the NIDR, the award of grants pursuant to this RFA is also contingent upon availability of funds for this purpose. RESEARCH OBJECTIVES The primary goal of this initiative is to provide support for interrelated, multidisciplinary, basic, and clinical research leading to the development of new improved restorative dental materials and methodologies as well as to facilitate and establish collaboration among basic materials scientists, biomedical engineers, clinical dental researchers, and industrial researchers. A secondary goal is to create an environment in which these researchers can interact to conduct studies aimed at providing an understanding of the physical, chemical, clinical, and biological characteristics of novel materials and technologies. Although funds are not provided for training, centers are expected to provide a focus for training of scientists dedicated to the pursuit of careers in dental materials research. The development of the new restorative materials should be accompanied by development of procedures and guidelines for their optimal use. STUDY POPULATIONS SPECIAL INSTRUCTIONS FOR INCLUSION OF WOMEN AND MINORITIES IN CLINICAL RESEARCH STUDIES For projects involving clinical research, NIH requires applicants to give special attention to the inclusion of women and minorities in study populations. If women or minorities are not included in the study populations for clinical studies, a special justification for this exclusion must be provided. Applications without such documentation will not be accepted for review. LETTER OF INTENT Prospective applicants are asked to submit, by September 24, 1993, a letter of intent that includes a descriptive title of the proposed or existing center, the name, address and telephone number of the center director, the identities of other key personnel and the participating institution(s) and a descriptive title of each sub project, and the number and title of the RFA in response to which the application may be submitted. Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains is helpful to the NIDR staff in planning for timely review of applications. It allows Institute staff to estimate the potential workload and to avoid possible conflict of interest in review. The letter of intent is to be addressed to Dr. Joyce A. Reese at the address listed under INQUIRIES. APPLICATION PROCEDURES Applications must be received by October 21, 1993. Applications are to be submitted on the grant application form PHS 398 (rev. 9/91). Application kits are available at most institutional offices of sponsored research; from the Office of Grant Inquiries, Division of Research Grants, National Institutes of Health, 5333 Westbard Avenue, Room 449, Bethesda, MD 20892, telephone 301/594-7648; and from the NIDR Program Director listed under INQUIRIES. REVIEW CONSIDERATIONS This application must be directed toward the objectives identified in the RFA. The primary factors that will be considered in the review of the application will be the demonstrated ability or potential to achieve the goals and the scientific merit of the research plans. AWARD CRITERIA Applicants should be aware that, in addition to scientific merit, program priorities and program balance, the total cost of the Specialized Materials Science Research Centers to the NIDR will be considered by NIDR staff and the National Advisory Dental Research Council in making funding recommendations. An additional consideration will be the extent to which complementary projects, supported from non-NIDR funds, will contribute to the cost-effectiveness of the proposed Specialized Materials Science Research Centers. INQUIRIES Written and telephone inquiries concerning this RFA are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues, requests for the RFA, and address the letter of intent to: Joyce A. Reese, D.D.S., M.P.H. Biomaterials, Pulp Biology and Dental Implants Program National Institute of Dental Research Westwood Building, Room 509 Bethesda, MD 20892 Telephone: (301) 594-7648 FAX: (301) 594-7616 Inquiries regarding fiscal matters may be directed to: Ms. Theresa Ringler Grants Management Office National Institute of Dental Research Westwood Building, Room 510 Bethesda, MD 20892 Telephone: (301) 594-7629 FAX: (301) 594-7600 AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.121. Awards are made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78- 410, as amended by Public Law 99-158,42 USC 241 and 285) and administered under PHS grants policies and Federal Regulations 42 CFR 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. $$R1 END ************************************************************ $$R2 BEGIN HL-93-014 FULL-TEXT ************************************** IN UTERO STEM CELL TRANSPLANTATION FOR GENETIC DISEASES NIH Guide, Volume 22, Number 14, April 9, 1993 RFA AVAILABLE: HL-93-014 P.T. 34; K.W. 0715032, 0745065, 0755020 National Heart, Lung, and Blood Institute Letter of Intent Receipt Date: October 1, 1993 Application Receipt Date: November 17, 1993 THE REQUEST FOR APPLICATION (RFA) ANNOUNCED IN THIS NOTICE CONTAINS ESSENTIAL INFORMATION FOR THE PREPARATION OF AN APPLICATION. POTENTIAL APPLICANTS MAY OBTAIN THE RFA FROM THE CONTACT NAMED IN INQUIRIES, BELOW. PURPOSE The Cellular Hematology Branch, Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute (NHLBI), announces the availability of an RFA to encourage the development of methodologies to perform in utero hematopoietic stem cell transplants to cure genetic blood diseases that can both be diagnosed in utero, and are curable by postnatal marrow transplantation. The specific focus will be on animal models but human studies will also be considered. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This RFA, In Utero Stem Cell Transplantation for Genetic Diseases, is related to the priority areas of Cooley's anemia, sickle cell anemia, other genetic blood diseases, and hematopoietic stem cell transplantation. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-782-3238). ELIGIBILITY REQUIREMENTS All domestic public and private, for-profit and non-profit, institutions and organizations are eligible to apply in response to this RFA. Awards in connection with this announcement will be made to foreign institutions only for research of very unusual merit, need and promise, and in accordance with PHS policy governing such awards. Foreign institutions are not eligible for First Independent Research Support and Transition (FIRST) awards (R29). MECHANISM OF SUPPORT This RFA will use the National Institutes of Health (NIH) individual research grant (R01) and FIRST (R29) awards and is a one-time solicitation. Applicants, who will plan and execute their own research programs, are requested to furnish their own estimates of the time required to achieve the objectives of the proposed research project. Up to five years of support may be requested. At the end of the official award period, renewal applications may be submitted for peer review and competition for support through the regular grant programs of the NHLBI. It is anticipated that support for the present program will begin on July 1, 1994. Administrative adjustments in project period and/or amount of support may be required at the time of the award. All current policies and requirements that govern the research grant programs of the NIH will apply to grants awarded in connection with this RFA. Since a variety of approaches would represent valid responses to this announcement, it is anticipated that there will be a range of costs among individual grants awarded. FUNDS AVAILABLE Although the financial plans for fiscal year 1994 include $1.5 million for this program, award of grants pursuant to this RFA is contingent upon receipt of funds for this purpose. It is anticipated that about six new grants will be awarded under this program. The specific amount to be funded will, however, depend on the merit and scope of the applications received and on the availability of funds. If collaborative arrangements involve sub-contracts with other institutions, the NHLBI Grants Operations Branch (telephone 301/594-7436) should be consulted regarding procedures to be followed. The NHLBI will sponsor annual meetings to encourage the exchange of information among investigators who participate in this program. In the preparation of the budget for the grant application, applicants should request additional travel funds for one meeting each year to be held in Bethesda, Maryland. Applicants should also include a statement in the applications indicating their willingness to participate in such meetings. RESEARCH OBJECTIVES The following are only examples and prospective applicants are urged to use their own ideas as to the area of research on which to focus. The major areas that need further investigation before the procedure can be applied in clinical practice include, among others: (a) improved donor cell engraftment; (b) early expression of donor cell activity; (c) the use of alternate sources of donor stem cells, such as fetal liver, adult peripheral blood, adult bone marrow, and hematopoietic stem cells that have been expanded in culture; and (d) quality control issues regarding the collection, processing, storage and use of donor hematopoietic stem cells. STUDY POPULATIONS SPECIAL INSTRUCTIONS FOR INCLUSION OF WOMEN AND MINORITIES IN CLINICAL RESEARCH STUDIES For projects involving clinical research, NIH requires applicants to give special attention to the inclusion of women and minorities in study populations. If women or minorities are not included in the study populations for clinical studies, a specific justification for this exclusion must be provided. Applications without such documentation will not be accepted for review. LETTER OF INTENT The NHLBI requests that prospective applicants submit a letter of intent that includes a descriptive title of the proposed research, the name, address, and telephone number of the Principal Investigator, the identities of other key personnel and participating institutions and the number and title of the RFA in response to which the application may be submitted. Such letters are requested only for the purpose of providing an indication of the number and scope of applications to be received; therefore their receipt is not acknowledged. A letter of intent is not binding, will not enter into the review of any application subsequently submitted, nor is it a necessary requirement for applications. This letter of intent, is to be received by October 1, 1993, and sent to: Chief, Centers and Special Projects Review Section Division of Extramural Affairs National Heart, Lung, and Blood Institute Westwood Building, Room 553 Bethesda, MD 20892 Telephone: (301) 594-7448 FAX: (301) 594-7407 APPLICATION PROCEDURES Applications must be received by November 17, 1993. Applications are to be submitted on the research grant application form PHS 398 (rev. 9/91). This form is available in an applicant institution's office of sponsored research. FIRST (R29) award applications must include at least three sealed letters of reference attached to the face page of the original application. FIRST award applications submitted without the required number of reference letters will be considered incomplete and will be returned without review. The National Institute of Allergy and Infectious Diseases (NIAID) also has an interest in the subject matter of this RFA. REVIEW CONSIDERATIONS Upon receipt, applications will be reviewed for their responsiveness to the objectives of the RFA. If an application is judged unresponsive, the applicant will be contacted to withdraw the application or have it considered as an unsolicited application. Applications judged to be responsive will be reviewed for scientific and technical merit by an initial review group, which will be convened by the Division of Extramural Affairs, NHLBI, solely to review these applications. This initial review may include a preliminary evaluation to determine scientific merit relative to the other applications received in response to the RFA (triage); the NIH will withdraw from further consideration applications judged to be noncompetitive and promptly notify the principal investigator/program director and the official signing for the applicant organization. Those applications judged to be competitive will be further evaluated for scientific/technical merit by the usual peer review procedures. The second level review will be by the National Heart, Lung, and Blood Advisory Council. INQUIRIES Inquiries regarding this program and requests for the RFA may be addressed to: Dr. Alan Levine Division of Blood Diseases and Resources National Heart, Lung, and Blood Institute Federal Building, Room 5A12 Bethesda, MD 20892 Telephone: (301) 496-5911 FAX: (301) 496-9940 For fiscal and administrative matters, contact: Ms. Jane R. Davis Division of Extramural Affairs National Heart, Lung, and Blood Institute Westwood Building, Room 4A11 Bethesda, MD 20892 Telephone: (301) 594-7436 AUTHORITY AND REGULATIONS The programs of the Division of Blood Diseases and Resources, NHLBI, are described in the Catalog of Federal Domestic Assistance Number 93.839. Awards will be made under the authority of the Public Health Service Act, Section 301 (42 USC 241) and administered under PHS grants policies and Federal regulations, most specifically 42 CFR Part 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372, or to Health Systems Agency review. $$R2 END ************************************************************ $$R3 BEGIN DK-93-020 FULL-TEXT ************************************** CORE GRANTS FOR CLINICAL NUTRITION RESEARCH UNITS NIH Guide, Volume 22, Number 14, April 9, 1993 RFA AVAILABLE: DK-93-020 P.T. 34; K.W. 0710095, 0715145, 0710030 National Institute of Diabetes and Digestive and Kidney Diseases Letter of Intent Receipt Date: October 8, 1993 Application Receipt Date: November 18, 1993 THE REQUEST FOR APPLICATIONS (RFA) ANNOUNCED IN THIS NOTICE CONTAINS ESSENTIAL INFORMATION FOR THE PREPARATION OF AN APPLICATION. POTENTIAL APPLICANTS MAY OBTAIN THE RFA FROM THE CONTACT NAMED IN INQUIRIES, BELOW. PURPOSE The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) invites applications for funding of three Clinical Nutrition Research Unit (CNRU) grant to be competitively awarded in Fiscal Year 1995. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This Request for Applications (RFA), Core Grants for Clinical Nutrition Research Units, is related to the priority areas of nutrition, physical activity and fitness, heart disease and stroke, cancer, diabetes and chronic disabling conditions. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal government. Minority individuals and women are encouraged to submit as Principal Investigators. Foreign institutions are not eligible to apply. MECHANISM OF SUPPORT Support of this program will be through the NIH core center grants (P30). Responsibility for the planning, direction, and execution of the proposed project will be solely that of the applicant. Except as otherwise stated in the announcement, awards will be administered under PHS grants policy as stated in the PHS Grants Policy Statement. The earliest anticipated award date will be December 1, 1994. The receipt of three competing continuation applications is anticipated, which will be in competition together with other applications received in response to this announcement. The anticipated awards will be for five years and will be contingent upon the availability of appropriated funds. Requests for support must be limited to no more than $700,000 per year. Any application exceeding this amount will be returned to the applicant. FUNDS AVAILABLE NIDDK anticipates awarding three CNRU Grant in Fiscal Year 1995 on a competitive basis. RESEARCH OBJECTIVES The NIDDK-supported CNRUs are part of an integrated program of nutrition and obesity-related research support provided by the NIDDK. These centers have provided a focus for increasing collaboration and cost effectiveness among groups of successful investigators at institutions with established comprehensive nutritional sciences and obesity research bases. The objectives of the CNRUs are to bring together investigators from relevant disciplines in a manner which will enhance and extend the effectiveness of research related to the nutritional sciences, obesity and related disorders. Applicants should consult with NIDDK staff concerning plans for the development of the center. STUDY POPULATIONS SPECIAL INSTRUCTIONS FOR INCLUSION OF WOMEN AND MINORITIES IN CLINICAL RESEARCH STUDIES For projects involving clinical research, NIH requires applicants to give special attention to the inclusion of women and minorities in study populations. If women or minorities are not included in the study populations for clinical studies, a specific justification for this exclusion must be provided. Applications without such documentation will not be accepted for review. LETTER OF INTENT Prospective applicants are asked to submit a letter of intent, by October 8, 1993. The letter of intent should include a descriptive title of the proposed research, the name, address, and telephone number of the Principal Investigator, the identities of other key personnel and participating institutions, and the number and title of the RFA in response to which the application may be submitted. Although a letter of intent is not required, is not binding, and does not enter into the review of subsequent applications, the information that it contains is helpful in planning for the review of applications. It allows ICD staff to estimate the potential review workload and to avoid possible conflict of interest in the review. The letter of intent is to be sent to the Chief, Review Branch, NIDDK at the address listed under INQUIRIES. APPLICATION PROCEDURES Applications are to be submitted on grant application form PHS 398 (rev. 9/91), available at most institutional offices of sponsored research and from the Office of Grants Inquiries, Division of Research Grants, National Institutes of Health, Westwood Building, Room 449, Bethesda, MD 20892, telephone (301) 594-7248. The RFA label available in the PHS 398 application form must be affixed to the bottom of the face page. The RFA title and number must be typed on line 2a of the face page of the application for and the "YES" box must be marked. Applications must be received by November 18, 1993, the original and three copies of the application must be sent or delivered to: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** Two additional copies of the application under separate cover must be sent to: Review Branch National Institute of Diabetes and Digestive and Kidney Diseases Westwood Building, Room 406 Bethesda, MD 20892 REVIEW CONSIDERATIONS Applications for a CNRU grant will be evaluated in national competition by the NIH grant peer review process. Applications will be reviewed initially by an ad hoc review group convened by the NIDDK and subsequently by the National Diabetes and Digestive and Kidney Diseases Advisory Council. A full description of the review process and the criteria to be used in initial review are given in the RFA. INQUIRIES Prospective applicants should request the RFA and a copy of "Guidelines for Clinical Nutrition Research Units" before developing their applications. These guidelines contain important additional information of the format, content and review criteria. Prospective applicants may address inquiries to and obtain the RFA and guidelines from: Van S. Hubbard, M.D., Ph.D. Division of Digestive Diseases and Nutrition National Institute of Diabetes and Digestive and Kidney Diseases Westwood Building, Room 3A18B Bethesda, MD 20892 Telephone: (301) 594-7573 FAX: (301) 594-7504 Ms. Nancy Dixon Division of Extramural Activities National Institute of Diabetes and Digestive and Kidney Diseases Westwood Building, Room 637A Bethesda, MD 20892 Telephone: (301) 594-7543 AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.847. Awards are made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99- 158, 42 USC 241 and 285) and administered under PHS grants policies and Federal Regulations 42 CFR 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. $$R3 END ************************************************************ ONGOING PROGRAM ANNOUNCEMENTS $$P1 BEGIN PAR-93-069 *********************************************** ACADEMIC AWARD IN ENVIRONMENTAL/OCCUPATIONAL MEDICINE NIH Guide, Volume 22, Number 12, March 26, 1993 PAR NUMBER: PAR-93-069 P.T. 34; K.W. 0725020, 1007003 National Institute of Environmental Health Sciences Application Receipt Date: June 1, 1993 PURPOSE The National Institute of Environmental Health Sciences (NIEHS) announces its fourth national competition for Environmental/Occupational Medicine Academic Awards (E/OMAA) which last appeared in the NIH Guide for Grants and Contracts, Vol. 21, No. 7, February 21, 1992, Page 22. The award will have the dual purpose of improving the quality of environmental/occupational medicine curricula and of fostering graduate research careers in environmental/occupational medicine. For the purposes of the Environmental/Occupational Medicine Academic Award, the term environmental/occupational medicine refers to the area of medicine concerned with the development of knowledge and the application of knowledge directed at the diagnosis, treatment, and prevention of adverse human health effects from environmental/occupational exposures to toxic agents. This includes adverse health effects in infants, children, and adults who are at risk of developing such health problems and the reduction of preventable complications or disability in persons of all ages who have already developed such diseases. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This Program Announcement, Academic Award in Environmental/Occupational Medicine, is related to the priority area of environmental health. Potential applicants may obtain a copy of Healthy People 2000 (Full Report: Stock No. 017-001-00474-0) or Healthy People 2000 (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Only schools of medicine or osteopathy in the United States and its possessions or territories are eligible to compete for Environmental/Occupational Medicine Academic Award for a project period that does not exceed five years and, if successful, to receive the award once only. MECHANISM OF SUPPORT Mechanism of support for this activity will be the research career program (academic) (K07) award. RESEARCH OBJECTIVES The NIEHS initiated the Environmental/Occupational Medicine Academic Award Program to provide a stimulus for development of an environmental/occupational medicine curriculum in those schools that do not have one and to strengthen and improve the environmental/occupational medicine curriculum in schools that do. Awards provide support to applicant faculty members for their educational development and for implementation or expansion of the curriculum in environmental/occupational medicine. APPLICATION PROCEDURES Applications are to be submitted on the grant application form PHS 398 (rev. 9/91). Application deadline date is June 1, 1993. Application kits are available at most institutional offices of sponsored research and may be obtained from the Office of Grants Inquiries, Division of Research Grants, National Institutes of Health, Westwood Building, Room 449, Bethesda, MD 20892, telephone 301/594-7248. The title and number of the announcement must be typed in Section 2a on the face page of the application. The completed original application and five legible copies must be sent or delivered to: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** REVIEW PROCEDURES Applications will be assigned on the basis of established PHS referral guidelines. Applications will be reviewed for technical merit by a special study section convened by NIEHS in accordance with the standard NIH peer review procedures. Following technical review, the applications will receive a second-level review by the National Advisory Environmental Health Sciences Council. AWARD CRITERIA Applications will compete for available funds with all other approved applications in the Career (K) category assigned to the NIEHS. Applications will be evaluated for evidence of commitment by both the sponsoring institution and the sponsoring department or division to the accomplishment of the objectives of the award, as well as the qualification, interest, and commitment of the candidate to undertake the responsibility for implementing a high-quality environmental/occupational medicine curriculum. Additional criteria are included in the program guidelines available from NIEHS program staff. INQUIRIES Program Guidelines for the E/OMAA award are available. Written and telephone inquiries are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues to: Annette G. Kirshner, Ph.D. Division of Extramural Research and Training National Institute of Environmental Health Sciences P.O. Box 12233 Research Triangle Park, NC 27709 Telephone: (919) 541-0488 Direct inquiries regarding fiscal matters to: David L. Mineo Division of Extramural Research and Training National Institute of Environmental Health Sciences P.O. Box 12233 Research Triangle Park, NC 27709 Telephone: (919) 541-1373 AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.894. Awards are made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grants policies and Federal Regulations 42 CFR 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. $$P1 END ************************************************************ $$P2 BEGIN PA-93-070 ************************************************ CANCER PREVENTION AND CONTROL RESEARCH SMALL GRANT PROGRAM NIH Guide, Volume 22, Number 14, April 9, 1993 PA NUMBER: PA-93-070 P.T. 34; K.W. 0715035, 0795003, 0745035, 0745027, 0414000, 0417000 National Cancer Institute Application Receipt Dates: June 1 and October 1 of 1993, 1994, and 1995 PURPOSE The National Cancer Institute (NCI) invites applications for small research grants (R03) in cancer prevention and control. This program announcement is designed to aid and facilitate the growth of a nationwide cohort of scientists with a high level of research expertise in the field of human cancer control intervention research. New and experienced investigators in relevant fields and disciplines (e.g., disease prevention and control, medicine, public health, health promotion, epidemiology, social work, nursing research, nutrition, health policy, health services research, and behavioral sciences, such as psychology, health education, sociology, and community organization) may submit applications to test ideas or do pilot studies. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This PA, Cancer Prevention and Control Research Small Grant Program, is related to the priority areas of cancer, nutrition and tobacco. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone (202) 783-3238). ELIGIBILITY REQUIREMENTS Eligible applicants include established researchers, new investigators, qualified staff of public health and collaborating agencies, and predoctoral investigators currently enrolled in an accredited doctoral degree program. Ineligible applicants are those who are or have previously been Principal Investigator (PI) on an NCI funded Cancer Control grant or contract for more than two years; previous recipients (PIs) of a DCPC Small Grant; and foreign institutions. Small grant research support may NOT be used to supplement research projects currently supported by Federal or non-Federal funds, or to provide interim support of projects under review by the Public Health Service. MECHANISM OF SUPPORT Support of this program will be the small grant (R03) funding mechanism. Total direct costs up to $50,000 are allowed. The total project period may not exceed two years. RESEARCH OBJECTIVES This program is designed to encourage investigators from a variety of academic, scientific, and public health disciplines to apply their skills to scientific investigations in the field of human cancer control intervention research. The research may occur in a variety of settings, such as universities, cancer centers, communities, schools, health departments, laboratories, and worksites. Investigators may choose any of the full range of scientific approaches to their work. Many studies and research designs may contribute to the design, implementation, or evaluation of future phase III-V studies, e.g., descriptive baseline surveys, testing, modification and validation of surveys or program materials for use in the proposed population groups, testing of recruitment or compliance procedures for participants, and the like. Applications should include justification of study design and sample size, as well as clearly indicate the significance of the research and where it will lead. The following cancer control program areas are appropriate for Human Intervention research grant applications: o Prevention - chemoprevention, diet and nutrition intervention studies. o Screening and early detection - pilot studies of new methods; application of the "NCI Guidelines for Early Detection." In the area of breast screening and detection, studies of breast self-examination as a single modality will not be accepted. o Cancer control sciences - studies to change current behaviors and/or institute new behaviors or health promotion interventions effective in reducing incidence, morbidity or mortality from cancer. o Smoking prevention and cessation - pilot studies targeted at improving utilization of current technologies in target populations or organizations are encouraged. Minor enhancements of existing technology are not encouraged. o Applications research - in modifying, feasibility testing, and adopting proven state-of-the-art intervention programs and strategies from other research projects (e.g., screening, smoking prevention, etc.) for use in special populations, state and local health agencies, or other organizational and community setting. In addition, planning, epidemiologic, and survey studies aimed at developing cancer control operations research and evaluation studies are appropriate for human intervention research grant applications. o Community oncology - improving the application of patient management, pain and symptom management, rehabilitation and continuing care research advances into community settings. o Applied epidemiology studies - using epidemiologic methods to determine the association between exposure to an intervention and its impact on disease. Although the specific study proposed may attempt only to obtain preliminary data and/or conduct pilot studies in support of a future, more detailed Phase III-V study, it is important that a long-term human cancer control hypothesis and supporting scientific justification be presented. Exclusions Studies to determine the efficacy of chemotherapy, surgery, radiotherapy and other primary treatment interventions are not considered cancer control research under this PA. Any laboratory animal studies are not allowed. STUDY POPULATIONS SPECIAL INSTRUCTIONS TO APPLICANTS REGARDING IMPLEMENTATION OF NIH POLICIES CONCERNING INCLUSION OF WOMEN AND MINORITIES IN CLINICAL RESEARCH STUDY POPULATIONS NIH policy is that applicants for NIH clinical research grants and cooperative agreements are required to include minorities and women in study populations so that research findings can be of benefit to all persons at risk of the disease, disorder or condition under study; special emphasis should be placed on the need for inclusion of minorities which disproportionately affect them. This policy is intended to apply to males and females of all ages. If women or minorities are excluded or inadequately represented in clinical research, particularly in proposed population-based studies, a clear compelling rationale should be provided. The composition of the proposed study population must be described in terms of gender and racial/ethnic group. In addition, gender and racial/ethnic issues should be addressed in developing a research design and sample size appropriate for the scientific objectives of the study. This information should be included in the form PHS 398 (rev. 9/91) in Sections 1-4 of the Research Plan AND summarized in Section 5, Human Subjects. Applicants are urged to assess carefully the feasibility of including the broadest possible representation of minority groups. However, NIH recognizes that it may not be feasible or appropriate in all research projects to include representation of the full array of Unites States racial/ethnic minority populations [i.e., Native Americans (including American Indians or Alaskan Natives), Asian/Pacific Islanders, Blacks, Hispanics]. The rationale for studies on single minority population groups must be provided. For the purpose of this policy, clinical research is defined as human biomedical and behavioral studies or etiology, epidemiology, prevention (and preventive strategies), diagnosis, or treatment of diseases, disorders or conditions, including but not limited to clinical trials. The usual NIH policies concerning research on human subjects also apply. Basic research or clinical studies in which human tissues cannot be identified or linked to individuals are excluded. However, every effort should be made to include human tissues from women and racial/ethnic minorities when it is important to apply the results of the study broadly, and this should be addressed by applicants. If the required information is not contained within the application, the review will be deferred until the information is provided. Peer reviewers will address specifically whether the research plan in the application conforms to these policies. If the representation of women or minorities in a study design is inadequate to answer the scientific question(s) addressed AND the justification for the selected study population is inadequate, it will be considered a scientific weakness or deficiency in the study design and will be reflected in assigning the priority score to the application. APPLICATION PROCEDURES Applications are to be submitted on the grant application from PHS 398 (rev. 9/91) and will be accepted at the application deadlines indicated in this announcement. Applications received after the October 1 receipt date will be returned to the applicant. Application kits are available at most institutional office of sponsored research and may be obtained from the Office of Grant Inquires, Division of Research Grants, National Institutes of Health, Westwood Building, Room 449, Bethesda, MD 20892, telephone (301) 594-7248. The title and number of this announcement must be typed in Section 2a on the face page of the application. Note that the following additional page limitations (typewritten, single-spaced) apply to the Research Plan of the application: Research Plan (14 pages total; a suggested page distribution is as follows): o Specific Aims - one page. Clearly state the cancer control hypothesis and intervention to be studied. o Background and Significance - one page. o Progress Report and Preliminary Studies - if applicable, two pages. o Research Design and Methods - 10 pages. Following the research plan, include the discussion of Human Subjects and the literature cited. Appendices are acceptable. These page limitations and others in the PHS 398 Application Instructions must be observed or the application will not be accepted. The completed original application and four copies must be sent or delivered to: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** Also send a copy of the application to the Ms. Helen Meissner at the address listed under INQUIRIES when the grant is submitted. Applications responding to this PA should include one round trip, two- day meeting to Bethesda, MD in the budget. REVIEW PROCEDURES Applications will be assigned on the basis of established PHS referral guidelines. Applications will be reviewed for scientific and technical merit by an appropriate review group of the NIH. AWARD CRITERIA Applications will compete for available funds with all other approved applications assigned to the National Cancer Institute. Funding decisions will be based upon quality of the proposed project as determined by peer review, availability of funds, and program balance among research areas of the announcement. INQUIRIES Written and telephone inquiries are encouraged. Direct inquiries regarding programmatic issues to: Helen I. Meissner, Sc.M. National Cancer Institute Executive Plaza North, Room 330 Bethesda, MD 20892 Telephone: (301) 496-8520 Direct inquiries regarding fiscal matters to: Ms. Eileen Natoli Grants Administration Branch National Cancer Institute Executive Plaza South, Room 243 Bethesda, MD 20892 Telephone: (301) 496-7800, ext. 56 AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.399. Awards are made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grant policies and Federal Regulations 42 CFR 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. $$P2 END ************************************************************ $$P3 BEGIN PAR-93-071 *********************************************** MINORITY SCHOOL FACULTY DEVELOPMENT AWARD NIH Guide, Volume 22, Number 14, April 9, 1993 PAR NUMBER: PAR-93-071 P.T. 34, FF; K.W. 0720005, 0715032, 0715040, 0715165 National Heart, Lung, and Blood Institute Application Receipt Date: August 27, 1993 PURPOSE The National Heart, Lung, and Blood Institute (NHLBI) announces a program directed at developing the research capabilities of faculty investigators at minority schools in areas relevant to cardiovascular, pulmonary, and hematologic* diseases and resources. The purpose of the award is to encourage the enhancement of research skills in the areas of interest to the NHLBI by faculty members at minority institutions and to increase the number of minority individuals involved in research endeavors. * Within the NHLBI, the term "hematologic" covers research on thrombosis and hemostasis, immunohematology, blood cell disorders, hematopoiesis, thalassemia, sickle cell disease, transfusion medicine including blood component and derivative therapy, blood substitutes and blood resource management, aspects of AIDS-products in AIDS prevention and treatment, and AIDS-related bone marrow and hematologic disorders. Other Institutes of the NIH are responsible for research on disorders of white cells, including the leukemias and other blood malignancies, and basic immunology related to the lymphoid system. Therefore the NHLBI cannot provide support for such studies. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000", a PHS-led national activity for setting priority areas. This program announcement, the Minority School Faculty Development Award, is related to the priority area of heart disease and stroke. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Awards in this program will be made to domestic minority institutions on behalf of awardees, each of whom will work with a mentor at a nearby (within 100 miles) research center, who is recognized as an accomplished investigator in the research area proposed and who will provide guidance for the awardee's development and research plan. A minority school is defined as a domestic medical or non-medical college, university or equivalent school in which students of minority ethnic groups including Blacks, Hispanics, American Indians, and Asian or Pacific Islanders comprise a majority or significant proportion of the school enrollment. The commitment of the institution to the faculty candidate's research and development must clearly be presented in the application. This should include statements from the Dean and departmental chair indicating that the candidate will be provided with sufficient release time from other duties to accomplish the research goals stated in the application. Candidates for this award are minority school faculty members who (1) are citizens of the United States, non-citizen nationals or permanent residents at the time of application, (2) have a doctoral degree or equivalent in a biomedical or behavioral science, (3) wish to receive specialized training in cardiovascular, pulmonary, or hematologic research, and (4) have the background and potential to benefit from the training. Each candidate must identify and complete arrangements with a nearby mentor (within approximately 100 miles) who is recognized as an accomplished investigator in the research area proposed and who will provide guidance for the awardee's development and research plan. Plans for the intensive training during the summer period (2 - 3 months) as well as during the academic years should be developed with the mentor. MECHANISM OF SUPPORT The mechanism of support is the career development award (K14). Awards will be made to the minority institution on behalf of the awardee. Each award will have a duration of five years and is non-renewable. These awards may not be transferred to another institution or faculty member. Funding beyond the first year of the grant is contingent upon satisfactory progress during the preceding year. If funds are to be transferred to the mentor's institution for any purpose, arrangements for the transfer or conduct of activities must be formalized in a contract or written agreement with the mentor's institution. The awardee may receive salary support up to a maximum of $50,000 plus fringe benefits per year for five years. All funds must be used to support the awardee. Awardees must commit 100 percent of effort during summer and/or off quarter periods and at least 25 percent of effort during the academic year. In addition to the salary request for the candidate, support for up to 10 percent of the mentor's salary during the summer experience may also be requested. Up to $20,000 per year will be provided for research support. Details regarding the apportionment of these funds between the minority institution and the research center must be worked out with the mentor at the research center and agreed to by representatives of both institutions. Indirect costs will be awarded on 8 percent of total direct costs exclusive of equipment. The indirect cost rate on subcontract costs for the mentor's institution may not exceed 8 percent of total costs. RESEARCH OBJECTIVES The Minority School Faculty Development Award is intended to: 1. Encourage the development of faculty investigators at minority schools in areas relevant to cardiovascular, pulmonary and hematologic diseases and transfusion medicine. 2. Stimulate cardiovascular, pulmonary, and hematologic disease research, prevention, control and education by offering minority school faculty members the opportunity to enhance their research capabilities in these areas. STUDY POPULATIONS SPECIAL INSTRUCTIONS TO APPLICANTS REGARDING IMPLEMENTATION OF NIH POLICIES CONCERNING INCLUSION OF WOMEN AND MINORITIES IN CLINICAL RESEARCH STUDY POPULATIONS NIH policy is that applicants for NIH clinical research grants and cooperative agreements are required to include minorities and women in study populations so that research finds can be of benefits to all persons at risk of the disease, disorder or condition under study; special emphasis must be placed on the need for inclusion of minorities and women in studies of diseases, disorders and conditions which disproportionately affect them. This policy is intended to apply to males and females of all ages. If women or minorities are excluded or inadequately represented in clinical research, particularly in proposed population-based studies, a clear compelling rationale must be provided. The composition of the proposed study population must be described in terms of gender and racial/ethnic group. In addition, gender and racial/ethnic issues should be addressed in developing a research design and sample size appropriate for the scientific objectives of the study. This information must be included in the form PHS 398 in sections 1-4 of the Research Plan AND summarized in Section 5, Human Subjects. Applicants are urged to assess carefully the feasibility of including the broadest possible representation of minority groups. However, NIH recognizes that it may not be feasible or appropriate in all research projects to include representation of the full array of United States racial/ethnic minority populations (i.e., Native American (including American Indians or Alaskan Natives), Asian/Pacific Islanders, Blacks, Hispanics). The rationale for studies on single minority population groups must be provided. For the purpose of this policy, clinical research is defined as human biomedical and behavioral studies of etiology, epidemiology, prevention (and preventive strategies), diagnosis, or treatment of diseases, disorders or conditions, including but not limited to clinical trials. The usual NIH policies concerning research on human subjects also apply. Basic research or clinical studies in which human tissues cannot be identified or linked to individuals are excluded. However, every effort should be made to include human tissues from women and racial/ethnic minorities when it is important to apply the results of the study broadly, and this should be addressed by applicants. If the required information is not contained within the application, the review will be deferred until the information is provided. Peer reviewers will address specifically whether the research plan in the application conforms to these policies. If the representation of women or minorities in a study design is inadequate to answer the scientific question(s) addressed AND the justification for the selected study population is inadequate, it will be considered a scientific weakness or deficiency in the study design and will be reflected in assigning the priority score to the application. All applications for clinical research submitted to NIH are required to address these policies. NIH funding components will not award grants or cooperative agreements that do not comply with these policies. APPLICATION PROCEDURES Applications must be received by August 27, 1993. Applications are to be submitted on the grant application form PHS 398 (rev. 9/91). Application kits are available at most institutional offices of sponsored research and may be obtained from the Office of Grants Inquires, Division of Research Grants, National Institutes of Health, Westwood Building, Room 449, Bethesda, MD 20892, telephone 301/594-7248. The title and number of the announcement must be typed in section 2a on the face page of the application. The completed original application and three legible copies must be sent or delivered to: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** Two additional copies of the application must be sent to: Scientific Review Administrator Division of Extramural Affairs National Heart, Lung, and Blood Institute Westwood Building, Room 550 Bethesda, MD 20892 REVIEW PROCEDURES All applications will be reviewed for scientific and technical merit by the Research Training Review Committee of the Division of Extramural Affairs, NHLBI, followed by a second level review by the National Heart, Lung, and Blood Advisory Council. The factors to be considered in the evaluation of the proposed training program are: o the overall merit of the candidate's five year plan for research and the development of research skills. o the background and potential of the proposed candidate for developing into an independent biomedical investigator. o the candidate's commitment to a research career. o the ability of both the minority institution and the training center to provide facilities, resources, and opportunities necessary for the candidate's research development. o the qualifications, ability, and plans of the sponsor who will provide the candidate with the guidance necessary for career development in research. AWARD CRITERIA Applications will compete for available funds with other approved career development award applications assigned to the National Heart, Lung, and Blood Institute. The following will be considered in making funding decisions: o Technical merit of the application as determined by peer review o Availability of funds o Program balance among the research areas of the announcement INQUIRIES Written and telephone inquires are encouraged. Guidelines for this program may be obtained from: John Fakunding, Ph.D. Division of Heart and Vascular Diseases National Heart, Lung and Blood Institute Federal Building, Room 3C04 Bethesda, MD 20892 Telephone: (301) 496-1724 Helena O. Mishoe, Ph.D. Division of Blood Diseases and Resources National Heart, Lung and Blood Institute Federal Building, Room 5A12 Bethesda, MD 20892 Telephone: (301) 496-5911 Mary Reilly, M.S. Division of Lung Diseases National Heart, Lung, and Blood Institute Westwood Building, Room 640A Bethesda, MD 20892 Telephone: (301) 594-7466 For fiscal and administrative matters, contact: Jane Davis Division of Extramural Affairs National Heart, Lung, and Blood Institute Westwood Building, Room 4A15C Bethesda, MD 20892 Telephone: (301) 594-7436 AUTHORITY AND REGULATION This program is described in the Catalog of Federal Domestic Assistance numbers 93.837, 93.838, and 93.839. Awards will be made under the authority of the Public Health Service Act, Title III, Section 301 (Public Law 78-410, as amended; 42 USC 241) and administered under PHS grants policies and Federal Regulations at 42 CFR Part 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. $$P3 END ************************************************************ $$P4 BEGIN PAR-93-072 *********************************************** MINORITY INSTITUTIONAL RESEARCH TRAINING PROGRAM NIH Guide, Volume 22, Number 14, April 9, 1993 PAR NUMBER: PAR-93-072 P.T. 44, FF; K.W. 0720005, 0715032, 0715040, 0715165 National Heart, Lung, and Blood Institute Application Receipt Date: August 27, 1993 PURPOSE The National Heart, Lung, and Blood Institute (NHLBI) announces a program to support full time research training for investigative careers at minority schools in areas related to cardiovascular, pulmonary, and hematologic* diseases. * Within the NHLBI, the term "hematologic" covers research on thrombosis and hemostasis, immunohematology, blood cell disorders, sickle cell disease, blood resources, including blood component and derivative therapy, blood substitutes and blood resource management, aspects of AIDS products in AIDS prevention and treatment, and AIDS-related bone marrow and hematologic disorders. Other Institutes of the NIH are responsible for research on disorders of white cells, including the leukemias, and other blood malignancies, and basic immunology related to the lymphoid system. Therefore the NHLBI does not provide support for such studies. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This program announcement, Minority Institutional Research Training, is related to the priority area of heart disease and stroke. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Awards in this program will be made to minority institutions, each of which will collaborate with a research center that has well-established cardiovascular, pulmonary, or hematologic research and research training programs. The applicant institution must be a domestic medical or non-medical college, university or equivalent school in which students of underrepresented minority groups, including Blacks, Hispanics, American Indians, and Asian and Pacific Islanders, comprise a majority or a significant proportion of the school enrollment. The program director at the minority school will be responsible for the selection and appointment of trainees and the overall direction of the training program. The collaborating research center should be a medical school or comparable institution that has strong, well-established cardiovascular, pulmonary, or hematologic research and research training programs. Cooperation between institutions is needed to From owner-sci-resources@net.bio.net Sun Apr 11 23:00:00 1993 Path: biosci!agate!howland.reston.ans.net!newsserver.jvnc.net!newsserver.technet.sg!nuscc!nusunix3.nus.sg!ccewwm From: ccewwm@nusunix1.nus.sg (Wong Wui Ming) Newsgroups: bionet.sci-resources Subject: Biotech Job in Singapore Message-ID: <1993Apr12.061455.16502@nuscc.nus.sg> Date: 12 Apr 93 06:14:55 GMT Sender: usenet@nuscc.nus.sg Organization: National University of Singapore Lines: 49 X-Newsreader: TIN [version 1.1 PL6] [ Article crossposted from misc.jobs.offered ] [ Author was ] [ Posted on Mon, 12 Apr 1993 05:41:58 GMT ] Calling all CLONAL DESIGNERS and GENE MAPPERS!!! The Bioprocessing Technology Unit is looking for an INNOVATIVE and INVENTIVE post-doctoral molecular biologist who has had experience in identifying, isolating, mutating and cloning recombinant genes (using a variety of novel and conventional promoters) into Chinese Hamster Ovary (especially), insect, yeast or E. coli cells. Initially, s/he may be cloning snake venom or marine toxins into one of the above hosts for expression, structural and biological studies. S/he will also help the Cell Culture Group to understand the molecular basis of increased antibody production in hybridoma cells under stress conditions; the Fermentation Group to overexpress a cytokine in a soluble form, which currently exists as inclusion bodies; as well as undertaking other tasks such as developing PCR methods for diagnostic kits for the DNA/Peptide Synthesis Group.....etc. [Suffice to say, it will be a very challenging position and much will be learnt from our open interaction within our multi-disciplinary groups.] A 3 year contract will be offered and remuneration will be subject to work experience and equivalent to similar positions in academia in the U.S.A. Accommodation will be provided for to non-Singaporeans. Please send your applications with full resume and certificates to:- Dr. Miranda Yap or Dr. Steve Oh Director Project Leader, The Bioprocessing Technology Unit, National University of Singapore, 10 Kent Ridge Crescent, SINGAPORE 0511 FAX: 65 775 4933 Preferred e-mails of Dr. Steve Oh:1) engohkw@nusvm.nus.sg 2) engohkw@nuscc.nus.sg Thank you for your interest. Yours Biotechnologically, Dr. Steve Oh From owner-sci-resources@net.bio.net Sun Apr 11 23:00:00 1993 Path: biosci!NET.BIO.NET!kristoff From: kristoff@NET.BIO.NET (Dave Kristofferson) Newsgroups: bionet.sci-resources Subject: NSF - Summary of new documents on STIS - 11 April 1993 Message-ID: Date: 12 Apr 93 18:17:53 GMT Sender: kristoff@net.bio.net Distribution: bionet Lines: 70 ** NEW DOCUMENTS ON STIS ** Document Type: Issuance Title: Recovery of NSF Costs Under Interagency File size (bytes): 4573 STIS Filename: ib9311 Title: Delegation of Authority Under 31 U.S.C. 3711 File size (bytes): 2301 STIS Filename: iod9321 Document Type: Program Guideline Title: NSF93-49 Antartic Research Program Guide File size (bytes): 69071 STIS Filename: nsf9349 Also available: nsf9349.wp5 ------------------------------------------------------------------------ ** UPDATES TO EXISTING STIS DOCUMENTS ** Document Type: Committees Title: NSF Advisory Committee Meetings File size (bytes): 4178 STIS Filename: cmpublic ------------------------------------------------------------------------ ** FOR YOUR REFERENCE ** ------------------------------------------------------------------------ HOW TO OBTAIN DOCUMENTS The above files can be retrieved in electronic form using the STIS system. If you don't know how to use STIS, send an E-mail message to stisinfo@nsf.gov (Internet) or stisinfo@NSF (BITNET). You will receive a copy of the STIS flyer via E-mail. If you are already using STIS, you can use the information above to retrieve these files: Documents via E-mail: Send a message to stisserv@nsf.gov (Internet) or stisserv@NSF (BITNET). Use the "STIS Filename" shown above in the "get" command. For example, to retrieve cmpublic, the text of your message should be as follows: get cmpublic Anonymous FTP: FTP to stis.nsf.gov. Use the "STIS Filename" shown above to retrieve a file. For example, to retrieve cmpublic, you would enter: ftp> get cmpublic WAIS or Gopher: Do a word search on the filename as shown in the summary. If you want a *printed* copy of a document: Send your name and postal mailing address, and the document title and number to "firstop@nsf.gov" (Internet) or "firstop@nsf" (BITNET). If you have problems with the above procedures: Send a message to "stis@nsf.gov" (Internet) or "stis@NSF" (BITNET). From owner-sci-resources@net.bio.net Sun Apr 11 23:00:00 1993 Path: biosci!uwm.edu!zaphod.mps.ohio-state.edu!howland.reston.ans.net!gatech!usenet.ufl.edu!mailer.cc.fsu.edu!sun13!ds3.scri.fsu.edu!obey From: obey@ds3.scri.fsu.edu (Dr. Obeysekera) Newsgroups: bionet.sci-resources Subject: JonBb Announcement - West Palm Beach, Florida Message-ID: <12490@sun13.scri.fsu.edu> Date: 12 Apr 93 21:17:54 GMT Sender: news@sun13.scri.fsu.edu Organization: Supercomputer Computations Research Institute Lines: 21 SUPERVISING PROFESSIONAL ENVIRONMENTAL SCIENTIST The Department of Research of the South Florida Water Management District seeks a senior-level scientist to participate in and provide strong scientific leadership to research on the Lake Okeechobee, Kissimmee River, or estuarine ecosystems. M.S. in science with six years of experience, including two years supervision of a professional staff, required; Ph.D. in limnology or related aquatic science discipline and a proven publication record are preferred. The District offers competitive salaries, excellent benefits, a smoke-free workplace, and a sub-tropical environment. All new hires will be required to successfully complete a pre-placement drug test. For consideration send your resume (including your social security number) to: Human Resources Division, South Florida Water Management District, POB 24680, West Palm Beach, FL 33416-4680, or call Dr.Nicholas G. Aumen for further details (407 687-6601). Equal Opportunity Employer, M/F/D/V. Locations for advertisement: Science, distribute on Internet, direct mailing From owner-sci-resources@net.bio.net Tue Apr 13 23:00:00 1993 Path: biosci!nsf.gov From: parzberg@nsf.gov (Peter Arzberger) Newsgroups: bionet.sci-resources Subject: Human Brain Project program announcement Message-ID: Date: 14 Apr 93 18:45:52 GMT Sender: kristoff@net.bio.net Lines: 949 Below please find the program announcement for the Human Brain Project. Some of the key dates have been indicated as well as one type of proposals which is encouraged. For further information, please contact (see end of announcement): Michael Huerta, NIMN Christiana Leonard, NSF Dates for the submission of Phase I Human Brain Project applications for Fiscal Year 1993 and review cycles are as follows: Letter of intent April 19, 1993 Application receipt date June 15, 1993 Administrative review June, 1993 Scientific review July/August, 1993 Advisory Council review September, 1993 Earliest starting date September, 1993 Please note that although a letter of intent is not required, is not binding, and does not enter into the review of subsequent applications, the information that it contains is helpful in planning for the review of applications. In subsequent years, the dates for the submission of Phase I Human Brain Project applications and review cycles are as follows: Letter of intent July 1 Application receipt date October 15 Administrative review October Scientific review February/March Advisory Council review May/June Earliest starting date July Also note that one mechanism for support, the R01 mechanism, can be used for collaborative research initiation grants. These will foster the interactions of neuroscientists with computer and mathematical scientists or engineers to design and implement novel technological solutions to particular neuroscience questions. Program Announcement PA-93-068 The Human Brain Project: Phase I Feasibility Studies National Institute of Mental Health (NIMH) National Institute on Drug Abuse (NIDA) National Science Foundation (NSF) National Institute on Aging (NIA) National Institute on Child Health and Human Development (NICHD) National Institute on Deafness and Other Communication Disorders (NIDCD) National Center for Research Resources (NCRR) National Library of Medicine (NLM) Office of Naval Research (ONR) And National Aeronautics and Space Administration (NASA) March 1993 Introduction The Human Brain Project is a broadly based federal research initiative, supported by the National Institute of Mental Health (NIMH), the National Institute on Drug Abuse (NIDA), the National Science Foundation (NSF), the National Institute of Child Health and Human Development (NICHD), the National Institute on Aging (NIA), the National Institute on Deafness and Other Communication Disorders (NIDCD), the National Center for Research Resources (NCRR), the National Library of Medicine (NLM), and the Office of Naval Research (ONR). In addition, the National Aeronautics and Space Administration (NASA) will make available to Human Brain Project research its supercomputer and other resources of the Biocomputation Center. The general purpose of this initiative is to encourage and support investigator-initiated basic and clinical neuroscience research and investigator-initiated research on informatics resources which could be used to facilitate neuroscience research. Particular emphasis is placed on research on computer storage and manipulation of neuroscience information, network systems, and associated tools which will give neuroscientists access to the stored information. The networks will also provide electronic channels of communication and collaboration to geographically distant laboratories. Emphasis will also be placed on collaborations which result in new experimental technologies or new mathematical paradigms linked to empirical research. To optimize the utility of these technologies to neuroscience researchers, they will be developed in the context of specific neuroscience research. It is important to emphasize that the scientific question being addressed is as important as the technology being developed. Neuroscience is a vigorous, multidisciplinary field which has grown tremendously in the last two decades. This progress has, to a large extent, been fueled by information from many disciplines and across many levels of neural organization. An explosion of information at each of these levels, from gene to behavior, makes it increasingly difficult for individual neuroscientists to keep up with developments in their own circumscribed areas of interest. It is more difficult still for investigators to relate their findings to an integrated understanding of the nervous system. Yet it is precisely such integration which is necessary for the generation of meaningful hypotheses and continued rapid scientific progress. Limitations in the ability of scientists to manage and integrate information are forcing a return to the fragmented view of neuroscience which existed 30 years ago. Fortunately, computer, information, and telecommunication sciences offer solutions to this problem. The Human Brain Project will research these informatics solutions in the context of neuroscience research projects. Human Brain Project research will thus augment the ability of neuroscientists to integrate and synthesize information across disciplinary and geographic boundaries. In 1989, NIMH, NIDA and NSF requested the National Academy of Science's Institute of Medicine (IOM) to establish a Committee on a National Neural Circuitry Database. The Committee's charge was to consider the desirability, feasibility, and possible ways of implementing a family of resources, both electronic (e.g., computer networks) and digital (e.g., databases), for the enhancement of neuroscience research. After deliberations spanning almost 2 years and involving more than 150 scientific consultants, the IOM endorsed the concept of mapping the brain and its functions and issued several specific recommendations. Among these recommendations is that this initiative should be implemented in several phases by the research community. Phase I will consist of research feasibility studies which researchers will then refine and extend in Phase II. The participating agencies, institutes and center are requesting research grant applications for Phase I of the Human Brain Project. This ongoing program announcement pertains only to Phase I activities. Program Description Phase I of the Human Brain Project will support the research related to the development, storage, management, analysis, integration and dissemination of neuroscience information. This initiative will incorporate cutting-edge informatics research with neuroscience research in order to facilitate the integration of neuroscience information and to promote communication and collaboration across scientific disciplines and geographic locations. Consistent with the goal to integrate neuroscience information, the Human Brain Project research will lead to three-dimensional computerized maps and models of the structures, functions, connectivity, physiology, pharmacology, biochemistry, and molecular biology of human, monkey, and rat brains. Other mammalian, as well as nonmammalian vertebrate and invertebrate species, are also appropriate for study. It is expected that these maps and models will ultimately: span different developmental stages of organisms; reflect both normal and disease states; include numeric, textual, graphic, and image data; and be available via computer networks. Broad research objectives appropriate to the Human Brain Project include, but are not limited to, the following: o Storage and manipulation of neuroanatomical, neurochemical, neurophysiological, and other data which are portable at the source code, user interface, and platform levels o Network transmission of neuroscience data at varying levels of confidentiality o Ways to integrate neuroanatomical data, neurochemical data, neurophysiological data, and behavioral data o Approaches which permit access to and integration of information related to different areas of neuroscience (e.g., molecular biology, electrophysiology, and behavior) o Visualization of data related to the structure and function of the nervous system o Approaches for the intelligent navigation through a range of types of neuroscience information in heterogeneous environments over networks o Probabilistic, population-based anatomic atlases of brain images of normal subjects matched for handedness, age, and gender. o Approaches for the analysis of intersubject variability of structural and functional image data for circumscribed subject populations o Approaches for compression of neuroimaging data o Shared data resources and repositories for neuroscience data generated by the Human Brain Project o Ways to provide interactions between the Human Brain Project neuroscience information and pertinent national informational resources, such as those associated with the Human Genome Project o Approaches for electronic collaboration of neuroscientists o Assessment of behavior and ontogenetic brain changes in infants, children, and adolescents, particularly in populations at risk for consequently developing specific medical or behavioral disorders o Analysis and display techniques for optimizing functional brain imaging by integrating images from multiple modalities, e.g., EEG, MRI, PET, functional MRI o Ways to use neurobiologically realistic information and algorithms to guide implementation of Very Large Scale Integrated chip technologies o Use of intelligent control or neuroengineering paradigms to explain neurobiological results o Interactive graphics systems to facilitate real-time imaging o Approaches to allow interaction with stored neurobiological information to provide biological constraints on computational models o Qualitatively new types of biological sensors and sensor data processing systems o Massively parallel virtual supercomputing based on networks of small computers in multiple geographic locations to facilitate modeling of information processing in neurobiological systems. o Ways to interface humans with computers o Computerized search strategies for stored neuroscience information This list of broad objectives is meant to be illustrative and is not exclusive of other objectives appropriate to Phase I of this initiative. The Human Brain Project encourages informatics research carried out in concert with neuroscience research. This initiative will provide support either for an informatics component which is carried out with ongoing peer-reviewed neuroscience research or for both the informatics and the neuroscience components. In the former case, the funding of the neuroscience component may come from any source. Each project will be accountable for the attainment of proposed specific aims through progress reports and the timely publication and dissemination of results, including software, database designs, and source codes. Phase I projects will be investigator-initiated and can use the R01 mechanism or the P20 mechanism, explained below. As Phase I evolves, digital and electronic communication among projects will be supported. Supplemental funds may be competitively awarded to projects to support such interactions after they have been in existence for 3 years and have demonstrated the requisite capabilities within their own projects. A listing of investigators participating in Phase I, and the types of data, software, or other information that is available from or through them will be created to minimize scientifically unnecessary duplication of effort in Phase I. This list will indicate from whom particular data might be obtained. Grantees will be invited to contribute to this list and to participate in semiannual meetings of Human Brain Project investigators. These meetings will promote communication among different groups of investigators. Mechanisms This program will use R01 and P20 mechanisms. Listed below are opportunities and requirements which differ among these grant mechanisms: I. R01 Mechanism The R01 mechanism will be used for research project grants, which will allow investigators to work on highly focused projects related to the integration of neuroscience and informatics research. The R01 mechanism can be used for collaborative research initiation grants which will be directed towards fostering the interactions of computer and mathematical scientists or engineers and neuroscientists to design and implement novel technological solutions to particular neuroscience questions. Applications may include support for expenses for travel and per diem expenses to several laboratories to initiate or to explore the possibility of setting up a collaboration. It is essential that the scientific questions to be pursued and the unique contribution of each potential group member should be explicitly stated. II. P20 Mechanism These awards will provide the opportunity for multiple investigators using different approaches to focus on a common problem. P20 Exploratory Grants will facilitate coordinated communication across disciplinary and geographic boundaries. 1. Director. Each P20 Exploratory Grant will have a Director with a demonstrated ability to organize, administer, and direct the grant. The Director must commit at least 25 percent effort to the grant and be Principal Investigator on one of the projects. 2. Focus of research. The P20 Exploratory Grants will combine informatics and neuroscience research components in an effort to develop novel approaches for managing and distributing neuroscience information. Each P20 Exploratory Grant will focus on a specific research issue in neuroscience and will include investigations at multiple levels of neural organization (e.g., molecular, cellular, and systems levels) and/or using different methodological approaches (e.g., electrophysiological, anatomical and behavioral), thereby facilitating the integration of different types of neuroscience information. P20 Exploratory Grants are characterized by the synergy of their constituent projects. Each such grant application must, therefore, not only demonstrate the interrelationship of its constituent projects but also indicate how the inclusion of each project will enhance the overall goals of the grant. 3. Group members. Each P20 Exploratory Grant will comprise multiple, probably from three to five, laboratories or projects. It is expected that the Principal Investigators of the constituent laboratories or projects will be regarded as leaders in their respective fields. 4. Information sharing. In research funded by this mechanism, digital and electronic communication, especially via computer networks, will be established among different laboratories or projects within a given P20 Exploratory Grant group. An important goal of each P20 Exploratory Grant will be to develop the technology which will allow databases and computer network systems to handle and integrate data generated by all of the laboratories or projects supported by that grant. Communication among different P20 Exploratory Grant groups will promote the compatibility of the various technologies developed by each group. Therefore, digital communication, especially via computer networks, will be encouraged among different such groups. Investigators working on problems at the same level of neural organization, or using the same methodologies, are prime candidates for such interaction. Additionally, because of the pivotal role that computer networks will play in this initiative, laboratories participating in a given P20 exploratory Grant group need not all be at the same geographic location. Availability of Computational Resources The choice of computational resources to be used in Human Brain Project research is entirely that of the applicant, and the range of appropriate resources extends across the entire spectrum of computer technology. Nevertheless, some investigators may be interested in using, or collaborating with those using, supercomputers, massively parallel computers, and other advanced technology which may not be available at their institution. To facilitate such use and collaboration, the following information is provided. o The NSF supports High Performance Computer Centers and Science and Technology Centers. Individuals considering applications for supercomputer use should contact these centers early in the proposal development process. Cornell Theory Center Linda Callahan 514 Engineering and Theory Center Building Ithaca, NY 14853-3801 Phone: (607) 254-8610 Internet: cal@theory.tc.cornell.edu Bitnet: cal@CRNLTHRY National Center for Atmospheric Research, Scientific Computing Division Visitor/User Information P.O. Box 3000 Boulder, CO 80307 Phone: (303) 497-1225 Internet: scdinfo@ncar.ucar.edu Bitnet: scdinfo@ncario National Center for Supercomputing Applications Scott Lathrop 605 East Springfield Avenue Champaign, IL 61820-5518 Phone: (217) 244-1099 Internet: slathrop@ncsa.uiuc.edu Bitnet: ul3006@ncsagate Pittsburgh Supercomputing Center Robert B. Stock 4400 Fifth Avenue Pittsburgh, PA 15213 Phone: (412) 268-4960 Internet: stock@psc.edu Bitnet: stock@cpwpsca San Diego Supercomputer Center Mark Sheddon P.O. Box 85608 San Diego, CA 92186-9784 Phone: (619) 534-5130 Internet: sheddon@sdse.edu Bitnet: sheddon@sdsc o The ONR also supports a variety of supercomputer facilities. Those interested in these resources for Human Brain Project Research should contact the ONR contact listed at the end of this announcement early in the process of application development. o In addition, NASA will make available computational resources of the Biocomputation Center (BC) at Ames Research Center, Moffett Field, California. These resources include computer-controlled transmission electron microscopy for semiautomated 3 dimensional reconstruction of neural tissue, virtual environments, high-performance workstations, supercomputers, and massively parallel computers. A scientist interested in using the BC as part of Human Brain Project research will submit a written request for facility use to the BC Director prior to submitting an application to the Public Health Service. This request will state the objectives of the intended work and the approaches to be used. This request will also provide enough information to allow BC staff to assess whether the intended use is within the capability of the BC. In addition, this request will provide information necessary to allow BC staff to determine the amount of time the proposed work will require. On review of the request for BC use, the BC staff will provide the inquiring scientist with an itemized estimate of the costs for BC resources needed to achieve the stated objectives. The scientist will use this estimate as part of the budget justification in the Public Health Service application for funds to support the Human Brain Project research. Requests for BC use should be sent to: Dr. Muriel Ross Director Biocomputation Center MS 261-2 Ames Research Center Moffett Field, CA 94035-1000 Healthy People 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of Healthy People 2000, a PHS-led national activity for setting priority areas. This program announcement ("The Human Brain Project: Phase I Feasibility Studies") is related to the priority area of mental health and mental disorders (6). Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3228). Who May Submit Applications may be submitted by domestic or foreign, public or private, nonprofit or for-profit organizations such as universities, colleges, hospitals, laboratories, units of State or local governments, and eligible agencies of the Federal government. Women and minority investigators are encouraged to apply. Awards Annual awards will be made subject to continued availability of funds and progress achieved. A competing supplemental application may be submitted during an approved period of support to expand the scope of a project during the approved period. A competing continuation (i.e., renewal) application may be submitted before the end of an approved period of support to continue a project. Anticipated maximum annual budgets (direct and indirect costs) at time of award are $230,000 for the R01 mechanism and $1.1 million for the P20 mechanism. Support may be requested for a period of up to 5 years for R01 and P20 grant mechanisms (foreign grants are limited to 3 years duration). Applicants are strongly encouraged to contact the appropriate individual listed at the end of this announcement for information on specific grant mechanisms. Application Format and Content Applicants should use the grant application form PHS 398 (rev. 9/91). The number and title of the program announcement, "PA-93- THE HUMAN BRAIN PROJECT: PHASE I" should be typed in item number 2a on the face page of the PHS 398 application form. The mechanism, either R01 or P20, should be typed in item 2b on the face page of the PHS 398 application form. When applicable, consultant/collaborator information should be provided in section 7, and consortium/contractual arrangements should be provided in section 8 of the PHS 398 application form. This form may be obtained from business offices or offices of sponsored research at most universities, colleges, medical schools, and other major research facilities. If such a source is not available, any of the program officials listed below may be contacted for the necessary application material. I. R01 Mechanism: For the R01 mechanism, applicants should follow the instructions provided in grant application form PHS 398 (rev. 9/91). II. P20 Mechanism: The application must describe the specific research hypotheses to be tested and how they relate to the overall research issue addressed by the grant. In addition, the application should clearly articulate the manner in which technological components relate to neuroscience components. For the P20 Exploratory Grant applications only, the Research Plan Section of PHS Form 398 (Specific Aims, Background and Significance, Progress Report/Preliminary Studies, and Research Design and Methods) should be replaced by the following. General Description of the Overall Project (Not to exceed 10 pages) The applicant must provide an overview of the overall proposed project and its central theme and goals, describe the general objectives, and explain the proposed contribution of each of the individual projects and cores in achieving these objectives. Furthermore, the administrative arrangements and support necessary to effect the research should be carefully described in the application. In particular, when multiple institutional sites are involved, a detailed description and supporting documentation for the administrative arrangements should be included. Detailed information on collaborations, recruitment, facilities, and resources should also be provided. Cores (Not to exceed 5 pages for any one core) The applicant must describe how each core will contribute to the goals of the overall project as well as how each individual project will draw upon a particular core. The description of each core should clearly indicate the facilities, resources, services and professional skills that the facility will provide. Individual Projects (Not to exceed 15 pages for any one project) The applicant must describe the major objectives and goals of each individual project and its relationship to the effort of the entire group of constituent projects. In addition, detailed descriptions should be provided on the following: o Research Plan: The questions to be addressed and the hypotheses to be tested by the proposed research should be highly focused and fully explained. Full discussion is required on the status of current research efforts, the limitations of existing approaches, and how the research questions posed relate to the objectives of the Human Brain Project. In addition, the relationship between the neuroscience and the technological components should be made explicit. o Experimental Plan: The description of the experimental design should provide the specific strategies proposed to accomplish the specific aims of the project and should include a discussion of the innovative aspects of the approach. Nevertheless, the experimental procedures need not be spelled out in great detail if those procedures have already been extensively published and accepted by the scientific community. New methodology and its advantage over existing methodologies should, however, be fully described. Furthermore, the feasibility of the proposed experiments, the potential pitfalls, alternative approaches, and relevance to the goals of the project as a whole should be fully discussed. The methods to be used should be cited and referenced. It should be emphasized that these reduced requirements necessitate the inclusion of investigators that are considered to be leaders in their fields. o Operational Plan: A description of the resources and working arrangements required to implement the research plan should be fully elaborated. If a project includes a clinical component, attention should be devoted to a description of the clinical populations, tissue resources, etc. A distinction must be made between those resources which are already in place (including staff) and those resources which must be added to carry out the proposed research. Application Submission The signed original and five (5) legible copies of the completed application should be sent to: Division of Research Grants, NIH Westwood Building, Room 240 5333 Westbard Avenue Bethesda, Maryland 20892 It may be beneficial for applicants to contact the appropriate program official(s) listed below and submit a letter of intent. The letter should include a descriptive title of the proposed research, the name, address, and telephone number of the Principal Investigator (or Director), names of other key personnel, and participating institutions. Although a letter of intent is not required, is not binding, and does not enter into the review of subsequent applications, the information that it contains is helpful in planning for the review of applications. The letter should be submitted to Dr. Michael F. Huerta (see contact list at the end of the announcement). Each letter of intent will be distributed to all of the sponsoring agencies, institutes and center. Dates for the submission of Phase I Human Brain Project applications for Fiscal Year 1993 and review cycles are as follows: Letter of intent April 19, 1993 Application receipt date June 15, 1993 Administrative review June, 1993 Scientific review July/August, 1993 Advisory Council review September, 1993 Earliest starting date September, 1993 In subsequent years, the dates for the submission of Phase I Human Brain Project applications and review cycles are as follows: Letter of intent July 1 Application receipt date October 15 Administrative review October Scientific review February/March Advisory Council review May/June Earliest starting date July Evaluation of Applications Applications will be assigned to the appropriate agencies, institutes and center according to their goals and designs and in accordance with standard referral guidelines. Those deemed by the Division of Research Grants to be appropriate for this program announcement will be reviewed for scientific and technical merit by a special review committee (SRC) composed primarily of non- Federal scientists. The members of this committee will be determined by the participating agencies, institutes, and centers. Summaries of SRC recommendations will be sent to applicants as soon as possible after the meeting of the SRC. Subsequent processing of the application will follow the procedures of the respective agency, institute and/or center to which it has been assigned. For applications assigned to a Public Health Service (PHS) institute or center, the application will receive further review by the appropriate National Advisory Council. By law, only projects recommended for approval by Council may be considered for PHS funding. All successful projects will be identified as "A Unit of the NIH/NSF/ONR/NASA Human Brain Project." Criteria for review of applications will include the following: o Scientific, technical, or medical significance and originality of proposed research o Appropriateness and adequacy of the experimental approach and methodology proposed to carry out the research o Qualifications and research experience of the Principal Investigator and staff, particularly but not exclusively in the area of the proposed research o Availability of resources necessary to perform the research o Appropriateness of the proposed budget and duration in relation to the proposed research o Likelihood that the work will lead to significant integration of informatics and neuroscience research, to new discoveries, and/or to new technological developments o Feasibility and adequacy of the organizational and administrative plans o Mechanisms to evaluate the progress of the project o Adequacy of the project's plans for the protection of human and animal subjects Criteria for grant awards include the following: o Intrinsic interest of the neuroscience problem o Scientific merit of the proposed research o Responsiveness to the objectives outlined in this announcement and relevance of the research to the mission of the Human Brain Project o Availability of research funds and competing demands of other research funding requirements SPECIAL INSTRUCTIONS TO APPLICANTS REGARDING IMPLEMENTATION OF NIH POLICIES CONCERNING INCLUSION OF WOMEN AND MINORITIES IN CLINICAL RESEARCH STUDY POPULATIONS Applications for grants that involve human subjects are required to include minorities and both genders in study populations so that research findings can be of benefit to all persons at risk of the disease, disorder or condition under study; special emphasis should be placed on the need for inclusion of minorities and women in studies of diseases, disorders and conditions which disproportionately affect them. This policy applies to all research involving human subjects and human materials, and applies to males and females of all ages. If one gender and/or minorities are excluded or are inadequately represented in this research, particularly in proposed population-based studies, a clear compelling rationale for exclusion or inadequate representation should be provided. The composition of the proposed study population must be described in terms of gender and racial/ethnic group, together with a rationale for its choice. In addition, gender and racial/ethnic issues should be addressed in developing a research design and sample size appropriate for the scientific objectives of the study. Applicants are urged to assess carefully the feasibility of including the broadest possible representation of minority groups. However, it is recognized that it may not be feasible or appropriate in all research projects to include representation of the full array of United States racial/ethnic minority populations (i.e., American Indians or Alaskans Natives, Asians or Pacific Islanders, Blacks and Hispanics). Investigators must provide the rationale for studies on single minority population groups. Applications for support of research involving human subjects must employ a study design with minority and/or gender representation (by age distribution, risk factors, incidence/prevalence, etc.) appropriate to the scientific objectives of the research. It is not an automatic requirement for the study design to provide statistical power to answer the questions posed for men and women and racial/ethnic groups separately; however, whenever there are scientific reasons to anticipate differences between men and women, and racial/ethnic groups, with regard to the hypothesis under investigation, applicants should include an evaluation of these gender and minority group differences in the proposed study. If adequate inclusion of one gender and/or minorities is impossible or inappropriate with respect to the purpose of the research, because of the health of the subjects, or other reasons, or if in the only study population available, there is a disproportionate representation of one gender or minority/majority group, the rationale for the study population must be well explained and justified. The funding components will not make awards of grants, cooperative agreements or contracts that do not comply with this policy. For research awards which are covered by this policy, awardees will report annually on enrollment of women and men, and on the race and ethnicity of subjects. Protection of Human Subjects The Department of Health and Human Services has regulations for the protection of human subjects and has developed additional regulations for the protection of children. A copy of these regulations (45 CFR 46, Protection of Human Subjects) and those pertaining specifically to children are available from the Office of Protection from Research Risks, National Institutes of Health, Bethesda, Maryland 20892, telephone (301) 496-7041. Specific questions concerning protection of human subjects in research may be directed to NIMH staff listed under "Contacts." Availability of Funds It is estimated that approximately $4-5 million will be available to support new grants under this announcement in fiscal year 1993. The exact amount of funding available will depend on appropriated funds, the quality of applications, and program priorities at the time of award. Contacts The following representatives from each of the participating agencies, institutes and center can be contacted for further information or clarification. Potential applicants are strongly encouraged to contact the agency or institute representative to discuss their plans prior to preparing an application. Michael F. Huerta, Ph.D. National Institute of Mental Health 5600 Fishers Lane, Room 11-95 Rockville, Maryland 20857 Phone: (301) 443-3948 Fax: (301) 443-4822 E-mail: HMI@CU.NIH.GOV Christine R. Hartel, Ph.D. National Institute on Drug Abuse 5600 Fishers Lane, Room 10A-31 Rockville, Maryland 20857 Phone: (301) 443-1887 Fax: (301) 227-6043 E-mail: CHARTEL@AOADA.SSW.DHHS.GOV Christiana Leonard, Ph.D. National Science Foundation 1800 G Street, N.W., Room 321 Washington, D.C. 20550 Phone: (202) 357-7041 Fax: (202) 357-7846 E-mail: CMLEONAR@NSF.GOV Deborah Claman, Ph.D. National Institute on Aging Gateway Building, Room 3C307 7201 Wisconsin Avenue Bethesda, Maryland 20872 Phone: (301) 496-9350 Fax: (301) 496-1494 E-mail: CLAMAN@NIHNIAGW Norman Krasnegor, Ph.D. National Institute of Child Health and Human Development 6100 Building, Room 4B05 9000 Rockville Pike Bethesda, Maryland 20892 Phone: (301) 496-6591 Fax: (301) 402-2085 E-mail: KRASNEGN@NICHD01:NIH Judith Cooper, Ph.D. National Institute on Deafness and Other Communication Disorders EPS, Room 400B 6120 Executive Boulevard Rockville, MD 20852 Phone: (301) 496-5061 Fax: (301) 402-6251 Charles L. Coulter, Ph.D. National Center for Research Resources Westwood Building, Room 8A15 5333 Westbard Ave. Bethesda, MD 20892 Phone: (301) 496-5411 Fax: (301) 480-4691 E-mail: CCO@CU.NIH.GOV Peter A. Clepper National Library of Medicine Building 38A, Room 5S518 Bethesda, MD 20894 Phone: (301) 496-4221 Fax: (301) 402-0421 E-mail: CLEPPER@NLM.NIH.GOV Terry Allard, Ph.D. Office of Naval Research Department of the Navy 800 N. Quincy Street, Room 1142 Arlington, Virginia 22217-5660 Phone: (703) 696-4502 Fax: (703) 696-1212 E-mail: TERRY@TOMCAT.ONR.NAVY.MIL Frank M. Sulzman, Ph.D. National Aeronautics and Space Administration Code SBM NASA Headquarters Washington, D.C. 20546 Phone: (202) 358-2359 Fax: (202) 358-4168 E-mail: FSULZMAN@SMTPGMGW.OSSA.HQ.NASA.GOV The National Institute of Neurological Disorders and Stroke (NINDS) and the National Eye Institute (NEI), while not cosponsors of this Program Announcement, have continuing interest in the scientific areas related to the Human Brain Project. NINDS and NEI will continue to fund research on these topics through applications received through the regular receipt and referral processes of the Division of Research Grants. Applicants should contact the relevant NINDS or NEI program staff for further information. Authority and Regulations This program is described in the Catalogue of Federal Domestic Assistance Nos. 93.242 (NIMH), 93.279 (NIDA), 47.074 (NSF), 93.866 (NIA), 93.865 (NICHD), 93.173 (NIDCD), 93.371 (NCRR), 93.879 (NLM) and 12.300 (ONR). Awards are made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grants policies and Federal regulations 42 CFR 52 and 45 CFR part 74. Applications submitted in response to this announcement are not subject to the intergovernmental review requirements of Executive Order 12372 as implemented through Department of Health and Human Services regulations at 45 CFR part 100 or Health Systems Agency Review. From owner-sci-resources@net.bio.net Wed Apr 14 23:00:00 1993 Path: biosci!NET.BIO.NET!kristoff From: kristoff@NET.BIO.NET (Dave Kristofferson) Newsgroups: bionet.sci-resources Subject: NIH Guide, vol. 22, no. 15, pt. 2, 16 April 1993 Message-ID: Date: 15 Apr 93 22:44:07 GMT Sender: kristoff@net.bio.net Distribution: bionet Lines: 992 $$XID NIHGUIDE 19930416 V22N15 P2O2 ************************************ application must be sent to: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** REVIEW CONSIDERATIONS Applications will be reviewed for scientific and technical merit by an initial review group (IRG) composed primarily of non-Federal scientific experts. Final review is by the appropriate national advisory council; review by council may be based on policy considerations as well as scientific merit. By law, only applications recommended for consideration for funding by the council may be supported. Summaries of IRG recommendations are sent to applicants as soon as possible following IRG review. Criteria to be considered in evaluating applications for scientific/technical merit include: o Scientific, technical, or medical significance and originality of the proposed research o Appropriateness and adequacy of the research approach and methodology proposed to carry out the research o Qualifications and research experience of the Principal Investigators and staff, particularly, but not exclusively, in the area of the proposed research o Availability of resources necessary to the research o Appropriateness of the proposed budget and duration in relation to the proposed research o Adequacy of the proposed means for protecting against or minimizing adverse effects to human and/or animal subjects AWARD CRITERIA As part of the NIMH Public-Academic Liaison (PAL) initiative, special encouragement is given to applications that involve active collaborations between academic researchers and public sector agencies in planning, undertaking, analyzing, and publishing research pertaining to persons with severe mental illness. The PAL initiative is based on the premise that important new advances in understanding and treatment of severe mental illness can result from improved linkages between the Nation's scientific resources and the public sector agencies and programs in which many persons with severe mental illness receive their care. The scope of the PAL initiative encompasses public sector agencies of all types that deal with children, adolescents, adults, and elderly persons with severe mental disorders. Factors considered in determining which applications will be funded include IRG and Council recommendations, PHS program needs and priorities, and availability of funds. INQUIRIES NIMH staff are available for consultation concerning the development of an application in advance of or during the process of preparing an application. Potential applicants are encouraged to contact NIMH as early as possible for information and assistance in initiating the application process and developing an application. The NIMH program staff member listed below may be contacted for further information and assistance. Kimberly E. Hoagwood, Ph.D. Division of Epidemiology and Services Research National Institute of Mental Health 5600 Fishers Lane, Room 10C-06 Rockville, MD 20857 Telephone: (301) 443-4233 For further information on grants management issues, applicants may contact: Diana S. Trunnell Grants Management Branch National Institute of Mental Health 5600 Fishers Lane, Room 7C-15 Rockville, MD 20857 Telephone: (301) 443-3065 AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance 93.242, Mental Health Research Grants. Awards are made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grants policies and Federal Regulations 42 CFR 52 and 45 CFR Part 74. This announcement is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. $$P1 END ************************************************************ $$P2 BEGIN PA-93-076 ************************************************ HEALTH AND EFFECTIVE FUNCTIONING IN THE MIDDLE AND LATER YEARS NIH Guide, Volume 22, Number 15, April 16, 1993 PA NUMBER: PA-93-076 P.T. 34; K.W. 0710010, 0745035, 0414014, 0404000 National Institute on Aging PURPOSE The National Institute on Aging (NIA) invites the submission of research and career grant applications for projects designed to specify how psychosocial processes, interacting with biological processes, influence health and functioning in the middle and later years of life. This program announcement is part of the broad program of the NIA, which was established by law in 1974 for the conduct and support of biomedical, social, and behavioral research and training related to the aging process and the diseases and other special problems and needs of the aged. Under this mandate, health and well-being are viewed as the outcome of complex psychological, social, environmental, physiological, and medical processes. Four principles guiding NIA research are: (1) the dynamic character of aging as a process, and of social and historical changes that affect the age structure of society and the ways in which individuals age; (2) the interrelatedness of old age with earlier age; (3) the social, cultural, and individual variability of aging; and (4) the continuing interplay between psychosocial and biomedical aging processes. This initiative is coordinated with related programs in other agencies, including the National Institute of Child Health and Human Development, the National Institute of Mental Health, and the National Center for Nursing Research. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This program announcement, Health and Effective Functioning in the Middle and Later Years, is related to the priority area of age-related objectives for adults and older adults. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Applications may be submitted by foreign and domestic, for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal Government. Applications from minority individuals and women are encouraged. Foreign institutions are not eligible to apply for program projects (P01) or First Independent Research Support and Transition (FIRST) (R29) awards and can apply for National Research Service Training Awards (F32, F33) only if the applicant is a U.S. citizen or resident alien. Applicants for F32 and F33 awards must be U.S. citizens or resident aliens. MECHANISM OF SUPPORT The mechanisms of support for this program are the research grant (R01), the anticipated average award (direct costs) is $150,000 per year; the FIRST award (R29); program projects (P01); and Fellowships (F32, F33). RESEARCH OBJECTIVES The 20th century's triumph of extension of life means not only that the numbers of old people are increasing, but that more and more individuals can look forward to living out their lives to the full. As life expectancy has been extended, the proportion of adult life that might be spent in retirement has also increased. However, it remains to be seen whether and how people will benefit from these added years. How can the relatively vigorous health, effective functioning, and productivity of the middle years be continued into the later years? How can disability and dependency be postponed until the last years of the extended life course? Research findings suggest how the productive middle years might be extended, how many disabilities of old age might be prevented or postponed, and how the costs of health care and dependency might be contained. For example, intellectual decline with aging (when it occurs) can often be slowed or reversed by relatively simple training interventions; older people can often learn to compensate for declines in reaction time, memory, and other age-related deficits (e.g., through mnemonic strategies, carefulness, and persistence); for the visual impairments suffered by many older people, particular styles and sizes of type can facilitate reading, and training can improve the functional field of view and reduce a significant risk factor for driving accidents; food can be adapted to the age-related changes in taste and smell that influence eating behaviors; health can be promoted through changes in self-care behaviors and/or lifestyle (e.g., smoking, diet, and exercise) across the lifespan; illness can often be alleviated through social supports and improved coping behaviors; and many serious disabilities (even when experienced in nursing homes) can be reduced by regimens that reward activity and independence. Biological, psychological, and social processes of growing old are to a considerable extent malleable. However, the mechanisms and conditions that influence health and functioning during the middle and later years remain to be specified. NIA's goal in issuing this program announcement is to encourage basic research studies of these mechanisms and conditions that can extend the productive middle years of life by preventing, postponing, or reversing disabilities of old age. Specific Objectives Many research issues fall within the realm of health and effective functioning in the middle and later years. The following are offered as illustrations of appropriate topics. Applications need not, however, be limited to these issues. The PHS referral guidelines will be followed in assigning applications to the NIA or to other Institutes. The NIA will support research that extends the knowledge base underlying the provision of health services for the aging and the aged. However, the NIA does not support demonstration, control, and evaluation projects nor the provision of services per se. Services may be one of the "experimental" variables in a proposed study. 1. Work and Retirement (See Program Announcements on Economics of Aging, Health, and Retirement; on Cognitive Functioning and Aging; and Human Factors Research on Older People) o Aspects of work situations that stimulate intellectual competence, provide incentives and opportunities for sustained or enhanced performance. o Factors influencing vigor, intellectual functioning, memory, and other physical and psychological capacities, and motivations for continuing productivity and creativity. o Processes and conditions associated with retirement that influence physical and mental functioning. o Age-related disabilities specific to particular occupations; organizational and technological (human factors) innovations to remedy or compensate for these deficits. 2. Health Institutions (See Program Announcements on Aging and Formal Health Care; Home Health Care and Aging) o Psychological and social factors that reduce the need for long-term care of older people; alternatives to institutionalization. o Influence of institutionalization on health and functioning of the institutionalized elderly and of their significant others (spouse, children, other relatives, friends). o Psychosocial factors in the diagnosis and treatment of elderly by health-care practitioners, including clinical decision-making and treatment outcomes. o The influence of the organization of health care and related social institutions on health outcomes and quality of life for older people. 3. Social Support o Changes and stabilities in social networks as protections against disabilities in the middle and later years. o Positive and negative consequences of social relationships for health and functioning. 4. Health Behaviors and Attitudes (See Program Announcement on Health Behaviors and Aging: Psychosocial Geriatrics Research; Women's Health over the Life Course) o Biopsychosocial linkages between health and behavior and interacting influences of aging processes. o Age and/or cohort differences in health behaviors, attitudes, and beliefs (e.g., symptom recognition and care-seeking). o Factors influencing initiating and maintaining health behaviors associated with promoting health and preventing disease and disability. o Factors affecting adherence to prescribed therapies. o Ways of coping with stress, ranging from "daily hassles" to life-threatening events. 5. Personality and Self Concept (See Program Announcement on Sense of Control throughout the Life Course) o Etiology and developmental course of disease-prone personality configurations over the life course. o Nature, antecedents, and consequences of "sense of control" throughout the life course. o Individual differences in psychological and physiological response to chronic or persistent stressful situations. 6. Family and Household o Changes in household composition and resources and their interaction with health and functioning. o Family and household decision-making, and patterns of intergenerational exchanges of material and emotional support. 7. Cultural, Demographic, and Socioeconomic Variation o The processes or variables through which socioeconomic status affect health and effective functioning over the life course. o Health and effective functioning in special populations such as the very elderly, retarded, or rural older people. (See Program Announcements on the Oldest Old; Older Rural Populations; and Aging of Retarded Adults.) o Ethnic group and minority population variations in the processes affecting health and effective functioning. 8. Methodological Studies In addition to substantive topics, applications are sought for methodological projects that promise improved understanding of the complex processes that influence health and effective functioning in the middle and later years. (See, for example, Program Announcement on Forecasting Life and Health Expectancy in Older Populations.) o Improved longitudinal designs for examining the linkages between psychosocial and biomedical aging processes. o Development of cohort-comparative, cross-cultural, and historical-comparative designs for examining the interrelationship between societal changes and variations in the individual aging process. o Development of statistical and mathematical models of age-related behavioral changes that are suitable for the analysis of longitudinal and cohort-comparative data. o Improved measures of health, productivity, and functioning, suitable for use in the field or in the laboratory. o Development and improvement of measures of human performance and functioning suitable for tracing changes over the full life course. o Development of innovative qualitative or ethnographic methodologies, especially as related to studies of older special populations. Methodology While research applications need not be limited to any particular methodology of data collection or analysis, the use of objective, reliable, and valid measures of psychosocial, or biological health and performance is essential. Consideration should be given to the relative advantages and disadvantages of cross-sectional vs. longitudinal or cohort designs, or to the use of experimental and quasi-experimental designs in a variety of settings (including the laboratory, health-care institutions, the residence, the community, and the workplace). Given the expense associated with collecting original data, the secondary analysis of pre-existing data sets is encouraged. (The NIA sponsors the National Archive for Computerized Data on Aging at the Inter-university Consortium for Political and Social Research, University of Michigan, Ann Arbor, MI 48106-1248.) In many instances, however, the collection of new data may be required to meet particular objectives. STUDY POPULATIONS SPECIAL INSTRUCTIONS TO APPLICANTS REGARDING IMPLEMENTATION OF NIH POLICIES CONCERNING INCLUSION OF WOMEN AND MINORITIES IN CLINICAL RESEARCH STUDY POPULATIONS NIH policy is that applicants for NIH clinical research grants and cooperative agreements are required to include minorities and women in study populations so that research findings can be of benefit to all persons at risk of the disease, disorder or condition under study; special emphasis must be placed on the need for inclusion of minorities and women in studies of diseases, disorders, and conditions that disproportionately affect them. This policy is intended to apply to males and females of all ages. If women or minorities are excluded or inadequately represented in clinical research, particularly in proposed population-based studies, a clear compelling rationale must be provided. The composition of the proposed study population must be described in terms of gender and racial/ethnic group. In addition, gender and racial/ethnic issues should be addressed in developing a research design and sample size appropriate for the scientific objectives of the study. This information must be included in the form PHS 398 in Sections 1-4 of the Research Plan AND summarized in Section 5, Human Subjects. Applicants are urged to assess carefully the feasibility of including the broadest possible representation of minority groups. However, NIH recognizes that it may not be feasible or appropriate in all research projects to include representation of the full array of United States racial/ethnic minority populations (i.e., Native Americans (including American Indians or Alaskan Natives), Asian/Pacific Islanders, Blacks, Hispanics). The rationale for studies on single minority population groups must be provided. For the purpose of this policy, clinical research is defined as human biomedical and behavioral studies of etiology, epidemiology, prevention (and preventive strategies), diagnosis, or treatment of diseases, disorders or conditions, including but not limited to clinical trials. The usual NIH policies concerning research on human subjects also apply. Basic research or clinical studies in which human tissues cannot be identified or linked to individuals are excluded. However, every effort should be made to include human tissues from women and racial/ethnic minorities when it is important to apply the results of the study broadly, and this should be addressed by applicants. For foreign awards, the policy on inclusion of women applies fully; since the definition of minority differs in other countries, the applicant must discuss the relevance of research involving foreign population groups to the United States' populations, including minorities. If the required information is not contained within the application, the review will be deferred until the information is provided. Peer reviewers will address specifically whether the research plan in the application conforms to these policies. If the representation of women or minorities in a study design is inadequate to answer the scientific question(s) addressed AND the justification for the selected study population is inadequate, it will be considered a scientific weakness or deficiency in the study design and will be reflected in assigning the priority score to the application. All applications for clinical research submitted to NIH are required to address these policies. NIH funding components will not award grants or cooperative agreements that do not comply with these policies. APPLICATION PROCEDURES Receipt dates for applications are as follows: F-series grants: Apr 5, Aug 5, and Dec 5 New P01 and R-series: Feb 1, Jun 1, and Oct 1 Competing renewal and revisions: Mar 1, Jul 1, and Nov 1 Applications are to be submitted on grant application form PHS 398 (rev. 9/91) for research project and program project grants, PHS 416-1 (rev. 10/91) for Individual Fellowships, Applications will be accepted at the standard receipt dates as indicated in the application kit. The title and number of this announcement must be typed in Section 2a on the face page of the application. Application kits are available at most institutional offices of sponsored research and may be obtained from the Office of Grants Inquiries, Division of Research Grants, National Institutes of Health, Westwood Building, Room 449, Bethesda, MD 20892, telephone 301/594-7248. The original application and five copies of PHS 398 or two copies of PHS 416-1 must be sent to: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** REVIEW PROCEDURES Applications will be assigned on the basis of established PHS referral guidelines. Applications will be reviewed for scientific and technical merit in accordance with the standard NIH peer review procedures. Following scientific-technical review, the applications will receive a second-level review by the appropriate national advisory council. AWARD CRITERIA Applications recommended for further consideration by an appropriate Advisory Council will be considered for funding on the basis of overall scientific, clinical, and technical merit of the proposal as determined by peer review, appropriateness of budget estimates, program needs and balance, policy considerations, adequacy of provisions for the protection of human subjects, and availability of funds. INQUIRIES Written and telephone inquiries are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues to: Ronald P. Abeles, Ph.D. Behavioral and Social Research National Institute on Aging Gateway Building, Room 2C234 Bethesda, MD 20892 Telephone: (301) 496-3136 Direct inquiries regarding fiscal matters to: Ms. Linda Whipp Office of Grants and Contracts National Institute on Aging Gateway Building, Room 2N212 Bethesda, MD 20892 Telephone: (301) 496-1472 AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.866. Awards are made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grants policies and Federal Regulations 42 CFR 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. $$P2 END ************************************************************ $$P3 BEGIN PA-93-077 ************************************************ PERCEPTUAL AND COGNITIVE AGING: FROM STRUCTURE TO FUNCTION NIH Guide, Volume 22, Number 15, April 16, 1993 PA NUMBER: PA-93-077 P.T. 34; K.W. 0710010, 0414005 National Institute on Aging PURPOSE This program announcement seeks to encourage researchers with a strong background in cognition or perception, as well as those currently studying aging processes, to explore outcome variables of significance to middle-aged and older adults. Such outcome variables include, but are not limited to, independent activities of daily living, health status, financial status, and social relations. Applications exploring the role of affective processes, their interrelations with cognitive and perceptual processes and their contribution to functional outcome are also welcome. The announcement further specifies and extends the NIA initiative on Cognitive Functioning and Aging (NIH Guide for Grants and Contracts, Vol. 16, No. 41, December 18, 1987). It does not replace that announcement. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priorities. This Program Announcement, Perceptual and Cognitive Aging: From Structure to Function, addresses several priority areas, including chronic disabling conditions, physical activity and fitness, violent and abusive behavior, and unintentional injuries as they relate to older people. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202/783-3238). ELIGIBILITY REQUIREMENTS Applications may be submitted by foreign and domestic, for-profit and non-profit, public and private organizations such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal government. Women and minority investigators are encouraged to apply. Only domestic organizations are eligible to receive First Independent Research Support and Transition (FIRST) (R29) awards. MECHANISM OF SUPPORT This program announcement will use the National Institutes of Health (NIH) individual research grant (R01) and FIRST (R29) award mechanisms. Responsibility for the planning, direction, and execution of the proposed project will be solely that of the applicant. Support will be provided for a period of up to five years (renewable for subsequent periods), subject to continued availability of funds and progress achieved. Average direct costs of R01 awards were approximately $150,000 in FY 1992. Costs of individual projects vary widely. Direct costs of FIRST awards are capped at $100,000 in any one year and $350,000 across all years. RESEARCH OBJECTIVES Summary The overall objectives are to use what is known about cognitive and perceptual process in the general population and especially among middle-aged and older adults to explore outcome variables of significance to middle-aged and older adults. Do the age differences reported in numerous laboratory studies have significance for the functioning of normal middle-aged and older adults? Do the improvements observed after training or other kinds of intervention imply that similar improvements are possible in functioning in everyday contexts? Much is known about structure and process in cognition and perception, and the influence of aging upon them. That research has yielded a rich vocabulary of concepts and models, much of it useful in characterizing cognitive and perceptual aging (e.g., Salthouse, 1991; Hasher and Zacks, 1988). An integral part of testing the value of these concepts and models is examining their usefulness in spawning applications. An important research task, then, is to make the connection between the emerging web of revealed abilities and the challenges encountered by middle-aged and older adults. Applications in these areas will both enrich theory and methodology in cognition and perception, and also generate improvements in the lives of the relevant population. A smaller but growing area of the field is already focusing on the functional consequences of age differences in structure and process. For example, there is increasing research interest in the relations among perceptual/cognitive function and driving crashes and mobility among older adults (e.g., Owsley, Ball, Sloan, Roenker, and Bruni, 1991). Also a number of investigators have explored the relation between memory performance among older adults and adherence to medication schedules (e.g., Morrell, Park and Poon, 1990). Others are making connections among working memory, expertise, and the competency of older pilots (e.g., Morrow, Leirer and Altieri, 1992). The focus on relating intellectual and perceptual abilities to functional outcome offers several different research strategies. One such strategy is intervention research. Such research can both offer a scientific test of the role of hypothesized abilities on functional performance and generate practical strategies to improve performance. Another strategy is developing assessment tools for varied settings that yield satisfactory predictive validity for the relevant functional activity. However, the normal scientific process of developing theories and collecting data to establish relations among mental abilities, structures and processes, on the one hand, and relevant domains of function, on the other hand, is an important precursor to attaining these goals, and an important end in its own right. Therefore, individual applications are encouraged that focus on (1) developing a theoretically-guided and empirically-supported relationship between ability and outcome, (2) using such data to develop and validate assessment tools, (3) theoretically-guided and empirically-supported intervention research, or, on some combination of these aims. Applications using other research strategies to relate perceptual and cognitive structures and processes to functional outcome are also welcome. The research questions that are described below are illustrative only. Applications on other topics are also welcome. In each case, researchers are encouraged to build a connection between existing theories, models and paradigms in cognition and perception and the particular functional areas described. o How do cognitive strategies and processes used in evaluating advertising claims and similar product information vary by age? Do these variations affect decisions? When affect is involved in such evaluation, are age-related differences more or less apparent than under more neutral conditions? o Do older, middle-aged, and younger adults use similar heuristics and strategies in decision making? How are such heuristics affected by relevance of the decisions to problems and demands experienced by the different groups? o How well do measures of fluid ability predict need for assistive services in later adulthood? o In what ways can knowledge of comprehension and memory processes benefit the design of health insurance and other benefit forms used by older adults? o Does hearing impairment act to reduce the quality and number of social interactions, introduce negative affect, and thus contribute indirectly to increased use of services and avoidance of social interaction? o What are the relations among social network size, perceived quality of network connections, and cognitive functioning in older old adults? o What aspects of the cognitive and perceptual functioning of older adults facilitate or limit adherence to treatment, management, and monitoring schedules? o How can medical devices be best designed to suit the cognitive, and perceptual limitations of frail older users? o In what ways can knowledge of the comprehension and decision making processes of older adults facilitate health professionals' communication with them? o How do cognitive and perceptual factors that differ by age influence the detection, recognition, and avoidance of risk in natural situations, involving immediate risk (e.g., crossing the street as a pedestrian) and delayed risk (e.g., health dangers associated with eating habits)? o Given current knowledge of factors involved in driving crashes among older adults, how can risk of injury be reduced in this population without compromising their mobility? o What cognitive, perceptual, and affective factors predict preventive health behaviors among older adults (e.g., screening for age-associated conditions and diseases, influenza vaccination)? Methodology A sound research plan is essential. Most critical is achieving adequate between-individual variation in the intellectual abilities to be studied and choosing measures of outcome that are susceptible to analysis and yield sufficient data given the sampling strategy of the proposed work. Such a strategy will allow powerful tests of the hypothesized relation between ability level and functional outcome. Age-varied designs (e.g., young versus old, young-old versus old-old) may elucidate the relationship between ability and functional outcome where there are clear reasons for expecting different relations between ability and functional outcome among groups of different ages. Because of the stress on functional outcome, designs will likely require the assessment of function in some field setting. For some measures, available statistics may already exist (e.g., state records of driving crashes). However, for other measures (e.g., assessment of errors in personal financial management) new methodologies and instruments for data collection may have to be developed. Grant applications focusing on such development are welcome provided that they are themselves rooted in a strong theoretical and empirical base. Researchers may wish to use advances in voice-mail technology, in electronic recording of individual events, and in portable computers to assist in data-gathering in field settings. STUDY POPULATIONS NIH POLICY CONCERNING INCLUSION OF MINORITIES AND WOMEN AS SUBJECTS IN RESEARCH Applications for clinical research grants and cooperative agreements that involve human subjects are required to include minorities and both genders in study populations so that research findings can be of benefit to all persons at risk of the disease, disorder, or condition under study; special emphasis should be placed on the need for inclusion of minorities and women in studies of diseases, disorders, and conditions which disproportionately affect them. This policy applies to all research involving human subjects and human materials, and applies to males and females of all ages. If one gender and/or minorities are excluded or are inadequately represented in this research, particularly in proposed population-based studies, a clear, compelling rationale for exclusion or inadequate representation should be provided. The composition of the proposed study population must be described in terms of gender and racial/ethnic group, together with a rationale for its choice. In addition, gender and racial/ethnic issues should be addressed in developing a research design and sample size appropriate for the scientific objectives of the study. Applicants are urged to assess carefully the feasibility of including the broadest possible representation of minority groups. However, NIH recognizes that it may not be feasible or appropriate in all research projects to include representation of the full array of United States racial/ethnic minority populations (i.e., American Indians or Alaskan Natives, Asians or Pacific Islanders, Blacks, Hispanics). Investigators must provide the rationale for studies on single minority population groups. Applications for support of research involving human subjects must employ a study design with minority and/or gender representation (by age distribution, risk factors, incidence/prevalence, etc.) appropriate to the scientific objectives of the research. It is not an automatic requirement for the study design to provide statistical power to answer the questions posed for men and women and racial/ethnic groups separately; however, whenever there are scientific reasons to anticipate differences between men and women, and racial/ethnic groups, with regard to the hypothesis under investigation, applicants should include an evaluation of these gender and minority group differences in the proposed study. If adequate inclusion of one gender and/or minorities is impossible or inappropriate with respect to the purpose of the only study population available, or there is a disproportionate representation of one gender or minority/majority group, the rationale for the study population must be well explained and justified. The NIH funding components will not make awards of grants, cooperative agreements or contracts that do not comply with this policy. For research awards which are covered by this policy, awardees will report annually on enrollment of women and men, and on the race and ethnicity of subjects. APPLICATION PROCEDURES Applications are to be submitted on the grant application form PHS 398 (rev. 9/91) and will be accepted at the standard application deadlines as indicated in the application kit. Application kits are available at most institutional offices of sponsored research and may be obtained from the Office of Grant Inquiries, Division of Research Grants, National Institutes of Health, Westwood Building, Room 240, Bethesda, MD 20892, telephone (301) 594-7248. The title and number of the announcement must be typed in Section 2a on the face page of the application. Applicants for FIRST awards should note that three letters of reference must be submitted with the application. The completed original and five permanent, legible copies of the PHS 398 form must be submitted to: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** REVIEW PROCEDURES Applications received under this announcement will be assigned to an initial review group (IRG) in accordance with established PHS referral guidelines. The IRGs, consisting primarily of non-Federal scientific and technical experts, will review the applications for scientific and technical merit in accordance with the standard NIH peer review procedures. Notification of the review recommendations will be sent to the applicant after the initial review. Applications will receive a second-level review by an appropriate National Advisory Council, whose review may be based on policy considerations as well as scientific merit. Only applications recommended for further consideration by the Council may be considered for funding. AWARD CRITERIA Applications recommended for further consideration by an appropriate advisory council will be considered for funding on the basis of overall scientific, clinical, and technical merit of the proposal as determined by peer review, appropriateness of budget estimates, program needs and balance, policy considerations, adequacy of provisions for the protection of human subjects, and availability of funds. INQUIRIES Written and telephone inquiries are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues to: Dr. Robin A. Barr Behavioral and Social Research National Institute on Aging Gateway Building, Room 2C234 Bethesda, MD 20892 Telephone: (301) 496-3136 FAX: (301) 402-0051 E-mail: Barr@NIHNIAGW.BITNET Questions on fiscal matters may be directed to: Ms. Linda Whipp Grants and Contracts Management National Institute on Aging Gateway Building, Room 2N212 Bethesda, MD 20892 Telephone: (301) 496-1472 AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance, No. 93.866. Awards are made under the authority of the Public Health Service Act, Section 301 (42 USC 241) and administered under PHS grants policies and Federal Regulations, most specifically at 42 CFR Part 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. References Hasher, L. & Zacks, R.T. (1988). Working memory, comprehension and aging: A review and a new view. In G.H. Bower (Ed.) The psychology of learning and motivation: Vol. 22 (pp. 193-225). San Diego, CA, Academic Press. Morrell, R.W., Park, D.C. & Poon, L.W. (1990). Effects of labeling techniques on memory and comprehension of prescription information in young and old adults. Journal of Gerontology: Psychological Sciences, 45, P166-172. Morrow, D.G., Leirer, V.O. & Altieri, P.A. (1992). Aging, expertise and narrative processing. Psychology and Aging, 7, 376-388. Owsley, C., Ball, K., Sloan, M.E., Roenker, D.L & Bruni, J.R. (1991). Visual/cognitive correlates of vehicle accidents in older drivers. Psychology and Aging, 6, 403- 415. Salthouse, T.A. (1991). Theoretical perspectives on cognitive aging. Hillsdale, NJ: Lawrence Erlbaum Associates. $$P3 END ************************************************************ ERRATUM $$E1 BEGIN R2 19930409 APPEND RFA HL-93-014 FULL *********************** IN UTERO STEM CELL TRANSPLANTATION FOR GENETIC DISEASES NIH Guide, Volume 22, Number 15, April 16, 1993 RFA: HL-93-014 P.T. 34; K.W. 0715032, 0745065, 0755020 National Heart, Lung, and Blood Institute Letter of Intent Receipt Date: October 1, 1993 Application Receipt Date: November 17, 1993 The RESEARCH OBJECTIVES for RFA HL-93-014 were incorrectly transmitted in the electronic NIH Guide, Vol. 22, No. 14, April 9, 1993. The corrected version appears below. RESEARCH OBJECTIVES In the past twenty years, allogeneic bone marrow transplantation increasingly has become used as a cure for a variety of genetic defects of the hematopoietic and immune systems and for lysosomal storage diseases. Genetic diseases that have been successfully cured by bone marrow transplantation include Cooley's anemia, sickle cell anemia, Fanconi anemia, Blackfan-Diamond anemia, severe combined immunodeficiency, Wiskott-Aldrich syndrome, ataxia telangiectasia, infantile agranulocytosis, Chediak-Higashi disease, chronic mucocutaneous candidiasis, mucopolysaccharidosis, cartilage-hair hypoplasia, Gaucher's and other storage diseases. Some of these diseases, such as Cooley's anemia (beta-thalassemia) and sickle cell anemia, are major worldwide public health problems. Others are devastating orphan diseases that are extremely costly to treat. Genetic diseases that cause death in utero, such as homozygous alpha-thalassemia, may also possibly be cured by in utero stem cell transplantation. Collectively, these diseases occur in tens-of-thousands of births per year. However, conventional bone marrow transplantation has several drawbacks: (1) only about 35 percent of transplant candidates will have a suitably matched marrow donor; (2) the long-term effects of the preparative regimen of lethal doses of irradiation and/or cytotoxic drugs are not known; (3) post-transplant complications such as infection and graft-versus-host disease are significant and contribute to the morbidity and mortality of the procedure; (4) for some diseases, the disease process has caused irreversible damage prior to the transplant; and (5) the significant cost of the procedure which could be as much as $250,000, not including the possible long-term care for chronic graft-versus-host disease. In the sheep and monkey animal models, recent progress seems to indicate that donor fetal liver hematopoietic stem cells can be successfully transplanted into an unrelated pre-immune recipient fetus. After birth, the chimeric animals still appear healthy and normal up to five years post-transplant. This procedure has been performed without the need for tissue matching, without marrow ablation, without immunosuppressive drugs, and without the development of graft-versus-host disease. This suggests that the fetus is both an ideal recipient and donor of hematopoietic stem cells, as has recently been demonstrated by the long-term engraftment and expression of human stem cells in preimmune sheep fetuses. In a number of diseases (e.g., storage diseases), an early expression of donor cells activity (i.e., soon after transplant and before birth) is a critical requirement since even at birth significant clinical disease exists. In diseases such as Cooley's anemia and other hemoglobinopathies, a higher level of donor cell engraftment is needed to be of therapeutic benefit. In this regard, recent findings of improved donor hematopoietic stem cell engraftment as the result of homing receptor manipulations by growth factors are promising. The technical and quality control issues that are involved when fetal donor stem cells are used may limit the applicability of this source of stem cells. Although in animal studies and in limited clinical studies, T-depleted adult stem cells have failed to engraft adequately in utero. The significant progress in stem cell purification and characterization provides for new sources of donor stem cells. Moreover, the possibility of employing in vitro expanded fetal or adult stem cells for use in in utero transplants has not been explored. The possibility now exists for correcting genetic diseases in utero, without the significant problems that were described above for bone marrow transplantation. Therefore, this initiative is for the development of methodologies to perform in to perform in utero hematopoietic stem cell transplants to cure genetic diseases that can be diagnosed in utero and that are curable by postnatal marrow transplantation. Examples of Areas of Interest The following are only examples and prospective applicants are urged to use their own ideas as to the area of research on which to focus. The major areas that need further investigation before the procedure can be applied in clinical practice include, among others: (a) improved donor cell engraftment; (b) early expression of donor cell activity; (c) the use of alternate sources of donor stem cells, such as fetal liver, adult peripheral blood, adult bone marrow, and hematopoietic stem cells that have been expanded in culture; and (d) quality control issues regarding the collection, processing, storage and use of donor hematopoietic stem cells. Disciplines and Expertise Among the disciplines and expertise that may be appropriate for this program are hematology, immunology, cell biology, medicine, and neonatology. Exclusions Epidemiological studies, large-scale clinical trials, and large multi-project grant applications (program project grants) are specifically excluded from this RFA. $$E1 END ************************************************************ From owner-sci-resources@net.bio.net Wed Apr 14 23:00:00 1993 Path: biosci!NET.BIO.NET!kristoff From: kristoff@NET.BIO.NET (Dave Kristofferson) Newsgroups: bionet.sci-resources Subject: NIH Guide, vol. 22, no. 15, pt. 3, 16 April 1993 Message-ID: Date: 15 Apr 93 22:45:36 GMT Sender: kristoff@net.bio.net Distribution: bionet Lines: 896 $$XID RFA CA93020 CA-93-020 P1O1 *************************************** INTERDISCIPLINARY COLLABORATIVE STUDIES IN THE GENETIC EPIDEMIOLOGY OF CANCER NIH Guide, Volume 22, Number 15, April 16, 1993 RFA: CA-93-020 P.T. 34; K.W. 0715035, 1002019, 0785055, 1007003, 0710030 National Cancer Institute National Center for Human Genome Research Letter of Intent Receipt Date: May 20, 1993 Application Receipt Date: July 22, 1993 PURPOSE The Extramural Programs Branch, Division of Cancer Etiology, National Cancer Institute (NCI) and the Ethical, Legal, and Social Implications (ELSI) Branch of the National Center for Human Genome Research (NCHGR), invite investigator-initiated Collaborative Research Project Grant applications to encourage and facilitate collaborative and interdisciplinary genetic epidemiology investigations designed to evaluate the interaction of genetic and environmental factors in cancer etiology. The special feature of this program is the concurrent submission of research grant applications by investigators who wish to collaborate within the common theme of genetic epidemiology of cancer, but do not require extensive shared physical resources or core functions to conduct their research. In order to be responsive to this RFA, a minimum of three investigators with related research objectives should submit concurrent, collaborative, cross-referenced individual research grant applications that address a common theme. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This Request for Applications (RFA), Interdisciplinary Collaborative Studies in the Genetic Epidemiology of Cancer, is related to the priority area of cancer. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic and foreign for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, research laboratories, units of State and local governments, and eligible agencies of the Federal government. Applications from minority institutions, individuals, and women are encouraged. MECHANISM OF SUPPORT The support mechanism for this program will be the individual research grant (R01). Multi-institutional collaborative arrangements are encouraged and should be discussed with the program staff prior to the submission of the applications. The collaborative research grant program encourages the coordinated submission of related research project grants (R01) from investigators who wish to collaborate on their research efforts, but do not require extensive shared physical resources. These applications must share a common theme and describe, in section 7 of each application, the objectives and scientific importance of the interchange of ideas, data, materials, etc. among the collaborating investigators. A minimum of three independent investigators with related research objectives are encouraged to submit concurrent, collaborative, cross-referenced individual R01 applications. Applicants may be from one or several institutions. Applications will be reviewed independently for scientific merit. Applications judged to have significant and substantial merit will be considered for funding both as independent awards and in the context of the proposed R01 collaboration. Responsibility for the planning, direction, and execution of the proposed projects will be solely that of the applicants. The total project period for applications submitted in response to the present RFA must not exceed five years. Since a variety of approaches would represent valid responses to this announcement, a range of costs is expected among individual grants awarded. However, a collaborative group must not exceed $800,000 total request costs (direct and indirect) per year. This RFA is a one time-solicitation. Future unsolicited competing continuation applications will compete with all investigator-initiated applications and be reviewed according to the customary peer-review procedures. If the NCI determines that there is a sufficient continuing program need, the NCI may announce a request for renewal applications. FUNDS AVAILABLE The estimated funds (total costs) available for the first year of the support for the entire program is $2,250,000. It is expected that two to three collaborative group awards will be supported under this program. This funding level is dependent on the receipt of a sufficient number of applications of high scientific merit. Although this program is provided for in the financial plans of the NCI, the awards of grants pursuant to this RFA is also contingent upon the availability of funds for this purpose. RESEARCH OBJECTIVES Background Genetic epidemiology has classically been defined as the discipline studying the role of genetic factors and their interaction with environmental factors in the distribution and determinants of diseases within human populations. However, for many years, human geneticists have mostly focused on the genetic components of disease with less consideration of the effect of environment on phenotype. On the other hand, epidemiologists have primarily paid attention to the association of environmental factors with illness, often being unable to account for the role of genetic endowment. Classical epidemiology studies to identify specific environmental factors (such as diet, smoking, exposure to radiation, etc.) mostly failed to collect data or specimens that could be used to address genetic hypotheses of disease etiology. This dichotomy has been true as well for the rapidly advancing field of cancer research. The pursuit of an integrated, cross-disciplinary approach to the understanding of cancer etiology within the framework of genetic epidemiology studies has been constantly hampered by an insufficient integration of the underlying concepts and methods, by the lack of a common scientific language, and by the shortage of appropriate supporting technology and biostatistical methods. Therefore, a workshop entitled "Genetic Epidemiology of Cancer: a Multidisciplinary Approach" was convened by the National Cancer Institute in May 1992, with the goals of developing scientific and programmatic recommendations for cross-disciplinary studies and for facilitating technological, methodological and conceptual transfer within the framework of genetic epidemiology of cancer. The participants emphasized that the field of molecular genetics has enormous potential for application to epidemiologic studies, but it has developed a vocabulary and methodology that may sound very foreign to epidemiologists. Conversely, laboratory scientists and clinical oncologists are often unfamiliar with epidemiologic principles and study designs. Epidemiologists should consider collecting family histories and extending pedigrees identified in cohort and case-control studies, and storing blood and tissue specimens for present and future use. Geneticists should benefit from epidemiological expertise in matters of proper sampling, data management, sources of population information of special interest, selection of controls and proper development of denominators. During the last decade, revolutionary advances in molecular biology and their applications to human genetics have provided new ways to analyze the human genome and to look at the relationship between phenotype and genotype. The Human Genome Project effort, leading to continuous improvement of the human genome map, has facilitated localization of genes in restricted chromosomal areas. Investigators in genetic epidemiology can now incorporate developments in molecular genetics into population studies, and greatly increase their insights into the genetic and environmental determinants of cancer. In addition, traditional statistical methods used in genetics are yielding to new methodologies developed to encompass both genetic and environmental factors. As genes are identified, mapped and cloned, the possibility of describing the distribution of various genes in the general population, as well as the ways in which environmental factors and genes interact, becomes feasible. This approach has been used successfully in the study of cardiovascular and psychological disorders, and is being explored for the study of cancer etiology. Genetic determinants have been recognized to play a role in cancer etiology through studies at the cell and population levels; at least 8 percent of the known or suspected Mendelian traits in humans have neoplasia as a feature or a complication. Several syndromes of familial aggregation of cancer have been recognized, and others still remain to be characterized. On the other hand, epidemiologic studies have demonstrated that a wide array of environmental factors (e.g., smoking, diet, environmental pollutants) substantially contribute to cancer development. Current theories of carcinogenesis hypothesize that most forms of cancer result from the variable effects of environmental influences on a broad range of genetic susceptibilities, in a multistage process that can be delineated and modified at each step by environmental and host factors. Supportive evidence for this theory has been provided in recent years by molecular, genetic and epidemiologic studies of specific cancers, such as colon, breast and lung, in which susceptibility genes and environmental factors are involved. Because of the complex nature of these diseases, it is important that genetic epidemiology studies be performed by multidisciplinary research groups capable to investigate both environmental and genetic determinants of cancer in well-defined pedigrees and in case-control studies. As the genetic and environmental contributions to cancer become further defined, there will be the potential to test individuals for genetic factors to assess their cancer risks. Studies regarding the benefits, risks, and psychosocial impact of testing and counseling for genetic contributions to cancer are needed to help elaborate professional practice standards. However, the road to this kind of cross-disciplinary research is not without obstacles: the ties among experts in the different fields of epidemiologic, biologic, psychosocial and behavioral research that may contribute to genetic epidemiology are still weak, and it is clear that the elucidation of cancer etiologies will require a high level of integration of concepts and analytical strategies developed within the framework of these studies. Workshop participants agreed that research to advance knowledge into genetic and environmental risk factors for cancer will be promoted if epidemiologists are encouraged to work effectively with scientists from a variety of other disciplines. The objectives of this RFA focus on major recommendations of the NCI workshop. Other The main goal of this initiative is to facilitate cross-disciplinary technological, methodological and conceptual transfer in order to advance research on the genetic epidemiology of cancer in families and populations. Interinstitutional collaborations between epidemiologists, laboratory scientists, clinical oncologists and geneticists, epidemiologists, biostatisticians, psychosocial and biobehavioral researchers and experts in related disciplines working on the same cancer site/syndrome are encouraged. Although this research will ultimately lead to more targeted prevention efforts and novel therapeutic designs, the latter are beyond the scope of this RFA. Studies of breast, ovarian, lung, prostate, and uterine cancers are particularly encouraged. Each component of collaborative proposals could include, but should not be limited to: o Ascertainment of cancer-prone families from large, population-based samples, and creation of extended multi-generational pedigrees with the establishment of related epidemiological data bases and blood/tissue specimen repositories. o Studies of inherited variation in genetic susceptibility to environmental carcinogens and, conversely, studies to determine the mode of inheritance of susceptibility to malignancies with known environmental or endogenous risk factors. o Studies of loss of heterozygosity in tumors, to suggest candidate regions for cancer-related genes and to define etiologic subgroups. o Development and validation of novel statistical models to evaluate gene/environment interactions, genetic heterogeneity and alternative modes of inheritance (e.g., gene imprinting) within existing cohort or family datasets. o Feasibility and validation studies to test the applicability of developing experimental laboratory techniques to genetic epidemiology investigations. o Studies to test innovative hypotheses on the molecular mechanisms underlying the genetic components of cancer etiology using the biological resources made available through family and case-control studies. o Genetic epidemiology studies of precancerous lesions in familial clusters, including the analysis of heritable and environmental factors affecting the progression of the precursor state to malignancy. o Studies to evaluate the potential benefits, risks, and psychosocial impact of testing and counseling for individuals at increased risk to develop cancer and their families. SPECIAL REQUIREMENTS Applicants must state clearly, in section 7 of the application form PHS 398, how they plan to collaborate. Applicants who already have ongoing collaborations must indicate how their response to this RFA will augment their current collaboration. Applicants are encouraged to establish collaborations that will enable them to use established resources and facilities (e.g., cancer registries and/or designated cancer centers) to facilitate the collection of patients and pedigrees and to increase cost effectiveness. Applicants from institutions that have a General Clinical Research Center (GCRC) funded by the NIH National Center for Research Resources may wish to identify the GCRC as a resource for conducting the proposed research. If so, a letter of agreement from either the GCRC program director or Principal Investigator could be included with the application. Successful grant awardees under this RFA are strongly encouraged to participate in an annual program meeting of one or two days duration which may be held in Bethesda, Maryland, or in other convenient locations. The program director from NCI will coordinate the meeting to review and assess overall progress and provide the opportunity for investigators to exchange information and discuss research issues. The respondents should request sufficient funds within the budget to accommodate expenses for one participant per R01 to these two-day meetings. STUDY POPULATIONS SPECIAL INSTRUCTIONS TO APPLICANTS REGARDING IMPLEMENTATION OF NIH POLICIES CONCERNING THE INCLUSION OF WOMEN AND MINORITIES IN CLINICAL RESEARCH STUDY POPULATIONS NIH policy is that applicants for NIH clinical research grants and cooperative agreements are required to include minorities and women in study populations so that research findings can be of benefit to all persons at risk for the disease, disorder or condition under study; special emphasis must be placed on the need for the inclusion of minorities and women in studies of diseases, disorders and conditions that disproportionally affect them. This policy is intended to apply to males and females of all ages. If women and minorities are excluded or inadequately represented in clinical research, particularly in proposed population-based studies, a clear compelling rationale must be provided. The composition of the proposed study population must be described in terms of gender and racial/ethnic group. In addition, gender and racial/ethnic issues must be addressed in developing a research design and sample size appropriate for the scientific objectives of the study. This information must be included in the form PHS 398 (rev. 9/91) in Sections 1-4 of the research plan AND summarized in Section 5, Human Subjects. Applicants are urged to assess carefully the feasibility of including the broadest possible representation of minority groups. However, NIH recognizes that it may not be feasible or appropriate in all research projects to include representation of the full array of United States racial/ethnic minority populations (i.e., Native Americans, including American Indians or Alaskan Natives, Asian/Pacific Islanders, Blacks, Hispanics). The rationale for studies on single minority population groups should be provided. For the purpose of this policy, clinical research is defined as human, biomedical and behavioral studies of etiology, epidemiology, prevention (and preventive strategies), diagnosis, or treatment of diseases, disorders or conditions, including, but not limited to, clinical trials. The usual policies concerning research on human subjects also apply. Basic research or clinical studies in which human tissues cannot be identified or linked to individuals are excluded. However, every effort should be made to include human tissue from women and racial/ethnic minorities when it is important to apply the result of the study broadly, and this should be addressed by applicants. For foreign awards, the policy on the inclusion of women applies fully; since the definition of minority differs in other countries, the applicant must discuss the relevance of research involving foreign populations groups to the United States populations, including minorities. If the required information is not contained within the application, the application will be returned. Peer reviewers will address specifically whether the research plan in the application conforms to these policies. If the representation of women or minorities in a study design is inadequate to answer the scientific question(s) addressed AND the justification for the selected study population is inadequate, it will be considered a scientific weakness or deficiency in the study design and reflected in assigning the priority score to the application. All applications for clinical research submitted to NIH are required to address these policies. NIH funding components will not award grants or cooperative agreements that do not comply with these policies. LETTER OF INTENT Prospective applicants are asked to submit, by May 20, 1993, a letter of intent that includes a descriptive title of the proposed research, the name, address, and telephone number of the Principal Investigator, the identification of any other participant investigators and institutions, and the number and title of the RFA in response to which the application may be submitted. Although a letter of intent is not required, is not binding, and does not enter in the review of subsequent applications, the information that it contains allows NCI staff to estimate the potential review workload and to avoid conflict of interest in the review. The letter of intent is to be sent to Dr. Daniela Seminara at the address listed under INQUIRIES. APPLICATION PROCEDURES Applications are to be submitted on form PHS 398 (rev. 9/91), available at most institutional offices of sponsored research and from the Office of Grants Inquiries, Division of Research Grants, National Institute of Health, Westwood Building, Room 449, Bethesda, MD 20892, telephone 301/594-7248. Submit a signed, typewritten original of the application, including the Checklist and three signed, exact, clear and single-sided photocopies in one package to: Division of Research Grants National Institute of Health Westwood Building, Room 240 Bethesda, MD 20892** At the time of submission, send two additional copies of the application to: Ms. Toby Friedberg, Referral Officer Division of Extramural Activities National Cancer Institute Executive Plaza North, Room 650 6130 Executive Boulevard Rockville, MD 20892 Applications must be received by July 22, 1993. If an application is received after that date, it will be returned. If the application submitted in response to this RFA is substantially similar to a research grant application already submitted to the NIH for review, but has not yet been reviewed, the applicant will be asked to withdraw either the pending application or the new one. Simultaneous submission of identical applications will not be allowed, nor will essentially identical applications be reviewed by different committees. Therefore, an application cannot be submitted in response to this RFA which is essentially identical to one that has already been reviewed. This does not preclude the submission of substantial revisions of applications already reviewed, but such applications must include an introduction addressing the previous critique. The RFA label available in the application form PHS 398 must be affixed to the bottom of the face page. Failure to use this label could result in delayed processing of the application, such that it may not reach the review committee in time for review. In addition, the number and title of the RFA must be typed on line 2a of the face page of the application and YES must be checked. REVIEW CONSIDERATIONS Upon receipt, applications will be reviewed by the Division of Research Grants (DRG) for completeness. Incomplete applications will be returned to the applicant without further consideration. Evaluation for responsiveness to the program requirements and criteria stated in the RFA is an NCI program staff function. Applications that are judged non-responsive will be returned by the NCI, but may be submitted as investigator-initiated collaborative research grants at the next regular receipt date. Questions concerning the responsiveness of proposed research to the RFA should be directed to program staff. If the number of applications is large compared to the number of awards to be made, the NCI may conduct a preliminary scientific peer review to eliminate those which are clearly not competitive. The NCI will remove from competition those applications judged to be noncompetitive for award and notify the applicant and institutional business official. Those applications judged to be both competitive and responsive will be further evaluated according to the review criteria stated below for scientific and technical merit by an appropriate peer review group convened by the Division of Extramural Activities, NCI. The second level of review by the National Cancer Advisory Board considers the special needs of the Institute and the priorities of the National Cancer Program. Applications should be responsive to the stated purpose and objectives of the RFA. Applicants are encouraged to submit and describe their own ideas on how to best meet the goals of this announcement. Applications will be judged according to the criteria stated below: o the availability of and access to a suitable patient population; o scientific, technical, or medical significance and originality of proposed research; o appropriateness and adequacy of the experimental approach and methodology proposed to carry out the research; o the experience of the investigators in the conduct of similar epidemiologic or interdisciplinary research and their capability to conduct the work proposed; o availability of resources necessary to perform the research; o willingness to work cooperatively with other awardees. For each application that is scored, the review group will assign an adjectival descriptor that reflects the extent and effectiveness of its collaboration(s) with the other collaborative R01 applications. This assessment will be documented in a brief administrative note in the summary statement to assist the NCI in making final decisions on each application in the context of the overall cluster of collaborative projects. The review group will also examine the proposed budget and will recommend an appropriate budget and period of support for each meritorious application. AWARD CRITERIA The earliest anticipated date of award is April 1, 1994. Applications will compete for available funds with all other meritorious applications. The following will be considered for making funding decisions: o quality of the proposed project as determined by peer review; o availability of funds; o program balance among research areas. INQUIRIES Written and telephone inquiries concerning this RFA are encouraged. The opportunity to clarify any issue or questions from potential applicants are welcome. Direct inquiries regarding programmatic issues related to the overall RFA and address the letter of intent to: Dr. Daniela Seminara Division of Cancer Etiology National Cancer Institute Executive Plaza North, Suite 535 6130 Executive Boulevard Bethesda, MD 20892 Telephone: (301) 496-9600 FAX: (301) 4O2-4279 Direct enquiries regarding programmatic issues on the ethical, legal and social aspects of this RFA to: Elizabeth J. Thomson, M.S., R.N. Ethical, Legal and Social Implications Branch National Center for Human Genome Research Building 38A, Room 604 Bethesda MD 20892 Telephone: (301) 402-0911 FAX: (301) 402-1950 Direct inquiries regarding fiscal matters to: Ms. Lauren Newmann Grants Administrative Branch National Cancer Institute Executive Plaza South, Suite 216 6120 Executive Boulevard Rockville, MD 20892 Telephone: (301) 496-7800, ext. 47 AUTHORITIES AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.393. Awards are made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grants policies and Federal Regulations 42 CFR 52 and 45 CFR part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency Review. $$XID RFA HD94002 HD-94-002 P1O1 *************************************** POPULATION RESEARCH CENTERS NIH Guide, Volume 22, Number 15, April 16, 1993 RFA: HD-94-002 P.T. 04; K.W. 0413001, 0417000, 0413003, 1004005, 0413002, 0404000 National Institute of Child Health and Human Development Letter of Intent Receipt Date: July 1, 1993 Application Receipt Date: October 13, 1993 PURPOSE The Demographic and Behavioral Sciences Branch (DBSB), Center for Population Research (CPR), National Institute of Child Health and Human Development (NICHD) supports population research using a variety of approaches found in the social and behavioral sciences. DBSB supports a fixed number of Population Research Centers which are designed to provide either integrated groups of research projects and supporting core services (P50) or core services and facilities in support of a large number of active research projects that are supported by a variety of NIH and outside funding sources (P30). These centers are given a commitment of five years of support and are renewable at five year intervals. Two existing center grants are due for competitive renewal in FY 94. This announcement is a solicitation for the competition for center grants in this program. BACKGROUND DBSB supports a national network of population research centers that provide both infrastructure and direct support of a wide range of topics relevant to the causes and consequences of population change. These centers are given a commitment for five years of support and are subject to competitive renewal at which time they must compete with other institutions in the field to win an additional five years of support. In FY 94 two centers are subject to competitive renewal and it is anticipated that these centers will submit renewal applications. The FY 94 competition will allow institutions to compete for awards. Depending on quality of applications and resources available, DBSB anticipates making two or three awards. HEALTHY PEOPLE 2000 The Public Health Service is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This RFA, Population Research Centers, is related to the family planning, educational and community based programs, maternal and infant health, HIV infection and immunization and infectious diseases objectives of the report. Potential applicants may obtain a copy of "Healthy People 2000" (Stock No. 017-001-00474-0) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of state and local governments, and eligible agencies of the Federal government. A center core grant (P30) must be predicated on the existence of a substantial number of research grants that will be active on July 1, 1994, and that contain at least one NIH and two other federally funded grants. A minimum of three cores are required for each year of a funded P30 grant. Each core unit must provide essential facilities and services for a least three federally funded research projects, at least one of which is NIH funded. These grants must be active users of the core facilities and services proposed in the center grant application. The applications should be consistent with the guidelines contained in P30 CENTER CORE GRANT GUIDELINES that are available from DBSB. Cooperation between independent institutions is allowed in some circumstances. In these instances core facilities may be located in both institutions as long as they are cost effective and promote the overall goals of the center program. Please consult the statement of clarification about center program principles that is available from DBSB. A specialized research center (P50) must have three or more related, integrated, and high quality research projects that provide a multidisciplinary, yet thematic, approach to the problems to be investigated. These research projects may be accompanied by an appropriate number and type of core facilities providing cost-effective technical support. The projects and theme of the center must be relevant to the DBSB funding mission. The applications should be consistent with the guidelines contained in P50 SPECIALIZED RESEARCH CENTER GRANT GUIDELINES that are available from DBSB. MECHANISM OF SUPPORT The support mechanisms for this program are the Specialized Research Center Grant (P50) and the Center Core Grant (P30). Applications should be consistent with the guidelines governing these two mechanisms that are available from DBSB. These centers are given a commitment of five years of support and are renewable at five year intervals. Renewals must be invited by a specific RFA that also will give interested organizations a chance to compete with the incumbent for the award. Because population research center grants are complex entities, it is strongly recommended that interested applicants contact the DBSB staff for a personal consultation regarding the centers program. The current policies and requirements that govern the research grant programs of NIH will prevail (Code of Federal Regulations, Title 42, Part 52 and Title 45, Part 74). The total project period for applications submitted to this RFA is five years. The anticipated award date will be July 1, 1994. FUNDS AVAILABLE DBSB anticipates funding at least two and possibly three centers in FY 94. $2,300,000 of first year total cost support has been set aside for this competition. This is contingent on the approval of funds in the FY 94 appropriations. New P50 applications should not request more than $600,000 in first year direct cost support. New P30 applications should not request more than $500,000 in first year, direct cost support and previously funded centers should not request more than 120% of the Council approved amount in the last year of the old grant as the first year of the renewal application. Applications exceeding these budget guidelines will be returned to the applicant unless they receive written permission from NICHD to exceed them. The award of a center is dependent on the receipt of a sufficient number of applications of high scientific merit and the availability of funds to support new centers. RESEARCH OBJECTIVES The Demographic and Behavioral Sciences Branch (DBSB), Center for Population Research (CPR), National Institute of Child Health and Human Development (NICHD) supports research on population dynamics using a variety of approaches found in the social and behavioral sciences. This RFA is specifically designed to stimulate the research community to organize or to maintain population research centers of high quality which will serve as a national research network that fosters communication, innovation and high quality research. Applications are encouraged for the population research topics listed below: 1. Fertility and Family Planning 2. Social acceptability of measures for the biological regulation of human fertility 3. Sexual behavior, sexually transmitted diseases, Aids, and contraception 4. Family and household dynamics 5. Age at marriage and first birth, child spacing, family size and fertility 6. Status and roles of women in relation to fertility, with special emphasis on implications for the U.S. 7. Relation of economic development to population growth and decline 8. Antecedents and consequences of stability or change in the size of the U.S. population 9. Population modelling for the projection and/or prediction of human population change in the U.S. 10. Migration of human population groups 11. Population redistribution 12. Population composition and structure 13. Mortality of human population groups 14. Population and physical environment 15. Status of children 16. Demographic aspects of health, morbidity, and disability in pre-retirement populations SPECIAL REQUIREMENTS Applicants must request travel funds to attend an annual meeting of the directors of P50s and P30s in Bethesda, MD. STUDY POPULATIONS SPECIAL INSTRUCTIONS TO APPLICANTS REGARDING IMPLEMENTATION OF NIH POLICIES CONCERNING INCLUSION OF WOMEN AND MINORITIES IN CLINICAL RESEARCH STUDY POPULATIONS NIH policy is that applicants for NIH clinical research grants and cooperative agreements will be required to include minorities and women in study populations so that research findings can be of benefit to all persons at risk of the disease, disorder or condition under study; special emphasis should be placed on the need for inclusion of minorities and women in studies of diseases, disorders and conditions which disproportionately affect them. This policy is intended to apply to males and females of all ages. If women or minorities are excluded or inadequately represented in clinical research, particularly in proposed population-based studies, a clear compelling rationale should provided. The composition of the proposed study population must be described in terms of gender and racial/ethnic group. In addition, gender and racial/ethnic issues should be addressed in developing a research design and sample size appropriate for the scientific objectives of the study. This information should be included in the from PHS 398 (rev. 9/91) in Sections 1-4 of the Research Plan AND summarized in Section 5, Human Subjects. Applicants are urged to assess carefully the feasibility of including the broadest possible representation of minority groups. However, NIH recognizes that it may not be feasible or appropriate in all research projects to include representation of the full array of United States racial/ethnic minority populations (i.e., Native Americans (including American Indians or Alaskan Natives), Asian/Pacific Islanders, Blacks, Hispanics). The rationale for studies on single minority population groups should be provided. For the purpose of this policy, clinical research includes human biomedical and behavioral studies of etiology, epidemiology, prevention (and preventive strategies), diagnosis, or treatment of diseases, disorders or conditions, including but no limited to clinical trials. The usual NIH policies concerning research on human subjects also apply. Basic research or clinical studies in which human tissues cannot be identified or linked to individuals are excluded. However, every effort should be made to include human tissues from women and racial/ethnic minorities when it is important to apply the results of the study broadly, and this should be addressed by applicants. For foreign awards, the policy on inclusion of women applies fully; since the definition of minority differs in other countries, the applicant must discuss the relevance of research involving foreign population groups to the United States populations, including minorities. If the required information is not contained within the application, the application will be returned. Peer reviewers will address specifically whether the research plan in the application conforms to these policies. If the representation of women or minorities in a study design is inadequate to answer the scientific question(s) addressed AND the justification for the selected study population is inadequate, it will be considered a scientific weakness or deficiency in the study design and will be reflected in assigning the priority score to the application. All applications for clinical research submitted to NIH are required to address these policies. NIH funding components will not award grants or cooperative agreement that do not comply with these policies. LETTER OF INTENT Prospective applicants are asked to submit, by July 1, 1993, a letter of intent that includes a descriptive title of the proposed center, the name, address, and telephone number of the Principal Investigator and the number and title of the RFA in response to which the application may be submitted. The letter of intent is not binding, is not required, and will not be considered in the review of the application. The purpose of the letter of intent is to alert the program staff of the proposed application so that the program may be of assistance in explaining the complex nature of the mechanism and it allows NICHD staff to estimate potential workload and avoid possible conflict of interest in the review. The letter of intent is to be sent to Dr. V. Jeffery Evans at the address listed under INQUIRIES. APPLICATION PROCEDURES Grant application form PHS 398 (rev. 9/91) is to be used in applying for these grants. The type of center grant requested (P30) must be indicated on the face page of the application in item #2b. The RFA label available in the PHS 398 must be affixed to the bottom of the face page. Failure to use this label could result in delayed processing of the application such that it may not reach the review committee in time for the review. In addition, the RFA title and number must be typed on line 2a of the face page of the application form and the YES box must be marked. The PHS 398 is available from most institutional offices of sponsored research and can also be obtained from the Office of Grants Inquiries, Division of Research Grants, National Institutes of Health, 5333 Westbard Avenue, Room 449, Bethesda, MD 20892, telephone (301) 594-7248. Submit a signed, typewritten original of the application, including the checklist, and four signed, photocopies, in one package to: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** At the time of submission, two additional copies of the application must also be sent to: Susan Streufert, Ph.D. Scientific Review Program National Institute of Child Health and Human Development Building 6100, Room 5E01 Bethesda, MD 20892 Applications must be received at the Division of Research Grants by October 13, 1993. If an application is received after that date, it will be returned to the applicant. REVIEW CONSIDERATIONS The applications will be reviewed by the Population Research Committee of the NICHD for scientific merit and the Institute's Advisory Council for program relevance and policy issues before awards for meritorious applications are made. Review procedures and criteria are detailed in P30 CORE CENTER GRANT GUIDELINES that are available from DBSB staff. Applications may be triaged by an ICD peer review group on the basis of relative competitiveness. The NIH will withdraw from further competition those applications judged to be non-competitive for award and notify the applicant Principal Investigator and institutional official. Those applications judged to be competitive will undergo further scientific merit review. Only those applications that are complete and responsive will be evaluated. AWARD CRITERIA The anticipated date of award is July 1, 1994. Funding decisions will be based on the IRG and NACHHD Council recommendations, program relevance, and the availability of funds. INQUIRIES Written and telephone inquiries concerning this RFA are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues and address the letter of intent to: V. Jeffery Evans, Ph.D., J.D. Demographic and Behavioral Sciences Branch National Institute of Child Health and Human Development Building 6100, Room 8B13 Bethesda, MD 20892 Telephone: (301) 496-1174 FAX: (301) 496-0962 Direct Inquiries regarding fiscal matters to: Ms. Melinda Nelson Office of Grants and Contracts National Institute of Child Health and Human Development Building 6100, Room 8A17 Bethesda, MD 20892 Telephone: (301) 496-5481 FAX: (301) 402-0915 AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.864 (Population Research). Awards are made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grants policies and Federal Regulations, 42 CFR Part 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health systems Agency review. From owner-sci-resources@net.bio.net Wed Apr 14 23:00:00 1993 Path: biosci!kristoff From: kristoff@net.bio.net (David Kristofferson) Newsgroups: bionet.sci-resources Subject: Re: 803 area code access? Message-ID: Date: 15 Apr 93 21:43:49 GMT References: <1993Apr14.212946.22511@ornl.gov> Organization: BIOSCI International Newsgroups for Biology Lines: 1077 ednobles@sacam.OREN.ORTN.EDU (Edward d Nobles) writes: >My brother is an M.D. in the Spartanburg/Greenville area of South Carolina. >He has asked me to try and locate a local Internet access site. He has had >no luck in his attempts. And neither have I so far. I tried PDIAL but >came up empty. Also no success on the ?????.access.wanted newsgroups. >If anyone can steer us in the right direction it would be appreciated. >We know there has got to be something local to his practice. >Cordially, >Jim Nobles Here is a list of public access sites that is available for FTP as explained at the end of the message. Sincerely, Dave Kristofferson BIOSCI/bionet Manager kristoff@net.bio.net ---------------------------------------------------------------------- nixpub long listing Open Access UNIX (*NIX) Sites [both Fee and No Fee] [ January 28, 1993 ] Systems listed (138) [ a2i aa7bq abode actrix admiral agora alchemy ] [ alphacm amaranth anomaly anubis aquila atrium bdt ] [ bigtex bitsko blkbox bluemoon btr bucket cavebbs ] [ cellar chinet cinnet clinet cns compunet conexch ] [ coyote cpumagic crash cruzio cyber ddsw1 debug ] [ dhw68k digex dircon dorsaidm edsi eklektik eskimo ] [ exuco1 fullfeed gagme genesis gna gold gorn ] [ grebyn grex halcyon hcs helpex highlite holonet ] [ ibmpcug ichlibix infocom isys-hh ixgch jabber jack ] [ jwt kcbbs kralizec latour loft386 lopez lunapark ] [ lunatix m-net m2xenix madnix magpie marob medsys ] [ metronet micor mindlink mixcom mv ncoast nervous ] [ netcom netlink nuchat nucleus nyx oaknet odbffm ] [ oldcolo pallas panix pnet51 polari portal quack ] [ quake r-node raider rgm rock sactoh0 schunix ] [ scuzzy sdf seanews sir-alan sixhub solaria stanton ] [ starnet sugar szebra techbook telerama telesys telly ] [ tmsoft tnc tnl tronsbox tutor uunet uuwest ] [ vicstoy vpnet wa9aek wariat wb3ffv well wet ] [ woodowl world wybbs wyvern xroads ] Updated Last Telephone # Sys-name Location Baud Hours ----- ------------ -------- ----------- ------- ----- 12/91 201-759-8450^ tronsbox Belleville NJ 3/12/24/96 24 Generic 386, UNIX 3.2; Provides shell for some users, USENET, E-Mail (feeds available) at $15 a month flat; Multiple line (-8568 300 - 2400 baud). 04/92 203-661-1279 admiral Greenwich CT 3/12/24/96 24 SCO Unix 3.2.2. (HST/V32) 203-661-2873, (PEP/V32) 203-661-1279, (V32) 203-661-0450, (MNP6) 203-661-2967. Magpie BBS for local conversation and Waffle for Internet mail/Usenet news. Interactive chat and games. BBS name is "The Grid." Willing to give newsfeeds and mail access. Shell (tcsh, ksh avail) accounts available at no charge. Direct connect to Internet site (Yale) via UUCP. 230 megs disk space. For more information contact uunet!admiral!doug (Doug Fields) or fields-doug@cs.yale.edu. 09/91 206-328-4944^ polari Seattle WA 12 24 Equip ???; 8-lines, Trailblazer on 206-328-1468; $50/year (flat rate); Multi-user games, chat, full USENET. Contact: bruceki%polari.uucp@sumax.seattleu.edu 10/92 206-367-3837^ eskimo Seattle WA 3/12/24/96/ 24 Sun 3/180 SUN/OS 4.1.1_U1 - Everett Tel 206-742-1150 Fast 206-362-6731 14 Lines including TB World Blazer and TB-3000. Free 2-week trial account. Rates $10/month or $96/year. Everybody gets their choice of sh, csh, tcsh, ksh, bash, or zsh. Full Usenet News feed 7 day expire. Unique real-time conference, message and files system. UUCP mail and news feeds available. Home of the Western Washington BBS List. Many applications online. Lots of Unix source code archived online. Internet ftp/telnet coming soon! 09/92 206-382-6245^ halcyon Seattle WA 3/12/24/96 24 ULTRIX 4.1, (PEP/V.32) 206-382-6245; monthly and annual fee schedules available. 56kBaud commercial Internet link to the T-3 backbone; NNTP news feed. Waffle bbs available. Irc server, archie and gopher clients, hytelnet, spop; dialup or telnet: login as 'bbs' and provide account information. For more information, contact: info@remote.halcyon.com, or call voice (PST, USA) +1 206 426 9298 01/93 206-747-6397^ seanews Redmond WA 12/24/96/14 24 Xenix 386 2.3.2. SEANEWS is a free public service, providing access to Usenet and Internet mail. There are no games, very limited files, etc. However SEANEWS does have up-to-date Usenet news and excellent mail-handling capability. 10/92 212-420-0527^ magpie NYC NY 3/12/24/96 24 ? - UNIX SYSV - 2, Magpie BBS, no fee, Authors: Magpie/UNIX,/MSDOS No Shell; Muli-line (using Telebit Worldblazers) plus anonymous uucp; Contact: Steve Manes, manes%magpie@nycenet.nycenet.edu 12/90 212-675-7059^ marob NYC NY 3/12/24/96 24 386 SCO-XENIX 2.2, XBBS, no fee, limit 60 min. Telebit Trailblazer (9600 PEP) only 212-675-8438 Contact: {philabs|rutgers|cmcl2}!{phri|hombre}!marob!clifford 12/92 212-787-3100^ panix New York City NY 12/24/96/19 24 Sun Sparc2, 32MB RAM, 4GB disk, Cisco router & Annex terminal server. Use any of 7 unix shells, or our own custom-written mneu system. 20 dialins- five are V.32bis, the rest 2400bps, all 20 do V.42bis & MNP. We are now a full internet site with a high-speed leased line- telnet to panix.com or to 198.7.0.1. Full UseNet feed; rn, nn, GNUs; more newsreaders coming soon. ELM, Pine, MM, emacs, and other mail-readers. Vi, Pico, Emacs editors. Compile your own sources if you like. $10/mn or $100/yr, no hourly charge. $27/quarter plus $40 startup for internet access, add'l. UUCP feeds with mail and/or news available- you can subdomain in panix.com or get your own. Coming in December: 5 more V.32bis modems and 5 more 2400bps modems Contact: Alexis Rosen (alexis@panix.com or uunet!panix!alexis), 212-877-4854, or Jim Baumbach (jsb@panix.com), 212-603-3572 04/92 214-436-3281^ sdf Dallas TX 3/12/24/96 24 i386-25, ISC SysVr3.2 UNIX; 4-way rotary at 436-3281, 2400bps except PEP on 436-5935. Unrestricted free shell access, PinkBBS available. Operated and funded entirely by users. 500MB on-line storage. 1000+ newsgroup full feed. Internet mail. On-line software includes emacs, trn, nn, elm, nethack, tinyMUD, etc. Mail and news feeds available. Contact iczer@sdf.lonestar.org (Ted Uhlemann). 01/93 214-705-2901^ metronet Dallas TX 3/12/24/96 24 HP-UX 8.07, HP 9000/705; Texas Metronet Communications Service. 10 14.4k dialups (7052901), 10 2400 dialups (7052917). Offers shell accounts w/ ftp, telnet, irc, UseNet, etc. Also UUCP and SLIP. Flat monthly fees from $10-$50, depending on service type. telnet connections to feenix.metronet.com welcome. For more information login as info/info, or mail info@metronet.com, or call voice at 7052900. 12/92 215-348-9727 jabber Doylestown PA 3/12/24/96 24 80386, ISC 386/ix 3.0; Trailblazer+ (PEP) on dial in line, Worldblazer (V.32[bis] and TurboPEP) on -8129, 2400 baud on -1932; No fee services: "*NIX Depot" BBS, BBS for UNIX/Xenix users; Fee services: UUCP feeds, providing access to Internet E-mail and full USENET News (2150+ groups); Anonymous UUCP available for access to the latest nixpub lists, please see the footer of this list for more details; Contact: Phil Eschallier (phil@bts.com). anon-uucp: ogin: nuucp (No passwd) 11/91 215-654-9184^ cellar Horsham PA 3/12/24/96 24 DTK 386/33, SCO Unix 3.2, Waffle BBS - The Cellar BBS, no shell; USR Dual-Standard modems, three lines and growing. BBS is free; net news (full feed) and net mail by subscription. $7/mo, $35/6-mo, or $60/yr. 06/92 216-481-9445 wariat Cleveland OH 3/12/24/96 24 ISC Unix SysV/386; USR DS on 481-9445, T-3000 on 481-9425. Shell and UUCP/Internet mail access availble. News and mail feeds are available; also, DOS and UNIX files. Ananymous uucp: login: nuucp, no password; request /x/files/ls-lR.Z; nuucp account does not allow mail exchange; UnixBBS distribution point. BBS free (with e-mail) for shell/uucp/newsfeed donation requested. For details, e-mail to: zbig@wariat.org (Zbigniew Tyrlik) 12/90 216-582-2460^ ncoast Cleveland OH 12/24/96 24 80386 Mylex, SCO Xenix; 600 meg. storage; XBBS and Shell; USENET (newsfeeds available), E-Mail; donations requested; login as "bbs" for BBS and "makeuser" for new users. Telebit used on 216-237-5486. 07/91 217-789-7888 pallas Springfield IL 3/12/24/96 24 AT&T 6386, 600 meg disk space; 4 lines w/ USRobotics Dual Standard modems; BBS available at no fee (UBBS), shell access for $50/year; E-Mail, Usenet; "guest" login available. 09/92 301-220-0462^ digex Greenbelt MD 3/12/24 24 Express Access Online Communications. Local to Washington, Baltimore, Annapolis and Northern Virginia (area code 703); Baltimore dialup 410-766-1855, Gaithersburg/Damascus 301-570-0001. SunOS shell, full Usenet, and e-mail $15/month or $150/year; Internet services incl. Telnet, FTP, IRC with news/mail $25/month or $250/year; includes unlimited usage 3am - 3pm and 1 hour between 3pm and 3am. Login as new (no password) for info and account application, major credit cards accepted. Telnet to digex.com or mail to info@digex.com for more info; voice phone 301-220-2020. 01/93 301-924-5998 highlite Laurel MD 12/24/96 24 Equip ???; Gotham Communications Research. Washington, DC METRO calling area; Northern VA and Southern MD included; Login as guest (password guest); 8N1; $10/month or $100/yr, 20 free hrs/month (then $1/hour); Usenet news; Internet E-mail; Shell access; All modems V.32 or faster. Contact: Dave at uunet!highlite!dlreed or dlreed@gotham.com 10/92 303-871-3324^ nyx Denver CO 3/12/24/96 24 A sort of "social experiment" aimed at providing Internet access to the public with minimal operational costs with a "friendly" front end (a home-made menu system). Completely donation and volunteer operated, no user fees at all. Log in as 'new' to create an account. Equipment: Sun SparcServer II + Pyramid 90x, ~6Gb disk space, 16 phone lines (+ network logins; usually ~50 users logged in). Public domain file area, private file area, games, full USENET news, internet e-mail. Provides shell and more network access with proof of identity. Contact: Andrew Burt, aburt@nyx.cs.du.edu 01/92 309-676-0409 hcs Peoria IL 3/12/24/96 24 VAX/BSD SGI/SV Network - Public Access UNIX Systems - Mult.Lines / 1.8GB Linked 386 bbs (Free). Network Fee structure based on usage with $0.02 minute connection. Shells (sh,ksh,csh,tcsh,bash) Compilers (C,Pascal, Fortran,Lisp,Ratfor oths), games, File and Pic. Libs., UUCP and USENET access with NetNews (nn reader), U.S. Patent and other databases, general timesharing and programmed on-line applications. Self register. Contact: Victoria Kee {uunet!hcsvax!sysop sysop%hcsvax@uunet.uu.net} 08/91 312-248-0900 ddsw1 Chicago IL 3/12/24/96 24 80386 systems, ISC 2.2; guest users 1 hr daily in AKCS BBS; fee for shell, Full Usenet access, unlimited use, and offsite mail; Authors of AKCS bbs; 1.5GB storage, fee $75/year or $20/bi-monthly, 19200 V.32/PEP available on (312) 248-6295 anonymous uucp (nuucp) from 12 midnight to 6 AM, ~/DIRECTORY/README for info on anon uucp. Newsfeeds and mail connections available; Internet access in the works (PLEASE contact us if interested). Contact: Karl Denninger (karl@ddsw1.MCS.COM) 10/92 312-282-8606^ gagme Chicago IL 12/24/96 24 3B2/400 - System V 3.2. E-mail, netnews, sources, access to anonymous ftp, GIFs, UUCP, local message base, games, etc. PEP and V.32 available for logins and UUCP. Send mail to info@gagme.chi.il.us for more information. 04/90 312-283-0559^ chinet Chicago IL 3/12/24/96 24 '386, SysVr3.2.1; Multiple lines including Telebit and HST; Picospan BBS (free), USENET at $50/year (available to guests on weekends). 06/90 313-623-6309 nucleus Clarkston MI 12/24 24 AMI 80386 - ESIX 5.3.2, large online sources archive accessable by anonymous UUCP, login: nuucp, nucleus!/user/src/LISTING lists available public domain/shareware source code. Contact: jeff@nucleus.mi.org 06/92 313-761-3000 grex Ann Arbor MI 3/12/24 24 Sun 2, SunOS 2.0; Internet E-Mail/USENET, shell access, Picospan; Fee: $6/month; 04/92 313-996-4644^ m-net Ann Arbor MI 3/12/24 24 Altos 68020 - Sys III, no limits; merged with Arbornet; non-profit organization; tax deductable donations accepted; fee for extended service; Picospan software; 15 lines, 160 Megs, 100% user supported; on-line games (including nethack, empire, and rotisserie baseball); E-Mail; UUCP accounts available; C compiler, multi-user party, access to Bourne, Korn, C, BBS & Menu; on-line man pages; login access via Internet: "telnet m-net.ann-arbor.mi.us". contact: help@m-net.ann-arbor.mi.us 09/92 401-455-0347 anomaly Esmond RI 3/12/24/96 24 Informtech 486 mongrel; SCO Open Desktop 1.1; Trailblazer+ (0347) and v.32 T2500 (401-331-3706) dialins. Directly connected to the Internet: IP Address: 155.212.2.2, or 'anomaly.sbs.risc.net'. Current fees: $15/mo. includes complete Internet access. Mail and USENET Newsfeeds available, limited feeds for non-PEP sites. SCO software archive site, anonymous UUCP login: xxcp, pass: xenix. Anonymous FTP also supported. Software listing & download directions in anomaly!~/SOFTLIST 12/92 403-569-2882 debug Calgary AB 3/12/24/96 24 386, SCO-Xenix; Login: gdx; Telebit, HST, V.32bis, MNP-5 supported; 6 phone lines: (403) 569-2882, 569-2883, 569-2884, 569-2885, 569-2886; System runs modified GDX BBS software; Services: Usenet, Internet email, IRC, local-chat, 50+ games, legal-forms, programming, ftp-via-email, and much more; Fee: $10/month-3hrs/day to $25/month-24hrs/day; Visa & Amex accepted. Demo accounts with limmited access are free. Contact: Rob Franke root@debug.cuc.ab.ca 09/91 407-299-3661^ vicstoy Orlando FL 12/24 24 ISC 386/ix 2.0.2. Partial USENET, e-mail (feeds available); Login as bbs, no passwd (8N1); Free shell access; Orlando BBS list, games; cu to Minix 1.5.10 system (weather permitting); USENET includes Unix/Minix source groups. Contact: uunet!tarpit!bilver!vicstoy!vickde or vickde@vicstoy.UUCP (Vick De Giorgio). 01/92 407-438-7138^ jwt Orlando FL 12/24/96 24 80386/33, System V.3.2, Waffle BBS, no shell access, two lines, V.32, V.32bis, PEP, Usenet news, no fee, login as "bbs". Contact: john@jwt.UUCP (John W. Temples) 08/92 408-241-9760^ netcom San Jose CA 12/24/96 24 UNIX, Sun Network SunOS 4.1; Netcom - Online Communication Services; 70 Telebit lines V.32/V.42 9600/2400/; USENET (16 days), Lrg archive, News/Mail Feeds, Shell, Internet (ftp, telnet, irc), Slip Connections, Local access via CALNet San Jose, Palo Alto, Red Wd Cty, San Fran, Oklnd, Berkly, Alameda, Plesanton, Los Angeles, and Santa Cruz; Fee $17.50/mo + Reg fee of $15.00. Login: guest (510)865-9004, (408)241-9760,(408)459-9851,(310)842-8835,(415)424-0131,(510)426-6860; Just Say No to connect fees, Login as guest (no password). 09/89 408-245-7726^ uuwest Sunnyvale CA 3/12/24 24 SCO-XENIX, Waffle. No fee, USENET news (news.*, music, comics, telecom, etc) The Dark Side of the Moon BBS. This system has been in operation since 1985. Login: new Contact: (UUCP) ames!uuwest!request (Domain) request@darkside.com 09/92 408-249-9630^ quack Santa Clara CA 3/12/24/96 24 Sun 3/160, SunOS 4.1.1; Aka - The Duck Pond; 3 lines: -9630 PEP, -9631 HST/v.32bis/v.42bis, -9632 v.32bis/v.42bis + PEP, all 3 lines MNP 1-4; Shell - $5/mo; New users should login as 'guest'; Contact: postmaster@quack.sac.ca.us 08/92 408-293-9010 a2i San Jose CA 12/24/96 24 Usenet/Email/Internet/SunOS (Unix). Eight lines. Dial 408-293-9010 (v.32bis, v.32) or 408-293-9020 (PEP) and log in as "guest". Or telnet to a2i.rahul.net, 192.160.13.1. Or send any message to info@rahul.net; a daemon will auto-reply. $12/month for 6-month prepaid subscription. 08/91 408-423-9995 cruzio Santa Cruz CA 12/24 24 Tandy 4000, Xenix 2.3.*, Caucus 3.*; focus on Santa Cruz activity (ie directory of community and goverment organizations, events, ...); USENET Support; Multiple lines; no shell; fee: $15/quarter. Contact: ...!uunet!cruzio!chris 04/92 408-458-2289 gorn Santa Cruz CA 3/12/24/96 24 Everex 386, SCO xenix 2.3.2; 2 lines, -2837 telebit for PEP connects; Standard shell access, games, email injection into the internet, up to date archive of scruz-sysops information, upload/download, usenet news including scruz.* heircarchy for santa cruz area information; UUCP set up on as-requested; No charge, donations accepted; newuser: log in as ``gorn'' and fill out online form. Contact: falcon@gorn.echo.com 11/91 408-725-0561^ portal Cupertino CA 3/12/24/96 24 Networked Suns (SunOS), multiple lines, Telenet access, no shell access fees: $13.95/month + Telenet charges (if used) @ various rates/times conferencing, multi user chats, usenet, computer special interest groups 11/91 408-739-1520^ szebra Sunnyvale CA 3/12/24/96 24 386PC, AT&T SVR4v3; Trailblazer+; Full Usenet News, email (Internet & UUCP), first time users login: bbs, shell access/files storage/email available (registration required); GNU, X11R4 and R5 source archives. viet-net/SCV and VNese files/sftware archives. contact: tin@szebra.Saigon.COM or {claris,zorch,sonyusa}!szebra!tin 10/92 410-661-2598 wb3ffv Baltimore MD 12/24/96/14 24 80486, UNIX V.3.2.x; XBBS for HAM radio enthusiasts; 1.6 Gigabytes online; Multiple lines, dial in - TB WorldBlazer, 2475 - USR HST DS V.32bis/42bis, 2648 - Tb+ PEP; Some USENET; Anon-UUCP available; Login as bbs (8-N-1). 06/91 412-431-8649^ eklektik Pittsburgh PA 3/12/24 24 UNIX PC- SYSV - UNaXcess BBS, donation requested for shell, login: bbs for BBS, limited Usenet news (amiga and gaming groups). RPG mailing list, rec.games.frp and rec.music.dylan archive. Alternate number: 431-3064, Contact: anthony@eklektik.pgh.pa.us or anthony@cs.pitt.edu 01/93 412-481-5302 telerama Pittsburgh PA 3/12/24 24 4.3BSD UNIX - Telerama, $6/mo = 10 hrs/mo, additional hours $0.60 login: new to create a new account, Full USENET news, Clarinet news, Full internet connectivity - telnet - ftp - irc - MUDs - Email Contact: info@telerama.pgh.pa.us for more info. 04/92 414-241-5469^ mixcom Milwaukee WI 12/24/96 24 80386, SCO UNIX 3.2; MIX (Milwaukee Internet eXchange); $9/mo access to Internet services including email, Usenet BBS and file archives; MIX has comprehensive and easy to use menus, along with shell access; Multiple lines; login as 'newuser' password 'newuser'. Contact: Dean Roth (sysop@mixcom.com) [414-962-8172 voice] 10/92 414-321-9287 solaria Milwaukee WI 3/12/24 24 Sun 3/60LE, SunOS 4.1. Internet E-mail, limited USENET news, shell access, Telebit WorldBlazer soon. Feeds available. Donations requested, registration required. One hop off of the Internet. Contact: jgreco@solaria.mil.wi.us (Joe Greco) or log in as "help" 09/91 414-734-2499 edsi Appleton WI 3/12/24 24 IBM PS/2 Model 55SX, SCO Xenix 2.3.2; Running STARBASE II Software. Enterprise Data Systems Incorporated (Non-profit). 100+ local rooms, PLUS USENET, Multi Channel Chat, 9 ports, $15 yr, flat rate for full access to net news, mail. The Fox Valley's only public access Unix based BBS. Contact: Chuck Tomasi (chuck@edsi.plexus.COM) 08/92 415-332-6106^ well Sausalito CA 12/24/96 24 6-processor Sequent Symmetry (i386); Internet, UUCP and USENET access; multiple lines; access via CPN and Internet (well.sf.ca.us); PICOSPAN BBS; $15/mo + $2/hr (CPN or 9600 +$4/hr); Contact (415) 332-4335 06/91 415-826-0397^ wet San Francisco CA 12/24 24 386 SYS V.3. Wetware Diversions. $15 registration, $0.01/minute. Public Access UNIX System: uucp, PicoSpan bbs, full Usenet News, Multiple lines (6), shell access. Newusers get initial credit! contact:{ucsfcca|hoptoad|well}!wet!editor (Eric Swanson) 04/91 415-949-3133^ starnet Los Altos CA 3/12/24/96 24 SunOS 4.1. 8-lines. MNP1-5 and v42/bis, or PEP on all lines. Shell access for all users. USENET--900+ groups. E-mail (feeds available). smart mail. Publically available software (pd/shareware). $12/mo. Contact: admin@starnet.uucp or ...!uunet!apple!starnet!admin 12/91 415-967-9443^ btr Mountain View CA 3/12/24/96 24 Sun (SunOS UNIX), shell access, e-mail, netnews, uucp, can access by Telenet PC Pursuit, multiple lines, Telebit, flat rate: $12.50/month. For sign-up information please send e-mail to Customer Service at cs@btr.com or ..!{decwrl,fernwood,mips}!btr!cs or call 415-966-1429 Voice. 08/92 416-249-5366 r-node Etobicoke ON 3/12/24/96 24 80386, ISC SV386; SupraModem2400 on Dial-in line, Worldblazer and Cardinal2400 on other two lines; No fee services: Uniboard BBS for BBS users; shell access for those who ask; Fee services: access to subsequent lines, unlimited dl/ul access; full USENET News and International E-mail access through Usenet/Internet mail; Free UUCP connections; Contact: Marc Fournier (marc@r-node.gts.org) 11/89 416-452-0926 telly Brampton ON 12/24/96 24 386 SysVr3.2; proprietary menu-based BBS includes Usenet site searching. News (all groups, incl biz, pubnet, gnu, CanConfMail), mail (including to/from Internet, Bitnet), many archives. Feeds available. $75(Cdn)/year. Contact: Evan Leibovitch, evan@telly.on.ca, uunet!attcan!telly!evan 12/88 416-461-2608 tmsoft Toronto ON 3/12/24/96 24 NS32016, Sys5r2, shell; news+mail $30/mo, general-timesharing $60/mo All newsgroups. Willing to setup mail/news connections. Archives:comp.sources.{unix,games,x,misc} Contact: Dave Mason / Login: newuser 12/92 502-231-5908 compunet Louisville KY 3/12/24/96 24 386 clone, Interactive System V 3.2, 2 gig. Also 502-231-5910, both lines support V.32 and HST. Carrying most USENET groups, Shell access, multi-user games( including The Realm(c) ) multi-user chat, downloads including the AB20 and SIMTEL20 CD-ROMS, and more. Rate info available via a guest information account. 10/92 503-220-0636^ techbook Beaverton OR 3/12/24/96 24 33MHz/486, Sys5.4, 1.3GB disk; 8 lines and support PEP/V.32/V.32bis; E-Mail/USENET; Shell access for $45 / year includes Korn, C, or tcsh; $90 / year includes full internet (ftp, telnet, irc, mud) access; Free access to BBS; 08/91 503-254-0458^ bucket Portland OR 3/12/24/96 24 Tektronix 6130, UTek 3.0(4.2bsd-derived). Bit Bucket BBS no longer online. Modem is Telebit Trailblazer+ (PEP). Users intereseted in access to Unix should send EMail to rickb@pail.rain.com. Services include USENET News, EMail (fast due to local Internet access), and access to all tools/utilities/games. UUCP connections (1200, 2400, 9600V.32, 9600PEP, 19200PEP) available (through another local system which is not publically available) to sites which will poll with reasonable regularity and reliability. 12/92 503-293-1772^ agora PDX OR 12/24/96 24 Intel Unix V/386, $6/mo or $60/yr, news, mail, ftp, telnet, irc. Six lines with trunk-hunt, all V.32bis. Agora is part of RAINet. Contact: Alan Batie, batie@agora.rain.com 02/91 503-297-3211^ m2xenix Portland OR 3/12/24/96 24 '386/20, Xenix 2.3. 2 Lines (-0935); Shell accounts available, NO BBS; No fee; E-mail, USENET News, program development. Contact: ...!uunet!m2xenix!news or on Fido at 297-9145 01/92 508-664-0149 genesis North Reading MA 12/24/96 24 Gateway 2000 386/25, Minix-386; Three lines; Internet mail; Usenet News; Multi-user chat, games; Shell access and menu system; Full access to all users; No Fees; 200 megabytes; One hop from the Internet; HST & V.32. Contact: steve1@genesis.nred.ma.us (Steve Belczyk) 12/92 508-752-9121 schunix Worcester MA 24/96/14.4 24 5 lines ,SUN 4/75(Sparc 2), SunOS 4.1.1(BSD),1.9GB; 2400 buad on dial-in, 14.4k (T3000) on -8305; Shell, Usenet, E-mail, $15/month or $150/yr for up to 1 hr/day, 1 time Reg fee of $10; 5 megabyte quota; 4 week free trial; login as "guest" Contact: ...!uunet!lectroid!jjmhome!schu@schunix.uucp (Robert Schultz) SCHUNIX c/o Ostrow Electric, 9 Mason Street, Worcester, MA 01609 Voice: 508-752-4522 12/91 510-294-8591 woodowl Livermore CA 12/24/19.2 24 Xenix/386 3.2.1. Waffle BBS, Usenet Access; Reasonable users welcome. No fee; For more information contact: william@woodowl.UUCP, lll-winken!chumley!woodowl!william, or call and just sign up on system. 08/92 510-530-9682 bdt Oakland CA 12/24/96 24 Sun 4, SunOS 4.1; BBS access to Usenet news, E-mail (Internet and UUCP). PEP/V.32 on 510-530-6915. First time users login: bbs. Unix, Atari ST, and IBM-PC sources and PD/shareware. $35 annual fee. 30-day free trial. Newsfeeds and UUCP access by special arrangement. Contact: David Beckemeyer david@bdt.com 09/91 510-623-8652^ jack Fremont CA 3/12/24/96 24 Sun 4/470 running Sun O/S 4.1.1 offers downloading of netnews archives and all uploaded software. Each user can log in as bbs or as the account which they create for themselves. This is a free Public Access Unix System that is part of a network of 4 machines. The primary phone line is on a rotary to three other lines. 08/92 510-704-1058 HoloNet Berkeley CA 12/24/96/14 24 DECstations, ULTRIX; Commercial network, over 850 cities; Custom shell; Full Internet, IRC, telnet, USENET, USA Today Descisionline, games; $2/hr off-peak; Telnet: holonet.net, Info sever: info@holonet.net, Contact: support@holonet.net 06/91 512-346-2339^ bigtex Austin TX 96 24 SysVr3.