From owner-sci-resources@net.bio.net Tue Jun 04 23:00:00 1996 Path: biosci!biosci!not-for-mail From: BIOSCI Administrator Newsgroups: bionet.sci-resources Subject: NSF - Summary of new documents on STIS, 3 June 1996 Date: 5 Jun 1996 10:44:51 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 136 Sender: daemon@net.bio.net Approved: biosci-help@net.bio.net Distribution: world Message-ID: <4p4h2j$gt9@net.bio.net> NNTP-Posting-Host: net.bio.net This message contains a summary of the documents added to the NSF STIS system for the week ending June 3, 1996. Reference material concerning STIS follows the summary. ------------------------------------------------------------------------ ** NEW DOCUMENTS ON STIS ** Document Type: News Title: How to Succeed in Molecular Design Without Really Trying File size (bytes): 1518 STIS Filename: mpslect2.txt Title: Media Tipsheet May 24, 1996 File size (bytes): 4406 STIS Filename: tip60524.txt Document Type: Press Release Title: MAJOR SHIFTS IN WORLD ECONOMY CONFRONT U.S. STATUS AS INDUSTRIAL LEADER, SAYS NEW S&E INDICATORS REPORT File size (bytes): 9838 STIS Filename: pr9622.txt Title: TORNADO SEASON STRIKES File size (bytes): 3927 STIS Filename: pr9623.txt Title: PLANES, MOBILE RADARS ANALYZE CHEMISTRY OF THUNDERSTORMS File size (bytes): 3513 STIS Filename: pr9624.txt Title: AMERICANS LEAD THE WORLD IN COMPUTER USE, BUT HAVE LITTLE UNDERSTANDING OF SCIENCE, SAYS NEW REPORT File size (bytes): 3821 STIS Filename: pr9625.txt Title: NSF WILL INVEST $48 MILLION TO SPARK FOUR NEW ENGINEERING RESEARCH CENTERS File size (bytes): 9207 STIS Filename: pr9626.txt Title: NSF WINS APPEAL TO MAINTAIN CONFIDENTIALITY OF ITS PROPOSAL REVIEWERS File size (bytes): 3129 STIS Filename: pr9627.txt Title: SCIENTISTS DISCOVER NEW CLASS OF GENES File size (bytes): 3941 STIS Filename: pr9628.txt Document Type: Program Guideline Title: NSF 96-102 RESEARCH EXPERIENCES FOR UNDERGRADUATES PROGRAM (REU) File size (bytes): 46740 STIS Filename: nsf96102.txt Title: NSF 96-93 Antarctic Research Opportunities and Proposal Guide File size (bytes): 150005 STIS Filename: nsf9693.txt Title: NSF 96-99 MULTIDISCIPLINARY RESEARCH AND EDUCATION IN COST-REDUCING HEALTH CARE TECHNOLOGIES File size (bytes): 17936 STIS Filename: nsf9699.txt Document Type: Recruit Title: EPSCoR Program Director, AD-4 (Interdisciplinary position File size (bytes): engineering, biological, computational or geological sciences) STIS Filename: vex9619.txt (NSF) ------------------------------------------------------------------------ ** UPDATES TO EXISTING STIS DOCUMENTS ** Document Type: General Publication Title: NSF 95-138 -- Guide to Programs Chapter 1 File size (bytes): 40991 STIS Filename: ns95138b.txt Document Type: News Title: Artificial Antibody Binding Sites and Combinatorial Synthesis File size (bytes): 1527 STIS Filename: mpslect.txt Document Type: Press Release Title: NSF WINS APPEAL TO MAINTAIN CONFIDENTIALITY OF ITS PROPOSAL REVIEWERS File size (bytes): 3129 STIS Filename: pr9627.txt ------------------------------------------------------------------------ ** FOR YOUR REFERENCE ** ------------------------------------------------------------------------ HOW TO OBTAIN DOCUMENTS The above files can be retrieved in electronic form using the STIS system. If you don't know how to use STIS, send an E-mail message to stisinfo@nsf.gov (Internet). You will receive a copy of the STIS flyer via E-mail. If you are already using STIS, you can use the information above to retrieve these files: Documents via E-mail: Send a message to stisserve@nsf.gov (Internet). Use the "STIS Filename" shown above in the "get" command. For example, to retrieve pr9627.txt, the text of your message should be as follows: get pr9627.txt Anonymous FTP: FTP to stis.nsf.gov. Use the "STIS Filename" shown above to retrieve a file. For example, to retrieve pr9627.txt, you would enter: ftp> get pr9627.txt WAIS or Gopher: Do a word search on the filename as shown in the summary. If you want a *printed* copy of a document: Send your name and postal mailing address, and the document title and number to "pubs@nsf.gov" (Internet). If you have problems with the above procedures: Send a message to "stis@nsf.gov" (Internet). From owner-sci-resources@net.bio.net Tue Jun 04 23:00:00 1996 Path: biosci!biosci!not-for-mail From: jan@ultr5.vub.ac.be (DeJean) Newsgroups: bionet.sci-resources Subject: Collab. Belgium <-> Poland, Hungary or Roumania Date: 5 Jun 1996 11:09:57 -0700 Organization: Molecular Biology Institutes - Free Universities of Brussels Lines: 28 Sender: daemon@net.bio.net Approved: biosci-help@net.bio.net Distribution: world Message-ID: <4p393r$sln@imol2.vub.ac.be> NNTP-Posting-Host: net.bio.net The Flemish government (Belgium) provides funding for scientific cooperation between Flemish universities (institutions) and Polish, Hungarian or Romanian research labs. The grants can be used for visits, travel, equipment, meetings, etc. The department of Ultrastructure at the free University of Brussels is doing research in the fields of protein crystallography and protein engineering. Please look at our WWW page for more details. http://imol.vub.ac.be/ULTR/ULTR.html We are looking for scientific partners (university labs, research institutes) in these countries with joined scientific interests to start cooperative research on the above subjects. If any interest, please contact Jan Steyaert (JSTEYAER@VUB.AC.BE). Prof. Dr. Ir. Jan Steyaert Department of ULTRASTRUCTURE Free University of Brussels, Paardenstraat 65, B-1640 Sint-Genesius-Rode, Belgium Email jsteyaer@vub.ac.be Tel ++ 32 2 359 02 68 Fax ++ 32 2 359 02 89 Fax 32-2-359 02 89 From owner-sci-resources@net.bio.net Wed Jun 05 23:00:00 1996 Path: biosci!biosci!not-for-mail From: BIOSCI Administrator Newsgroups: bionet.sci-resources Subject: NSF - Summary of new documents on STIS, 3 June 1996 Date: 5 Jun 1996 20:06:35 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 137 Sender: daemon@net.bio.net Approved: biosci-help@net.bio.net Distribution: world Message-ID: <4p5hvr$iv3@net.bio.net> NNTP-Posting-Host: net.bio.net This message contains a summary of the documents added to the NSF STIS system for the week ending June 3, 1996. Reference material concerning STIS follows the summary. ------------------------------------------------------------------------ ** NEW DOCUMENTS ON STIS ** Document Type: News Title: How to Succeed in Molecular Design Without Really Trying File size (bytes): 1518 STIS Filename: mpslect2.txt Title: Media Tipsheet May 24, 1996 File size (bytes): 4406 STIS Filename: tip60524.txt Document Type: Press Release Title: MAJOR SHIFTS IN WORLD ECONOMY CONFRONT U.S. STATUS AS INDUSTRIAL LEADER, SAYS NEW S&E INDICATORS REPORT File size (bytes): 9838 STIS Filename: pr9622.txt Title: TORNADO SEASON STRIKES File size (bytes): 3927 STIS Filename: pr9623.txt Title: PLANES, MOBILE RADARS ANALYZE CHEMISTRY OF THUNDERSTORMS File size (bytes): 3513 STIS Filename: pr9624.txt Title: AMERICANS LEAD THE WORLD IN COMPUTER USE, BUT HAVE LITTLE UNDERSTANDING OF SCIENCE, SAYS NEW REPORT File size (bytes): 3821 STIS Filename: pr9625.txt Title: NSF WILL INVEST $48 MILLION TO SPARK FOUR NEW ENGINEERING RESEARCH CENTERS File size (bytes): 9207 STIS Filename: pr9626.txt Title: NSF WINS APPEAL TO MAINTAIN CONFIDENTIALITY OF ITS PROPOSAL REVIEWERS File size (bytes): 3129 STIS Filename: pr9627.txt Title: SCIENTISTS DISCOVER NEW CLASS OF GENES File size (bytes): 3941 STIS Filename: pr9628.txt Document Type: Program Guideline Title: NSF 96-102 RESEARCH EXPERIENCES FOR UNDERGRADUATES PROGRAM (REU) File size (bytes): 46740 STIS Filename: nsf96102.txt Title: NSF 96-93 Antarctic Research Opportunities and Proposal Guide File size (bytes): 150005 STIS Filename: nsf9693.txt Title: NSF 96-99 MULTIDISCIPLINARY RESEARCH AND EDUCATION IN COST-REDUCING HEALTH CARE TECHNOLOGIES File size (bytes): 17936 STIS Filename: nsf9699.txt Document Type: Recruit Title: EPSCoR Program Director, AD-4 (Interdisciplinary position File size (bytes): engineering, biological, computational or geological sciences) STIS Filename: vex9619.txt (NSF) ------------------------------------------------------------------------ ** UPDATES TO EXISTING STIS DOCUMENTS ** Document Type: General Publication Title: NSF 95-138 -- Guide to Programs Chapter 1 File size (bytes): 40991 STIS Filename: ns95138b.txt Document Type: News Title: Artificial Antibody Binding Sites and Combinatorial Synthesis File size (bytes): 1527 STIS Filename: mpslect.txt Document Type: Press Release Title: NSF WINS APPEAL TO MAINTAIN CONFIDENTIALITY OF ITS PROPOSAL REVIEWERS File size (bytes): 3129 STIS Filename: pr9627.txt ------------------------------------------------------------------------ ** FOR YOUR REFERENCE ** ------------------------------------------------------------------------ HOW TO OBTAIN DOCUMENTS The above files can be retrieved in electronic form using the STIS system. If you don't know how to use STIS, send an E-mail message to stisinfo@nsf.gov (Internet). You will receive a copy of the STIS flyer via E-mail. If you are already using STIS, you can use the information above to retrieve these files: Documents via E-mail: Send a message to stisserve@nsf.gov (Internet). Use the "STIS Filename" shown above in the "get" command. For example, to retrieve pr9627.txt, the text of your message should be as follows: get pr9627.txt Anonymous FTP: FTP to stis.nsf.gov. Use the "STIS Filename" shown above to retrieve a file. For example, to retrieve pr9627.txt, you would enter: ftp> get pr9627.txt WAIS or Gopher: Do a word search on the filename as shown in the summary. If you want a *printed* copy of a document: Send your name and postal mailing address, and the document title and number to "pubs@nsf.gov" (Internet). If you have problems with the above procedures: Send a message to "stis@nsf.gov" (Internet). From owner-sci-resources@net.bio.net Sun Jun 09 23:00:00 1996 Path: biosci!biosci!not-for-mail From: BIOSCI Administrator Newsgroups: bionet.sci-resources Subject: NSF - Summary of new documents on STIS, 8 June 1996 Date: 9 Jun 1996 23:02:36 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 144 Sender: daemon@net.bio.net Approved: biosci-help@net.bio.net Distribution: world Message-ID: <4pgdps$e6g@net.bio.net> NNTP-Posting-Host: net.bio.net This message contains a summary of the documents added to the NSF STIS system for the week ending June 8, 1996. Reference material concerning STIS follows the summary. ------------------------------------------------------------------------ ** NEW DOCUMENTS ON STIS ** Document Type: Bulletin Title: BUL 96-06 NSF June/July/August 1996 Bulletin V-23; No.10 File size (bytes): 58408 STIS Filename: bul9606.txt Document Type: Letter Title: NSF 96-96 Dear Colleague File size (bytes): 3328 STIS Filename: nsf9696.txt Document Type: Press Release Title: PROGRESS IN MATH AND SCIENCE PERFORMANCE PROMPTS "CAUTIOUS OPTIMISM" AT NSF File size (bytes): 5810 STIS Filename: pr9615.txt Title: NEVER THE SAME SONG TWICE FROM SONG File size (bytes): 3480 STIS Filename: pr9619.txt Title: SCIENTISTS TO PRESENT RESULTS OF ‘SOLAR STORM' RESEARCH; MASSIVE EVENTS DISRUPT POWER, CAUSE AURORA DISPLAYS File size (bytes): 3569 STIS Filename: pr9620.txt Title: NATIONAL SCIENCE BOARD ELECTS NEW LEADERS File size (bytes): 2385 STIS Filename: pr9621.txt Title: FIRST RESULTS FROM GLOBAL ARRAY THAT EAVESDROPS ON SOUNDS OF THE SUN File size (bytes): 3970 STIS Filename: pr9629.txt Title: NSF FUNDS INTERNATIONAL PROTEIN DATA BANK FUELS RESEARCH IN BIOTECHNOLOGY File size (bytes): 3216 STIS Filename: pr9630.txt Title: NSB APPROVES MULTIMILLION DOLLAR AWARD FOR ST. LOUIS' SYSTEM-WIDE EDUCATION REFORM File size (bytes): 3549 STIS Filename: pr9631.txt Title: NSB APPROVES MULTIMILLION DOLLAR AWARD FOR MILWAUKEE'S SYSTEM-WIDE EDUCATION REFORM File size (bytes): 3541 STIS Filename: pr9632.txt Title: NSB APPROVES MULTIMILLION DOLLAR AWARD FOR SAN DIEGO'S SYSTEM-WIDE EDUCATION REFORM File size (bytes): 3510 STIS Filename: pr9633.txt Document Type: Recruit Title: Assistant Director for Geosciences File size (bytes): 5355 STIS Filename: vep9600.txt Title: Director, Division of Advanced Scientific Computing File size (bytes): 8891 STIS Filename: vep965.txt Title: EPSCoR Program Director (Interdisciplinary position File size (bytes): Engineering, Biological, Computational, or Geological Sciences) STIS Filename: vex9619a.txt (NSF) ------------------------------------------------------------------------ ** UPDATES TO EXISTING STIS DOCUMENTS ** Document Type: Phone Book Title: NSF Alpha Telephone Directory File size (bytes): 114263 STIS Filename: phnalpha.txt Also available: phnalpha.dlm phnalpha.xls Title: NSF Organization Telephone Directory File size (bytes): 123396 STIS Filename: phnorg.txt Document Type: Program Guideline Title: NSF 93-130 -- Research Planning Grants and Career Advancement Awards for Women Scientists and Engineers File size (bytes): 27685 STIS Filename: nsf93130.txt Document Type: Recruit Title: Senior Executive Service Nationwide Vacancy Listing File size (bytes): 58838 STIS Filename: sesvac.txt ------------------------------------------------------------------------ ** FOR YOUR REFERENCE ** ------------------------------------------------------------------------ HOW TO OBTAIN DOCUMENTS The above files can be retrieved in electronic form using the STIS system. If you don't know how to use STIS, send an E-mail message to stisinfo@nsf.gov (Internet). You will receive a copy of the STIS flyer via E-mail. If you are already using STIS, you can use the information above to retrieve these files: Documents via E-mail: Send a message to stisserve@nsf.gov (Internet). Use the "STIS Filename" shown above in the "get" command. For example, to retrieve sesvac.txt, the text of your message should be as follows: get sesvac.txt Anonymous FTP: FTP to stis.nsf.gov. Use the "STIS Filename" shown above to retrieve a file. For example, to retrieve sesvac.txt, you would enter: ftp> get sesvac.txt WAIS or Gopher: Do a word search on the filename as shown in the summary. If you want a *printed* copy of a document: Send your name and postal mailing address, and the document title and number to "pubs@nsf.gov" (Internet). If you have problems with the above procedures: Send a message to "stis@nsf.gov" (Internet). From owner-sci-resources@net.bio.net Tue Jun 11 23:00:00 1996 Path: biosci!biosci!not-for-mail From: BIOSCI Administrator Newsgroups: bionet.sci-resources Subject: NIH Guide, vol. 25, no. 18, pt. 1of1, 7 June 1996 Date: 11 Jun 1996 21:14:17 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 1485 Sender: daemon@net.bio.net Approved: biosci-help@net.bio.net Distribution: world Message-ID: <4plg6p$9b3@net.bio.net> NNTP-Posting-Host: net.bio.net $$XID NIHGUIDE 19960607 V25N18 P1O1 ************************************ X-comment: RFAS described: GM-96-011, HL-96-009, HL-96-010, HL-96-011, HL-96- X-URL: gopher://gopher.nih.gov:70/11/res/nih-guide/guide-files/96.06.07 A-96-056, PA-96-057 NIH GUIDE - Vol. 25, No. 18 - June 7, 1996 $$INDEX BEGIN ******************************************************* NOTICES $$INDEX N1 ********************************************************** SYMPOSIUM ON THE PAST, PRESENT AND FUTURE OF PEER REVIEW National Institutes of Health INDEX: NATIONAL INSTITUTES OF HEALTH $$INDEX N2 ********************************************************** CONTINUATION AND TERMINATION OF NIAID PROGRAM ANNOUNCEMENTS National Institute of Allergy and Infectious Diseases INDEX: ALLERGY, INFECTIOUS DISEASES $$INDEX N3 ********************************************************** THE NATIONAL CELL CULTURE CENTER National Center for Research Resources INDEX: RESEARCH RESOURCES $$INDEX N4 ********************************************************** NATIONAL ANIMAL WELFARE EDUCATION WORKSHOPS National Institutes of Health INDEX: NATIONAL INSTITUTES OF HEALTH $$INDEX N5 ********************************************************** NATIONAL HUMAN SUBJECT PROTECTIONS WORKSHOPS National Institutes of Health Food and Drug Administration INDEX: NATIONAL INSTITUTES OF HEALTH; FOOD AND DRUG ADMINISTRATION NOTICES OF AVAILABILITY (RFPs/RFAs/PAs) $$INDEX R1 ********************************************************** EFFICACY TRIAL OF SPERMICIDAL AGENTS (RFP NICHD-CRE-96-09) National Institute of Child Health and Human Development INDEX: CHILD HEALTH, HUMAN DEVELOPMENT $$INDEX R2 08/07/96 ************************************************* SUPPORT OF MORE PROGRAM SCIENTIFIC MEETINGS, CONFERENCES, AND WORKSHOPS (RFA GM-96-011) National Institute of General Medical Sciences INDEX: GENERAL MEDICAL SCIENCES $$INDEX R3 08/23/96 ************************************************* NHLBI SHORT-TERM RESEARCH TRAINING FOR MINORITY STUDENTS PROGRAM (RFA HL-96-009) National Heart, Lung, and Blood Institute INDEX: HEART, LUNG, BLOOD $$INDEX R4 08/23/96 ************************************************* NHLBI MINORITY INSTITUTIONAL RESEARCH TRAINING PROGRAM (RFA HL-96-010) National Heart, Lung, and Blood Institute INDEX: HEART, LUNG, BLOOD $$INDEX R5 08/23/96 ************************************************* NHLBI MINORITY INSTITUTION FACULTY MENTORED RESEARCH SCIENTIST DEVELOPMENT AWARD (RFA HL-96-011) National Heart, Lung, and Blood Institute INDEX: HEART, LUNG, BLOOD $$INDEX R6 08/23/96 ************************************************* NHLBI MENTORED RESEARCH SCIENTIST DEVELOPMENT AWARD FOR MINORITY FACULTY (RFA HL-96-012) National Heart, Lung, and Blood Institute INDEX: HEART, LUNG, BLOOD $$INDEX R7 08/27/96 ************************************************* BIOLOGICAL EFFECTS OF POWER FREQUENCY EMF (RFA ES-96-007) National Institute of Environmental Health Sciences INDEX: ENVIRONMENTAL HEALTH SCIENCES $$INDEX R8 10/29/96 ************************************************* OBESITY/NUTRITION RESEARCH CENTERS (RFA DK-96-011) National Institute of Diabetes and Digestive and Kidney Diseases INDEX: DIABETES, DIGESTIVE, KIDNEY DISEASES $$INDEX R9 01/15/97 ************************************************* ASTHMA, ALLERGIC AND IMMUNOLOGIC DISEASES COOPERATIVE RESEARCH CENTERS (RFA AI-96-005) National Institute of Allergy and Infectious Diseases INDEX: ALLERGY, INFECTIOUS DISEASES $$INDEX P1 ********************************************************** SMALL MOLECULE TRANSPORTER PROTEINS IN BLOOD, RENAL AND PROSTATE CELLS (PA-96-055) National Institute of Diabetes and Digestive and Kidney Diseases INDEX: DIABETES, DIGESTIVE, KIDNEY DISEASES $$INDEX P2 ********************************************************** POSTDOCTORAL TRAINING IN COMPLEMENTARY/ALTERNATIVE MEDICINE (PA-96-056) Office of Alternative Medicine National Institutes of Health INDEX: ALTERNATIVE MEDICINE $$INDEX P3 ********************************************************** QTL MAPPING OF ALCOHOL-RELATED BEHAVIORAL TRAITS IN RODENTS (PA-96-057) National Institute on Alcohol Abuse and Alcoholism INDEX: ALCOHOL ABUSE, ALCOHOLISM ERRATA $$INDEX E1 ********************************************************** COLLABORATIVE OPPORTUNITIES FOR RESEARCH ON MINORITY ORAL HEALTH (RFA DE-96-002) National Institute of Dental Research INDEX: DENTAL RESEARCH THE NIH GUIDE IS AVAILABLE ELECTRONICALLY VIA BITNET OR INTERNET, BY SUBSCRIPTION, AND IS ALSO ON THE NIH GOPHER (GOPHER.NIH.GOV) AND THE NIH WEBSITE (HTTP://WWW.NIH.GOV). ALTERNATIVE ACCESS IS THROUGH THE NIH GRANT LINE VIA MODEM (DATA LINE 301/402-2221); CONTACT DR. JOHN JAMES AT 301/435-2801 FOR DETAILS ON THE NIH GRANT LINE. THE PHS STRONGLY ENCOURAGES ALL GRANT AND CONTRACT RECIPIENTS TO PROVIDE A SMOKE-FREE WORKPLACE AND PROMOTE THE NON-USE OF ALL TOBACCO PRODUCTS. IN ADDITION, PUBLIC LAW 103-227, THE PRO-CHILDREN ACT OF 1994, PROHIBITS SMOKING IN CERTAIN FACILITIES (OR IN SOME CASES, ANY PORTION OF A FACILITY) IN WHICH REGULAR OR ROUTINE EDUCATION, LIBRARY, DAY CARE, HEALTH CARE OR EARLY CHILDHOOD DEVELOPMENT SERVICES ARE PROVIDED TO CHILDREN. THIS IS CONSISTENT WITH THE PHS MISSION TO PROTECT AND ADVANCE THE PHYSICAL AND MENTAL HEALTH OF THE AMERICAN PEOPLE. ALL COMPETING GRANT APPLICATIONS SUBMITTED TO THE NATIONAL INSTITUTES OF HEALTH MUST BE SENT TO: DIVISION OF RESEARCH GRANTS NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC 7710 BETHESDA, MD 20892-7710 BETHESDA, MD 20817 (for express/courier service) THE GRANTS INFORMATION OFFICE, DRG, HAS BEEN INCORPORATED INTO THE NEW OFFICE OF EXTRAMURAL OUTREACH & INFORMATION RESOURCES, OFFICE OF EXTRAMURAL RESEARCH, OFFICE OF THE DIRECTOR, NIH. REQUESTS FOR APPLICATION FORMS, PUBLICATIONS, AND OTHER INFORMATION MAY BE DIRECTED TO THE FOLLOWING: OFFICE OF EXTRAMURAL OUTREACH & INFORMATION RESOURCES 6701 ROCKLEDGE DRIVE, MSC 7910 BETHESDA, MD 20892-7910 TELEPHONE: (301) 435-0714 EMAIL: ASKNIH@ODROCKM1.OD.NIH.GOV $$INDEX END ********************************************************* NOTICES $$N1 BEGIN ********************************************************** SYMPOSIUM ON THE PAST, PRESENT AND FUTURE OF PEER REVIEW NIH GUIDE, Volume 25, Number 18, June 7, 1996 P.T. 42; K.W. 1014006, 1014004 National Institutes of Health Division of Research Grants 1996 marks the 50th anniversary of the founding of the Division of Research Grants. The National Institutes of Health and the Division of Research Grants are marking this occasion with a symposium on the Past, Present, and Future of Peer Review. This symposium will be held Thursday, June 20 at the Natcher Conference Center on the Bethesda campus of NIH. The symposium will start at 8:00 a.m. and conclude with a reception at the Natcher Center in the late afternoon. This is an opportunity for colleagues, friends, and others to discuss fifty years of excellence in peer review and its impact on biomedical research. There is no fee for the symposium, but advance registration is required. The registration deadline is May 31, 1996. The Natcher facility is fully accessible in compliance with the Americans with Disabilities Act. INQUIRIES Information is available on the DRG home page - http://www.drg.nih.gov or can be requested from: Administrative Office Division of Research Grants 6701 Rockledge Drive MSC 7760 Bethesda, MD 20892-7760 Telephone: (301) 435-1099 FAX: (301) 480-3963 Questions about the symposium may be addressed to: Suzanne E. Fisher, Ph.D. Division of Research Grants National Institutes of Health Rockledge Building, Room 2030 - MSC 7720 Bethesda, MD 20892-7720 Telephone: (301) 435-0715 FAX: (301) 480-1987 Email: fys@drgpo.drg.nih.gov $$N1 END ************************************************************ $$N2 BEGIN ********************************************************** CONTINUATION AND TERMINATION OF NIAID PROGRAM ANNOUNCEMENTS NIH GUIDE, Volume 25, Number 18, June 7, 1996 P.T. 34; K.W. 1014006 National Institute of Allergy and Infectious Diseases This notice is to inform the research community that the National Institute of Allergy and Infectious Diseases (NIAID) will continue to support selected Program Announcements (PAs) and is withdrawing support for other PAs. Further, additional PAs will be published over the next few months as NIAID continues to adjust and expand the use of PAs to inform the scientific community of its areas of current research emphasis (See NIH Guide, Volume 25, April 19, 1996 for NIAID Notice on Program Announcements and Research Emphasis Areas). CONTINUATIONS. NIAID will continue to accept applications in response to the following PAs through January 2, 1998 (unless the individual PA states otherwise). For each PA, the number, title, and date of publication in the NIH Guide for Grants and Contracts is cited below. These PAs can be viewed and printed through the NIH Grants and Contracts Home Page (http://www.nih.gov:80/grants). On this home page, select ~NIH GUIDE FOR GRANTS AND CONTRACTS~; then select ~NIH Guide-Flat Text Files Printed Edition~; then select the publication date(s) for the PA(s) in which you are interested. PA-92-54 Cytokines in Autoimmunity, March 20, 1992 PA-93-014 The Immunology of Aging, November 6, 1992 PA-93-034 Mucosal Immunity in the Urogenital Tract, January 8, 1993 PA-93-037 Asthma as a T-Cell-Mediated Disease, January 15, 1993 PA-93-041 Minority Investigators in Asthma and Allergy, January 22, 1993 PA-93-108 Behavioral Research in Sexually Transmitted Diseases, September 3, 1993 PA-93-114 Autoimmune Endocrine Disease, September 24, 1993 PA-94-019 Infectious Causes of Diarrhea/Wasting Syndrome in People with AIDS, December 17, 1993 PA-94-049 Studies on Environmental Toxicants and the Immune System, March 18, 1994 PA-94-062 Environmental Agents and Asthma, April 29, 1994 PA-94-092 New Insights into Chronic Fatigue Syndrome, August 4, 1994 PA-94-095 Drug Discovery for Opportunistic Infections Associated with AIDS, September 16, 1994 PAR-95-047 National Cooperative Drug Discovery Groups, HIV Treatment, April 14, 1995 PA-95-062 Fellowships and Career Development in Inflammatory Bowel Disease, May 19, 1995 PA-96-014 Models for HIV Disease and AIDS-related Malignancies, January 26, 1996 PAR-96-031 NIDDK-NIAID International Collaboration: Small Grant Awards, March 8, 1996 TERMINATIONS. The following program announcements (PAs) are being withdrawn; NIAID will no longer accept applications in response to these PAs. This notice is effective immediately and applies to the application receipt deadlines of May 1, 1996 and after. ALL NIAID-SPONSORED PAs PUBLISHED IN THE NIH GUIDE FOR GRANTS AND CONTRACTS PRIOR TO MARCH 20, 1992. PA-92-55 Exercise Induced Fatigue in Chronic Fatigue Syndrome, March 20, 1992 PA-92-60 Prevent Insulin Dependent Diabetes by Immunomodulation, March 27, 1992 PA-92-76 AIDS-Associated Kaposi~s Sarcoma, May, 8, 1992 PA-92-84 Research to Better Understand and Prevent Measles, June 5, 1992 PA-92-96 Research Career Development in Mycobacterium Tuberculosis, August 14, 1992 PA-93-049 Neurological Aspects of Lyme Disease, February 5, 1993 PA-93-061 Congenital Cytomegalovirus: Study of Infection and Sequelae, March 5, 1993 PA-93-085 Biological Factors Influencing Sexual Transmission of HIV, May 21, 1993 PA-93-090 Basic Rubella Research Leading to Improved Rubella Vaccines, June 4, 1993 PA-93-096 Research on DNA Vaccines for Infectious Diseases, June 18, 1993 PA-93-105 Helicobacter Pylori Pathogenesis, August 8, 1993 PA-94-023 HIV-Related Therapeutics in Drug Users, January 7, 1994 INQUIRIES For questions or further information, contact: Office of the Director Division of Extramural Activities National Institute of Allergy and Infectious Diseases Solar Building, Room 3C20 Bethesda, MD 20892-7610 Telephone: (301) 496-7291 FAX: (301) 402-0369 Email: ac20a@nih.gov $$N2 END ************************************************************ $$N3 BEGIN ********************************************************** THE NATIONAL CELL CULTURE CENTER NIH GUIDE, Volume 25, Number 18, June 7, 1996 P.T. 32; K.W. 0780015 National Center for Research Resources The National Cell Culture Center is a resource facility that provides large-scale mammalian cell culture services. The Center, available to researchers throughout the United States and Canada, has been established to alleviate the shortage of facilities and expertise required to meet the cell culture needs of the biomedical research community. Specifically, the Cell Culture Center supports basic biomedical research by providing investigators with the following customized services: o Large quantity production of mammalian cells in suspension or monolayer cultures. Quantities range from 1 to 200 liters per day. o Large quantity production of monoclonal antibodies. Quantities range from 0.5 to 100 grams. o Large quantity production of non-hybridoma cell secreted proteins. Quantities vary depending on individual cell lines. A request form, obtained from the Cell Culture Center, must be submitted with a description of the relevant research project. After the request form is reviewed, the cell line is sent to the Center, and grown to the requested amount. Researchers are charged only for the consumable materials and a portion of the labor costs required for each project. The Cell Culture Center is supported by a cooperative agreement award from the National Center for Research Resources, NIH. INQUIRIES Direct programmatic inquiries regarding this resource to: Elaine Young, Ph.D. Comparative Medicine National Center for Research Resources 6705 Rockledge Drive, Room 6158, MSC 7965 Bethesda, MD 20892-7965 Telephone: (301) 435-0776 Email: elainey@ep.ncrr.nih.gov Direct requests for applications and resource inquiries to: Dr. Mark Hirschel Director, National Cell Culture Center 8500 Evergreen Boulevard Minneapolis, MN 55433 Telephone: (800) 325-1112 Email: ncccinfo@nccc.com $$N3 END ************************************************************ $$N4 BEGIN ********************************************************** NATIONAL ANIMAL WELFARE EDUCATION WORKSHOPS NIH GUIDE, Volume 25, Number 18, June 7, 1996 P.T. 42; K.W. 0201011, 1014003 National Institutes of Health The National Institutes of Health (NIH), Office of Extramural Research (OER), Office for Protection from Research Risks (OPRR) is continuing to sponsor workshops on implementing the Public Health Service Policy on Humane Care and Use of Laboratory Animals. Each of the workshops scheduled for Fiscal Year 1996 will focus on a specific theme. The workshops are open to institutional administrators, members of Institutional Animal Care and Use Committees, laboratory animal veterinarians, investigators and other institutional staff who have responsibility for high-quality management of sound institutional animal care and use programs. Ample opportunities will be provided to exchange ideas and interests through question and answer sessions and informal discussions. DATES: September 19-20, 1996 TOPIC: Institutional Responsibilities for Animal Care and Use Programs: Balancing Regulatory and Scientific Perspectives LOCATION: Adams Park Hotel, 1550 Court Place, Denver, CO 80202, telephone (303) 893-3333, FAX (303) 623-0303 SPONSORS: University of Colorado Health Sciences Center, Denver, CO; University of Southern Colorado, Pueblo, CO CONTACT: Ms. Joann Bauer or Dr. James O. Stevens Continuing Medical Education Office University of Colorado Health Sciences Center 4200 East 9th Avenue, Campus Box C295 Denver, CO 80262 Telephone: (303) 372-9054 or (303) 270-4648 FAX: (303) 372-9065 REGISTRATION FEE: $175.00 INQUIRIES For further information concerning future NIH/OPRR Animal Welfare Education Workshops, contact: Ms. Darlene Marie Ross Office for Protection from Research Risks National Institutes of Health 6100 Executive Boulevard, Suite 3B01 - MSC 7507 Rockville, MD 20892-7507 Telephone: (301) 496-8101 x233 Email: RossD@od6100m1.od.nih.gov $$N4 END ************************************************************ $$N5 BEGIN ********************************************************** NATIONAL HUMAN SUBJECT PROTECTIONS WORKSHOPS NIH GUIDE, Volume 25, Number 18, June 7, 1996 P.T. 42; K.W. 0783005 National Institutes of Health Food and Drug Administration The National Institutes of Health (NIH) and the Food and Drug Administration (FDA) are continuing to sponsor a series of workshops on responsibilities of researchers, Institutional Review Boards (IRBs), and institutional officials for the protection of human subjects in research. The workshops are open to everyone with an interest in research involving human subjects. The meetings should be of special interest to those persons currently serving or about to begin serving as a member of an IRB. Issues discussed at these workshops are relevant to all other Public Health Service agencies. The current schedule includes the following: DATES: July 25-26, 1996 TITLE: Protecting the Rights of Human Subjects in Research: Sharing the Benefits and Burdens of Research LOCATION: Alana Waikiki Hotel, 1956 Ala Moana Boulevard, Honolulu, HI 96815, telephone (808) 941-7275 SPONSORS: Kapi'olani Health Research Institute, Honolulu, HI; University of Hawaii, Honolulu, HI; Tripler Army Medical Center, Honolulu, HI REGISTRATION: Ms. Lora Young, Grants Assistant Kapi'olani Health Research Institute 1441 Kapi'olani Boulevard (18th Floor) Honolulu, HI 96814 Telephone: (808) 973-4759 FAX: (808) 973-8080 FEE: $120 DESCRIPTION: Topics to be discussed include: Protecting the Rights of Human Subjects: Today's Challenges; FDA Compliance Update; Report of Advisory Committee on Human Radiation Experiments; The IRB in Depth (Regulations; Policies and Procedures - What You Can and Cannot Review, Informed Consent, Expedited Reviews, Cooperative Agreements); Legal Issues in the Protection of Human Subjects (Access to Records: Hawaii Laws and Federal Regulations; Informed Consent; Liability Issues: The Institution Staff and Committee Members); Resolving Ethical Principles; Stressors for the IRB: Adverse Reaction Reporting Surviving Audits; The IRB's Obligation Regarding the Continuing Review of the Protocols; and Points for the IRB to Consider in Research Related to Human Genetics. INQUIRIES For further information regarding these workshops or future NIH/FDA National Human Subject Protections Workshops, contact: Ms. Darlene Marie Ross Office for Protection from Research Risks National Institutes of Health 6100 Executive Boulevard, Suite 3B01 - MSC 7507 Rockville, MD 20892-7507 Telephone: (301) 496-8101 x233 FAX: (301) 402-0527 Email: RossD@od6100m1.od.nih.gov $$N5 END ************************************************************ NOTICES OF AVAILABILITY (RFPs/RFAs/PAs) $$R1 BEGIN NICHD-CRE-96-09 ****************************************** EFFICACY TRIAL OF SPERMICIDAL AGENTS NIH GUIDE, Volume 25, Number 18, June 7, 1996 RFP AVAILABLE: NICHD-CRE-96-09 P.T. 34; K.W. 0750020, 0413002 National Institute of Child Health and Human Development The Contraceptive and Reproductive Evaluation Branch of the Center for Population Research, National Institute of Child Health and Human Development (NICHD), requires information on the contraceptive efficacy of different spermicide formulations marketed in the U.S. Secondary objectives include measurement of safety (adverse reactions) and acceptability. A clinical trial is requested that will rely on an educational/motivational component to maximize the number of consistent and correct users of spermicides during the trial period. The NICHD is seeking organization(s) capable of designing and conducting an observational study among women of reproductive age, obtaining reproductive histories, training subject in coital log use, and perform clinical testing to ascertain chemical pregnancies. Offerors should have knowledge of reproduction and contraception, expertise in the conduct of large clinical trials, and experience in analysis of large research data sets. Emphasis will be placed in the ability of the Offeror to recruit and follow adequate numbers of subjects during the course of the study. The Government estimates the total required effort to be approximately 17.1 staff years to complete a six-month follow-up of at least 300 women in each of four observational arms over a performance period of four years. It is estimated that from one to four cost-reimbursement, incrementally funded contract will be awarded. INQUIRIES This announcement is not a Request for Proposals (RFP). RFP NICHD-CRE-96-09 will be issued on or about June 10, 1996, and proposals will be due 90 days thereafter. Copies of the RFP may be obtained by FAX request or by sending a written request, along with a self-addressed mailing label to: Charles W. Grewe Contracts Management Branch National Institute of Child Health and Human Development 6100 Executive Boulevard, Suite 7A07 Bethesda, MD 20892-7510 FAX: (301) 402-3676 $$R1 END ************************************************************ $$R2 BEGIN GM-96-011 FULL-TEXT ************************************** SUPPORT OF MORE PROGRAM SCIENTIFIC MEETINGS, CONFERENCES, AND WORKSHOPS NIH GUIDE, Volume 25, Number 18, June 7, 1996 RFA AVAILABLE: GM-96-011 P.T. 42, FF; K.W. 0710030 National Institute of General Medical Sciences Letter of Intent Receipt Date: July 1, 1996 Application Receipt Dates: August 7, 1996 PURPOSE The National Institute of General Medical Sciences (NIGMS) invites cooperative agreement (U13) applications to support meetings, conferences, and/or workshops that are relevant to the mission of the Division of Minority Opportunities in Research (MORE). Applicants may propose more than one activity in the same application such as a conference and a workshop, or recurring activities such as a yearly meeting. The total project period for an application submitted in response to this RFA may not exceed five years. It is anticipated that up to $1,500,000 will be available to fund one to four grants. Administrative costs may be requested as direct costs. The MORE Division seeks innovative ways to provide technical assistance to improve the skills and abilities (competitiveness) of program directors, faculty and students supported by their MORE programs. For purposes of this request for applications (RFA), underrepresented minority individuals are defined as persons belonging to a particular ethnic or racial group that is underrepresented in biomedical research. INQUIRIES The RFA, which describes the research objectives, application procedures, review considerations, and award criteria for this solicitation, may be obtained electronically through the NIH Grant Line (data line 301/402-2221), the NIH GOPHER (gopher.nih.gov), and the NIH Website (http://www.nih.gov), and by mail and email from the program contact listed below. Clifton Poodry, Ph.D. Minority Opportunities in Research Division National Institutes of General Medical Sciences 45 Center Drive, Room 2AS.37, MSC 6200 Bethesda, MD 20892-6200 Telephone: (301) 594-3900 FAX: (301) 480-2573 Email: PoodryC@gm1.nigms.nih.gov $$R2 END ************************************************************ $$R3 BEGIN HL-96-009 FULL-TEXT ************************************** NHLBI SHORT-TERM RESEARCH TRAINING FOR MINORITY STUDENTS PROGRAM NIH GUIDE, Volume 25, Number 18, June 7, 1996 RFA AVAILABLE: HL-96-009 P.T. 44, FF; K.W. 0720005, 0715040, 0715165, 0715032, 0715187 National Heart, Lung, and Blood Institute Letter of Intent Receipt Date: August 2, 1996 Application Receipt Date: August 23, 1996 The National Heart, Lung, and Blood Institute (NHLBI) invites grant applications for the Short-Term Research Training for Minority Students Program. The purpose of the award is to encourage institutions to provide opportunities for underrepresented minority students at the undergraduate and graduate level to become exposed to biomedical research in areas relevant to cardiovascular, pulmonary, and hematologic diseases and sleep disorders through a short-term research experience. Awards in this program will be made to domestic institutions or organizations, including minority institutions, engaged in research in areas related to heart, lung, blood or sleep disorders. These grants will support short-term research training experiences of two to three months duration for minority students at the undergraduate or graduate level, including health professional students. Students appointed to the program must be U.S. citizens, noncitizen nationals, or permanent residents of the U.S. Individuals holding Ph.D., M.D., D.V.M., or equivalent doctoral degrees in the health sciences are not eligible. The grantee institution will be responsible for the selection and appointment of trainees. The program is intended to introduce students to research that would not otherwise be available through their regular course of studies. The mechanism of support will be the National Institutes of Health (NIH) Short-Term Training grant (T35). The total project period for an application submitted in response to this RFA may not exceed five years. The anticipated award date is May 1, 1997. The estimated funds (total costs) available for the first year of support for the entire program is expected to be $300,000 in fiscal year 1997. The number of awards is estimated to be 10 awards for the Short-Term Research Training for Minority Students Program. The actual amounts may vary, depending on the response to the RFA and availability of funds. Funding beyond the first and subsequent years of the grant will be contingent upon satisfactory progress during the preceding years and availability of funds. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This RFA, NHLBI Short-Term Research Training for Minority Students Program, is related to the priority areas of heart disease and stroke, maternal and infant health, environmental health, and educational and community-based programs. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0 or Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-512-1800). INQUIRIES The RFA, which describes the research objectives, application procedures, review considerations, and award criteria for this solicitation, may be obtained electronically through the NIH Grant Line (data line 301/402-2221), the NIH GOPHER (gopher.nih.gov), and the NIH Website (http://www.nih.gov), and by mail and email from the program contact listed below. Mary S. Reilly, M.S. Division of Lung Diseases National Heart, Lung, and Blood Institute 6701 Rockledge Drive MSC 7952 Bethesda, MD 20892-7952 Telephone: (301) 435-0222 FAX: (301) 480-3557 Email: mary_reilly@nih.gov $$R3 END ************************************************************ $$R4 BEGIN HL-96-010 FULL-TEXT ************************************** NHLBI MINORITY INSTITUTIONAL RESEARCH TRAINING PROGRAM NIH GUIDE, Volume 25, Number 18, June 7, 1996 RFA AVAILABLE: HL-96-010 P.T. 44, FF; K.W. 0720005, 0715040, 0715165, 0715032, 0715187 National Heart, Lung, and Blood Institute Letter of Intent Receipt Date: August 2, 1996 Application Receipt Date: August 23, 1996 The NHLBI invites applications for the Minority Institutional Research Training program directed at developing the research capabilities of minority individuals in areas relevant to cardiovascular, pulmonary, and hematologic diseases, and sleep disorders. The purpose of this program is to encourage the enhancement of research skills by minority individuals and to increase the number of minority individuals involved in research endeavors in the areas of interest to the NHLBI. Awards in this program will be made to non federal domestic minority institutions (institutions in which a majority of the students are minority) engaged in health related-research. These grants will are intended to support the research training of predoctoral students, health-professional students, and/or postdoctoral trainees at the minority institution. Training will be provided in conjunction with a collaborating research center (university, medical school, or comparable institution) that has strong, well-established research and research training programs in are as relevant to heart, lung, and blood diseases and sleep disorders. Trainees appointed to the program by the minority institution will be placed with a mentor at the cooperating research center who is an accomplished investigator and who will assist the advisor at the minority institution in the trainee's development and research plan. The mechanism of support will be the NIH Institutional NRSA (T32) award. The total project period for an application in response to this RFA may not exceed five years. The estimated funds (total costs) available for the first year of support for the entire program is expected to be $300,000 in fiscal year 1997. Three new awards for Minority Institutional Research Training Program are anticipated. The actual amounts awarded for this specific program may vary, depending on the response to the RFA and availability of funds. HEALTHY PEOPLE 2000 The PHS is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This RFA, NHLBI Minority Institutional Research Training Program, is related to the priority areas of heart disease and stroke, educational and community-based programs, maternal and infant health, and environmental health. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0 or Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-512-1800). INQUIRIES The RFA, which describes the research objectives, application procedures, review considerations, and award criteria for this solicitation, may be obtained electronically through the NIH Grant Line (data line 301/402-2221), the NIH GOPHER (gopher.nih.gov), and the NIH Website (http://www.nih.gov), and by mail and email from the program contact listed below. Michael Commarato, Ph.D. Division of Heart and Vascular Diseases National Heart, Lung, and Blood Institute 6701 Rockledge Drive, Room 9204 - MSC 7940 Bethesda, MD 20892-7940 Telephone: (301) 435-0530 FAX: (301) 480-1454 Email: michael_commarato@nih.gov $$R4 END ************************************************************ $$R5 BEGIN HL-96-011 FULL-TEXT ************************************** NHLBI MINORITY INSTITUTION FACULTY MENTORED RESEARCH SCIENTIST DEVELOPMENT AWARD NIH GUIDE, Volume 25, Number 18, June 7, 1996 RFA AVAILABLE: HL-96-011 P.T. 44, FF; K.W. 0720005, 0715040, 0715165, 0715032, 0715187 National Heart, Lung, and Blood Institute Letter of Intent Receipt Date: August 2, 1996 Application Receipt Date: August 23, 1996 The NHLBI invites applications for the Minority Institution Faculty Mentored Research Scientist Development Award. The purpose of this program is to encourage the development of faculty investigators at minority institutions in areas relevant to cardiovascular, pulmonary, and hematologic diseases and sleep disorders research and stimulate cardio-vascular, pulmonary, and hematologic disease and sleep disorder research, prevention, control and education by offering faculty members of minority institutions the opportunity to enhance their research capabilities in these areas. Awards in this program will be made to domestic minority institutions on behalf of the applicant. Candidates for this award are faculty members of minority institutions who are citizens of the United States, non-citizen nationals, or permanent residents at the time of application and have a doctoral degree or equivalent in a biomedical or behavioral science. Applicants should propose a research development program that includes arrangements to work with a mentor at a nearby (within 100 miles) research center. The mentor should be recognized as an accomplished investigator in the area proposed and should provide guidance for the awardee's development and research plan in research areas related to heart, lung, or blood disorders. The mechanism of support will be the NIH K01 award. The total project period for an application submitted in response to this RFA may not exceed five years. The estimated funds (total costs) available for the first year of support for the entire program is expected to be $250,000 in fiscal year 1997. Three new awards for the NHLBI Minority Institution Faculty Mentored Research Scientist Development Award are anticipated. HEALTHY PEOPLE 2000 The PHS is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This RFA is related to the priority areas of heart disease and stroke, maternal and child health, environment health, and educational and community-based programs. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0 or Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-512-1800). INQUIRIES The RFA, which describes the research objectives, application procedures, review considerations, and award criteria for this solicitation, may be obtained electronically through the NIH Grant Line (data line 301/402-2221), the NIH GOPHER (gopher.nih.gov), and the NIH Website (http://www.nih.gov), and by mail and email from the program contact listed below. LeeAnn Jensen, Ph.D. Division of Blood Diseases and Resources National Heart, Lung, and Blood Institute 6701 Rockledge Drive MSC 7950 Bethesda, MD 20892-7950 Telephone: (301) 435-0065 Email: leeann_jensen@nih.gov $$R5 END ************************************************************ $$R6 BEGIN HL-96-012 FULL-TEXT ************************************** NHLBI MENTORED RESEARCH SCIENTIST DEVELOPMENT AWARD FOR MINORITY FACULTY NIH GUIDE, Volume 25, Number 18, June 7, 1996 RFA AVAILABLE: HL-96-012 P.T. 44, FF; K.W. 0720005, 0715040, 0715165, 0715032, 0715187 National Heart, Lung, and Blood Institute Letter of Intent Receipt Date: August 2, 1996 Application Receipt Date: August 23, 1996 The NHLBI invites grant applications for the Mentored Research Scientist Development Award (K01) for Minority Faculty program. The purpose of the award is to encourage the enhancement of the research skills of minority faculty members at non-minority and minority institutions in the areas of interest to the NHLBI and to increase the number of minority individuals involved in research endeavors. Individuals applying for this program must have been awarded a doctoral degree (Ph.D., M.D., D.V.M., D.O. degree or its equivalent), have a faculty appointment at an accredited college or university at the time of award, and be members of an underrepresented minority group. For the purpose of this program, underrepresented minority faculty members are defined as individuals belonging to a particular ethnic or racial group that has been determined to be underrepresented in biomedical or behavioral research. In making grant awards under this program, the NHLBI will give priority to projects involving Black, Hispanic, American Indians, Alaska Natives, Pacific Islander, and/or other ethnic or racial group members who are underrepresented in biomedical or behavioral research nationally. Candidates must be nominated by an institution on the basis of qualifications, interests, accomplishments, motivation, and potential for performing quality research. The candidate's academic background, previous experience, and career goals should determine both the necessary length and the kind of program that is appropriate. Each candidate must identify a sponsor(s) who is an accomplished investigator in the research area proposed, who is engaged in research in areas related to heart, lung, blood, or sleep disorders, and has experience in developing independent investigators. Awardees, under this program, may receive salary support up to a maximum of $50,000 plus fringe benefits per year for five years. A minimum of 80 percent effort must be devoted to the research program. In addition to the salary request for the candidate, support for up to five percent of the sponsor's salary and $30,000 per year for research support may be requested. The estimated funds (total costs) available for the first year of support for this program are expected to be $1 million in fiscal year 1997. It is estimated that 12 awards will be made in response to this RFA. HEALTHY PEOPLE 2000 The PHS is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This RFA, NHLBI Mentored Research Scientist Development Award for Minority Faculty, is related to the priority areas of heart disease and stroke, maternal and infant health, environment health, and educational and community-based programs. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0 or Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-512-1800). INQUIRIES The RFA, which describes the research objectives, application procedures, review considerations, and award criteria for this solicitation, may be obtained electronically through the NIH Grant Line (data line 301/402-2221), the NIH GOPHER (gopher.nih.gov), and the NIH Website (http://www.nih.gov), and by mail and email from the program contact listed below. Mary S. Reilly, M.S. Division of Lung Diseases National Heart, Lung, and Blood Institute 6701 Rockledge Drive, Room 10112 - MSC 7952 Bethesda, MD 20892-7952 Telephone: (301) 435-0222 FAX: (301) 480-3557 Email: mary_reilly@nih.gov $$R6 END ************************************************************ $$R7 BEGIN ES-96-007 FULL-TEXT ************************************** BIOLOGICAL EFFECTS OF POWER FREQUENCY EMF NIH GUIDE, Volume 25, Number 18, June 7, 1996 RFA AVAILABLE: ES-96-007 P.T. 34; K.W. 0725015, 1007003 National Institute of Environmental Health Sciences Letter of Intent Receipt Date: August 2, 1996 Application Receipt Date: August 27, 1996 PURPOSE To accomplish the goals established in the 1992 Energy Policy Act, the National Institute of Environmental Health Sciences (NIEHS) initiated a research program in 1994. Recently reported preliminary studies suggest new directions for Electromagnetic Fields (EMF) research that may further contribute to the assessment of a possible EMF hazard. The goal of this Small Grants Program (R03) Request for Applications (RFA) is to support studies that provide data needed for the hazard assessment of EMF. The total estimated funds available for this small grants program is $2.25 million, which will support approximately 15 to 30 awards. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This RFA, Biological Effects of Power Frequency EMF, is related to the priority area of environmental health. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0 or Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington DC 20402-9325 (telephone 202-512-1800). INQUIRIES The RFA, which describes the research objectives, application procedures, review considerations, and award criteria for this solicitation, may be obtained electronically through the NIH Grant Line (data line 301/402-2221), the NIH GOPHER (gopher.nih.gov), and the NIH Website (http://www.nih.gov), and by mail and email from the program contact listed below. Michael J. Galvin, Ph.D. Division of Extramural Research and Training National Institute of Environmental Health Sciences P.O. Box 12233, MD 3-02 Research Triangle Park, NC 27709 Telephone: (919) 541-7825 FAX: (919) 541-2843 Email: Galvin@niehs.nih.gov $$R7 END ************************************************************ $$R8 BEGIN DK-96-011 FULL-TEXT ************************************** OBESITY/NUTRITION RESEARCH CENTERS NIH GUIDE, Volume 25, Number 18, June 7, 1996 RFA AVAILABLE: DK-96-011 P.T. 04; K.W. 0715145, 0765020, 0710095, 0710030 National Institute of Diabetes and Digestive and Kidney Diseases Letter of Intent Receipt Date: September 26, 1996 Application Receipt Date: October 29, 1996 PURPOSE The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) invites applications for Obesity/Nutrition Research Centers (Core Centers: P30) for conducting basic and clinical research on obesity and the related fields of energy metabolism, body composition, satiety, adipocyte metabolism, eating disorders, and weight management. The centers will be awarded in Fiscal Year 1997. The award of at least two Obesity/Nutrition Research Centers by NIDDK is anticipated. Two existing Centers are expected to submit competitive renewal applications. For FY 97, up to $1,434,000 total costs will be available to fund applications submitted in response to this Request for Applications (RFA). HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention goals of Healthy People 2000, a PHS-led national activity for setting priorities. This RFA, Obesity/Nutrition Research Centers, is related to the priority areas of nutrition, physical activity and fitness, heart disease and stroke, cancer, diabetes, and chronic disabling conditions. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No 017-001-00474-0, or Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-512-1800). INQUIRIES The RFA, which describes the research objectives, application procedures, review considerations, and award criteria for this solicitation, may be obtained electronically through the NIH Grant Line (data line 301-402-2221), the NIH GOPHER (gopher.nih.gov), the NIH website (http://www.nih.gov), and by mail and email from the program contact listed below. Van S. Hubbard, M.D., Ph.D. Division of Digestive Diseases and Nutrition National Institute of Diabetes and Digestive and Kidney Diseases 45 Center Drive, MSC 6600 Bethesda, MD 20892-6600 Telephone: (301) 594-8883 FAX: (301) 480-8300 Email: hubbardv@ep.niddk.nih.gov $$R8 END ************************************************************ $$R9 BEGIN AI-96-005 FULL-TEXT ************************************** ASTHMA, ALLERGIC AND IMMUNOLOGIC DISEASES COOPERATIVE RESEARCH CENTERS NIH GUIDE, Volume 25, Number 18, June 7, 1996 RFA AVAILABLE: AI-96-005 P.T. 04; K.W. 0715013, 0715110, 0710070 National Institute of Allergy and Infectious Diseases Letter of Intent Receipt Date: September 15, 1996 Application Receipt Date: January 15, 1997 APPLICATIONS IN RESPONSE TO THIS REQUEST FOR APPLICATIONS (RFA) MUST BE PREPARED USING A MODIFIED (ABBREVIATED) GRANT APPLICATION FORMAT; SPECIFIC INSTRUCTIONS FOR COMPLETING THE APPLICATION ARE IN THE RFA. PURPOSE The Division of Allergy, Immunology and Transplantation of the National Institute of Allergy and Infectious Diseases (NIAID), invites applications for Asthma, Allergic and Immunologic Diseases Cooperative Research Centers (AAIDCRCs). This program is designed to support basic and clinical research on mechanisms of, intervention in, and prevention of asthma, allergic and immunologic diseases. Applications are to be designed around a central scientific theme demonstrating relevance to one or more diseases in these areas. A minimum of three biomedical research projects must be proposed, plus a Demonstration and Education (D&E) research component to study interventions for asthma in defined populations. It is anticipated that approximately $3,750,000 will be available to fund up to five multiproject cooperative agreement (U19) grants in response to this RFA. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This RFA, Asthma, Allergic and Immunologic Diseases Cooperative Research Centers, is related to the priority areas of education and community-based programs, environmental health, diabetes and chronic disabling conditions, and immunization and infectious diseases. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0 or Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-0325 (telephone 202-512-1800). INQUIRIES The RFA, which describes the research objectives, application procedures, review considerations, and award criteria for this solicitation, may be obtained electronically through the NIH Grant Line (data line 301/402-2221), the NIH GOPHER (gopher.nih.gov), and the NIH Website (http://www.nih.gov), and by mail and email from the program contact listed below. Daniel Rotrosen, M.D. Division of Allergy, Immunology and Transplantation National Institute of Allergy and Infectious Diseases Solar Building, Room 4A24 Bethesda, MD 20892-7640 Telephone: (301) 496-8974 FAX: (301) 402-2571 Email: dr17g@nih.gov $$R9 END ************************************************************ $$P1 BEGIN PA-96-055 FULL-TEXT ************************************** SMALL MOLECULE TRANSPORTER PROTEINS IN BLOOD, RENAL AND PROSTATE CELLS NIH GUIDE, Volume 25, Number 18, June 7, 1996 PA AVAILABLE: PA-96-055 P.T. 34; K.W. 0785070, 1002004, 0790005 National Institute of Diabetes and Digestive and Kidney Diseases PURPOSE The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through its Division of Kidney, Urologic and Hematologic Diseases, supports fundamental and applied research aimed at understanding the fundamental processes underlying the normal and pathologic function of blood cells and the blood forming system. Also supported is fundamental and applied research directed at normal renal structure, function and regulation. This includes studies utilizing whole kidney and/or the selected segments of the kidney or individual cells or any of their subcellular components as models. Urologic research is supported, including cellular and molecular approaches to the study of tissue-specific and cell-specific regulation of prostate growth. The ability to maintain a constant systemic environment is a critical requirement to maintain the normal health of an organ. At the cellular level, specific transport pathways maintain both the intracellular environment as well as providing the mechanisms which drive the maintenance of systemic balance. Cellular transport is mediated by specific membrane proteins. To understand the physiology and pathophysiology of homeostatic balance requires an understanding of how they are regulated. Methods for identifying and isolating the proteins or the genes for the proteins are available using contemporary cellular and molecular biological approaches. Such approaches have been used successfully to isolate a number of transporters from kidney, prostate, red blood cells, and other cells, making it possible to understand normal homeostatic mechanisms, as well as those leading to pathology of the homeostatic system. This PA will use the National Institutes of Health (NIH) individual research project grant (R01) and FIRST (R29) award mechanisms. Examples of applications responsive to this program announcement include, but are not limited to: (1) development of integrated programs to study the structure and function of the different transport proteins that are expressed in the red cell, prostate, and the kidney; (2) molecular biological approaches to study tissue specific expression of the various isoforms of the proteins; (3) development of information on structural biology of the proteins; (4) immunochemical localization of different proteins in various blood, renal and prostatic cells; (5) functional analysis of the proteins using tissue-specific knockout strategies; (6) definition of mutations responsible for human diseases; (7) definition of the functional consequences of protein-protein interactions in the membrane, and of membrane protein-cytoskeletal interactions; (8) the study of lipid-protein interactions, such as membrane microdomains; and (9) the study of the regulation of transport protein function by accessory molecules which act as regulators of these transporters under various pathophysiological conditions. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0 or Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-512-1800). INQUIRIES The PA, which describes the research objectives, application procedures, review considerations, and award criteria for this solicitation, may be obtained electronically through the NIH Grant Line (data line 301/402-2221), the NIH GOPHER (gopher.nih.gov), the NIH Website (http://www.nih.gov), the NIDDK Website (http://www.niddk.nih.gov), and by mail or email from the program official contact listed below. David G. Badman, Ph.D. Division of Kidney, Urologic and Hematologic Diseases National Institute of Diabetes and Digestive and Kidney Diseases 45 Center Drive, Room AS-13C MSC 6600 Bethesda, MD 20892-6600 Telephone: (301) 594-7717 FAX: (301) 480-3510 Email: David_Badman@nih.gov $$P1 END ************************************************************ $$P2 BEGIN PA-96-056 FULL-TEXT ************************************** POSTDOCTORAL TRAINING IN COMPLEMENTARY/ALTERNATIVE MEDICINE NIH GUIDE, Volume 25, Number 18, June 7, 1996 PA AVAILABLE: PA-96-056 P.T. 44; K.W. 0720005,0710030 Office of Alternative Medicine National Institutes of Health Application Receipt Dates: April 5, August 5, and December 5 PURPOSE The Office of Alternative Medicine (OAM) is planning to fund, through the various Institutes and Centers at the National Institutes of Health (NIH), National Research Service Award (NRSA) individual postdoctoral fellowships (F32). The purpose is to provide a cadre of investigators capable of conducting systematic studies on safety, efficacy, cost-effectiveness, or mechanisms of action of unconventional methods for treating major diseases and promoting well-being. This training is expected to attract postdoctoral candidates who are in the early stages of their careers. They will have obtained expertise in conventional research methodology and some familiarity with/or interest in alternative medical procedures. Prospective trainees will be expected to form an alliance with established researchers to provide a mutual learning experience. This program announcement (PA) on Alternative Medicine is based on a larger, NIH-wide PA on NRSA Individual Postdoctoral Fellowships, which should be requested from the contact person listed under INQUIRIES. The mechanism of support is the Individual National Research Service Award (F32). Individuals may request up to three years of aggregate NRSA support at the postdoctoral level. The stipend level for the first year of NRSA support is determined by the number of years of relevant postdoctoral experience at the time the award is issued. The range of support is from $18,600 (less than one full year of experience) to $32,300 (seven or more years of experience). Relevant experience includes research experience, teaching, internship, residency, and clinical duties. Supplementation, when provided, must not require obligation from the fellow. Under no circumstances may PHS grant funds be used for supplementation. NIH will provide an institutional allowance of $3,000 per 12-month period to non-federal non-profit sponsoring institutions to help defray such awardee expenses as tuition and fees, self-only health insurance, research supplies, equipment, travel to scientific meetings, and related items. For individuals sponsored by Federal laboratories, or for-profit institutions, the NIH will provide up to $2,000 for scientific meeting travel expenses, self-only health insurance, tuition fees, and books. Fellows in the first twelve months of postdoctoral NRSA support will incur a service obligation of one month for each month of support. Additional information is contained in the NIH Guide, Vol. 22, July 1993. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This PA, Training in Complementary/Alternative Medicine, is related to the priority area of complementary and alternative medicine. Potential applicants may obtain a copy of Healthy People 2000" (Full Report: Stock No. 017-001-00474-0 or Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-512-1800). INQUIRIES The PA, which describes the research objectives, application procedures, review considerations, and award criteria for this solicitation, may be obtained electronically through the NIH Grant Line (data line 301/402-2221), the NIH GOPHER (gopher.nih.gov), and the NIH Website (http://www.nih.gov), and by mail and email from the program contact listed below. Dr. Richard L. Nahin Office of Alternative Medicine National Institutes of Health Building 31, Room 5B36 Bethesda, MD 20892 Telephone: (301) 496-4792 FAX: (301) 402-4741 Email: nahinr@od31em1.od.nih.gov $$P2 END ************************************************************ $$P3 BEGIN PA-96-057 FULL-TEXT ************************************** QTL MAPPING OF ALCOHOL-RELATED BEHAVIORAL TRAITS IN RODENTS NIH GUIDE, Volume 25, Number 18, June 7, 1996 PA AVAILABLE: PA-96-057 P.T. 34; K.W. 0404003, 0414015, 0755044 National Institute on Alcohol Abuse and Alcoholism PURPOSE The National Institute on Alcohol Abuse and Alcoholism (NIAAA) is seeking research grant applications to map quantitative trait loci (QTL) influencing rat and mouse behavioral traits that model human behavioral traits predisposing to alcoholism. Mapping of such QTL will permit subsequent testing of human homologues of these genes for linkage to alcoholism in human pedigrees. Such a test will help to establish which animal behavioral traits are most relevant to human alcoholism. Mapping of the QTL will also serve as a prologue to the isolation of the relevant genes and the identification of the products they encode. This approach can provide a novel route to elucidating the physiological mechanisms for predisposition to alcoholism and to developing intervention strategies to diminish harmful effects of alcohol. Grants awarded under this program announcement (PA) will use the research project grant (R01) and First Independent Research Support and Transition (FIRST) (R29) award mechanisms. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This PA, QTL Mapping of Alcohol-Related Behavioral Traits in Rodents, is related to the priority areas of alcohol abuse reduction and alcoholism treatment. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0, or Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-512-1800). INQUIRIES The PA, which describes the research objectives, application procedures, review considerations, and award criteria for this solicitation, may be obtained electronically through the NIH Grant Line (data line 301/402-2221), the NIH GOPHER (gopher.nih.gov), and the NIH Website (http://www.nih.gov), and by mail and email from the program contact listed below. Robert W. Karp, Ph.D. Division of Basic Research National Institute on Alcohol Abuse and Alcoholism Willco Building, Suite 402 6000 Executive Boulevard MSC 7003 Bethesda, MD 20892-7003 Telephone: (301) 443-4223 FAX: (301) 594-0673 Email: rkarp@willco.niaaa.nih.gov $$P3 END ************************************************************ ERRATA $$E1 BEGIN R2 19960426 APPEND RFA DE-96-002 BOTH *********************** COLLABORATIVE OPPORTUNITIES FOR RESEARCH ON MINORITY ORAL HEALTH NIH GUIDE, Volume 25, Number 18, June 7, 1996 RFA: DE-96-002 P.T. 34, FF; K.W. 0502009, 0730050, 0715148, 0785040 National Institute of Dental Research Letter of Intent Receipt Date: May 1, 1997 Application Receipt Date: June 20, 1997 The following correction is issued for RFA DE-96-002, which was published in the NIH Guide, Vol. 25, No. 13, April 26, 1996. The last sentence of the first paragraph under ELIGIBILITY REQUIREMENTS should read: "In order to expand the base of support, applications from institutions receiving concurrent funding through the Regional Research Centers in Minority Oral Health (RRCMOH) program are not eligible for funding under the Collaborative Opportunities for Research on Minority Oral Health (CORMOH) program." In addition, the list of institutions eligible as "research intensive" is provided for the convenience of potential applicants. APPENDIX INSTITUTIONS DESIGNATED AS "RESEARCH INTENSIVE" (IN ALPHABETICAL ORDER) Baylor College of Medicine Boston University Brigham and Women's Hospital Case Western Reserve University Columbia University Cornell University Duke University Emory University Fred Hutchinson Cancer Research Center Harvard University Indiana University Johns Hopkins University Massachusetts General Hospital Massachusetts Institute of Technology New York University Northwestern University Ohio State University Pennsylvania State University Scripps Research Institute Stanford University University of Alabama at Birmingham University of Arizona University of California, Berkeley University of California, Davis University of California, Los Angeles University of California, San Diego University of California, San Francisco University of Chicago University of Colorado Health Sciences Center University of Florida University of Iowa University of Maryland Baltimore Professional School University of Miami University of Michigan University of Minnesota University of North California, Chapel Hill University of Pennsylvania University of Pittsburgh University of Rochester University of Southern California University of Texas Health Science Center, San Antonio University of Texas South West Medical Center, Dallas University of Utah University of Virginia University of Washington University of Wisconsin at Madison Vanderbilt University Washington University Yale University Yeshiva University $$E1 END ************************************************************ From owner-sci-resources@net.bio.net Tue Jun 11 23:00:00 1996 Path: biosci!biosci!not-for-mail From: BIOSCI Administrator Newsgroups: bionet.sci-resources Subject: NIH GUIDE - PA-96-057 - V25(18) 06/07/96 Date: 11 Jun 1996 21:17:34 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 636 Sender: daemon@net.bio.net Approved: biosci-help@net.bio.net Distribution: world Message-ID: <4plgcu$9pg@net.bio.net> NNTP-Posting-Host: net.bio.net $$XID RFA PA96057 PA-96-057 P1O1 *************************************** QTL MAPPING OF ALCOHOL-RELATED BEHAVIORAL TRAITS IN RODENTS NIH GUIDE, Volume 25, Number 18, June 7, 1996 PA NUMBER: PA-96-057 P.T. 34; K.W. 0404003, 0414015, 0755044 National Institute on Alcohol Abuse and Alcoholism PURPOSE The National Institute on Alcohol Abuse and Alcoholism (NIAAA) is seeking research grant applications to map quantitative trait loci (QTL) influencing rat and mouse behavioral traits that model human behavioral traits predisposing to alcoholism. Mapping of such QTL will permit subsequent testing of human homologues of these genes for linkage to alcoholism in human pedigrees. Such a test will help to establish which animal behavioral traits are most relevant to human alcoholism. Mapping of the QTL will also serve as a prologue to the isolation of the relevant genes and the identification of the products they encode. This approach can provide a novel route to elucidating the physiological mechanisms for predisposition to alcoholism and to developing intervention strategies to diminish harmful effects of alcohol. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of Healthy People 2000," a PHS-led national activity for setting priority areas. This Program Announcement, QTL Mapping of Alcohol-Related Behavioral Traits in Rodents, is related to the priority areas of alcohol abuse reduction and alcoholism treatment. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0 or Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-512-1800). ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic and foreign, for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal government. Racial/ethnic minority individuals, women, and persons with disabilities are encouraged to apply as Principal Investigators. Foreign institutions are not eligible for First Independent Research Support and Transition (FIRST) Awards (R29). Regular research grant applications (R01) from foreign institutions are limited to three years. MECHANISM OF SUPPORT Research support may be obtained through applications for a research project grant (R01) or First Independent Research Support and Transition (FIRST) Award (R29). Applicants may also submit Investigator-Initiated Interactive Research Project Grants (IRPG) under this program announcement. Interactive Research Project Grants require the coordinated submission of related regular research project grant applications and, to a limited extent, FIRST Award applications from investigators who wish to collaborate on research, but do not require extensive shared physical resources. Further information on the IRPG mechanism is available in program announcement PA-96-001, NIH Guide for Grants and Contracts, Vol. 24, No. 35, October 6, 1995. RESEARCH OBJECTIVES Genetic Basis of Alcoholism Alcoholism has been recognized for over a century as a familially transmitted condition. Over the past 25 years, considerable evidence >From family, twin, and adoption studies supports important roles for both genes and environment in its etiology in both men (Cloninger, et al., 1981; Merikangas, 1990; McGue, et al., 1992) and women (Kendler, et al., 1992). The specific etiological factors underlying susceptibility to alcoholism remain, however, unknown. Ongoing efforts to discover genes linked to alcoholism in human pedigrees are challenged by the heterogeneous, polygenic nature of alcoholism, along with the incompletely understood role of the environment in its etiology (Aston and Hill, 1990). These efforts could be greatly bolstered by a strategy taking advantage of powerful genetic methods permitting identification of genes influencing ethanol-related behavior in experimental animals (Zeng, 1994; Jansen and Stam, 1994; Crabbe, et al., 1994a). Human homologues of these genes could then be tested directly for linkage to alcoholism in human pedigrees. The recent large increase in the density of markers on the mouse genetic map (Dietrich, et al., 1995), along with the development of new and more powerful methods of data analysis (Zeng, 1994; Jansen and Stam, 1994), have now made it possible to map individual quantitative trait loci (QTL), the genes contributing jointly to the determination of genetically complex traits (such as behavior) (Crabbe, et al., 1994a). Since mapped genes can be isolated and their encoded products characterized, QTL mapping offers a powerful reductionistic approach for dissecting the complex physiological bases of alcohol-related behavior. A detailed human-mouse synteny map can accurately predict the map location of potential human homologues of mouse genes (Nadeau, et al., 1992), so that these predicted loci can then be tested for linkage to alcoholism in human alcoholic pedigrees. This strategy would permit the direct application of knowledge gained from an animal behavior genetic study, for which behavioral measures are precisely defined and powerful genetic techniques can be brought to bear, to a human genetic study of alcoholism. A finding of linkage would, moreover, provide additional evidence for the relevance of the animal behavior under study to human alcoholism. Human Behavioral Indicators of Predisposition to Alcoholism Because family history of alcoholism is a significant risk factor for alcoholism (Cotton, 1979), researchers have examined psychological, biological, and behavioral characteristics that distinguish children of alcoholics from children of non-alcoholics as a means of identifying indicators of vulnerability to alcoholism. The most prominent theories of vulnerability to alcoholism have centered on temperament, baseline sensitivity, and acute tolerance to alcohol. Temperament models of vulnerability to alcoholism propose that deviations in dispositional traits mediate transmission of alcoholism (Tarter, 1991; Cloninger, 1987). According to Tarter, who used Rowe and Plomin's (1977) six dimensions of temperament, children at high risk for developing alcoholism have traits such as high behavioral activity, low attention span and persistence, low soothability, high emotionality, and low sociability. These disturbances of temperament in children of alcoholics are attributed to neurological dysfunction in the prefrontal, limbic, and midbrain areas. This theory is supported by observations of a number of differences between children of alcoholics and children of nonalcoholics, including increased incidence of psychopathology (attention deficit hyperactivity disorder, childhood conduct disorder, anxiety disorders and depression, antisocial personality disorder), behavioral disturbances (impulsiveness, aggression, emotionality), neuropsychological deficits (abstraction/ conceptualization, verbal ability), and neurophysiological variations (reduced amplitude of the P3 component of event-related potentials) (see Tarter, 1991; Sher, 1991 for reviews). In a similar vein, Cloninger's model of Type 1 and Type 2 alcoholism (Cloninger, 1987) is based on temperamental differences (novelty seeking, harm avoidance, reward dependence), which are related to selective neurological substrates and predispose an individual to certain types of alcoholism. For example, Type 2 alcoholics are high in novelty seeking, associated with impulsiveness, distractibility, and positively motivated drinking. Variation in novelty seeking has recently been associated with variants of the gene encoding the dopamine D4 receptor (Benjamin, et al., 1996). Type 1 alcoholics, on the other hand, are high in harm avoidance and reward dependence associated with anxiety, shyness, emotional dependence, and negatively motivated drinking (i.e., escape from dysphoric feelings). The sensitivity hypothesis of vulnerability to alcoholism, first elaborated by Schuckit and his colleagues in the early 1980s, postulated that children of alcoholics are less sensitive to the subjective intoxicating effects of alcohol, and therefore, are susceptible to drinking excessively (Schuckit, 1980, 1984). However, subsequent studies designed to test this hypothesis demonstrated opposite effects, i.e., children of alcoholics were more sensitive to the reinforcing effects of alcohol as measured by muscle relaxing, stress-dampening, electroencephalographic and mood effects (see Sher, 1991 for review). A recent interpretation proposed by Newlin and Thomson (1990) may resolve this conflict. Compared to sons of nonalcoholic fathers, sons of alcoholic fathers show greater acute sensitivity to the reinforcing effects of alcohol (euphoria, muscle relaxation, stress-response dampening) on the ascending limb of the blood alcohol curve, and less sensitivity (greater acute tolerance) to the aversive effects of alcohol (nausea, dysphoria) on the descending limb of the blood alcohol curve. Measuring Animal Behaviors Related to Human Traits Predicting Alcoholism Investigators are now mapping QTL influencing various ethanol-related behaviors in mice, including preference for drinking, sensitivity to sedation, locomotor activation, hypothermia, and withdrawal severity (for review, see Crabbe, et al., 1994a). More recently, they have begun mapping genes influencing more complex behaviors, such as acute functional tolerance to ataxia (Crabbe, et al., 1994a) and hypothermia (Crabbe, et al., 1994b), conditioned place preference (a measure of reinforcement) (Cunningham, 1995), and conditioned taste aversion (a measure of aversive effects) (Risinger and Cunningham, 1994). Aspects of more complex rodent behaviors could conceivably be homologous to human traits predisposing to alcoholism. Some of the corresponding assays could, in principle, be adapted for QTL mapping. Examples are given below. (These examples are for illustrative purposes only, and are not intended to exclude other behavioral tests >From this RFA.) Tests that assess intrinsic traits of temperament or personality predisposing humans to alcoholism, such as impulsiveness, novelty seeking, aggression, hyperactivity, emotionality, anxiety, and stress reactivity, can be administered to rodents. Impulsiveness in individuals at risk for alcoholism has been attributed to prefrontal- limbic brain dysfunction (Tarter, 1991) and is comparable to difficulties in response inhibition observed in rodents with prefrontal lesions (see Kolb, 1984 for review). Evidence of impaired response inhibition in rodents has been measured by reversal learning tasks (i.e., the animal first learns to respond to a particular stimulus or location for a reward, and then must reverse its response to a different place or stimulus), tests of response extinction (a previously rewarded response is no longer rewarded), or go/no go tasks (reward is presented for responding to a stimulus on "go" trials, and for not responding on "no go" trials) (Kolb, 1984; Sakurai and Sugimoto, 1985). Animals with deficits in response inhibition have difficulty shifting responses on reversal tasks, continue responding when rewards are no longer presented, and fail to suppress responding on "no go" trials. Research on alcohol and aggression in humans and animals has focused on whether alcohol consumption increases violent/aggressive behavior toward family members, peers, or rivals (see Miczek, et al., 1993 for review). However, whether a history of antisocial personality or aggressive behavior predisposes a person to excessive alcohol consumption has received little study. Measures of aggressive behavior in rodents that might reflect aspects of human antisocial behavior include social interaction/social conflict paradigms, such as isolation-induced aggression between male pairs, resident-intruder encounters, and possibly frustration-induced aggression (omission of reward) (Cairns, et al., 1983; Miczek, et al., 1993; Brain, et al., 1993). Measures of other traits potentially serving as markers of human alcoholism, such as anxiety, emotionality, activity level, and novelty- seeking, could be applied to rodents. Novelty or "sensation-seeking" can be measured by nose-poke or hole-board behavior in which the animal places its nose or head into a board with equally spaced holes. Activity level can easily be measured with activity wheels or by the number of boxes crossed in an open field. Hole-board behavior and exploratory open field activity, along with number of defecations and rearings in the open field, have also been used to quantitate levels of anxiety and emotionality. Other experimental paradigms for measuring anxiety include conflict paradigms, acoustic startle response, and elevated plus-maze (see Crawley, 1985; Shepard, 1986; Heilig, et al., 1994; Stout and Weiss, 1994 for reviews of all of these paradigms). A further related behavior is stress reactivity, which could be measured by responses to various stressors (social stress, isolation, early weaning), such as changes in vocalization pattern, disruption of circadian rhythms, or autonomic responses such as changes in blood pressure or heart rate (see Pohorecky, 1990; Brown, et al., 1991 for reviews). Acute behavioral tolerance to a single challenge dose of alcohol can be demonstrated in animals by comparing the extent of functional impairment at a given blood alcohol concentration on the ascending limb of the blood alcohol curve with the extent of impairment when the same alcohol concentration is reached on the descending limb. The development of acute tolerance within a single session to alcohol's effects such as motor impairment, hypothermia, and operant responding has been shown by several studies (LeBlanc, et al., 1975; Crabbe, et al., 1994b; Le, et al., 1992; Hiltunen and Jarbe, 1992). Finally, because frequency and amount of alcohol consumed are significant discriminators of alcoholic subtypes (Babor, et al., 1992; Morley and Skinner, 1986), measures of temporal patterns of alcohol consumption in rodents may be informative behavioral markers. Using operant techniques, distinctive temporal patterns of alcohol consumption have been demonstrated in the selectively bred alcohol-preferring and - nonpreferring rats (Schwarz-Stevens, et al., 1991). Such techniques could possibly be adapted to permit QTL mapping. Methodological Considerations Most QTL mapping of behavioral traits has been done in mice because of the well-developed genetic map available for this species. However, the rat genome map is now undergoing rapid development (Jacob, et al., 1995) and has already proven suitable for QTL mapping (Brown, et al., 1996; Galli, et al., 1996; Gauguier, et al., 1996). Because many interesting behavioral paradigms have been developed in rats to study ethanol- related behaviors, NIAAA encourages investigators studying rat behavior to respond to this RFA. While the choice of animal strains for study is an important feature of experimental design, applicants are encouraged to consider using any of a wide variety of strains, rather than confining their attention only to those already used extensively in alcohol research. While recombinant inbred (RI) strains have been used extensively to map QTL influencing behavioral traits (Crabbe et al., 1994a), applicants should consider carefully whether the small size of most extant batteries of RI strains (<25 strains) affords sufficient statistical power to detect QTL of modest to moderate effect size. Applicants are encouraged (when cost and experimental considerations permit) to test more than one behavioral paradigm on the same group of animals. Applicants may also wish to consider neurochemical measurements (e.g., receptor binding studies, in situ hybridization, other histological measurements) on the same group of animals. Such studies offer the prospect of a rigorous determination of genetic correlations among multiple behaviors and neurochemical parameters, as well as mapping of the genes responsible for those correlations. Some behavioral paradigms of great potential interest may be so complex as to preclude measurements on the hundreds of animals required for QTL mapping. Investigators working with such paradigms are strongly encouraged to attempt modifying them so as to permit measurements on hundreds of animals, without degrading their informativeness about the principal aspect of the behavior under study. SPECIAL REQUIREMENTS This program announcement is intended to publicize NIAAA's interest in the genetic analysis of animal behaviors not previously analyzed, in the hope that these behaviors may usefully model human traits related to predisposition to alcoholism. Investigators wishing to obtain support for such research who lack expertise in genetic analysis should seek collaboration with investigators experienced in QTL mapping, insofar as such experience will prove essential for proper study design and data analysis. Investigators desiring to establish such collaborations are encouraged to contact one of the individuals mentioned under INQUIRIES, below. Awardees will be expected to attend one joint meeting per year in or near Washington, DC, in order to review progress, and should request sufficient funds in their budgets to support such attendance. APPLICATION PROCEDURES Applications are to be submitted on the grant application form PHS 398 (rev. 5/95) and will be accepted at the standard application deadlines as indicated in the application kit. Application kits are available at most institutional offices of sponsored research and may be obtained from the Grants Information Office, Office of Extramural Outreach and Information Resources, National Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, telephone 301/435-0715, Email: asknih@odrockm1.od.nih.gov. The title and number of the program announcement must be typed in section 2 on the face page of the application. Applications for the FIRST award (R29) must include at least three sealed letters of reference attached to the face page of the original application. FIRST award (R29) applications submitted without the required number of reference letters will be considered incomplete and will be returned without review. The completed original application and five legible copies must be sent or delivered to: DIVISION OF RESEARCH GRANTS NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC 7710 BETHESDA, MD 20892-7710 BETHESDA, MD 20817-7710 (for express/courier service) REVIEW CONSIDERATIONS Applications that are complete will be evaluated for scientific and technical merit by an appropriate peer review group convened in accordance with the standard NIH peer review procedures. As part of the initial merit review, all applications will receive a written critique and undergo a process in which only those applications deemed to have the highest scientific merit, generally the top half of the applications under review, will be discussed, assigned a priority score, and receive a second level review by the appropriate national advisory council. Review Criteria Criteria to be used in the scientific and technical merit review of alcohol research grant applications will include the following: 1. The scientific, technical, or medical significance and originality of the proposed research. 2. The appropriateness and adequacy of the experimental approach and methodology proposed to carry out the research. 3. The adequacy of the qualifications (including level of education and training) and relevant research experience of the principal investigator and key research personnel. 4. The availability of adequate facilities, general environment for the conduct of the proposed research, other resources, and collaborative arrangements necessary for the research. 5. The reasonableness of budget estimates and duration in relation to the proposed research. 6. Where applicable, the adequacy of procedures to protect or minimize effects on animal and human subjects and the environment. The review criteria for FIRST Awards (R29) are contained in the FIRST program announcement (revised February 1994). AWARD CRITERIA Applicatons will compete for available funds with all other approved applications. The following will be considered in making funding decisions: quality of the proposed project as etermined by peer review, availability of funds, and program priority. Applications assigned to the National Advisory Council on Alcohol Abuse and Alcoholism will be considered for funding on the basis of the overall scientific and technical merit of the application as determined by peer review, NIAAA programmatic needs and balance, and the availability of funds. Priority will be given to applications analyzing behavioral and neurochemical traits not yet subject to QTL analysis. Applicants desiring further information about funding priorities are encouraged to contact one of the persons listed under INQUIRIES. INQUIRIES The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding genetic aspects of proposed research to: Robert W. Karp, Ph.D. Division of Basic Research National Institute on Alcohol Abuse and Alcoholism Willco Building, Suite 402 6000 Executive Boulevard MSC 7003 Bethesda, MD 20892-7003 Telephone: (301) 443-4223 FAX: (301) 594-0673 Email: rkarp@willco.niaaa.nih.gov Direct inquiries regarding behavioral aspects of proposed research to: Ellen Witt, Ph.D. Division of Basic Research National Institute on Alcohol Abuse and Alcoholism Willco Building, Suite 402 6000 Executive Boulevard MSC 7003 Bethesda, MD 20892-7003 Telephone: (301) 443-4223 FAX: (301) 594-0673 Email: ewitt@willco.niaaa.nih.gov Direct inquiries regarding fiscal matters to: Linda Hilley Office of Planning and Resource Management National Institute on Alcohol Abuse and Alcoholism Willco Building, Suite 504 6000 Executive Boulevard MSC 7003 Bethesda, MD 20892-7003 Telephone: (301) 443-4703 FAX: (301) 443-3891 Email: lhilley@willco.niaaa.nih.gov AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance, No. 93.273. Awards are made under the authorization of the Public Health Service Act, Sections 301 and 464H, and administered under the PHS policies and Federal Regulations at Title 42 CFR Part 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency Review. The PHS strongly encourages all grant recipients to provide a smoke-free workplace and promote the non-use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people. References Aston CE, Hill SY (1990): Segregation analysis of alcoholism in families ascertained through a pair of male alcoholics. Am J Hum Genet 46:879- 887. Babor TF, Hofmann M, DelBoca FK, Hesselbrock V, Meyer RE, Dolinsky ZS, Rounsaville B (1992): Types of alcoholics, I. Evidence for an empirically derived typology based on indicators of vulnerability and severity. Arch Gen Psychiatry 49:599-608. Benjamin J, Li L, Patterson C, Greenberg BD, Murphy DL, Hamer DH (1996): Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking. Nature Genetics 12:81-84. Brain PF, Miras RL, Berry MS (1993): Diversity of animal models of aggression: their impact on the putative alcohol/aggression link. J Stud Alc Supp No. 11, pp. 140-145. Brown DM, Provoost AP, Daly MJ, Lander ES, Jacob HJ (1996): Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. Nature Genetics 12:44-51. Brown MR, Koob GF, Rivier C (1991): Stress: Neurobiology and Neuroendocrinology. New York: Marcel Dekker. Cairns RB, MacCombie DJ, Hood KE (1983): A developmental-genetic analysis of aggressive behavior in mice: I. Behavioral outcomes. J Comp Psych 97:69-89. Cloninger CR, Bohman M, Sigvardsson (1981): Inheritance in alcohol abuse. Arch Gen Psychiatry 38:861-868. Cloninger CR (1987): Neurogenetic adaptive mechanisms in alcoholism. Science 236:410-416. Cotton NS (1979): The familial incidence of alcoholism. J Stud Alcohol 40:89-116. Crabbe JC, Belknap JK, Buck KJ (1994a): Genetic animal models of alcohol and drug abuse. Science 264:1715-1723. Crabbe JC, Belknap JK, Mitchell SR, Crawshaw LI (1994b): QTL mapping of genes influencing sensitivity and tolerance to ethanol hypothermia in mice. Alcohol Clin Exp Res 18:451, abstract no. 191. Crawley JN (1985) Exploratory behavior models of anxiety in mice. Neurosci Biobehav Rev 9:37-44. Cunningham CL (1995): Localization of genes influencing ethanol-induced conditioned place preference and locomotor activity in BXD recombinant inbred mice. Psychopharmacology (Berl) 120:28-41. Dietrich WF, Copeland NG, Gilbert DJ, Miller JC, Jenkins NA, Lander ES (1995): Mapping the mouse genome: current status and future prospects. Proc Natl Acad Sci USA 92:10849-10853. Galli J, Li LS, Glaser A, Ostenson CG, Jiao H, Fakhrai-Rad H, Jacob HJ, Lander ES, Luthman H (1996): Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nature Genetics 12:31-37. Gauguier D, Froguel P, Parent V, Bernard C, Bihoreau MT, Portha B, James MR, Penicaud L, Lathrop M, Ktorza A (1996): Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat. Nature Genetics 12:38-43. Heilig M, Koob GF, Ekman R, Britton KT (1994): Corticotropin-releasing factor and neuropeptide Y: role in emotional integration. Trends Neurosci 17:80-85. Hiltunen AJ, Jarbe TUC (1992): Acute and chronic ethanol tolerance: operant behavior in naive and ethanol tolerant rats. Psychopharmacology 107:511-516. Jansen RC, Stam P (1994): High resolution of quantitative traits into multiple loci via interval mapping. Genetics 136:1447-1455. Jacob HJ, Brown DM, Bunker RK, Daly MJ, Dzau VJ, Goodman A, Koike G, Kren V, Kurtz T, Lernmark A, et al. (1995): A genetic linkage map of the laboratory rat, Rattus norvegicus. Nature Genetics 9:63-69. Kendler KS, Heath AC, Neale MC, Kessler RC, Eaves LJ (1992): A population-based twin study of alcoholism in women. JAMA 268:1877-1882. Kolb B (1984): Functions of the frontal cortex of the rat: a comparative review. Brain Res Rev 8:65-98. Le AD, Mana M, Quan B, Kalant H (1992): Differential development of acute tolerance to the motor impairment and anticonvulsant effects of ethanol. Psychopharmacology 109:107-111. LeBlanc AE, Kalant H, Gibbins RJ (1975): Acute tolerance to ethanol in the rat. 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Newlin DB, Thomson JB (1990): Alcohol challenge with sons of alcoholics: a critical review and analysis. Psychological Bulletin 108:383-402. Pohorecky LA (1990): Interaction of ethanol and stress: research with experimental animals -- an update. Alcohol Alcoholism 25:263-276. Risinger FO, Cunningham CL (1994): Identification of genetic markers associated with sensitivity to ethanol-induced conditioned taste aversion. Alcohol Clin Exp Res 18:451, abstract no. 187. Rowe D, Plomin R (1977): Temperament in early childhood. J Pers Assess 41:150-156. Sakurai Y, Sugimoto S (1985): Effects of lesions of prefrontal cortex and dorsomedial thalamus on delayed go/no-go alternation in rats. Behav Brain Res 17:213-219. Sher KJ (1991): Children of Alcoholics. Chicago: University of Chicago Press. Schuckit MA (1980): Self-rating of alcohol intoxication by young men with and without family histories of alcoholism. J Stud Alcohol 41:242- 249. 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From owner-sci-resources@net.bio.net Tue Jun 11 23:00:00 1996 Path: biosci!biosci!not-for-mail From: BIOSCI Administrator Newsgroups: bionet.sci-resources Subject: NIH GUIDE - PA-96-056 - V25(18) 06/07/96 Date: 11 Jun 1996 21:16:50 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 353 Sender: daemon@net.bio.net Approved: biosci-help@net.bio.net Distribution: world Message-ID: <4plgbi$9ki@net.bio.net> NNTP-Posting-Host: net.bio.net $$XID RFA PA96056 PA-96-056 P1O1 *************************************** POSTDOCTORAL TRAINING IN COMPLEMENTARY/ALTERNATIVE MEDICINE NIH GUIDE, Volume 25, Number 18, June 7, 1996 PA NUMBER: PA-96-056 P.T. 44; K.W. 0720005, 0710030 Office of Alternative Medicine National Institutes of Health Application Receipt Dates: April 5, August 5, and December 5 PURPOSE The Office of Alternative Medicine (OAM) is planning to fund, through the various Institutes and Centers at the National Institutes of Health (NIH), National Research Service Award (NRSA) individual postdoctoral fellowships (F32). The purpose is to provide a cadre of investigators capable of conducting systematic studies on safety, efficacy, cost-effectiveness, or mechanisms of action of unconventional methods for treating major diseases and promoting well-being. This training is expected to attract postdoctoral candidates who are in the early stages of their careers. They will have obtained expertise in conventional research methodology and some familiarity with/or interest in alternative medical procedures. Prospective trainees will be expected to form an alliance with established researchers to provide a mutual learning experience. This program announcement (PA) on Alternative Medicine is based on a larger, NIH-wide PA on NRSA Individual Postdoctoral Fellowships, which should be requested from the contact person listed under INQUIRIES. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This PA, Postdoctoral Training in Complementary/Alternative Medicine, is related to the priority area of complementary and alternative medicine. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0 or Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-512-1800). ELIGIBILITY REQUIREMENTS Individuals must be citizens or noncitizen nationals of the United States, or have been lawfully admitted to the U.S. for permanent residence (i.e., in possession of a currently valid Alien Registration Receipt Card 1-551 or in possession of other legal verification of such status.) Prior to beginning the award the applicant must have received a Ph.D., M.D., D.O., D.D.S., D.V.M., O.D., D.P.M., Sc.D., Eng.D, Dr. P.H., D.N.S., D.Pharm., D.S.W., or D.Psy. or equivalent doctoral degree from an accredited domestic or foreign institution. Before submitting a fellowship application, the applicant must arrange for appointment to an accredited university, hospital, or other institution with research facilities including staff for postdoctoral training. This may include institutions that train in areas such as acupuncture, naturopathy or homeopathy that are outside conventional medicine. The candidate must be accepted by a sponsor who will actively supervise the training. The sponsor must have research experience in clinical medicine and/or basic pre-clinical research along with an involvement in the evaluation of alternative medicine. Thus, the sponsor must be qualified to supervise in the application of rigorous study design to the assessment of individual alternative therapies. Because of the novelty of some procedures, it is recognized that the sponsor may not have reached the level of "senior" investigator in a particular field of alternative medicine. The Office of Alternative Medicine has recently funded ten clinical research centers in complementary/alternative medicine. Prospective post-doctoral applicants may wish to contact one or more of these centers to learn if suitable training opportunities exist. The list of these centers can be found at the end of this program announcement. Applicants proposing training at their doctorate institution or at the institution where they have been training for more than a year must document thoroughly the opportunity for new training experiences that will increase their scientific background relating to Alternative Medicine. MECHANISM OF SUPPORT The mechanism of support is the Individual National Research Service Award (F32). Individuals may request up to 3 years of aggregate NRSA support at the postdoctoral level. The stipend level for the first year of NRSA support is determined by the number of years of relevant postdoctoral experience at the time the award is issued. The range of support is from $18,600 (less than l full year of experience) to $32,300 (7 or more years of experience). Relevant experience includes research experience, teaching, internship, residency, and clinical duties. Supplementation, when provided, must not require obligation from the fellow. Under no circumstances may PHS grant funds be used for supplementation. NIH will provide an institutional allowance of $3,000 per 12-month period to non-Federal nonprofit sponsoring institutions to help defray such awardee expenses as research supplies, equipment, travel to scientific meetings, and related items. For individuals sponsored by Federal laboratories, or for-profit institutions, beginning with fellowship awards made in fiscal year 1997, the NIH will also provide funds to off-set the combined costs of tuition, fees, and health insurance. These funds will cover 100 percent of such combined costs up to $2,000 and 60 percent of such combined costs above $2,000. Fellows in the first twelve months of postdoctoral NRSA support will incur a service obligation of one month for each month of support. Additional information is contained in the NIH Guide, Vol 22, July 30, 1993. RESEARCH OBJECTIVES The OAM was established in 1992 to evaluate and determine the efficacy of various unconventional, alternative, and complementary medical practices. A recent survey demonstrated that as many as 34 percent of adults utilized at least one alternative therapy for the treatment of a serious or bothersome medical condition during the previous year (Eisenberg, D. et al, New England J. Med. 328: 246-252, 1993). The cost for services provided by alternative practitioners is estimated to be more than $13 billion a year. Many of these interventions have not, however, been subjected to scientific scrutiny using conventional research methods. Existing research in this area is limited by a paucity of well designed trials, and there are few research databases which allow for systematic review or meta-analysis of treatment efficacy. OAM feels that it is important to better understand if any of these therapies benefit the patients that use them. Unconventional practices include medical interventions that are not widely taught at medical schools or are not generally available at hospitals within the United States. For the most part, such treatments are not reimbursable by third party (insurance companies) payers. Examples of areas of interest include, but are not limited to: acupuncture; homeopathy; structural manipulation including chiropractic/massage; visual imagery, relaxation techniques, meditation, herbal therapies, or diet and life style. The OAM is especially interested in alternative procedures in the treatment of life threatening diseases, e.g., women's breast cancer, or HIV-AIDS, and cardiovascular problems the subsequent impact on either/and: a) course of disease; b) wellness/quality of life/ prevention; c) statistical/population disease trends; d) basic, pre-clinical biological systems. However, any particular health problem such as arthritis, depression, drug or alcohol addiction is acceptable. Research evaluating the use of alternative therapies in focused populations such as women, children and minorities is also encouraged. APPLICATION PROCEDURES Applicants must submit a completed Application for Public Health Service Individual National Research Service Award (PHS 416-1 rev. 8/95). Included with the application must be at least three letters of recommendation. Application kits are available at most institutional offices of sponsored research and may be obtained from the Office of Extramural Outreach and Information Resources, National Institutes of Health, 6701 Rockledge Drive, Room 6207, Bethesda, MD 20892, telephone (301) 435-0714, email: asknih@odrockmi.od.nih.gov. Applicants must carefully follow all instructions and mail the original and two copies of the completed application to: DIVISION OF RESEARCH GRANTS NATIONA INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE, ROOM 1040, MSC 7710 BETHESDA, MD 20892-7710 BETHESDA, MD 20817 (for express/courier service) Applicants and sponsoring institutions must comply with policies and procedures governing the protection of human subjects, the humane care and use of live vertebrate animals, and the inclusion of women and minorities in study populations. To identify the application as a response to this PA, enter PA-96- 056, and the title of this program announcement in item 3 on the face page of the application form. REVIEW CONSIDERATIONS Applications will be assigned on the basis of established PHS referral guidelines. The review criteria are: a) the applicant's academic preparation; b) the scientific merit of the proposed research including the clarification of treatment efficacy of a particular alternative medical procedure; c) training potential for the student; d) the training resources and environment, including the sponsor. A second level of review will be provided by a committee or staff from the relevant institute and the OAM. AWARD CRITERIA The following criteria will be used by the NIH in making awards: a) individual review group (IRG) recommendation of the overall merit of the application; b) relevance of the application to the research priorities and program balance of the institute and the OAM; c) availability of funds. INQUIRIES Written and telephone inquiries concerning this PA and requests for the F32 progran guidelines are encouraged. The opportunity to clarify any issue or question(s) from potential applicants is welcome. Direct inquiries regarding programmatic issues to: Dr. Richard L. Nahin Office of Alternative Medicine National Institutes of Health Building 31, Room 5B36 Bethesda, MD 20892 Telephone: (301) 496-4792 FAX: (301) 402-4741 Email: nahinr@od31em1.od.nih.gov AUTHORITY AND REGULATIONS NRSAs are made under the authority of Section 487 of the Public Health Service Act as amended (42 USC 288) and Title 42 of the Code of Federal Regulations, Part 66. Complementary and Alternative Medicine Research Centers Bastyr University, Center for CAM Research in HIV/AIDS Leanna J. Standish, N.D., Ph.D. (Principal Investigator) Director of Research Bastyr University 144 NE 54th Street Seattle, WA 98105 Telephone: (206) 517-3522 FAX: (206) 517-3599 Email: ljs@bastyr.edu Columbia University College of Physicians and Surgeons, Center for CAM Research in Women's Health Fredi Kronenberg, Ph.D. (Principal Investigator) Director, Richard and Hinda Rosenthal Center for Complementary and Alternative Medicine College of Physicians and Surgeons of Columbia University 630 West 168th Street New York, NY 10032 Telephone: (212) 305-4755 FAX: (212) 305-1495 Email: FK11@columbia.edu University of California Davis, Center for CAM Research in Asthma, Allergy and Immunology Merrill Eric Gershwin, M.D. (Principal Investigator) Jack and Donald Chia Professor of Medicine; Chief University of California, Davis Division of Rheumatology, Allergy, and Clinical Immunology, Department of Internal Medicine TB 192 Division of Rheumatology-Clinical Immunology Davis, CA 95616 Telephone: (916) 752-2884 FAX: (916) 752-4669 Email: megershwin@ucdavis.edu Harvard Medical School, Center for CAM Research in General Medical Conditions David M. Eisenberg, M.D. (Principal Investigator) Director, Center for Alternative Medicine Research Beth Israel Hospital and Harvard Medical School Department of Medicine 330 Brookline Avenue, LY-314 Boston, MA 02215 Telephone: (617) 667-3995 FAX: (617) 667-7070 Email: deisenbe@bih.harvard.edu Kessler Institute for Rehabilitation, Center for CAM Research in Stroke and Neurological Conditions Samuel C. Shiflett, Ph.D. (Principal Investigator) Director, Alternative Medicine Research Kessler Institute for Rehabilitation 1199 Pleasant Valley Way West Orange, NJ 07052 Telephone: (201) 243-6972 FAX: (201) 243-6984 Email: shiflesc@umdnj.edu University of Maryland, School of Medicine, Center for CAM Research in Pain Brian M. Berman, M.D. (Principal Investigator) University of Maryland Division of Complementary Medicine 2200 North Forest Park Kernan Hospital Mansion Baltimore, MD 21207-6697 Telephone: (410) 448-6871 FAX: (410) 448-6875 Email: bberman@umabnet.ab.umd.edu Minneapolis CAM Research Center, Center for CAM Research In Addictions Thomas J. Kiresuk, Ph.D. (Principal Investigator) Chief Clinical Psychologist, Professor of Health Psychology Hennepin County Medical Center and University of Minnesota Medical School Director, Program Evaluation Resource Center 914 South Eighth Street, Suite D917 Minneapolis, MN 55404 Telephone: (612) 337-7377 FAX: (612) 347-7669 Email: caamr@ulysses.net Stanford University, Center for CAM Research in Aging William L. Haskell, Ph.D. (Principal Investigator) Professor, School of Medicine Stanford University 730 Welch Road, Suite B Palo Alto, CA 94304-1583 Telephone: (415) 725-5012 FAX: (415) 723-7018 Email: haskell@scrdp.stanford.edu University of Texas Health, Science Center Center for CAM Research in Cancer Guy S. Parcel, Ph.D. (Principal Investigator) Professor and Director, Center for Health Promotion Research and Development The University of Texas, Houston P.O. Box 20186 Houston, TX 77225 Telephone: (713) 792-8547 FAX: (713) 794-1756 Email: guy@utsph.sph.uth.tmc.edu University of Virginia School of Nursing, Center for CAM Research in Pain Ann Gill Taylor, EdD. (Principal Investigator) Professor and Director, Center for the Study of Complementary and Alternative Therapies (CSAT) University of Virginia School of Nursing McLeod Hall 15th and Lane Street Charlottesville, VA 22903-3395 Telephone: (804) 924-0113 FAX: (804) 982-1809 Email: agt@Virginia.edu From owner-sci-resources@net.bio.net Tue Jun 11 23:00:00 1996 Path: biosci!biosci!not-for-mail From: BIOSCI Administrator Newsgroups: bionet.sci-resources Subject: NIH GUIDE - PA-96-055 - V25(18) 06/07/96 Date: 11 Jun 1996 21:15:13 -0700 Organization: BIOSCI International Newsgroups for Molecular Biology Lines: 316 Sender: daemon@net.bio.net Approved: biosci-help@net.bio.net Distribution: world Message-ID: <4plg8h$9d3@net.bio.net> NNTP-Posting-Host: net.bio.net $$XID RFA PA96055 PA-96-055 P1O1 *************************************** SMALL MOLECULE TRANSPORTER PROTEINS IN BLOOD, RENAL AND PROSTATE CELLS NIH GUIDE, Volume 25, Number 18, June 7, 1996 PA NUMBER: PA-96-055 P.T. 34; K.W. 0785070, 1002004, 0790005 National Institute of Diabetes and Digestive and Kidney Diseases PURPOSE The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through its Division of Kidney, Urologic and Hematologic Diseases, supports fundamental and applied research aimed at understanding the fundamental processes underlying the normal and pathologic function of blood cells and the blood forming system. Also supported is fundamental and applied research directed at normal renal structure, function and regulation. This includes studies utilizing whole kidney and/or the selected segments of the kidney or individual cells or any of their subcellular components as models. Urologic research is supported, including cellular and molecular approaches to the study of tissue-specific and cell-specific regulation of prostate growth. The ability to maintain a constant systemic environment is a critical requirement to maintain the normal health of an organ. At the cellular level, specific transport pathways maintain both the intracellular environment as well as providing the mechanisms that drive the maintenance of systemic balance. Cellular transport is mediated by specific membrane proteins. To understand the physiology and pathophysiology of homeostatic balance requires an understanding of how they are regulated. Methods for identifying and isolating the proteins or the genes for the proteins are available using contemporary cellular and molecular biological approaches. Such approaches have been used successfully to isolate a number of transporters from kidney, prostate, red blood cells, and other cells, making it possible to understand normal homeostatic mechanisms, as well as those leading to pathology of the homeostatic system. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0 or Summary Report: Stock No.017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-512-1800). ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic and foreign for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal government. Foreign institutions are not eligible for First Independent Research Support and Transition (FIRST) (R29) awards. Racial/ethnic minority individuals, women, and persons with disabilities are encouraged to apply as principal investigators. MECHANISM OF SUPPORT This PA will use the National Institutes of Health (NIH) individual research project grant (R01) and FIRST (R29) award mechanisms. Responsibility for planning, direction, and execution of the proposed project will be solely that of the applicant. Because the nature and scope of the research proposed in response to this PA may vary, it is anticipated that the size of an award will vary also; however, the support of requests exceeding the NIDDK average grant size of $160,000 direct cost for R01 grants would be unusual and require ample justification. FIRST (R29) awards are limited to $350,000 direct cost over the five year period. RESEARCH OBJECTIVES Examples of applications responsive to the announcement include: (1) development of integrated programs to study the structure and function of the different transport proteins that are expressed in the red cell, prostate, and the kidney; (2) molecular biological approaches to study tissue specific expression of the various isoforms of the proteins; (3) development of information on structural biology of the proteins; (4) immunochemical localization of different proteins in various blood, renal and prostatic cells; (5) functional analysis of the proteins using tissue-specific knockout strategies; (6) definition of mutations responsible for human diseases; (7) definition of the functional consequences of protein-protein interactions in the membrane, and of membrane protein-cytoskeletal interactions; (8) the study of lipid-protein interactions, such as membrane microdomains; and (9) the study of the regulation of transport protein function by accessory molecules that act as regulators of these transporters under various pathophysiological conditions. Fundamental information has been accumulated on the molecular architecture of the red cell membrane skeleton. It is becoming increasingly clear that red cell structural proteins and their isoforms are present in a wide variety of cells, including epithelial and endothelial cells. Knowledge of the dynamics of protein-protein interactions in the red cell membrane is likely to contribute to our understanding of the structure and function of plasma membranes of nucleated cells. Red cell blood group antigens are epitopes on membrane-spanning proteins whose functions may include anion exchange (Band 3--ABH antigens and Diego antigens), water transport (Colton antigens), urea transport (Kidd antigens), degradation of circulating peptide hormones (Kell antigens), removal of circulating chemokines (Duffy antigens), or possibly provision of structural supports for localized lipid environments (Rh antigens). Several of these proteins have been identified also in renal tubules. There also has been a recent rapid increase in information on the identification and isolation of small molecule t