John Budny describes the ideal animal model in which to study
human disease syndromes - using as an example the time course and
relative virulence of M.tuberculosis-induced disease in the
cynomolgus monkey as compared with the comparable response
characteristics of the rhesus monkey. If the response pattern to the
specific agent in the proposed animal model is closely similar to
that of humans in general, what better crterion is there for choice
of animal model?
Why should there be any question that the best animal models to
use in toxicology are those used in pharmacology and experimental
therapeutics? If the pharmacologic response is studied in one animal
model, the toxic responses to the samne agent should be studied in
the same animal model - else how can you know whether the toxic
responses to the same agent in a different animal model may not be due
to the effects of a different background genome?
Tel: (501) 543-7522
FAX: (501) 543-7635/7662
NCTR HFT-140
3900 NCTR Road
Jefferson, AR 72079-9502
