GWOLFF at NCTR.FDA.GOV ("George L. Wolff") wrote:
>Similarities of the time course of a disease in humans and in a
>proposed animal model for determining toxic effects of agents used
>to prevent/treat the human disease is an excellent criterion for a
>relevant animal model. The agent may induce toxic effects only at
>specific timepoints during progression of the disease - these might
>be missed if an animal model with a time course of the disease which
>is different than that in the human is used.
>>Do the differences between the time course of M.tuberculosis-induced
>disease in rhesus and cynomolgus monkeys actually define two
>DIFFERENT diseases? After all, the "disease" is really the toxic
>response to M.tuberculosis which appears to be different in the two
>species.
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>>
George,
Good question re "two different diseases". Perhaps that is actually was
what was observed - intersting thought. Also, your concept of "disease"
from M. tuberculosis and "disease" from a toxicant is an intersting way
of looking at it. Are there any comments from others out there?
John A. Budny
