Animal Models in Toxicology

Jason Ram ramjoshi at duke.usask.ca
Mon Feb 12 17:27:22 EST 1996

On 12 Feb 1996, DrJackBud wrote:

> Someone, anyone - help Whitehead and myself.  There must be a better
> reason for doing toxicological investigations and research other than for
> "regulatory authority demands".  Otherwise, why try to develop models?
> Some of you toxicologists surely must have some thoughts that would help
> Whithead and myself???

Well... animal models (e.g., in vitro studies) can help determine whether 
certain drugs are worthwhile pursuing as a course of treatment in various 
pathological conditions (e.g., cellular damage) brought about when the 
system is challenged by toxins (e.g., pesticides).  If data from the 
model shows good supporting evidence for the effectiveness of the drug 
against the toxin, then the drug can go to the next stage for testing 
and evaluation.  Animal models are useful as they usually give good 
preliminary indications whether a drug has the potential for its ultimate 
use in humans.  

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