(Fwd) Re: Animal Models in Toxicology

John Budny jabudny at earthlink.net
Sat Feb 17 13:03:54 EST 1996

It appears that you are refering to animal models as representatives for 
humans in describing and studing spontaneous or naturally occurring 
disease conditions.  Further it sounds as if your focus in the post was 
aimed at inborn-errors which resut in diseases.  Would what you're saying 
also apply to structural and functional damage caused by xenobiotic?  You 
said that models should not be based on phenotypical characteristics.  
That may be true if one is studying geniticaly-based diseases but I'm not 
so sure that such a broad statement is applicable if one wishes to 
examine the structural or tissue damage brought about by an insult from a 
chemical.  Phenotypic expression, especially involving the target organ 
of toxicity, seems to very important.

Does anyone else have any comments?

Maybe the question we need to address is "Why do we use/need animal 
models??????  I think I identified this as an important question in my 
original post that initiated this discussion (1Feb96): "Why do we use 
animals in toxicology (which may be related to the question: Why do we 
use animal models in biology?)"

I may be wrong, but I get the distinct impression that the comments in 
Wolff's post are directed at areas other than those which would have as 
an end-point (or at least a milestone) a dose response curve.  Does 
anyone else get thatis impression??????

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